{"id":"https://openalex.org/W1996422166","doi":"https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.09.013","title":"Early Neurologic Improvement Based on the National Institutes of Health Stroke Scale Score Predicts Favorable Outcome within 30 Minutes after Undergoing Intravenous Recombinant Tissue Plasminogen Activator Therapy","display_name":"Early Neurologic Improvement Based on the National Institutes of Health Stroke Scale Score Predicts Favorable Outcome within 30 Minutes after Undergoing Intravenous Recombinant Tissue Plasminogen Activator Therapy","publication_year":2012,"publication_date":"2012-11-16","ids":{"openalex":"https://openalex.org/W1996422166","doi":"https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.09.013","mag":"1996422166","pmid":"https://pubmed.ncbi.nlm.nih.gov/23164483"},"language":"en","primary_location":{"id":"doi:10.1016/j.jstrokecerebrovasdis.2012.09.013","doi":"https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.09.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.09.013","pdf_url":null,"source":{"id":"https://openalex.org/S4210174059","display_name":"Journal of Stroke and Cerebrovascular Diseases","issn_l":"1052-3057","issn":["1052-3057","1532-8511"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Stroke and Cerebrovascular Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025032219","display_name":"Toshinori Takagi","orcid":"https://orcid.org/0000-0002-6375-9941","observed_orcids":["https://orcid.org/0000-0002-6375-9941"]},"institutions":[{"id":"https://openalex.org/I4405285478","display_name":"National Hospital Organization Toyohashi Medical Center","ror":"https://ror.org/05h4rp246","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285478"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshinori Takagi","raw_affiliation_strings":["Department of Neurosurgery, National Hospital Organization Toyohashi Medical Center, Aichi, Japan. Electronic address: ttakagi@gifu-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, National Hospital Organization Toyohashi Medical Center, Aichi, Japan. Electronic address: ttakagi@gifu-u.ac.jp","institution_ids":["https://openalex.org/I4405285478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101869345","display_name":"Takayuki Kato","orcid":"https://orcid.org/0000-0002-7210-9457","observed_orcids":["https://orcid.org/0000-0002-7210-9457"]},"institutions":[{"id":"https://openalex.org/I4405285478","display_name":"National Hospital Organization Toyohashi Medical Center","ror":"https://ror.org/05h4rp246","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285478"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Kato","raw_affiliation_strings":["Department of Neurosurgery, National Hospital Organization Toyohashi Medical Center, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, National Hospital Organization Toyohashi Medical Center, Aichi, Japan","institution_ids":["https://openalex.org/I4405285478"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hideki Sakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285478","display_name":"National Hospital Organization Toyohashi Medical Center","ror":"https://ror.org/05h4rp246","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285478"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Sakai","raw_affiliation_strings":["Department of Neurosurgery, National Hospital Organization Toyohashi Medical Center, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, National Hospital Organization Toyohashi Medical Center, Aichi, Japan","institution_ids":["https://openalex.org/I4405285478"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113494489","display_name":"Yasuaki Nishimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285478","display_name":"National Hospital Organization Toyohashi Medical Center","ror":"https://ror.org/05h4rp246","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285478"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuaki Nishimura","raw_affiliation_strings":["Department of Neurosurgery, National Hospital Organization Toyohashi Medical Center, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, National Hospital Organization Toyohashi Medical Center, Aichi, Japan","institution_ids":["https://openalex.org/I4405285478"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025032219"],"corresponding_institution_ids":["https://openalex.org/I4405285478"],"apc_list":{"value":2170,"currency":"USD","value_usd":2170},"apc_paid":null,"fwci":0.5981,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.67847048,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"23","issue":"1","first_page":"69","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.984000027179718},{"id":"https://openalex.org/keywords/intravenous-thrombolysis","display_name":"intravenous thrombolysis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/alteplase","display_name":"alteplase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nihss","display_name":"NIHSS","score":0.8349999785423279},{"id":"https://openalex.org/keywords/functional-outcome-prediction","display_name":"functional outcome prediction","score":0.8270000219345093},{"id":"https://openalex.org/keywords/modified-rankin-scale","display_name":"modified Rankin Scale","score":0.7990000247955322},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9440438747406006},{"id":"https://openalex.org/C2780931571","wikidata":"https://www.wikidata.org/wiki/Q568775","display_name":"Modified Rankin Scale","level":4,"score":0.8480085730552673},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.7105094194412231},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6310620307922363},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.5854196548461914},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5538974404335022},{"id":"https://openalex.org/C2911092318","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Recombinant tissue plasminogen activator","level":5,"score":0.4800632894039154},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.46180102229118347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4556853771209717},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.35115504264831543},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.1606186330318451},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017131","descriptor_name":"Thrombectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jstrokecerebrovasdis.2012.09.013","doi":"https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.09.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.09.013","pdf_url":null,"source":{"id":"https://openalex.org/S4210174059","display_name":"Journal of Stroke and Cerebrovascular Diseases","issn_l":"1052-3057","issn":["1052-3057","1532-8511"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Stroke and Cerebrovascular Diseases","raw_type":"journal-article"},{"id":"pmid:23164483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23164483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W31674920","https://openalex.org/W132472807","https://openalex.org/W1971169378","https://openalex.org/W1972753581","https://openalex.org/W1976352262","https://openalex.org/W2000931407","https://openalex.org/W2004886383","https://openalex.org/W2013830780","https://openalex.org/W2014881713","https://openalex.org/W2032308540","https://openalex.org/W2033053304","https://openalex.org/W2038278057","https://openalex.org/W2043649070","https://openalex.org/W2046549176","https://openalex.org/W2046629096","https://openalex.org/W2048480423","https://openalex.org/W2070074850","https://openalex.org/W2112328442","https://openalex.org/W2138411396","https://openalex.org/W2139899738","https://openalex.org/W2144716609","https://openalex.org/W2148738704","https://openalex.org/W2153606909","https://openalex.org/W2158551075","https://openalex.org/W2164763924","https://openalex.org/W2292308933","https://openalex.org/W2399155639","https://openalex.org/W2464582673","https://openalex.org/W2531503442","https://openalex.org/W4240994847","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2153506238","https://openalex.org/W3084390508","https://openalex.org/W1971169378","https://openalex.org/W1985164004","https://openalex.org/W2310297169","https://openalex.org/W1992037470","https://openalex.org/W3028858165","https://openalex.org/W2754075344","https://openalex.org/W2001844684","https://openalex.org/W2276982679"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}