{"id":"https://openalex.org/W1996546697","doi":"https://doi.org/10.1016/s1567-5769(02)00083-8","title":"Expression of c-fos, rather than c-jun or glucocorticoid-receptor mRNA, correlates with decreased glucocorticoid response of peripheral blood mononuclear cells in asthma","display_name":"Expression of c-fos, rather than c-jun or glucocorticoid-receptor mRNA, correlates with decreased glucocorticoid response of peripheral blood mononuclear cells in asthma","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W1996546697","doi":"https://doi.org/10.1016/s1567-5769(02)00083-8","mag":"1996546697","pmid":"https://pubmed.ncbi.nlm.nih.gov/12400872"},"language":"en","primary_location":{"id":"doi:10.1016/s1567-5769(02)00083-8","doi":"https://doi.org/10.1016/s1567-5769(02)00083-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1567-5769(02)00083-8","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089006067","display_name":"Eriko Takahashi","orcid":"https://orcid.org/0000-0002-2046-7180","observed_orcids":["https://orcid.org/0000-0002-2046-7180"]},"institutions":[{"id":"https://openalex.org/I149964584","display_name":"Tokyo University of Pharmacy and Life Sciences","ror":"https://ror.org/057jm7w82","country_code":"JP","type":"education","lineage":["https://openalex.org/I149964584"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eriko Takahashi","raw_affiliation_strings":["Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, Japan","Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, Japan","institution_ids":["https://openalex.org/I149964584"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan)","institution_ids":["https://openalex.org/I149964584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017611425","display_name":"Kenji Onda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149964584","display_name":"Tokyo University of Pharmacy and Life Sciences","ror":"https://ror.org/057jm7w82","country_code":"JP","type":"education","lineage":["https://openalex.org/I149964584"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kenji Onda","raw_affiliation_strings":["Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan","institution_ids":["https://openalex.org/I149964584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040543323","display_name":"Toshihiko Hirano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149964584","display_name":"Tokyo University of Pharmacy and Life Sciences","ror":"https://ror.org/057jm7w82","country_code":"JP","type":"education","lineage":["https://openalex.org/I149964584"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiko Hirano","raw_affiliation_strings":["Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan","institution_ids":["https://openalex.org/I149964584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111867350","display_name":"Kitaro Oka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149964584","display_name":"Tokyo University of Pharmacy and Life Sciences","ror":"https://ror.org/057jm7w82","country_code":"JP","type":"education","lineage":["https://openalex.org/I149964584"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kitaro Oka","raw_affiliation_strings":["Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan","institution_ids":["https://openalex.org/I149964584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001588693","display_name":"\u6559\u9686 \u4e38\u5ca1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noritaka Maruoka","raw_affiliation_strings":["3rd Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008772976","display_name":"M Tsuyuguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miyako Tsuyuguchi","raw_affiliation_strings":["3rd Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028273614","display_name":"Yasuhiro Matsumura","orcid":"https://orcid.org/0000-0003-4331-8177","observed_orcids":["https://orcid.org/0000-0003-4331-8177"]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Matsumura","raw_affiliation_strings":["3rd Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070646188","display_name":"Tomoyuki Niitsuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Niitsuma","raw_affiliation_strings":["3rd Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103639840","display_name":"Tohru Hayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Hayashi","raw_affiliation_strings":["3rd Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017611425"],"corresponding_institution_ids":["https://openalex.org/I149964584"],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":null,"fwci":0.7211,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.73923038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"10","first_page":"1419","last_page":"1427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.041099999099969864,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-resistance","display_name":"glucocorticoid resistance","score":0.9629999995231628},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9179999828338623},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.949999988079071},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glucocorticoid-receptor-alpha","display_name":"glucocorticoid receptor alpha","score":0.9070000052452087},{"id":"https://openalex.org/keywords/glucocorticoid-receptor-beta","display_name":"glucocorticoid receptor beta","score":0.9980000257492065},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":0.9129999876022339},{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":1.0},{"id":"https://openalex.org/keywords/glucocorticoid-response","display_name":"glucocorticoid response","score":0.8259999752044678},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.7490000128746033},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.7847862243652344},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.780904233455658},{"id":"https://openalex.org/C2780372218","wikidata":"https://www.wikidata.org/wiki/Q417222","display_name":"Methylprednisolone","level":2,"score":0.7440229654312134},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.7084474563598633},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.6691891551017761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5652171969413757},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5529711246490479},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.48749780654907227},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.46967846155166626},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.4673604965209961},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46384575963020325},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4212169945240021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4206653833389282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4025774300098419},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3752131462097168},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1403060257434845},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05864974856376648}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016758","descriptor_name":"Genes, jun","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016762","descriptor_name":"Genes, fos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1567-5769(02)00083-8","doi":"https://doi.org/10.1016/s1567-5769(02)00083-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1567-5769(02)00083-8","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},{"id":"pmid:12400872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12400872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8816624883","display_name":null,"funder_award_id":"09672337","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1517035469","https://openalex.org/W1745264954","https://openalex.org/W1968671826","https://openalex.org/W1969304196","https://openalex.org/W1974791065","https://openalex.org/W1982453454","https://openalex.org/W1996401609","https://openalex.org/W1998304198","https://openalex.org/W2001914805","https://openalex.org/W2005193871","https://openalex.org/W2007169317","https://openalex.org/W2029045019","https://openalex.org/W2032543151","https://openalex.org/W2043559115","https://openalex.org/W2048445979","https://openalex.org/W2054197433","https://openalex.org/W2060037483","https://openalex.org/W2064033395","https://openalex.org/W2065596872","https://openalex.org/W2081068229","https://openalex.org/W2094699273","https://openalex.org/W2109810111","https://openalex.org/W2123562583","https://openalex.org/W2146101502","https://openalex.org/W2147533486","https://openalex.org/W2155280531","https://openalex.org/W2158717799","https://openalex.org/W2167083884","https://openalex.org/W2171589499","https://openalex.org/W2183263828","https://openalex.org/W2328990695"],"related_works":["https://openalex.org/W2070036625","https://openalex.org/W2011307440","https://openalex.org/W1968671826","https://openalex.org/W2048445979","https://openalex.org/W2068469647","https://openalex.org/W2002245140","https://openalex.org/W2044005758","https://openalex.org/W6964350607","https://openalex.org/W2163117238","https://openalex.org/W2171589499"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
