{"id":"https://openalex.org/W1996542032","doi":"https://doi.org/10.1016/s0169-328x(97)00261-1","title":"Enhanced neuronal death from focal ischemia in AMPA-receptor transgenic mice","display_name":"Enhanced neuronal death from focal ischemia in AMPA-receptor transgenic mice","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W1996542032","doi":"https://doi.org/10.1016/s0169-328x(97)00261-1","mag":"1996542032","pmid":"https://pubmed.ncbi.nlm.nih.gov/9495544"},"language":"en","primary_location":{"id":"doi:10.1016/s0169-328x(97)00261-1","doi":"https://doi.org/10.1016/s0169-328x(97)00261-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0169-328x(97)00261-1","pdf_url":null,"source":{"id":"https://openalex.org/S158036907","display_name":"Molecular Brain Research","issn_l":"0169-328X","issn":["0169-328X","1872-6941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0169-328x(97)00261-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109984700","display_name":"Dean A. Le","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Le","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","Department of Neurology, Massachusetts General Hospital, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017137382","display_name":"Saumya Das","orcid":"https://orcid.org/0000-0002-4521-4606","observed_orcids":["https://orcid.org/0000-0002-4521-4606"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saumya Das","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049657174","display_name":"Yanming F. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanming F. Wang","raw_affiliation_strings":["Division of Neuroscience, Children's Hospital, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroscience, Children's Hospital, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018952929","display_name":"Toshihiro Yoshizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshihiro Yoshizawa","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101500903","display_name":"Y. Sasaki","orcid":"https://orcid.org/0000-0003-2614-7038","observed_orcids":["https://orcid.org/0000-0003-2614-7038"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasnory F. Sasaki","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081771060","display_name":"Mari A. Takasu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mari Takasu","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109276533","display_name":"Adriana Nemes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adriana Nemes","raw_affiliation_strings":["Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109152734","display_name":"Monica M. Mendelsohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Mendelsohn","raw_affiliation_strings":["Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041258339","display_name":"Pieter Dikkes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pieter Dikkes","raw_affiliation_strings":["Division of Neuroscience, Children's Hospital, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroscience, Children's Hospital, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066753734","display_name":"Stuart A. Lipton","orcid":"https://orcid.org/0000-0002-3490-1259","observed_orcids":["https://orcid.org/0000-0002-3490-1259"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart A. Lipton","raw_affiliation_strings":["Division of Neuroscience, Children's Hospital, Boston, MA 02115, USA","Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroscience, Children's Hospital, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112635558","display_name":"Nobuki Nakanishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nobuki Nakanishi","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5112635558"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":1.1647,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.75321948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"52","issue":"2","first_page":"235","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampa-receptors","display_name":"AMPA receptors","score":0.9559999704360962},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.828000009059906},{"id":"https://openalex.org/keywords/focal-cerebral-ischemia","display_name":"focal cerebral ischemia","score":0.8600000143051147},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.7490000128746033},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.8199999928474426},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.6399999856948853},{"id":"https://openalex.org/keywords/glutamate-receptor-antagonists","display_name":"glutamate receptor antagonists","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.671999990940094},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.9245427846908569},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.7892688512802124},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.785294234752655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.697446346282959},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5917842984199524},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5219687223434448},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.4963133931159973},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4635348320007324},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.45454996824264526},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.44720685482025146},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43150627613067627},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3959650695323944},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3253691792488098},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27893954515457153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16791945695877075},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12008163332939148},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05630478262901306}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019579","descriptor_name":"Neocortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019579","descriptor_name":"Neocortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0169-328x(97)00261-1","doi":"https://doi.org/10.1016/s0169-328x(97)00261-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0169-328x(97)00261-1","pdf_url":null,"source":{"id":"https://openalex.org/S158036907","display_name":"Molecular Brain Research","issn_l":"0169-328X","issn":["0169-328X","1872-6941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Brain Research","raw_type":"journal-article"},{"id":"pmid:9495544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9495544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research. Molecular brain research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0169-328x(97)00261-1","doi":"https://doi.org/10.1016/s0169-328x(97)00261-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0169-328x(97)00261-1","pdf_url":null,"source":{"id":"https://openalex.org/S158036907","display_name":"Molecular Brain Research","issn_l":"0169-328X","issn":["0169-328X","1872-6941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Brain Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1484211220","display_name":"GLUTAMATE RECEPTOR MUTANT MICE AND CORTICAL DEVELOPMENT","funder_award_id":"R01MH053535","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3497745897","display_name":null,"funder_award_id":"P01 HD29587-05","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5720824472","display_name":"Cellular/Molecular Pathophysiology of Intellectual and Developmental Disabilities","funder_award_id":"P01HD029587","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7159061164","display_name":null,"funder_award_id":"R01 MH 53535-01","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W78740994","https://openalex.org/W1971069963","https://openalex.org/W1978817835","https://openalex.org/W1996712322","https://openalex.org/W2016575029","https://openalex.org/W2023811880","https://openalex.org/W2035750459","https://openalex.org/W2044839361","https://openalex.org/W2051395367","https://openalex.org/W2063987809","https://openalex.org/W2068649586","https://openalex.org/W2074187719","https://openalex.org/W2080152563","https://openalex.org/W2084369020","https://openalex.org/W2085273994","https://openalex.org/W2095358033","https://openalex.org/W2110534885","https://openalex.org/W2112505121","https://openalex.org/W2129108032","https://openalex.org/W2152991303","https://openalex.org/W2294709860","https://openalex.org/W2316145923"],"related_works":["https://openalex.org/W1969417742","https://openalex.org/W1608463547","https://openalex.org/W4246313199","https://openalex.org/W2118740391","https://openalex.org/W1629617176","https://openalex.org/W2014696835","https://openalex.org/W2053573128","https://openalex.org/W2098302636","https://openalex.org/W1980146474","https://openalex.org/W7097002432"],"abstract_inverted_index":{"Excitatory":[0,68],"amino":[1],"acid":[2],"(EAA)":[3],"receptors":[4],"play":[5],"an":[6],"important":[7],"role":[8,38,153],"in":[9,13,32,39,70,158,174,189],"neuronal":[10,164,192],"cell":[11,30,165,193],"death":[12,31],"acute":[14],"cerebral":[15,34,126],"ischemia.":[16,35],"Blocking":[17],"the":[18,57,124,130,151,159,183],"alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate":[19],"(AMPA)":[20],"subtype":[21],"of":[22,123,154,161,178,185],"EAA":[23,85],"receptor":[24,59,187],"has":[25,44],"been":[26],"shown":[27],"to":[28,77,84,104,112,119,138],"reduce":[29],"global":[33],"However":[36],"their":[37],"focal":[40,121,162],"stroke,":[41],"although":[42],"suggestive,":[43],"remained":[45],"more":[46,79],"contentious.":[47],"To":[48],"clarify":[49],"this":[50,91],"issue,":[51],"we":[52,142],"generated":[53],"transgenic":[54,72,96,116],"mice":[55,73,97,117],"overexpressing":[56],"AMPA":[58],"(AMPAR)":[60],"subunit":[61],"GluR2-flip":[62,157],"which":[63],"would":[64],"increase":[65],"AMPAR-mediated":[66],"currents.":[67],"neurons":[69,83,94],"these":[71],"are":[74],"thus":[75],"predicted":[76],"be":[78,170],"susceptible":[80],"than":[81],"wild-type":[82,113,139],"(glutamate)-induced":[86],"excitotoxic":[87],"damage.":[88],"Consistent":[89],"with":[90],"prediction,":[92],"cultured":[93],"from":[95],"had":[98],"a":[99,145,171],"lower":[100],"LD50":[101],"for":[102,108],"exposure":[103],"glutamate":[105,179,186],"(10(-3)-10(-5)":[106],"M":[107],"5":[109],"min)":[110],"compared":[111,137],"neurons.":[114],"Moreover,":[115],"subjected":[118],"permanent":[120],"ischemia":[122],"middle":[125],"artery":[127],"(MCA)":[128],"using":[129],"intralumenal":[131],"filament":[132],"model":[133,148,168],"sustained":[134],"larger":[135],"infarctions":[136],"controls.":[140],"Hence":[141],"have":[143],"developed":[144],"genetic":[146],"mouse":[147],"that":[149],"demonstrates":[150],"crucial":[152],"AMPAR":[155],"containing":[156],"pathogenesis":[160],"hypoxic-ischemic":[163],"death.":[166,194],"This":[167],"will":[169],"valuable":[172],"tool":[173],"elucidating":[175],"molecular":[176],"mechanisms":[177],"excitotoxicity":[180],"and":[181],"evaluating":[182],"efficacy":[184],"antagonists":[188],"attenuating":[190],"post-ischemic":[191]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}