{"id":"https://openalex.org/W1996429246","doi":"https://doi.org/10.4155/bio.15.7","title":"Development of Supported Liquid-Phase Microextraction Probes for In Vivo PK Studies","display_name":"Development of Supported Liquid-Phase Microextraction Probes for In Vivo PK Studies","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1996429246","doi":"https://doi.org/10.4155/bio.15.7","mag":"1996429246","pmid":"https://pubmed.ncbi.nlm.nih.gov/25871585"},"language":"en","primary_location":{"id":"doi:10.4155/bio.15.7","doi":"https://doi.org/10.4155/bio.15.7","is_oa":false,"landing_page_url":"https://doi.org/10.4155/bio.15.7","pdf_url":null,"source":{"id":"https://openalex.org/S159955403","display_name":"Bioanalysis","issn_l":"1757-6180","issn":["1757-6180","1757-6199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioanalysis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075134303","display_name":"Paul J Donabella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Donabella","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Albany College of Pharmacy &amp; Health Sciences, 106 New Scotland Avenue, Albany, NY12208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Albany College of Pharmacy &amp; Health Sciences, 106 New Scotland Avenue, Albany, NY12208, USA","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047246215","display_name":"Nathan J. Rogers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Rogers","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Albany College of Pharmacy &amp; Health Sciences, 106 New Scotland Avenue, Albany, NY12208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Albany College of Pharmacy &amp; Health Sciences, 106 New Scotland Avenue, Albany, NY12208, USA","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042687042","display_name":"Robert M. Levin","orcid":"https://orcid.org/0000-0003-1578-6870","observed_orcids":["https://orcid.org/0000-0003-1578-6870"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Levin","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Albany College of Pharmacy &amp; Health Sciences, 106 New Scotland Avenue, Albany, NY12208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Albany College of Pharmacy &amp; Health Sciences, 106 New Scotland Avenue, Albany, NY12208, USA","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030392599","display_name":"Florin Marcel Musteata","orcid":"https://orcid.org/0000-0001-6143-2171","observed_orcids":["https://orcid.org/0000-0001-6143-2171"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Florin Marcel Musteata","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Albany College of Pharmacy &amp; Health Sciences, 106 New Scotland Avenue, Albany, NY12208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Albany College of Pharmacy &amp; Health Sciences, 106 New Scotland Avenue, Albany, NY12208, USA","institution_ids":["https://openalex.org/I365282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I365282"],"apc_list":null,"apc_paid":null,"fwci":0.2593,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55803769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"7","issue":"6","first_page":"661","last_page":"670"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxybutynin","display_name":"oxybutynin","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9819999933242798},{"id":"https://openalex.org/keywords/polyacrylonitrile-membranes","display_name":"polyacrylonitrile membranes","score":0.7850000262260437},{"id":"https://openalex.org/keywords/two-compartment-model","display_name":"two-compartment model","score":0.7860000133514404},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7228549718856812},{"id":"https://openalex.org/C2778533135","wikidata":"https://www.wikidata.org/wiki/Q903970","display_name":"Solid-phase microextraction","level":4,"score":0.5939722657203674},{"id":"https://openalex.org/C3017397382","wikidata":"https://www.wikidata.org/wiki/Q3242293","display_name":"Liquid liquid","level":2,"score":0.49352729320526123},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.4802406430244446},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47674593329429626},{"id":"https://openalex.org/C2781448156","wikidata":"https://www.wikidata.org/wiki/Q1570182","display_name":"Coating","level":2,"score":0.472481906414032},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44834771752357483},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.37479162216186523},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3219709098339081},{"id":"https://openalex.org/C205345274","wikidata":"https://www.wikidata.org/wiki/Q873009","display_name":"Gas chromatography\u2013mass spectrometry","level":3,"score":0.15821155905723572},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1258590817451477},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.11179715394973755},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008333","descriptor_name":"Mandelic Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008333","descriptor_name":"Mandelic Acids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D008333","descriptor_name":"Mandelic Acids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053000","descriptor_name":"Analytic Sample Preparation Methods","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059627","descriptor_name":"Liquid Phase Microextraction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4155/bio.15.7","doi":"https://doi.org/10.4155/bio.15.7","is_oa":false,"landing_page_url":"https://doi.org/10.4155/bio.15.7","pdf_url":null,"source":{"id":"https://openalex.org/S159955403","display_name":"Bioanalysis","issn_l":"1757-6180","issn":["1757-6180","1757-6199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioanalysis","raw_type":"journal-article"},{"id":"pmid:25871585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25871585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioanalysis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1504268714","https://openalex.org/W1777543990","https://openalex.org/W1968059729","https://openalex.org/W1971788892","https://openalex.org/W1977774203","https://openalex.org/W1977783319","https://openalex.org/W1997646161","https://openalex.org/W2001939199","https://openalex.org/W2009650252","https://openalex.org/W2014440033","https://openalex.org/W2016843475","https://openalex.org/W2029596059","https://openalex.org/W2048439051","https://openalex.org/W2058085003","https://openalex.org/W2061730489","https://openalex.org/W2069588232","https://openalex.org/W2080867626","https://openalex.org/W2086227232","https://openalex.org/W2104795433","https://openalex.org/W2137231580","https://openalex.org/W2139544932","https://openalex.org/W2148019288","https://openalex.org/W2165879755","https://openalex.org/W2167895469","https://openalex.org/W4251667231"],"related_works":["https://openalex.org/W2062206391","https://openalex.org/W1999326276","https://openalex.org/W2048439051","https://openalex.org/W2142632334","https://openalex.org/W1968059729","https://openalex.org/W2013367689","https://openalex.org/W4388492888","https://openalex.org/W2031012531","https://openalex.org/W2530243631","https://openalex.org/W2128968645"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"new":[2],"sample":[3],"preparation":[4],"method":[5,78,88],"termed":[6],"supported":[7],"liquid-phase":[8,35],"microextraction":[9,36],"is":[10,18],"proposed.":[11],"With":[12],"this":[13],"technique,":[14],"the":[15,23,67,77,94],"extraction":[16,63],"phase":[17],"a":[19,26,30,102,106,114],"liquid":[20],"immobilized":[21],"inside":[22,55],"pores":[24],"of":[25,64,71,76,97,108,110,116],"membrane":[27],"coated":[28],"on":[29],"solid":[31],"support.":[32],"METHODOLOGY:":[33],"Supported":[34],"probes":[37,52],"were":[38,53],"prepared":[39],"by":[40,47],"coating":[41],"wires":[42],"with":[43,49,105],"porous":[44],"polyacrylonitrile":[45],"followed":[46,101],"saturation":[48],"1-octanol.":[50],"The":[51,73,86,99],"introduced":[54],"hypodermic":[56],"needles":[57],"and":[58,69,113],"used":[59],"for":[60],"in":[61],"vivo":[62],"oxybutynin":[65],"from":[66,80],"blood":[68],"tissues":[70],"rabbits.":[72],"linear":[74],"range":[75],"was":[79,89],"0.5":[81],"to":[82,92],"500":[83],"ng/ml.":[84],"CONCLUSION:":[85],"proposed":[87],"successfully":[90],"applied":[91],"monitor":[93],"PK":[95],"profile":[96],"oxybutynin.":[98],"drug":[100],"two-compartment":[103],"model,":[104],"volume":[107],"distribution":[109],"14":[111],"l/kg":[112],"half-life":[115],"76":[117],"min.":[118]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
