{"id":"https://openalex.org/W1996650656","doi":"https://doi.org/10.3892/mmr.2015.3249","title":"Radix Dipsaci total saponins stimulate MC3T3-E1 cell differentiation via the bone morphogenetic protein-2/MAPK/Smad-dependent Runx2 pathway","display_name":"Radix Dipsaci total saponins stimulate MC3T3-E1 cell differentiation via the bone morphogenetic protein-2/MAPK/Smad-dependent Runx2 pathway","publication_year":2015,"publication_date":"2015-01-26","ids":{"openalex":"https://openalex.org/W1996650656","doi":"https://doi.org/10.3892/mmr.2015.3249","mag":"1996650656","pmid":"https://pubmed.ncbi.nlm.nih.gov/25625570"},"language":"en","primary_location":{"id":"doi:10.3892/mmr.2015.3249","doi":"https://doi.org/10.3892/mmr.2015.3249","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2015.3249","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2015.3249/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/mmr.2015.3249/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113753804","display_name":"Yinbo Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YIN-BO NIU","raw_affiliation_strings":["Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010674978","display_name":"Xianghe Kong","orcid":"https://orcid.org/0000-0002-2990-3313","observed_orcids":["https://orcid.org/0000-0002-2990-3313"]},"institutions":[{"id":"https://openalex.org/I25355098","display_name":"Chang'an University","ror":"https://ror.org/05mxya461","country_code":"CN","type":"education","lineage":["https://openalex.org/I25355098"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIANG-HE KONG","raw_affiliation_strings":["Graduate School of Chang'an University, Xi'an, Shaanxi 710064, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Chang'an University, Xi'an, Shaanxi 710064, P.R. China","institution_ids":["https://openalex.org/I25355098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008543831","display_name":"YU-HUA LI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YU-HUA LI","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100373603","display_name":"Fan Li","orcid":"https://orcid.org/0000-0003-3550-0243","observed_orcids":["https://orcid.org/0000-0003-3550-0243"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"LI FAN","raw_affiliation_strings":["Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100717342","display_name":"Yalei Pan","orcid":"https://orcid.org/0000-0002-3579-4395","observed_orcids":["https://orcid.org/0000-0002-3579-4395"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YA-LEI PAN","raw_affiliation_strings":["Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115588171","display_name":"Chenrui Li","orcid":"https://orcid.org/0009-0007-2361-7053","observed_orcids":["https://orcid.org/0009-0007-2361-7053"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CHEN-RUI LI","raw_affiliation_strings":["Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100687853","display_name":"Xianglong Wu","orcid":"https://orcid.org/0000-0002-0420-3118","observed_orcids":["https://orcid.org/0000-0002-0420-3118"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIANG-LONG WU","raw_affiliation_strings":["Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076639501","display_name":"Tingli Lu","orcid":"https://orcid.org/0000-0001-5860-098X","observed_orcids":["https://orcid.org/0000-0001-5860-098X"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"TING-LI LU","raw_affiliation_strings":["Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055309139","display_name":"Qibing Mei","orcid":"https://orcid.org/0000-0001-7460-5115","observed_orcids":["https://orcid.org/0000-0001-7460-5115"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"QI-BING MEI","raw_affiliation_strings":["Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, P.R. China","institution_ids":["https://openalex.org/I17145004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8076,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.68705647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"11","issue":"6","first_page":"4468","last_page":"4472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.041999999433755875,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.777999997138977},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.6899999976158142},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7630000114440918},{"id":"https://openalex.org/keywords/smad1-5-8","display_name":"Smad1/5/8","score":0.9509999752044678},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mc3t3-e1-cells","display_name":"MC3T3-E1 cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.847000002861023},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bone-mineralization","display_name":"bone mineralization","score":0.8519999980926514},{"id":"https://openalex.org/keywords/noggin","display_name":"noggin","score":0.890999972820282},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.5569999814033508},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.8820328116416931},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.7828043699264526},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.6390057802200317},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.6122333407402039},{"id":"https://openalex.org/C2778761762","wikidata":"https://www.wikidata.org/wiki/Q18252680","display_name":"Noggin","level":4,"score":0.6076743006706238},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.5872194766998291},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.5773173570632935},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5765920281410217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5302552580833435},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.49619799852371216},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.49105024337768555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4666072726249695},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4135516285896301},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39817675948143005},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3942027688026428},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.38761472702026367},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3717574179172516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36996883153915405},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20543020963668823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1354629099369049},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049851","descriptor_name":"Gastropoda","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049851","descriptor_name":"Gastropoda","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/mmr.2015.3249","doi":"https://doi.org/10.3892/mmr.2015.3249","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2015.3249","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2015.3249/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},{"id":"pmid:25625570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25625570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/mmr.2015.3249","doi":"https://doi.org/10.3892/mmr.2015.3249","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2015.3249","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2015.3249/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7863331812","display_name":null,"funder_award_id":"81202457","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321392","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1996650656.pdf","grobid_xml":"https://content.openalex.org/works/W1996650656.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1557285880","https://openalex.org/W1853548018","https://openalex.org/W1970867351","https://openalex.org/W1976969399","https://openalex.org/W1979208896","https://openalex.org/W1987381637","https://openalex.org/W1991110432","https://openalex.org/W1994738588","https://openalex.org/W2006950202","https://openalex.org/W2007218781","https://openalex.org/W2008131678","https://openalex.org/W2017549535","https://openalex.org/W2036920124","https://openalex.org/W2047947879","https://openalex.org/W2053708763","https://openalex.org/W2069668213","https://openalex.org/W2092233035","https://openalex.org/W2093101819","https://openalex.org/W2093271566","https://openalex.org/W2101408271","https://openalex.org/W2101785627","https://openalex.org/W2112407739","https://openalex.org/W2112725305","https://openalex.org/W2121848695","https://openalex.org/W2125272276","https://openalex.org/W2154771084","https://openalex.org/W4249057298","https://openalex.org/W4405993382"],"related_works":["https://openalex.org/W2053708763","https://openalex.org/W1980356900","https://openalex.org/W2028690318","https://openalex.org/W2370481188","https://openalex.org/W2351056385","https://openalex.org/W2995782051","https://openalex.org/W1729254075","https://openalex.org/W4313424915","https://openalex.org/W2994155035","https://openalex.org/W2356578124"],"abstract_inverted_index":{"Radix":[0,10],"Dipsaci":[1],"total":[2],"saponins":[3],"(RTS)":[4],"are":[5],"primary":[6],"active":[7],"components":[8],"of":[9,19,34,55,67,99,112,136,145],"Dipsaci,":[11],"which":[12],"is":[13],"administered":[14],"orally":[15],"for":[16,173],"the":[17,32,40,50,53,65,79,109,134,142],"treatment":[18],"osteoporosis":[20],"according":[21],"to":[22,30,57],"Chinese":[23],"Medicine.":[24],"RTS":[25,56,89,102,154],"have":[26],"also":[27],"been":[28],"shown":[29],"reduce":[31],"risk":[33],"bone":[35,113,175],"fractures":[36],"in":[37,71,108],"rats.":[38],"However,":[39],"detailed":[41],"molecular":[42,81],"mechanisms":[43],"underlying":[44],"their":[45],"action":[46],"remain":[47],"elusive.":[48],"In":[49,77],"present":[51],"study,":[52],"ability":[54],"increase":[58,107],"alkaline":[59],"phosphatase":[60],"activity,":[61],"osteocalcin":[62],"levels":[63,111,135,144],"and":[64,96,121,139,149,165],"degree":[66],"mineralization":[68],"was":[69,83,103],"investigated":[70],"MC3T3\u2011E1":[72],"mouse":[73],"osteoblast":[74],"precursor":[75],"cells.":[76],"addition,":[78],"associated":[80,104],"mechanism":[82],"detected.":[84],"The":[85],"results":[86],"revealed":[87],"that":[88,153,166],"exerted":[90],"an":[91,106],"effect":[92],"on":[93],"osteoblastic":[94,137,156],"maturation":[95],"differentiation.":[97],"Induction":[98],"differentiation":[100,138,157],"by":[101],"with":[105,130],"expression":[110,129,143],"morphogenetic":[114],"protein\u20112":[115],"(BMP\u20112),":[116],"phosphorylated":[117],"(P)\u2011Smad1/5/8,":[118],"P\u2011ERK1/2,":[119,147],"P\u2011p38":[120,148],"Runt\u2011related":[122],"transcription":[123],"factor":[124],"2":[125],"(Runx2).":[126],"Blocking":[127],"BMP\u20112":[128],"noggin":[131],"significantly":[132],"reduced":[133],"subsequently":[140],"attenuated":[141],"P\u2011Smad1/5/8,":[146],"Runx2.":[150],"This":[151],"indicated":[152],"induced":[155],"through":[158],"BMP\u20112/mitogen\u2011activated":[159],"protein":[160],"kinase/Smad1/5/8\u2011dependent":[161],"Runx2":[162],"signaling":[163],"pathways":[164],"it":[167],"may":[168],"be":[169],"a":[170],"promising":[171],"agent":[172],"enhancing":[174],"formation.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
