{"id":"https://openalex.org/W1996568795","doi":"https://doi.org/10.1002/tera.1420520204","title":"Physiologically based pharmacokinetics of methoxyacetic acid: Dose\u2013effect considerations in C57BL/6 mice","display_name":"Physiologically based pharmacokinetics of methoxyacetic acid: Dose\u2013effect considerations in C57BL/6 mice","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W1996568795","doi":"https://doi.org/10.1002/tera.1420520204","mag":"1996568795","pmid":"https://pubmed.ncbi.nlm.nih.gov/8588185"},"language":"en","primary_location":{"id":"doi:10.1002/tera.1420520204","doi":"https://doi.org/10.1002/tera.1420520204","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tera.1420520204","pdf_url":null,"source":{"id":"https://openalex.org/S4394736631","display_name":"Teratology","issn_l":"0040-3709","issn":["0040-3709","1096-9926"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057238207","display_name":"Ellen J. O\u2019Flaherty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen J. O'flaherty","raw_affiliation_strings":["Department of Environmental Health, University of Cincinnati College of Medicine, Ohio 45267, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati College of Medicine, Ohio 45267, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109943894","display_name":"Heinz Nau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heinz Nau","raw_affiliation_strings":["Institut fu\u0308r Toxikologie und Embryopharmakologie, Freie Universita\u0308t Berlin, D-14195, Berlin, Germany","Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, D\u201014195, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Toxikologie und Embryopharmakologie, Freie Universita\u0308t Berlin, D-14195, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Embryopharmakologie, Freie Universit\u00e4t Berlin, D\u201014195, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109078404","display_name":"David W. McCandless","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David McCandless","raw_affiliation_strings":["Department of Cell Biology and Anatomy, Chicago Medical School, North Chicago, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy, Chicago Medical School, North Chicago, Illinois 60064","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062360453","display_name":"Robert Pryor Beliles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P. Beliles","raw_affiliation_strings":["U.S. Environmental Protection Agency, Washington, D.C. 20460"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Environmental Protection Agency, Washington, D.C. 20460","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014522889","display_name":"Claire M. Schreiner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claire M. Schreiner","raw_affiliation_strings":["Division of Basic Science Research, Children's Hospital Research Foundation, Cincinnati, Ohio 45229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Science Research, Children's Hospital Research Foundation, Cincinnati, Ohio 45229","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103548077","display_name":"William J. Scott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"William J. Scott","raw_affiliation_strings":["Division of Basic Science Research, Children's Hospital Research Foundation, Cincinnati, Ohio 45229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Science Research, Children's Hospital Research Foundation, Cincinnati, Ohio 45229","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103548077"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2662,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.78035853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"52","issue":"2","first_page":"78","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methoxyacetic-acid","display_name":"methoxyacetic acid","score":1.0},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.6759999990463257},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tissue-ph","display_name":"tissue pH","score":0.8429999947547913},{"id":"https://openalex.org/keywords/pka","display_name":"pKa","score":0.8299999833106995},{"id":"https://openalex.org/keywords/physiologically-based-pharmacokinetic-model","display_name":"physiologically based pharmacokinetic modeling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5839999914169312},{"id":"https://openalex.org/keywords/area-under-the-curve","display_name":"area under the curve","score":0.7620000243186951},{"id":"https://openalex.org/keywords/protein-binding","display_name":"protein binding","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tissue-localization","display_name":"tissue localization","score":0.5479999780654907},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C2779906218","wikidata":"https://www.wikidata.org/wiki/Q7834818","display_name":"Transplacental","level":5,"score":0.7954078912734985},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7082139253616333},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6404309868812561},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6135615110397339},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.48216456174850464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4670884311199188},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.43325120210647583},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43221527338027954},{"id":"https://openalex.org/C2777928079","wikidata":"https://www.wikidata.org/wiki/Q2677027","display_name":"Rat\u00f3n","level":2,"score":0.42723965644836426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4119478464126587},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4044474959373474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3716903626918793},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.37099018692970276},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.28978195786476135},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2715792953968048},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16850683093070984},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12068521976470947},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0918470025062561}],"mesh":[{"descriptor_ui":"D000014","descriptor_name":"Abnormalities, Drug-Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008431","descriptor_name":"Maternal-Fetal Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018878","descriptor_name":"Limb Buds","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018878","descriptor_name":"Limb Buds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/tera.1420520204","doi":"https://doi.org/10.1002/tera.1420520204","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tera.1420520204","pdf_url":null,"source":{"id":"https://openalex.org/S4394736631","display_name":"Teratology","issn_l":"0040-3709","issn":["0040-3709","1096-9926"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratology","raw_type":"journal-article"},{"id":"pmid:8588185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8588185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306107","display_name":"U.S. Environmental Protection Agency","ror":"https://ror.org/03tns0030"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1810449496","https://openalex.org/W1969386360","https://openalex.org/W1974138916","https://openalex.org/W1994913657","https://openalex.org/W1997119631","https://openalex.org/W2003683923","https://openalex.org/W2011077582","https://openalex.org/W2015904774","https://openalex.org/W2017302789","https://openalex.org/W2027371120","https://openalex.org/W2041024806","https://openalex.org/W2048404424","https://openalex.org/W2053868673","https://openalex.org/W2054938160","https://openalex.org/W2070677797","https://openalex.org/W2093823226","https://openalex.org/W2096120477","https://openalex.org/W2128229492","https://openalex.org/W2155615078","https://openalex.org/W2165283513","https://openalex.org/W2258871915","https://openalex.org/W2415149616","https://openalex.org/W2487860174","https://openalex.org/W4235819947"],"related_works":["https://openalex.org/W1966718689","https://openalex.org/W2048404424","https://openalex.org/W2924929601","https://openalex.org/W2023925261","https://openalex.org/W2093823226","https://openalex.org/W2013088639","https://openalex.org/W1986973582","https://openalex.org/W2017873472","https://openalex.org/W3029160943","https://openalex.org/W2055596045"],"abstract_inverted_index":{"Methoxyacetic":[0],"acid":[1,5,36],"(MAA),":[2],"a":[3,7,68,80,99,168,324],"weak":[4,21],"with":[6,181,243,257],"pKa":[8,33,178],"of":[9,20,34,41,72,109,130,145,158,161,167,220,233,248,276,280,327,339],"3.57,":[10],"was":[11,121,152,205,254,264,301],"used":[12],"to":[13,47,95,118,137,208,213,236,286,304],"test":[14],"the":[15,32,35,38,142,146,159,185,244,251,258,268,274,277,281,290,293,312,343],"broad":[16],"hypothesis":[17],"that":[18,272],"distribution":[19,160],"acids":[22],"in":[23,64,78,84,88,111,195,226,267],"maternal":[24,112,197,209,294],"and":[25,37,43,46,75,107,113,176,191,198,217,314],"fetal":[26],"tissues":[27,200],"is":[28,273,347],"determined":[29,153],"principally":[30],"by":[31,154,311,342],"pH":[39,110,174,259],"values":[40,175],"tissue":[42,49,104,173,227,239],"fluid":[44],"compartments":[45,115],"examine":[48],"dose-teratogenesis":[50,56],"relationships,":[51],"as":[52,54,289,345],"well":[53,180],"administered":[55,122,305],"relationships.":[57],"Five":[58],"related":[59,94],"experimental":[60],"studies":[61,317],"were":[62,93,201,231,318],"conducted":[63],"pregnant":[65],"C57BL/6CrIBR":[66],"mice:":[67],"conventional":[69],"dose-response":[70,82,316],"study":[71,83],"developmental":[73],"toxicity":[74],"transplacental":[76],"pharmacokinetics":[77],"mice,":[79],"second":[81],"which":[85],"reproductive":[86],"outcomes":[87],"litters":[89],"from":[90,135],"individual":[91,96,315],"dams":[92],"pharmacokinetic":[97],"behavior,":[98],"protein-binding":[100],"experiment,":[101],"an":[102,148],"embryo":[103,297],"localization":[105],"study,":[106],"determination":[108],"embryonic":[114,199,214],"after":[116],"exposure":[117,285],"MAA.":[119,163],"MAA":[120,149,177,204,221,249,262,329],"intraperitoneally":[123],"at":[124,132,184,189,336],"9:00":[125],"a.m.":[126],"on":[127],"day":[128],"10":[129],"gestation,":[131],"doses":[133,219,338],"ranging":[134],"88":[136],"164":[138],"mg/kg.":[139],"Localization":[140],"within":[141,250],"forelimb":[143,252],"bud":[144,253],"embryo,":[147],"target":[150],"site,":[151],"computerized":[155],"image":[156],"analysis":[157],"radiolabeled":[162],"The":[164],"kinetic":[165],"predictions":[166],"physiologically":[169],"based":[170],"model":[171,344],"incorporating":[172],"agreed":[179],"observed":[182],"concentrations":[183,194,240,245],"lowest":[186],"dose.":[187],"However,":[188],"intermediate":[190],"higher":[192,218],"doses,":[193],"both":[196],"consistently":[202],"underestimated.":[203],"bound":[206],"neither":[207],"plasma":[210,295],"proteins":[211],"nor":[212],"proteins.":[215],"Intermediate":[216],"caused":[222],"dose-dependent":[223],"transient":[224],"depressions":[225],"pH,":[228],"but":[229,261,307],"these":[230],"not":[232,265,302],"sufficient":[234],"duration":[235],"bring":[237],"predicted":[238,335],"into":[241],"congruence":[242],"observed.":[246],"Distribution":[247],"broadly":[255],"consistent":[256],"hypothesis,":[260],"concentration":[263,298],"increased":[266],"distal":[269],"postaxial":[270],"sector":[271],"site":[275],"precursor":[278],"cells":[279],"missing":[282],"digits.":[283],"Internal":[284],"MAA,":[287],"defined":[288],"area":[291],"under":[292],"or":[296],"curve":[299],"(AUC),":[300],"proportional":[303],"dose,":[306,330],"AUC-response":[308],"relationships":[309],"generated":[310],"group":[313],"comparable.":[319],"While":[320],"AUC":[321],"may":[322],"be":[323,333],"useful":[325],"measure":[326],"effective":[328],"it":[331,346],"cannot":[332],"accurately":[334],"teratogenic":[337],"this":[340],"agent":[341],"presently":[348],"structured.":[349]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}