{"id":"https://openalex.org/W1996433976","doi":"https://doi.org/10.1016/j.ecl.2012.04.007","title":"Bisphosphonates in the Treatment of Osteoporosis","display_name":"Bisphosphonates in the Treatment of Osteoporosis","publication_year":2012,"publication_date":"2012-06-11","ids":{"openalex":"https://openalex.org/W1996433976","doi":"https://doi.org/10.1016/j.ecl.2012.04.007","mag":"1996433976","pmid":"https://pubmed.ncbi.nlm.nih.gov/22877426"},"language":"en","primary_location":{"id":"doi:10.1016/j.ecl.2012.04.007","doi":"https://doi.org/10.1016/j.ecl.2012.04.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ecl.2012.04.007","pdf_url":null,"source":{"id":"https://openalex.org/S151814236","display_name":"Endocrinology and Metabolism Clinics of North America","issn_l":"0889-8529","issn":["0889-8529","1558-4410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology and Metabolism Clinics of North America","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108797800","display_name":"Dima L. Diab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143084","display_name":"Cincinnati VA Medical Center","ror":"https://ror.org/045r80n66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210127612","https://openalex.org/I4210143084"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dima L. Diab","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Cincinnati VA Medical Center, University of Cincinnati, 3125 Eden Avenue, PO Box 670547, Cincinnati, OH 45267, USA. dima.diab@uc.edu","Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Cincinnati VA Medical Center, University of Cincinnati, 3125 Eden Avenue, PO Box 670547, Cincinnati, OH 45267, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Cincinnati VA Medical Center, University of Cincinnati, 3125 Eden Avenue, PO Box 670547, Cincinnati, OH 45267, USA. dima.diab@uc.edu","institution_ids":["https://openalex.org/I4210143084","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Cincinnati VA Medical Center, University of Cincinnati, 3125 Eden Avenue, PO Box 670547, Cincinnati, OH 45267, USA","institution_ids":["https://openalex.org/I4210143084","https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090665248","display_name":"Nelson B. Watts","orcid":"https://orcid.org/0000-0003-0719-9801","observed_orcids":["https://orcid.org/0000-0003-0719-9801"]},"institutions":[{"id":"https://openalex.org/I4210165260","display_name":"Mercy Health","ror":"https://ror.org/054bs2v13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210165260"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nelson B. Watts","raw_affiliation_strings":["Mercy Health Osteoporosis and Bone Health Services, 4760 E. Galbraith Road, Cincinnati, OH 45236, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mercy Health Osteoporosis and Bone Health Services, 4760 E. Galbraith Road, Cincinnati, OH 45236, USA","institution_ids":["https://openalex.org/I4210165260"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108797800"],"corresponding_institution_ids":["https://openalex.org/I4210143084","https://openalex.org/I63135867"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":1.6437,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.83920705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"41","issue":"3","first_page":"487","last_page":"506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":1.0},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/fracture-risk-reduction","display_name":"fracture risk reduction","score":0.8980000019073486},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.7239999771118164},{"id":"https://openalex.org/keywords/drug-holidays","display_name":"drug holidays","score":0.9670000076293945},{"id":"https://openalex.org/keywords/long-term-treatment","display_name":"long-term treatment","score":0.6449999809265137},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9550936222076416},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.8693106770515442},{"id":"https://openalex.org/C140206745","wikidata":"https://www.wikidata.org/wiki/Q5308895","display_name":"Drug holiday","level":3,"score":0.739599347114563},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.7206525206565857},{"id":"https://openalex.org/C2994343686","wikidata":"https://www.wikidata.org/wiki/Q1753467","display_name":"Osteoporotic fracture","level":4,"score":0.5297138690948486},{"id":"https://openalex.org/C2777556957","wikidata":"https://www.wikidata.org/wiki/Q2377991","display_name":"Osteonecrosis of the jaw","level":4,"score":0.5115224123001099},{"id":"https://openalex.org/C2777308945","wikidata":"https://www.wikidata.org/wiki/Q411781","display_name":"Teriparatide","level":4,"score":0.5037862658500671},{"id":"https://openalex.org/C2781104859","wikidata":"https://www.wikidata.org/wiki/Q2758338","display_name":"Etidronic acid","level":3,"score":0.46274334192276},{"id":"https://openalex.org/C2911223091","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone Density Conservation Agents","level":4,"score":0.4213983416557312},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40048831701278687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35436540842056274},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3497270345687866},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.21684736013412476},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.13206800818443298},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.0},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005264","descriptor_name":"Femoral Fractures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005264","descriptor_name":"Femoral Fractures","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005264","descriptor_name":"Femoral Fractures","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005264","descriptor_name":"Femoral Fractures","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D059266","descriptor_name":"Bisphosphonate-Associated Osteonecrosis of the Jaw","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D059266","descriptor_name":"Bisphosphonate-Associated Osteonecrosis of the Jaw","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D059266","descriptor_name":"Bisphosphonate-Associated Osteonecrosis of the Jaw","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D059352","descriptor_name":"Musculoskeletal Pain","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D059352","descriptor_name":"Musculoskeletal Pain","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ecl.2012.04.007","doi":"https://doi.org/10.1016/j.ecl.2012.04.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ecl.2012.04.007","pdf_url":null,"source":{"id":"https://openalex.org/S151814236","display_name":"Endocrinology and Metabolism Clinics of North America","issn_l":"0889-8529","issn":["0889-8529","1558-4410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology and Metabolism Clinics of North America","raw_type":"journal-article"},{"id":"pmid:22877426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22877426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology and metabolism clinics of North America","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W7229850","https://openalex.org/W134538178","https://openalex.org/W143767483","https://openalex.org/W162186431","https://openalex.org/W1518317880","https://openalex.org/W1526186357","https://openalex.org/W1585040018","https://openalex.org/W1756682386","https://openalex.org/W1823423766","https://openalex.org/W1907724197","https://openalex.org/W1966796789","https://openalex.org/W1966953299","https://openalex.org/W1970957816","https://openalex.org/W1974527667","https://openalex.org/W1976900035","https://openalex.org/W1978285705","https://openalex.org/W1980616242","https://openalex.org/W1990119475","https://openalex.org/W1990729029","https://openalex.org/W1990771263","https://openalex.org/W1993035292","https://openalex.org/W1993936282","https://openalex.org/W1994799035","https://openalex.org/W2007712506","https://openalex.org/W2007926230","https://openalex.org/W2008756438","https://openalex.org/W2009873137","https://openalex.org/W2010029465","https://openalex.org/W2012608865","https://openalex.org/W2013089207","https://openalex.org/W2016674211","https://openalex.org/W2019018649","https://openalex.org/W2019104204","https://openalex.org/W2022094899","https://openalex.org/W2022212934","https://openalex.org/W2024143452","https://openalex.org/W2024479120","https://openalex.org/W2024548298","https://openalex.org/W2025655954","https://openalex.org/W2025867729","https://openalex.org/W2028091580","https://openalex.org/W2028195029","https://openalex.org/W2029246637","https://openalex.org/W2030122753","https://openalex.org/W2033885211","https://openalex.org/W2038032924","https://openalex.org/W2038549255","https://openalex.org/W2038695908","https://openalex.org/W2041371036","https://openalex.org/W2041968613","https://openalex.org/W2042003256","https://openalex.org/W2042275235","https://openalex.org/W2043416310","https://openalex.org/W2045031638","https://openalex.org/W2047558199","https://openalex.org/W2048858394","https://openalex.org/W2051516578","https://openalex.org/W2055213889","https://openalex.org/W2055233141","https://openalex.org/W2057064011","https://openalex.org/W2057332307","https://openalex.org/W2060040289","https://openalex.org/W2060650029","https://openalex.org/W2060875355","https://openalex.org/W2062464921","https://openalex.org/W2064935416","https://openalex.org/W2068140668","https://openalex.org/W2069920483","https://openalex.org/W2072180405","https://openalex.org/W2073844603","https://openalex.org/W2076490579","https://openalex.org/W2080474315","https://openalex.org/W2080918625","https://openalex.org/W2081428765","https://openalex.org/W2085739273","https://openalex.org/W2089233716","https://openalex.org/W2090837925","https://openalex.org/W2092926455","https://openalex.org/W2094638050","https://openalex.org/W2095451755","https://openalex.org/W2099244701","https://openalex.org/W2104518011","https://openalex.org/W2106406207","https://openalex.org/W2107208293","https://openalex.org/W2107494198","https://openalex.org/W2111102192","https://openalex.org/W2111387898","https://openalex.org/W2113907498","https://openalex.org/W2114045187","https://openalex.org/W2120080073","https://openalex.org/W2125230559","https://openalex.org/W2134304734","https://openalex.org/W2136292511","https://openalex.org/W2142047714","https://openalex.org/W2147410460","https://openalex.org/W2150904792","https://openalex.org/W2156506192","https://openalex.org/W2159729767","https://openalex.org/W2163830908","https://openalex.org/W2163852287","https://openalex.org/W2167285261","https://openalex.org/W2169251377","https://openalex.org/W2169617586","https://openalex.org/W2188383788","https://openalex.org/W2324131830","https://openalex.org/W2338130968","https://openalex.org/W2405101239","https://openalex.org/W2410354332","https://openalex.org/W2413681335","https://openalex.org/W2414794411","https://openalex.org/W2417564437","https://openalex.org/W2472899265","https://openalex.org/W2624963411","https://openalex.org/W3149985527","https://openalex.org/W4233560672","https://openalex.org/W4239901602","https://openalex.org/W4246264500","https://openalex.org/W4252350389","https://openalex.org/W6600291341","https://openalex.org/W6638524100"],"related_works":["https://openalex.org/W1997286830","https://openalex.org/W4289257666","https://openalex.org/W96977846","https://openalex.org/W2016674211","https://openalex.org/W4406091309","https://openalex.org/W2059659899","https://openalex.org/W2007613753","https://openalex.org/W1826389272","https://openalex.org/W4392959522","https://openalex.org/W2325288280"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}