{"id":"https://openalex.org/W199646950","doi":null,"title":"Development of a digital microfluidic lab-on-a-chip for automated immunoassay with magnetically responsive beads","display_name":"Development of a digital microfluidic lab-on-a-chip for automated immunoassay with magnetically responsive beads","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W199646950","mag":"199646950"},"language":"en","primary_location":{"id":"mag:199646950","doi":null,"is_oa":false,"landing_page_url":"http://diginole.lib.fsu.edu/islandora/object/fsu:176191/datastream/PDF/view","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017330211","display_name":"Ramakrishna S. Sista","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ramakrishna Sista","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017330211"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9165,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.75510049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/digital-microfluidics","display_name":"digital microfluidics","score":0.8309999704360962},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"lab-on-a-chip","score":0.9620000123977661},{"id":"https://openalex.org/keywords/immunoassay","display_name":"immunoassay","score":0.8889999985694885},{"id":"https://openalex.org/keywords/magnetic-beads","display_name":"magnetic beads","score":0.8460000157356262},{"id":"https://openalex.org/keywords/droplet-microfluidics","display_name":"droplet microfluidics","score":0.9190000295639038},{"id":"https://openalex.org/keywords/insulin-detection","display_name":"insulin detection","score":0.5709999799728394},{"id":"https://openalex.org/keywords/interleukin-6-detection","display_name":"interleukin-6 detection","score":0.9869999885559082},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.781000018119812},{"id":"https://openalex.org/keywords/horseradish-peroxidase","display_name":"horseradish peroxidase","score":0.7699999809265137},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.8278067111968994},{"id":"https://openalex.org/C57528182","wikidata":"https://www.wikidata.org/wiki/Q1271842","display_name":"Miniaturization","level":2,"score":0.7623589038848877},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.6667555570602417},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6477091908454895},{"id":"https://openalex.org/C63662833","wikidata":"https://www.wikidata.org/wiki/Q6839341","display_name":"Microchannel","level":2,"score":0.5870065689086914},{"id":"https://openalex.org/C87892846","wikidata":"https://www.wikidata.org/wiki/Q864256","display_name":"Biochip","level":2,"score":0.500312328338623},{"id":"https://openalex.org/C92444450","wikidata":"https://www.wikidata.org/wiki/Q5276112","display_name":"Digital microfluidics","level":4,"score":0.4984622001647949},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.4622485637664795},{"id":"https://openalex.org/C87023908","wikidata":"https://www.wikidata.org/wiki/Q3870166","display_name":"Magnetic nanoparticles","level":3,"score":0.44105765223503113},{"id":"https://openalex.org/C115901376","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automation","level":2,"score":0.4292004108428955},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.4274140000343323},{"id":"https://openalex.org/C527607","wikidata":"https://www.wikidata.org/wiki/Q175538","display_name":"Microfabrication","level":4,"score":0.41217637062072754},{"id":"https://openalex.org/C2779673822","wikidata":"https://www.wikidata.org/wiki/Q907239","display_name":"Electrowetting","level":3,"score":0.4008205831050873},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38652122020721436},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3593529462814331},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2542940378189087},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.15595605969429016},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15151828527450562},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.14771142601966858},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.13026085495948792},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1056995689868927},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.09599289298057556},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.08194023370742798},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:199646950","doi":null,"is_oa":false,"landing_page_url":"http://diginole.lib.fsu.edu/islandora/object/fsu:176191/datastream/PDF/view","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W184947590","https://openalex.org/W1600828810","https://openalex.org/W1717854081","https://openalex.org/W1847836398","https://openalex.org/W1902734869","https://openalex.org/W1909235131","https://openalex.org/W1921020324","https://openalex.org/W1923960053","https://openalex.org/W1971148032","https://openalex.org/W1974486772","https://openalex.org/W1975687263","https://openalex.org/W1976018660","https://openalex.org/W1984651821","https://openalex.org/W1988572643","https://openalex.org/W1991313926","https://openalex.org/W1999820996","https://openalex.org/W2001661282","https://openalex.org/W2001974355","https://openalex.org/W2002513031","https://openalex.org/W2002793170","https://openalex.org/W2003062413","https://openalex.org/W2003501216","https://openalex.org/W2004732417","https://openalex.org/W2012424676","https://openalex.org/W2015713631","https://openalex.org/W2021257948","https://openalex.org/W2026854248","https://openalex.org/W2031056682","https://openalex.org/W2031256126","https://openalex.org/W2039382734","https://openalex.org/W2040512568","https://openalex.org/W2043491675","https://openalex.org/W2045072343","https://openalex.org/W2045508380","https://openalex.org/W2054115296","https://openalex.org/W2056024147","https://openalex.org/W2057256642","https://openalex.org/W2058743369","https://openalex.org/W2060224350","https://openalex.org/W2062070676","https://openalex.org/W2064205176","https://openalex.org/W2067342910","https://openalex.org/W2070047785","https://openalex.org/W2074532421","https://openalex.org/W2078235745","https://openalex.org/W2079438065","https://openalex.org/W2085451664","https://openalex.org/W2091761791","https://openalex.org/W2102204567","https://openalex.org/W2103207402","https://openalex.org/W2121757279","https://openalex.org/W2133623399","https://openalex.org/W2134745814","https://openalex.org/W2139712155","https://openalex.org/W2150068960","https://openalex.org/W2150323840","https://openalex.org/W2170218303","https://openalex.org/W2323106948","https://openalex.org/W2395335744","https://openalex.org/W2983363128"],"related_works":["https://openalex.org/W1578063900","https://openalex.org/W1990211442","https://openalex.org/W2767979178","https://openalex.org/W1542888488","https://openalex.org/W2090986081","https://openalex.org/W2990104147","https://openalex.org/W2489716892","https://openalex.org/W3213414929","https://openalex.org/W1556255183","https://openalex.org/W1992749420"],"abstract_inverted_index":{"The":[0,112,376,406],"emerging":[1],"paradigm":[2],"of":[3,40,45,61,70,101,118,154,179,198,211,216,224,226,253,265,302,338,361,379,404,408],"lab-on-a-chip":[4,41,235],"powered":[5],"by":[6,259,413],"microfluidics":[7],"is":[8,182,204,219,240,257,368,386,411,427],"expected":[9],"to":[10,57,104,122,173,185,242,331,340,429],"revolutionize":[11],"miniaturization,":[12],"automation":[13,79],"and":[14,24,80,192,222,262,283,285,322,336,374,381,389,423],"integration":[15],"in":[16,64,89,138,167,202,208,308,316],"the":[17,32,38,48,59,71,90,116,124,128,132,139,155,176,196,199,217,227,254,303,309,323,327,333,399,409,415,424],"point-of-care":[18],"centers":[19],"which":[20,53,161],"require":[21,77],"quick,":[22],"efficient":[23,78,300,346],"reproducible":[25],"results.":[26],"Furthermore,":[27,195],"high":[28],"throughput":[29],"requirement":[30],"from":[31,85],"life":[33,65],"sciences":[34,66],"laboratories":[35,92],"have":[36,170],"made":[37],"development":[39],"a":[42,106,205,232,357,402],"major":[43],"area":[44,126],"research":[46],"over":[47,401],"past":[49],"few":[50],"years.":[51],"Immunoassays,":[52],"are":[54,68,83,143,162,311,320,395],"routinely":[55],"used":[56,342],"determine":[58],"concentrations":[60],"various":[62],"analytes":[63,400],"laboratories,":[67],"one":[69],"most":[72],"important":[73],"laboratory":[74,87],"tests":[75,88,96],"that":[76,108,147,306],"integration.":[81],"These":[82],"different":[84,418,421],"other":[86],"clinical":[91],"such":[93,269,275,288],"as":[94,213,270,276,289],"colorimetric":[95],"because":[97,223],"they":[98],"involve":[99,115],"formation":[100],"antibody-antigen":[102],"complexes":[103],"generate":[105],"signal":[107],"can":[109],"be":[110,341,430],"measured.":[111],"immunoassays":[113,149,244],"also":[114],"application":[117],"magnetically":[119],"responsive":[120],"beads":[121,201,218,247,305,319,335,339,351],"increase":[123],"surface":[125],"for":[127,281,299,325,348,372,397],"reactions":[129],"thereby":[130],"enhance":[131],"signal.":[133],"Although":[134],"miniaturization":[135],"was":[136,354],"started":[137],"early":[140],"1990's":[141],"there":[142],"no":[144],"commercial":[145,158],"devices":[146],"perform":[148,243],"involving":[150],"magnetic":[151,200,214,246,297,304,318,329,334,350,366],"beads.":[152],"None":[153],"state-of-the":[156],"art":[157],"microfluidic":[159,234],"technologies,":[160],"based":[163,236],"on":[164,237,248,352,370,384,417,420],"continuous":[165,209],"flow":[166],"etched":[168],"microchannel,":[169],"been":[171],"able":[172],"fully":[174],"deliver":[175],"promised":[177],"benefits":[178],"microfluidics.":[180],"This":[181],"primarily":[183],"due":[184],"their":[186],"incompatability":[187],"with":[188,356],"common":[189],"sample":[190],"matrices":[191],"architectural":[193],"inflexibility.":[194],"transport":[197,264],"microchannels":[203],"difficult":[206],"task":[207],"mode":[210],"operation":[212],"susceptibility":[215],"rather":[220],"weak":[221],"demagnetization":[225],"particles.":[228],"In":[229],"this":[230],"thesis,":[231],"droplet-based":[233],"electrowetting":[238,255],"actuation":[239],"developed":[241,355,396],"using":[245],"human":[249,266],"physiological":[250,267],"samples.":[251],"Biocompatibility":[252],"system":[256],"established":[258,412],"demonstrating":[260],"repeatable":[261],"rapid":[263],"fluids":[268],"whole":[271],"blood,":[272],"serum,":[273],"proteins":[274],"bovine":[277],"serum":[278],"albumin,":[279],"antibodies":[280],"insulin":[282],"interleukin-6":[284],"enzymatic":[286],"reagents":[287],"horseradish":[290],"peroxidase":[291],"(HRP),":[292],"alkaline":[293],"phosphatase":[294],"(ALP).":[295],"Various":[296],"configurations":[298],"attraction":[301],"assist":[307],"washing":[310,317,349],"developed.":[312],"Several":[313],"parameters":[314],"involved":[315],"studied":[321],"buffer":[324],"resuspending":[326],"beads,":[328],"strength":[330],"attract":[332],"concentration":[337,378],"were":[343],"established.":[344],"An":[345],"protocol":[347],"chip":[353,371,385],"bead":[358],"retention":[359],"efficiency":[360],"almost":[362],"100%.":[363],"A":[364],"complete":[365],"immunoassay":[367],"performed":[369],"Insulin":[373,380],"Interleukin-6.":[375],"least":[377],"IL-6":[382],"detectable":[383],"0.24":[387],"pg/\u03bcL":[388],"4":[390],"fg/\u03bcL":[391],"respectively.":[392],"Standard":[393],"curves":[394],"both":[398],"range":[403],"concentrations.":[405],"repeatability":[407],"assays":[410],"performing":[414],"assay":[416],"samples":[419],"days":[422],"standard":[425],"error":[426],"shown":[428],"less":[431],"than":[432],"3%.":[433],"Magnetic":[434],"immunoassays\u2026":[435]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
