{"id":"https://openalex.org/W1996563532","doi":"https://doi.org/10.3109/00365529309096085","title":"Comparison between the Lactulose/Mannitol and51Cr-Ethylenediaminetetraacetic Acid/14C-Mannitol Methods for Intestinal Permeability Frequency Distribution Pattern and Variability of Markers and Marker Ratios in Healthy Subjects","display_name":"Comparison between the Lactulose/Mannitol and51Cr-Ethylenediaminetetraacetic Acid/14C-Mannitol Methods for Intestinal Permeability Frequency Distribution Pattern and Variability of Markers and Marker Ratios in Healthy Subjects","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W1996563532","doi":"https://doi.org/10.3109/00365529309096085","mag":"1996563532","pmid":"https://pubmed.ncbi.nlm.nih.gov/8446853"},"language":"en","primary_location":{"id":"doi:10.3109/00365529309096085","doi":"https://doi.org/10.3109/00365529309096085","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365529309096085","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109182729","display_name":"Lars Blomquist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"L. Blomquist","raw_affiliation_strings":["Dept. of Internal Medicine, Karolinska Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine, Karolinska Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034646164","display_name":"Tor H. Bark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"T. Bark","raw_affiliation_strings":["Depts. of Internal Medicine Surgery, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depts. of Internal Medicine Surgery, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048862904","display_name":"Gunilla Hedenborg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"G. Hedenborg","raw_affiliation_strings":["Depts. of Internal Medicine Surgery, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depts. of Internal Medicine Surgery, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007659358","display_name":"Torgny Svenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"T. Svenberg","raw_affiliation_strings":["Depts. of Internal Medicine Surgery, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depts. of Internal Medicine Surgery, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111811141","display_name":"A. Norman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A. Norman","raw_affiliation_strings":["Depts. of Internal Medicine Surgery, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depts. of Internal Medicine Surgery, and Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1335113835"],"apc_list":null,"apc_paid":null,"fwci":1.3768,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.80462891,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"28","issue":"3","first_page":"274","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.027400000020861626,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lactulose-mannitol-test","display_name":"lactulose/mannitol test","score":0.9549999833106995},{"id":"https://openalex.org/keywords/51cr-edta","display_name":"51Cr-EDTA","score":0.9160000085830688},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.703000009059906},{"id":"https://openalex.org/keywords/paracellular-permeability","display_name":"paracellular permeability","score":0.7760000228881836},{"id":"https://openalex.org/keywords/transcellular-permeability","display_name":"transcellular permeability","score":0.9980000257492065},{"id":"https://openalex.org/keywords/test-variability","display_name":"test variability","score":0.8410000205039978},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C2778445172","wikidata":"https://www.wikidata.org/wiki/Q407646","display_name":"Mannitol","level":2,"score":0.7502110004425049},{"id":"https://openalex.org/C2777448540","wikidata":"https://www.wikidata.org/wiki/Q422689","display_name":"Lactulose","level":2,"score":0.7265874147415161},{"id":"https://openalex.org/C2778973965","wikidata":"https://www.wikidata.org/wiki/Q408032","display_name":"Ethylenediaminetetraacetic acid","level":3,"score":0.6296912431716919},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5485997796058655},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.4691409468650818},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3985429108142853},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3223828673362732},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25226545333862305},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.1119106113910675},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.10109645128250122},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.07303830981254578}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D002860","descriptor_name":"Chromium Radioisotopes","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004492","descriptor_name":"Edetic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007792","descriptor_name":"Lactulose","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008353","descriptor_name":"Mannitol","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/00365529309096085","doi":"https://doi.org/10.3109/00365529309096085","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365529309096085","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:8446853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8446853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of gastroenterology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W99073066","https://openalex.org/W185696709","https://openalex.org/W1525871018","https://openalex.org/W1578437695","https://openalex.org/W1974431974","https://openalex.org/W1984910349","https://openalex.org/W1985739635","https://openalex.org/W1986300628","https://openalex.org/W2002214015","https://openalex.org/W2014068568","https://openalex.org/W2050647698","https://openalex.org/W2059218077","https://openalex.org/W2059958969","https://openalex.org/W2061679773","https://openalex.org/W2064048008","https://openalex.org/W2068040556","https://openalex.org/W2077198680","https://openalex.org/W2077366871","https://openalex.org/W2085985715","https://openalex.org/W2137014515","https://openalex.org/W2285643986","https://openalex.org/W2984066251"],"related_works":["https://openalex.org/W99073066","https://openalex.org/W2048594818","https://openalex.org/W2354162615","https://openalex.org/W2968220644","https://openalex.org/W2363701861","https://openalex.org/W2285149803","https://openalex.org/W2141669676","https://openalex.org/W1543491318","https://openalex.org/W2134296999","https://openalex.org/W2068040556"],"abstract_inverted_index":{"Urinary":[0],"excretion":[1,33,48,106,115,181],"of":[2,14,22,41,55,73,79,179,188],"lactulose":[3,51,64,103,123],"and":[4,18,37,52,67,104,110,113,126,135,166],"mannitol,":[5],"determined":[6,144],"by":[7,184],"gas-liquid":[8],"chromatography,":[9],"was":[10,83,100,139,154,182],"compared":[11],"with":[12],"that":[13],"51Cr-ethylenediaminetetraacetic":[15],"acid":[16],"(EDTA)":[17],"14C-mannitol":[19,70,114,129],"for":[20,35,50,90,141,147,156,161,167,173],"measurement":[21],"intestinal":[23],"permeability":[24],"in":[25,94,191],"28":[26],"healthy":[27],"humans.":[28],"The":[29],"0-":[30],"to":[31,65,69,86,124,128],"6-h":[32],"values":[34,49],"unlabelled":[36],"labelled":[38],"mannitol":[39,66,112,125,180,190],"(marker":[40],"transcellular":[42,75,164,175],"permeability)":[43,57],"were":[44,58,62],"normally":[45],"distributed,":[46,60],"whereas":[47],"51Cr-EDTA":[53,68,105,127],"(markers":[54],"paracellular":[56,81,158],"skewly":[59],"as":[61],"the":[63,74,80,122,148,162,174,185,192],"ratios.":[71],"Excretion":[72],"markers":[76,82],"but":[77,119],"not":[78,120],"significantly":[84],"correlated":[85],"urinary":[87,91],"volume;":[88],"correction":[89],"volume":[92],"resulted":[93],"decreased":[95],"test":[96,137],"variability.":[97],"Significant":[98],"correlation":[99],"found":[101],"between":[102,111,121],"(p":[107,116,131],"<":[108,117],"0.01)":[109],"0.001)":[118],"ratios":[130],"=":[132],"0.11).":[133],"Inter-":[134],"intraindividual":[136],"variability":[138,153],"greater":[140,155],"each":[142,157,168],"chemically":[143],"marker":[145,159,165,170,176],"than":[146,160,172],"corresponding":[149,163],"isotope-labelled":[150],"marker.":[151],"Similarly,":[152],"paracellular/transcellular":[169],"ratio":[171],"alone.":[177],"Variability":[178],"increased":[183],"frequent":[186],"presence":[187],"food-derived":[189],"urine.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}