{"id":"https://openalex.org/W1996498008","doi":"https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.0.co;2-0","title":"Extensive apoptosis in ductal carcinoma in situ of the breast","display_name":"Extensive apoptosis in ductal carcinoma in situ of the breast","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W1996498008","doi":"https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.0.co;2-0","mag":"1996498008","pmid":"https://pubmed.ncbi.nlm.nih.gov/8646681"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.0.co;2-0","doi":"https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.0.co;2-0","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.0.co;2-0","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819960501%2977%3A9%3C1831%3A%3AAID-CNCR11%3E3.0.CO%3B2-0","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819960501%2977%3A9%3C1831%3A%3AAID-CNCR11%3E3.0.CO%3B2-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009887943","display_name":"Stephan B. Bodis","orcid":"https://orcid.org/0000-0003-1078-8711","observed_orcids":["https://orcid.org/0000-0003-1078-8711"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephan Bodis","raw_affiliation_strings":["Division of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA","Division of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts","Joint Center for Radiation Therapy, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Division of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Joint Center for Radiation Therapy, Boston, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023484082","display_name":"Kalliopi P. Siziopikou","orcid":"https://orcid.org/0000-0002-8689-5508","observed_orcids":["https://orcid.org/0000-0002-8689-5508"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalliopi P. Siziopikou","raw_affiliation_strings":["Department of Pathology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007365512","display_name":"Stuart J. Schnitt","orcid":"https://orcid.org/0000-0002-3608-7828","observed_orcids":["https://orcid.org/0000-0002-3608-7828"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart J. Schnitt","raw_affiliation_strings":["Department of Pathology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112782911","display_name":"Jay R. Harris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jay R. Harris","raw_affiliation_strings":["Joint Center for Radiation Therapy, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center for Radiation Therapy, Boston, Massachusetts","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078874539","display_name":"David E. Fisher","orcid":"https://orcid.org/0000-0002-5506-0575","observed_orcids":["https://orcid.org/0000-0002-5506-0575"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David E. Fisher","raw_affiliation_strings":["Division of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078874539"],"corresponding_institution_ids":["https://openalex.org/I4210117453"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":1.8933,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.85866941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"77","issue":"9","first_page":"1831","last_page":"1835"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.45170000195503235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.45170000195503235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.39890000224113464,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.12150000035762787,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.9929999709129333},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tunel-staining","display_name":"TUNEL staining","score":0.8769999742507935},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/dcis-grade","display_name":"DCIS grade","score":0.6359999775886536},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7852857112884521},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.7507926225662231},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.6998274326324463},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6952705383300781},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6523497700691223},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6316914558410645},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.6161690354347229},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.6073229908943176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4522663652896881},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4516351819038391},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4444423317909241},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.41450974345207214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4085279405117035},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.39579448103904724},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.36855262517929077},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3621653914451599},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15784889459609985},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003856","descriptor_name":"Deoxyuracil Nucleotides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004253","descriptor_name":"DNA Nucleotidylexotransferase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.0.co;2-0","doi":"https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.0.co;2-0","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.0.co;2-0","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819960501%2977%3A9%3C1831%3A%3AAID-CNCR11%3E3.0.CO%3B2-0","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.3.co;2-n","doi":"https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.3.co;2-n","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.3.co;2-n","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:8646681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8646681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.0.co;2-0","doi":"https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.0.co;2-0","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1831::aid-cncr11>3.0.co;2-0","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819960501%2977%3A9%3C1831%3A%3AAID-CNCR11%3E3.0.CO%3B2-0","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306183","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19"},{"id":"https://openalex.org/F4320306706","display_name":"Charlotte Geyer Foundation","ror":"https://ror.org/04bq9z418"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1996498008.pdf","grobid_xml":"https://content.openalex.org/works/W1996498008.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W172018148","https://openalex.org/W177416928","https://openalex.org/W267182146","https://openalex.org/W1979319210","https://openalex.org/W1989963027","https://openalex.org/W1995117272","https://openalex.org/W2003194265","https://openalex.org/W2010875574","https://openalex.org/W2013330927","https://openalex.org/W2021326683","https://openalex.org/W2021651753","https://openalex.org/W2025369435","https://openalex.org/W2025955916","https://openalex.org/W2036547499","https://openalex.org/W2042040568","https://openalex.org/W2042696772","https://openalex.org/W2046883067","https://openalex.org/W2052853635","https://openalex.org/W2055926056","https://openalex.org/W2068889468","https://openalex.org/W2070356021","https://openalex.org/W2072110559","https://openalex.org/W2078003307","https://openalex.org/W2081110323","https://openalex.org/W2081894694","https://openalex.org/W2081948388","https://openalex.org/W2095445172","https://openalex.org/W2114698200","https://openalex.org/W2138302361","https://openalex.org/W2163761821","https://openalex.org/W2318327263","https://openalex.org/W2417622858","https://openalex.org/W2429694548","https://openalex.org/W2807907317","https://openalex.org/W3188489634","https://openalex.org/W4229662680","https://openalex.org/W4247453351"],"related_works":["https://openalex.org/W1986713818","https://openalex.org/W2074614984","https://openalex.org/W2042394503","https://openalex.org/W2100468222","https://openalex.org/W2063771816","https://openalex.org/W7099629639","https://openalex.org/W2024554790","https://openalex.org/W2039721040","https://openalex.org/W2080126852","https://openalex.org/W1969206518"],"abstract_inverted_index":{"BACKGROUND:":[0],"More":[1],"than":[2],"50%":[3],"of":[4,34,74,90,99,108,123,151,164,186],"breast":[5,26],"ductal":[6],"carcinomas":[7],"in":[8,169,194,219,226,232],"situ":[9],"(DCIS)":[10],"contain":[11],"significant":[12],"histologic":[13],"necrosis,":[14,138],"an":[15],"important":[16,225],"prognostic":[17],"factor":[18],"for":[19,69],"determining":[20],"recurrence":[21],"and":[22,72,88,93],"progression":[23],"to":[24,116,198],"invasive":[25],"cancer.":[27],"We":[28],"have":[29],"examined":[30,68],"whether":[31,118],"the":[32,155],"mechanism":[33],"this":[35,128,182,206],"spontaneous":[36,229],"cell":[37,56,129,230],"death":[38,231],"might":[39],"be":[40,49,224],"apoptosis,":[41,124],"a":[42,102,121,237],"genetically":[43],"encoded":[44],"suicide":[45],"pathway":[46],"that":[47,181,205],"may":[48,223],"triggered":[50],"by":[51,210],"various":[52],"events":[53],"including":[54],"dysregulated":[55],"proliferation.":[57],"METHODS:":[58],"Twenty-five":[59],"untreated":[60],"DCIS":[61,173,195,233],"cases":[62,135,174],"accessioned":[63],"at":[64],"our":[65],"institution":[66],"were":[67,158],"subtype,":[70],"grade,":[71],"presence":[73,148],"apoptosis":[75,183,207,215],"using":[76],"two":[77],"criteria:":[78],"(1)":[79],"cellular":[80,139],"morphology":[81,140],"(shrinkage,":[82],"nuclear":[83],"condensation,":[84],"fragmentation,":[85,101],"apoptotic":[86,144],"bodies,":[87],"lack":[89],"inflammatory":[91],"component);":[92],"(2)":[94],"terminal":[95],"transferase":[96],"(TUNEL)":[97],"staining":[98,111,166,179],"DNA":[100],"characteristic":[103],"though":[104],"less":[105],"specific":[106],"feature":[107],"apoptosis.":[109,200],"Immunohistochemical":[110,178],"was":[112,125,141,167,184],"also":[113],"carried":[114],"out":[115],"assess":[117],"wild-type":[119],"p53,":[120],"regulator":[122],"associated":[126,235],"with":[127,136,143,236],"death.":[130],"RESULTS:":[131],"In":[132],"all":[133,159],"19":[134],"intraductal":[137,176,192],"consistent":[142],"death,":[145],"despite":[146],"its":[147],"within":[149],"sheets":[150],"\"geographic":[152],"necrosis.\"":[153],"Additionally,":[154],"identical":[156],"regions":[157],"strongly":[160],"TUNEL-positive.":[161],"No":[162],"evidence":[163],"TUNEL":[165],"seen":[168],"5":[170],"Grade":[171],"I":[172],"without":[175],"necrosis.":[177],"suggested":[180],"independent":[185],"p53":[187],"mutational":[188],"status.":[189],"CONCLUSIONS:":[190],"Extensive":[191],"necrosis":[193],"is":[196,203,208,234],"likely":[197],"represent":[199],"However,":[201],"it":[202],"unlikely":[204],"regulated":[209],"p53.":[211],"The":[212],"apparently":[213],"abundant":[214],"identified":[216],"here,":[217],"particularly":[218],"high":[220],"grade":[221],"DCIS,":[222],"explaining":[227],"why":[228],"worse":[238],"prognosis.":[239]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}