{"id":"https://openalex.org/W1996376751","doi":"https://doi.org/10.1074/jbc.m113.484360","title":"MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)","display_name":"MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)","publication_year":2013,"publication_date":"2013-07-25","ids":{"openalex":"https://openalex.org/W1996376751","doi":"https://doi.org/10.1074/jbc.m113.484360","mag":"1996376751","pmid":"https://pubmed.ncbi.nlm.nih.gov/23884416","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3764800"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m113.484360","doi":"https://doi.org/10.1074/jbc.m113.484360","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.484360","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m113.484360","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018309136","display_name":"Zsolt Kasza","orcid":"https://orcid.org/0000-0003-0884-9562","observed_orcids":["https://orcid.org/0000-0003-0884-9562"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Zsolt Kasza","raw_affiliation_strings":["From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089325358","display_name":"Peder Fredlund Fuchs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Peder Fredlund Fuchs","raw_affiliation_strings":["From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110061476","display_name":"Christoffer Tamm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christoffer Tamm","raw_affiliation_strings":["From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anna S. Eriksson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna S. Eriksson","raw_affiliation_strings":["From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027380526","display_name":"Paul W. O'Callaghan","orcid":"https://orcid.org/0000-0003-3117-5367","observed_orcids":["https://orcid.org/0000-0003-3117-5367"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Paul O'Callaghan","raw_affiliation_strings":["From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077340506","display_name":"Femke Heindryckx","orcid":"https://orcid.org/0000-0002-1987-7676","observed_orcids":["https://orcid.org/0000-0002-1987-7676"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Femke Heindryckx","raw_affiliation_strings":["From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003511545","display_name":"Dorothe Spillmann","orcid":"https://orcid.org/0000-0002-6705-9192","observed_orcids":["https://orcid.org/0000-0002-6705-9192"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Dorothe Spillmann","raw_affiliation_strings":["From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050629872","display_name":"Erik Larsson","orcid":"https://orcid.org/0000-0003-1400-0119","observed_orcids":["https://orcid.org/0000-0003-1400-0119"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Erik Larsson","raw_affiliation_strings":["the Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE-405 30 G\u00f6teborg, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE-405 30 G\u00f6teborg, and","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067982939","display_name":"S\u00e9bastien Le Jan","orcid":"https://orcid.org/0000-0003-4027-2855","observed_orcids":["https://orcid.org/0000-0003-4027-2855"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Le Jan","raw_affiliation_strings":["From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111453314","display_name":"Inger Eriksson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Inger Eriksson","raw_affiliation_strings":["From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066856648","display_name":"P\u00e4r Gerwins","orcid":"https://orcid.org/0000-0003-3374-3372","observed_orcids":["https://orcid.org/0000-0003-3374-3372"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"P\u00e4r Gerwins","raw_affiliation_strings":["From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala,; the Department of Radiology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden","From the \u2021Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala,","the \u00b6Department of Radiology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala,; the Department of Radiology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I1342360035","https://openalex.org/I2800139495"]},{"raw_affiliation_string":"From the \u2021Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala,","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]},{"raw_affiliation_string":"the \u00b6Department of Radiology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070959908","display_name":"Lena Kjell\u00e9n","orcid":"https://orcid.org/0000-0003-3973-918X","observed_orcids":["https://orcid.org/0000-0003-3973-918X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lena Kjell\u00e9n","raw_affiliation_strings":["From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003103449","display_name":"Johan Kreuger","orcid":"https://orcid.org/0000-0002-2055-7776","observed_orcids":["https://orcid.org/0000-0002-2055-7776"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Johan Kreuger","raw_affiliation_strings":["From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala,. Electronic address: Johan.Kreuger@imbim.uu.se","From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala,. Electronic address: Johan.Kreuger@imbim.uu.se","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"From the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, P. O. Box 582, SE-751 23 Uppsala,","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003103449"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5321,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.78603945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"288","issue":"36","first_page":"25956","last_page":"25963"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.22089999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.12520000338554382,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna-24","display_name":"microRNA-24","score":0.996999979019165},{"id":"https://openalex.org/keywords/ndst1","display_name":"NDST1","score":0.996999979019165},{"id":"https://openalex.org/keywords/heparan-sulfate-sulfation","display_name":"heparan sulfate sulfation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/heparan-sulfate-proteoglycans","display_name":"heparan sulfate proteoglycans","score":0.9649999737739563},{"id":"https://openalex.org/keywords/vegf-a-signaling","display_name":"VEGF-A signaling","score":0.843999981880188},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/endothelial-cell-chemotaxis","display_name":"endothelial cell chemotaxis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.8716104030609131},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.601486086845398},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46458250284194946},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.46399590373039246},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.46355950832366943},{"id":"https://openalex.org/C14858245","wikidata":"https://www.wikidata.org/wiki/Q18028241","display_name":"Kinase insert domain receptor","level":5,"score":0.4629436731338501},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4503166675567627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3937303125858307},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3022673726081848},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2409828007221222},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.22673767805099487},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006497","descriptor_name":"Heparan Sulfate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006497","descriptor_name":"Heparan Sulfate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015238","descriptor_name":"Sulfotransferases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015238","descriptor_name":"Sulfotransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m113.484360","doi":"https://doi.org/10.1074/jbc.m113.484360","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.484360","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3125039","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3764800","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3764800","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3764800","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:23884416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23884416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m113.484360","doi":"https://doi.org/10.1074/jbc.m113.484360","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.484360","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W44384258","https://openalex.org/W1488121870","https://openalex.org/W1542515897","https://openalex.org/W1964026030","https://openalex.org/W1965214377","https://openalex.org/W1971747634","https://openalex.org/W1975437957","https://openalex.org/W1980445824","https://openalex.org/W2010199873","https://openalex.org/W2022064271","https://openalex.org/W2024743861","https://openalex.org/W2025174538","https://openalex.org/W2026581189","https://openalex.org/W2029176649","https://openalex.org/W2034982562","https://openalex.org/W2036607811","https://openalex.org/W2041620275","https://openalex.org/W2042004955","https://openalex.org/W2044702943","https://openalex.org/W2046372092","https://openalex.org/W2051403674","https://openalex.org/W2053582732","https://openalex.org/W2068208889","https://openalex.org/W2068963619","https://openalex.org/W2071000690","https://openalex.org/W2074987771","https://openalex.org/W2075329854","https://openalex.org/W2079245209","https://openalex.org/W2085236613","https://openalex.org/W2099979823","https://openalex.org/W2102307358","https://openalex.org/W2103904206","https://openalex.org/W2115094397","https://openalex.org/W2122370648","https://openalex.org/W2122965729","https://openalex.org/W2123422430","https://openalex.org/W2125043984","https://openalex.org/W2126616449","https://openalex.org/W2130154562","https://openalex.org/W2131736566","https://openalex.org/W2132014421","https://openalex.org/W2137730290","https://openalex.org/W2160554864","https://openalex.org/W2163199119","https://openalex.org/W2163294226","https://openalex.org/W2164079778","https://openalex.org/W2168230240","https://openalex.org/W2216554257","https://openalex.org/W2560367415","https://openalex.org/W4301159569","https://openalex.org/W7075715036"],"related_works":["https://openalex.org/W14488441","https://openalex.org/W2560061338","https://openalex.org/W6983643186","https://openalex.org/W7099979067","https://openalex.org/W1864029557","https://openalex.org/W3156118332","https://openalex.org/W152976053","https://openalex.org/W2179904086","https://openalex.org/W2163054103","https://openalex.org/W2115961969"],"abstract_inverted_index":{"Heparan":[0,169],"sulfate":[1,170],"(HS)":[2],"proteoglycans,":[3],"present":[4,62],"at":[5],"the":[6,15,37,47,61,77],"plasma":[7],"membrane":[8],"of":[9,49,80,86,93,101,129,134,151,212],"vascular":[10],"endothelial":[11,137,160,194],"cells,":[12],"bind":[13],"to":[14,20,71,106,142,166,181],"angiogenic":[16],"growth":[17],"factor":[18],"VEGFA":[19,29,97,115,175,191],"modulate":[21,174],"its":[22],"signaling":[23,192,211],"through":[24],"VEGFR2.":[25],"The":[26],"interactions":[27],"between":[28],"and":[30,75,95,153,185,193],"proteoglycan":[31,171],"co-receptors":[32,173],"require":[33],"sulfated":[34,50],"domains":[35,52],"in":[36,53,90,109,140,159,163],"HS":[38,54,73,81,183,186,200,222],"chains.":[39],"To":[40],"date,":[41],"it":[42],"is":[43,122],"essentially":[44],"unknown":[45],"how":[46,155],"formation":[48],"protein-binding":[51],"can":[55,202,215],"be":[56,216],"regulated":[57],"by":[58],"microRNAs.":[59],"In":[60],"study,":[63],"we":[64],"show":[65],"that":[66],"microRNA-24":[67],"(miR-24)":[68],"targets":[69,179],"NDST1":[70,102,125,147,157,180],"reduce":[72,182],"sulfation":[74,184],"thereby":[76],"binding":[78],"affinity":[79,187],"for":[82,188],"VEGFA.":[83,143,167],"Elevated":[84],"levels":[85,92],"miR-24":[87,152],"also":[88,118],"resulted":[89],"reduced":[91,136,164],"VEGFR2":[94,110,119],"blunted":[96],"signaling.":[98,176],"Similarly,":[99],"suppression":[100,158],"using":[103],"siRNA":[104],"led":[105],"a":[107,149],"reduction":[108,133],"expression.":[111],"Consequently,":[112],"not":[113],"only":[114],"binding,":[116],"but":[117],"protein":[120],"expression":[121],"dependent":[123],"on":[124],"function.":[126],"Furthermore,":[127],"overexpression":[128],"miR-24,":[130],"or":[131],"siRNA-mediated":[132],"NDST1,":[135],"cell":[138,195],"chemotaxis":[139],"response":[141],"These":[144],"findings":[145],"establish":[146],"as":[148],"target":[150],"demonstrate":[154],"such":[156],"cells":[161],"results":[162],"responsiveness":[165],"Background:":[168],"(HSPG)":[172],"Results:":[177],"MicroRNA-24":[178],"VEGFA,":[189],"suppressing":[190],"migration.":[196],"Conclusion:":[197],"MicroRNAs":[198],"targeting":[199],"biosynthesis":[201],"regulate":[203],"VEGFA-induced":[204],"chemotaxis,":[205],"essential":[206],"during":[207],"angiogenesis.":[208],"Significance:":[209],"HSPG-dependent":[210],"pathophysiological":[213],"importance":[214],"targeted":[217],"via":[218],"microRNA":[219],"interference":[220],"with":[221],"biosynthesis.":[223]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}