{"id":"https://openalex.org/W1996429447","doi":"https://doi.org/10.1159/000067959","title":"Maturation Alters Cyclic Nucleotide and Relaxation Responses to Nitric Oxide Donors in Ovine Cerebral Arteries","display_name":"Maturation Alters Cyclic Nucleotide and Relaxation Responses to Nitric Oxide Donors in Ovine Cerebral Arteries","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1996429447","doi":"https://doi.org/10.1159/000067959","mag":"1996429447","pmid":"https://pubmed.ncbi.nlm.nih.gov/12576757"},"language":"en","primary_location":{"id":"doi:10.1159/000067959","doi":"https://doi.org/10.1159/000067959","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000067959","pdf_url":null,"source":{"id":"https://openalex.org/S168252155","display_name":"Neonatology","issn_l":"1661-7800","issn":["1661-7800","1661-7819"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neonatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088032785","display_name":"Surya M. Nauli","orcid":"https://orcid.org/0000-0002-9676-0287","observed_orcids":["https://orcid.org/0000-0002-9676-0287"]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]},{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Surya M. Nauli","raw_affiliation_strings":["Division of Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, Calif 92350, USA","Division of Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, Calif 92350, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Division of Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, Calif., USA","institution_ids":["https://openalex.org/I1293502524","https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072723006","display_name":"Charles Ray White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]},{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles R. White","raw_affiliation_strings":["Division of Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, Calif., USA","institution_ids":["https://openalex.org/I1293502524","https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072621565","display_name":"Andrew Hull","orcid":"https://orcid.org/0000-0003-4465-1406","observed_orcids":["https://orcid.org/0000-0003-4465-1406"]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]},{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Hull","raw_affiliation_strings":["Division of Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, Calif., USA","institution_ids":["https://openalex.org/I1293502524","https://openalex.org/I26347476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082259652","display_name":"William J. Pearce","orcid":"https://orcid.org/0000-0002-5331-5677","observed_orcids":["https://orcid.org/0000-0002-5331-5677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William J. Pearce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7293,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.69886861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"83","issue":"2","first_page":"123","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cerebral-arteries","display_name":"cerebral arteries","score":0.6779999732971191},{"id":"https://openalex.org/keywords/postnatal-maturation","display_name":"postnatal maturation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.7710000276565552},{"id":"https://openalex.org/keywords/nitroglycerin","display_name":"nitroglycerin","score":0.7580000162124634},{"id":"https://openalex.org/keywords/s-nitroso-n-acetylpenicillamine","display_name":"S-nitroso-N-acetylpenicillamine","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9070000052452087},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.9929999709129333},{"id":"https://openalex.org/keywords/soluble-guanylate-cyclase","display_name":"soluble guanylate cyclase","score":0.8999999761581421},{"id":"https://openalex.org/keywords/posterior-communicating-artery","display_name":"posterior communicating artery","score":0.7590000033378601},{"id":"https://openalex.org/keywords/middle-cerebral-artery","display_name":"middle cerebral artery","score":1.0},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.4880000054836273},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C171614378","wikidata":"https://www.wikidata.org/wiki/Q5064093","display_name":"Cerebral arteries","level":2,"score":0.8410884141921997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.636370062828064},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.611355185508728},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5869444012641907},{"id":"https://openalex.org/C2780994212","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic guanosine monophosphate","level":3,"score":0.5636041164398193},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5217859745025635},{"id":"https://openalex.org/C2778524494","wikidata":"https://www.wikidata.org/wiki/Q967433","display_name":"Cyclic nucleotide","level":4,"score":0.5073468089103699},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4239791929721832},{"id":"https://openalex.org/C58141971","wikidata":"https://www.wikidata.org/wiki/Q906688","display_name":"Phosphodiesterase 3","level":4,"score":0.422167032957077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3551369309425354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35070234537124634},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.16597428917884827},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1472209095954895},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.1259010136127472},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1231096088886261},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002536","descriptor_name":"Cerebral Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002536","descriptor_name":"Cerebral Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002536","descriptor_name":"Cerebral Arteries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009712","descriptor_name":"Nucleotides, Cyclic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D026423","descriptor_name":"S-Nitroso-N-Acetylpenicillamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D026423","descriptor_name":"S-Nitroso-N-Acetylpenicillamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000067959","doi":"https://doi.org/10.1159/000067959","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000067959","pdf_url":null,"source":{"id":"https://openalex.org/S168252155","display_name":"Neonatology","issn_l":"1661-7800","issn":["1661-7800","1661-7819"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neonatology","raw_type":"journal-article"},{"id":"pmid:12576757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12576757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of the neonate","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W6947463","https://openalex.org/W101477879","https://openalex.org/W309736758","https://openalex.org/W1009510370","https://openalex.org/W1518970589","https://openalex.org/W1524509448","https://openalex.org/W1542201358","https://openalex.org/W1907994445","https://openalex.org/W1966654082","https://openalex.org/W1967882515","https://openalex.org/W1976851726","https://openalex.org/W1983409138","https://openalex.org/W1997444009","https://openalex.org/W2008723789","https://openalex.org/W2020383287","https://openalex.org/W2043466169","https://openalex.org/W2054710204","https://openalex.org/W2055351612","https://openalex.org/W2059250961","https://openalex.org/W2065332830","https://openalex.org/W2068117750","https://openalex.org/W2071645061","https://openalex.org/W2072308012","https://openalex.org/W2083303225","https://openalex.org/W2084433269","https://openalex.org/W2085823269","https://openalex.org/W2098887755","https://openalex.org/W2105657039","https://openalex.org/W2121581904","https://openalex.org/W2176647628","https://openalex.org/W2185837303","https://openalex.org/W2187176375","https://openalex.org/W2228760040","https://openalex.org/W2465190780","https://openalex.org/W2465900750","https://openalex.org/W2472000854"],"related_works":["https://openalex.org/W2055351612","https://openalex.org/W1542201358","https://openalex.org/W1997957551","https://openalex.org/W2138278822","https://openalex.org/W2043466169","https://openalex.org/W2122470567","https://openalex.org/W1971608258","https://openalex.org/W2077451110","https://openalex.org/W2052366845","https://openalex.org/W1966654082"],"abstract_inverted_index":{"To":[0],"examine":[1],"the":[2,19,65,162,204,228,244,303,325],"hypothesis":[3],"that":[4,177,201,210,227,251,274,288,302],"maturation":[5,202],"modulates":[6],"nitric":[7],"oxide":[8],"(NO)-induced":[9],"relaxation":[10,140],"in":[11,44,75,78,102,122,129,135,145,180,187,195,216,219,260,324],"cerebral":[12,49,80,126,131,147,221],"arteries,":[13,132,148],"we":[14,175,249,272],"quantified":[15],"concentration-relaxation":[16],"relations":[17],"and":[18,28,38,47,55,67,86,105,118,149,160,169,192,209,270,287,295,312,315],"corresponding":[20,185],"dynamic":[21],"responses":[22,151,284],"of":[23,36,69,84,89,97,164,233,254,306],"guanosine":[24],"3':5'-cyclic":[25,30],"monophosphate":[26,31],"(cGMP)":[27],"adenosine":[29],"(cAMP)":[32],"levels":[33],"following":[34],"administration":[35],"nitroglycerin":[37,101],"S-nitroso-N-acetyl-penicilamine":[39],"(SNAP),":[40],"an":[41],"NO":[42,70,90,153,183,196,236,266,307,322],"donor,":[43],"posterior":[45],"communicating":[46],"middle":[48],"arteries":[50],"from":[51,240],"newborn":[52,76,104,123,146],"(3-7":[53],"days)":[54],"adult":[56,79,106,125,130,263],"sheep.":[57],"The":[58,223],"results":[59],"offer":[60],"5":[61],"main":[62],"observations:":[63],"(1)":[64],"efficacy":[66],"potency":[68],"donors":[71,154],"were":[72,92,111,120,166,258],"generally":[73],"greater":[74,112,121,259],"than":[77,99,115,124,144,218,262],"arteries;":[81,107,127],"(2)":[82],"rates":[83,88,232],"relaxation,":[85,208],"presumably":[87],"release,":[91],"faster":[93,138],"for":[94,100,113,116],"equimolar":[95],"concentrations":[96,110],"SNAP":[98],"both":[103,119,268],"(3)":[108],"basal":[109,245,252],"cAMP":[114],"cGMP,":[117],"(4)":[128],"NO-induced":[133,207],"increases":[134],"cGMP":[136,159,241,269],"occurred":[137],"but":[139],"developed":[141],"more":[142,214],"slowly":[143],"(5)":[150],"to":[152,182,235,256,285],"involved":[155],"significant":[156],"cross-reactivity":[157],"between":[158],"cAMP,":[161,271],"characteristics":[163],"which":[165],"age,":[167],"artery,":[168],"agent":[170],"specific.":[171],"From":[172,243],"these":[173,299],"results,":[174],"conclude":[176,200,250],"postnatal":[178,293],"changes":[179,186],"reactivity":[181],"reflect":[184],"soluble":[188],"guanylate":[189],"cyclase":[190],"activity":[191],"possible":[193,280],"decreases":[194],"half-life.":[197],"We":[198],"also":[199,225],"slows":[203],"mechanisms":[205],"mediating":[206],"this":[211,289],"effect":[212],"is":[213,237],"pronounced":[215],"distal":[217],"proximal":[220],"arteries.":[222,264],"data":[224],"suggest":[226],"rate-limiting":[229],"step":[230],"governing":[231],"response":[234],"probably":[238],"downstream":[239],"synthesis.":[242],"cyclic":[246],"nucleotide":[247],"levels,":[248],"ratios":[253],"synthesis":[255],"hydrolysis":[257],"fetal":[261],"Because":[265],"increased":[267],"speculate":[273],"Type":[275],"III":[276],"phosphodiesterase":[277],"has":[278],"a":[279],"influence":[281,290],"upon":[282],"cerebrovascular":[283,304],"NO,":[286],"varies":[291],"with":[292],"age":[294,310],"artery":[296,313],"type.":[297],"Together,":[298],"findings":[300],"emphasize":[301],"effects":[305],"are":[308],"highly":[309],"dependent":[311],"specific,":[314],"should":[316],"be":[317],"carefully":[318],"considered":[319],"when":[320],"administering":[321],"therapeutically":[323],"neonate.":[326]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}