{"id":"https://openalex.org/W1996409136","doi":"https://doi.org/10.1097/00007890-200407271-01709","title":"INFLUENCE OF CALCINEURININHIBITORS ON NEPHROTOXICITY AND ON LIVER REGENERATION AFTER PARTIAL HEPATECTOMY IN RATS","display_name":"INFLUENCE OF CALCINEURININHIBITORS ON NEPHROTOXICITY AND ON LIVER REGENERATION AFTER PARTIAL HEPATECTOMY IN RATS","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W1996409136","doi":"https://doi.org/10.1097/00007890-200407271-01709","mag":"1996409136"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-200407271-01709","doi":"https://doi.org/10.1097/00007890-200407271-01709","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-200407271-01709","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059338299","display_name":"Uta Dahmen","orcid":"https://orcid.org/0000-0003-3483-3388","observed_orcids":["https://orcid.org/0000-0003-3483-3388"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U Dahmen","raw_affiliation_strings":["1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110517225","display_name":"Yanli Gu","orcid":"https://orcid.org/0009-0004-3022-4336","observed_orcids":["https://orcid.org/0009-0004-3022-4336"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Y L Gu","raw_affiliation_strings":["1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086901007","display_name":"Olaf Dirsch","orcid":"https://orcid.org/0000-0003-2791-2061","observed_orcids":["https://orcid.org/0000-0003-2791-2061"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O Dirsch","raw_affiliation_strings":["1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102011950","display_name":"Yuan Ji","orcid":"https://orcid.org/0000-0002-2631-9082","observed_orcids":["https://orcid.org/0000-0002-2631-9082"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Y Ji","raw_affiliation_strings":["1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103233563","display_name":"Qing He","orcid":"https://orcid.org/0000-0001-7027-0098","observed_orcids":["https://orcid.org/0000-0001-7027-0098"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Q He","raw_affiliation_strings":["1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113831304","display_name":"Haidong Chi","orcid":"https://orcid.org/0009-0006-2795-5255","observed_orcids":["https://orcid.org/0009-0006-2795-5255"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Chi","raw_affiliation_strings":["1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4210153755"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113763951","display_name":"C. E. Broelsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C E Broelsch","raw_affiliation_strings":["1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of General and Transplantation Surgery, University Hospital of Essen, Essen; 2Institute of Pathology, University Hospital of K\u00f6ln, K\u00f6ln, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I4210153755"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1515589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":null,"first_page":"635","last_page":"635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.10260000079870224,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0925000011920929,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcineurin-inhibitors","display_name":"calcineurin inhibitors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.8690000176429749},{"id":"https://openalex.org/keywords/fk506","display_name":"FK506","score":0.8579999804496765},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.7910000085830688},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.45500001311302185},{"id":"https://openalex.org/keywords/hepatic-clearance","display_name":"hepatic clearance","score":0.6119999885559082},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.35600000619888306},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.6639999747276306},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.39899998903274536},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7200000286102295},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.39500001072883606},{"id":"https://openalex.org/keywords/bromodeoxyuridine-labeling-index","display_name":"bromodeoxyuridine labeling index","score":0.8180000185966492},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.7573065757751465},{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.6135321259498596},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6114768981933594},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.6091450452804565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5701357126235962},{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.5212910175323486},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.48202526569366455},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.46401891112327576},{"id":"https://openalex.org/C2778260397","wikidata":"https://www.wikidata.org/wiki/Q419861","display_name":"Bromodeoxyuridine","level":3,"score":0.4299566149711609},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.4154003858566284},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.39293429255485535},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39109909534454346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3763240575790405},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3437252342700958},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28848394751548767},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.19928166270256042},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.15634840726852417},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.15272065997123718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11759796738624573},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00007890-200407271-01709","doi":"https://doi.org/10.1097/00007890-200407271-01709","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-200407271-01709","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2623669478","https://openalex.org/W2068152316","https://openalex.org/W2074715790","https://openalex.org/W2041731912","https://openalex.org/W6989768749","https://openalex.org/W1671770515","https://openalex.org/W2056836310","https://openalex.org/W2153851381","https://openalex.org/W1970593137","https://openalex.org/W2564297398"],"abstract_inverted_index":{"P1214":[0],"Aims:":[1],"Calcineurininhibitors":[2],"are":[3,33],"a":[4,22,50,137,422,483],"mainstay":[5],"of":[6,26,41,53,62,67,118,139,158,168,194,225,253,265,316,342,351,382,394,424,428,438,445,451,456,470,479],"the":[7,37,39,58,159,165,223,226,251,256,284,292,339,349,354,380,391,425,446,463,467],"immunosuppressive":[8],"therapy":[9],"after":[10,16,88,129,199,203,208,298,303,308,417,473],"full":[11],"size":[12,42,444],"as":[13,15,102,214,312,314],"well":[14,313],"partial":[17,54],"liver":[18,68,294,317,383,448,471,486],"transplantation.":[19],"Nephrotoxicity":[20],"is":[21],"well-known":[23],"side":[24],"effect":[25,413],"these":[27],"drugs.":[28],"As":[29,336],"CsA":[30,169,465],"and":[31,112,121,148,156,175,205,238,270,276,305,330],"FK506":[32],"both":[34,439],"metabolized":[35],"in":[36,49,57,72,171,178,230,235,241,273,283,322,327,333,338,363,372,406,410,432,454,462],"liver,":[38],"impact":[40],"reduction":[43],"on":[44],"renal":[45],"function":[46,245,344,453],"was":[47,70,106,133,219,246,345,377,397,414,459],"explored":[48],"surrogate":[51],"model":[52],"hepatectomy":[55],"(PH)":[56],"rat.":[59],"Methods:":[60],"Resection":[61],"30%,":[63,274],"70%":[64,204,236,328],"or":[65,83,189,255],"90%":[66,181,209,242,277,299,334,364,418],"mass":[69,295,384],"performed":[71],"Lewis":[73],"rats.":[74],"Animals":[75,93,124],"received":[76],"calcineurin":[77],"inhibitors,":[78],"either":[79,249],"cyclosporine":[80],"A":[81],"(5mg/kg/day)":[82],"FK":[84],"506":[85],"(1mg/kg/day)":[86],"subcutaneously":[87],"operation":[89,95],"(n=4":[90],"each":[91],"group).":[92],"without":[94],"but":[96],"treated":[97],"with":[98,164,348,400],"CNI":[99,440],"were":[100,125,151,281,289,441],"designed":[101],"control":[103],"group.":[104],"Blood":[105],"taken":[107],"at":[108,127,136],"4,":[109],"8,":[110],"12":[111],"24":[113],"hours":[114],"postoperatively":[115],"for":[116,153],"determination":[117,157],"drug":[119,258,287,357],"concentration":[120],"serum":[122],"analysis.":[123],"sacrificed":[126],"24hr":[128],"hepatectomy.":[130],"Bromodeoxyuridine":[131],"(BrdU)":[132],"injected":[134],"intravenously":[135],"dose":[138],"50":[140],"mg/kg":[141],"1":[142],"hr":[143],"prior":[144],"to":[145,184,187,222,261,291,379,390,421,443],"sacrifice.":[146],"Liver":[147,212],"kidney":[149,343,452],"tissue":[150],"sampled":[152],"histological":[154],"analysis":[155],"BrdU-labeling":[160],"index.":[161],"Results:":[162],"Treatment":[163],"same":[166,392],"amount":[167],"resulted":[170],"significantly":[172],"higher":[173,401],"peak":[174],"trough":[176,192],"levels":[177,193,218,259,288,358,437],"animals":[179],"undergoing":[180],"PH":[182,210,237,310,329],"compared":[183],"those":[185],"subjected":[186,389],"70%PH":[188,304],"30%PH":[190],"(CsA":[191],"865":[195],"+":[196],"90":[197],"ng/ml":[198,202,207,297,302,307],"30%PH,":[200],"1038+104":[201],"1342+36":[206],"(p<0.05).":[211],"damage":[213],"indicated":[215],"by":[216,250],"GOT":[217],"also":[220,247,346],"related":[221,290,378,442],"extent":[224,252,350,381,393],"resection":[227,254,262,352,419],"(1127+435":[228],"IU/L":[229,234,240,321,326,332],"30%":[231,309,323,373],"PH,":[232,324],"1518+313":[233],"3419+758":[239],"PH).":[243,278,335,374],"Kidney":[244],"affected":[248],"elevated":[257,356],"subsequent":[260],"(BUN":[263],"level":[264],"16.8+2.6":[266],"mg/dl,":[267],"21.3+0.9":[268],"mg/dl":[269,272,362,367,371],"39.8+11.3":[271],"70%,":[275],"Similar":[279],"results":[280],"obtained":[282],"FK-group.":[285,464],"Postdose":[286],"remnant":[293,447],"(63.7+19.9":[296],"PH;":[300,365,369],"27,2+8.9":[301],"8.9+4.2":[306],"(p<0.01))":[311],"elevation":[315,458],"enzymes":[318],"(GOT:":[319],"479+187":[320],"1490+140":[325],"4795+771":[331],"observed":[337,431],"CsA-group,":[340],"impairment":[341],"associated":[347,399],"resp.":[353],"subsequently":[355],"(BUN:":[359],"99.3":[360],"+8.3":[361],"30.5+7.4":[366],"in70%":[368],"13.5+3.1":[370],"The":[375],"BrdU-LI":[376],"reduction.":[385],"However,":[386],"comparing":[387],"groups":[388],"resection,":[395,475],"CsA-treatment":[396],"always":[398],"proliferation":[402],"index":[403],"(70%PH:":[404],"31%+/-9%":[405],"CsA-group":[407],"vs":[408],"20+/-9%":[409],"FK-group).":[411],"This":[412],"especially":[415],"pronounced":[416,461],"leading":[420],"reversal":[423],"delayed":[426,468],"onset":[427,469],"proliferation,":[429],"normally":[430],"this":[433],"model.":[434],"Conclusions:":[435],"Trough":[436],"mass.":[449],"Impairment":[450],"terms":[455],"BUN":[457],"more":[460],"reversed":[466],"regeneration":[472],"subtotal":[474],"which":[476],"might":[477],"be":[478],"advantage":[480],"when":[481],"using":[482],"very":[484],"small":[485],"graft.":[487]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}