{"id":"https://openalex.org/W1996473902","doi":"https://doi.org/10.1016/j.coph.2014.12.004","title":"The NMDA receptor \u2018glycine modulatory site\u2019 in schizophrenia: d-serine, glycine, and beyond","display_name":"The NMDA receptor \u2018glycine modulatory site\u2019 in schizophrenia: d-serine, glycine, and beyond","publication_year":2014,"publication_date":"2014-12-23","ids":{"openalex":"https://openalex.org/W1996473902","doi":"https://doi.org/10.1016/j.coph.2014.12.004","mag":"1996473902","pmid":"https://pubmed.ncbi.nlm.nih.gov/25540902","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4805108"},"language":"en","primary_location":{"id":"doi:10.1016/j.coph.2014.12.004","doi":"https://doi.org/10.1016/j.coph.2014.12.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coph.2014.12.004","pdf_url":null,"source":{"id":"https://openalex.org/S13215328","display_name":"Current Opinion in Pharmacology","issn_l":"1471-4892","issn":["1471-4892","1471-4973"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4805108","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051690277","display_name":"Darrick T. Balu","orcid":"https://orcid.org/0000-0003-3505-6832","observed_orcids":["https://orcid.org/0000-0003-3505-6832"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darrick T Balu","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA","Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA","Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA","institution_ids":["https://openalex.org/I2801148111"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056026158","display_name":"Joseph T. Coyle","orcid":"https://orcid.org/0000-0002-0702-1395","observed_orcids":["https://orcid.org/0000-0002-0702-1395"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph T Coyle","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA. Electronic address: joseph_coyle@hms.harvard.edu","Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA","Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA. Electronic address: joseph_coyle@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA","institution_ids":["https://openalex.org/I2801148111"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056026158"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"],"apc_list":{"value":3510,"currency":"USD","value_usd":3510},"apc_paid":null,"fwci":3.5298,"has_fulltext":false,"cited_by_count":208,"citation_normalized_percentile":{"value":0.96319921,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"20","issue":null,"first_page":"109","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.8389999866485596},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9779999852180481},{"id":"https://openalex.org/keywords/d-serine","display_name":"D-serine","score":0.8759999871253967},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.968999981880188},{"id":"https://openalex.org/keywords/nmda-receptor-hypofunction","display_name":"NMDA receptor hypofunction","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cortical-connectivity","display_name":"cortical connectivity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7919999957084656},{"id":"https://openalex.org/keywords/negative-symptoms","display_name":"negative symptoms","score":0.8169999718666077},{"id":"https://openalex.org/keywords/synaptic-deficits","display_name":"synaptic deficits","score":0.6790000200271606},{"id":"https://openalex.org/keywords/genetic-etiology","display_name":"genetic etiology","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.8270193934440613},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.8226797580718994},{"id":"https://openalex.org/C2778941446","wikidata":"https://www.wikidata.org/wiki/Q545365","display_name":"Anhedonia","level":3,"score":0.7655378580093384},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5776116847991943},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5111344456672668},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.4750896990299225},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.45265713334083557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4434839189052582},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.4326232671737671},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.40503108501434326},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3325347304344177},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.2518019676208496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15845707058906555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14900505542755127},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13679417967796326},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.coph.2014.12.004","doi":"https://doi.org/10.1016/j.coph.2014.12.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coph.2014.12.004","pdf_url":null,"source":{"id":"https://openalex.org/S13215328","display_name":"Current Opinion in Pharmacology","issn_l":"1471-4892","issn":["1471-4892","1471-4973"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pharmacology","raw_type":"journal-article"},{"id":"pmid:25540902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25540902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4805108","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4805108","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4805108","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4805108","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G126729192","display_name":"Glutamatergic Dysfunction and Schizophrenia","funder_award_id":"P50MH060450","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1308643265","display_name":"Psychosis and Brain Glutamate","funder_award_id":"R01MH051290","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1947604268","display_name":null,"funder_award_id":"R01MH05190","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G295794849","display_name":null,"funder_award_id":"P50MH0G0450","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7059551075","display_name":"NMDA receptor hypofunction contributes to the dendritic dysplasia in schizophreni","funder_award_id":"K99MH099252","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8339489448","display_name":"Drug Abuse, Schizophrenia, NMDA Receptor","funder_award_id":"R21DA035427","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W52175841","https://openalex.org/W116998682","https://openalex.org/W1964764373","https://openalex.org/W1974838199","https://openalex.org/W1980353756","https://openalex.org/W1980862554","https://openalex.org/W1985613691","https://openalex.org/W1987923616","https://openalex.org/W1989766588","https://openalex.org/W1992465104","https://openalex.org/W2003712515","https://openalex.org/W2009473514","https://openalex.org/W2014608077","https://openalex.org/W2014887893","https://openalex.org/W2017661386","https://openalex.org/W2019974245","https://openalex.org/W2022935525","https://openalex.org/W2023575575","https://openalex.org/W2023962370","https://openalex.org/W2025360676","https://openalex.org/W2026096441","https://openalex.org/W2028370746","https://openalex.org/W2028884770","https://openalex.org/W2036796078","https://openalex.org/W2048181000","https://openalex.org/W2049460016","https://openalex.org/W2049939184","https://openalex.org/W2050814939","https://openalex.org/W2051513718","https://openalex.org/W2051552021","https://openalex.org/W2053938654","https://openalex.org/W2055652253","https://openalex.org/W2060050678","https://openalex.org/W2062298313","https://openalex.org/W2066578437","https://openalex.org/W2067446209","https://openalex.org/W2067494870","https://openalex.org/W2072838806","https://openalex.org/W2073544062","https://openalex.org/W2076923795","https://openalex.org/W2078450450","https://openalex.org/W2079524104","https://openalex.org/W2083140052","https://openalex.org/W2087714907","https://openalex.org/W2101357408","https://openalex.org/W2102092558","https://openalex.org/W2104613739","https://openalex.org/W2113176926","https://openalex.org/W2114197624","https://openalex.org/W2114398221","https://openalex.org/W2117787632","https://openalex.org/W2117959142","https://openalex.org/W2120714531","https://openalex.org/W2128762670","https://openalex.org/W2129116806","https://openalex.org/W2131932927","https://openalex.org/W2132297623","https://openalex.org/W2138127477","https://openalex.org/W2149932734","https://openalex.org/W2151758903","https://openalex.org/W2161453950","https://openalex.org/W2166440827","https://openalex.org/W4297695483"],"related_works":["https://openalex.org/W2323841869","https://openalex.org/W2110754014","https://openalex.org/W2339017320","https://openalex.org/W2008020964","https://openalex.org/W3203729812","https://openalex.org/W1490991280","https://openalex.org/W2051829807","https://openalex.org/W4413438416","https://openalex.org/W2008639041","https://openalex.org/W4247165005"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":39},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":17}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
