{"id":"https://openalex.org/W199637631","doi":null,"title":"Intracellular proteins involved in Porphyromonas gingivalis-induced opsonophagocytic activities of a murine macrophage cell line (RAW264.7 cells).","display_name":"Intracellular proteins involved in Porphyromonas gingivalis-induced opsonophagocytic activities of a murine macrophage cell line (RAW264.7 cells).","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W199637631","mag":"199637631","pmid":"https://pubmed.ncbi.nlm.nih.gov/14723250"},"language":"en","primary_location":{"id":"pmid:14723250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14723250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035994385","display_name":"Wihaskoro Sosroseno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Wihaskoro Sosroseno","raw_affiliation_strings":["Department of Oral Biology, School of Dental Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia. wihaskoro@kb.usm.my"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, School of Dental Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia. wihaskoro@kb.usm.my","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104351447","display_name":"P. S. Bird","orcid":"https://orcid.org/0000-0002-2493-6108","observed_orcids":["https://orcid.org/0000-0002-2493-6108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip S Bird","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090240965","display_name":"Gregory John Seymour","orcid":"https://orcid.org/0000-0001-7595-5651","observed_orcids":["https://orcid.org/0000-0001-7595-5651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory J Seymour","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2902,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59667853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"36","issue":"4","first_page":"229","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porphyromonas-gingivalis","display_name":"Porphyromonas gingivalis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/opsonophagocytosis","display_name":"opsonophagocytosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9490000009536743},{"id":"https://openalex.org/keywords/periodontal-pathogens","display_name":"periodontal pathogens","score":0.6060000061988831},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-phosphatase","display_name":"protein phosphatase","score":0.796999990940094},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.9350000023841858},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9980000257492065},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.7260000109672546},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.551175057888031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.529560387134552},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.5086696743965149},{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.48409879207611084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4700288474559784},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46475186944007874},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.45252081751823425},{"id":"https://openalex.org/C2779084600","wikidata":"https://www.wikidata.org/wiki/Q5957181","display_name":"Staurosporine","level":4,"score":0.41182124614715576},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3631090521812439},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2769198417663574},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.14976558089256287},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015638","descriptor_name":"Cytochalasin D","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016966","descriptor_name":"Porphyromonas gingivalis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019384","descriptor_name":"Nucleic Acid Synthesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14723250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14723250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi","raw_type":"Comparative Study"},{"id":"mag:199637631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14723250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1545383294","https://openalex.org/W1569129572","https://openalex.org/W1576402354","https://openalex.org/W1589063951","https://openalex.org/W1755902553","https://openalex.org/W1926265140","https://openalex.org/W1970128167","https://openalex.org/W1998733027","https://openalex.org/W2021757024","https://openalex.org/W2029156619","https://openalex.org/W2029781087","https://openalex.org/W2054612131","https://openalex.org/W2057618822","https://openalex.org/W2059275874","https://openalex.org/W2064664675","https://openalex.org/W2097596325","https://openalex.org/W2098419854","https://openalex.org/W2100893341","https://openalex.org/W2122711376","https://openalex.org/W2134645893","https://openalex.org/W2134782454","https://openalex.org/W2154901790","https://openalex.org/W2156225506","https://openalex.org/W2163421864","https://openalex.org/W2344681112","https://openalex.org/W2413658434","https://openalex.org/W2508906859"],"related_works":["https://openalex.org/W2064664675","https://openalex.org/W4406657204","https://openalex.org/W2326756797","https://openalex.org/W1634890487","https://openalex.org/W2134789528","https://openalex.org/W2014523387","https://openalex.org/W2155808491","https://openalex.org/W1932069187","https://openalex.org/W3166752678","https://openalex.org/W7097981008"],"abstract_inverted_index":{"The":[0,118,181,226],"aim":[1],"of":[2,10,15,123,159,178,186,198,228],"this":[3,229],"study":[4],"was":[5,29],"to":[6,162,219,222,234],"determine":[7],"the":[8,108,113,121,124,129,157,164,176,196],"role":[9],"intracellular":[11],"proteins":[12],"in":[13],"phagocytosis":[14],"opsonized":[16,33,109,165],"Porphyromonas":[17],"gingivalis":[18,40,111,188],"by":[19,189,195],"RAW264.7":[20,43,160,190],"cells,":[21],"a":[22,64,70,97,223],"murine":[23,37],"macrophage-like":[24],"cell":[25],"line.":[26],"This":[27],"periodontopathogen":[28,230],"grown":[30],"anaerobically":[31],"and":[32,53,62,80,88,96,112,142,169,207,214,239],"with":[34,47,107,133,149],"an":[35,91],"IgG2a":[36],"monoclonal":[38],"anti-P.":[39],"lipopolysaccharide":[41],"antibody.":[42],"cells":[44,115,130,161,191],"were":[45,104,131],"preincubated":[46,132],"protein":[48,55,134,137,140,199,202,205],"tyrosine":[49,135,200],"kinase":[50,56,138,203],"inhibitors":[51,58,77,85,172],"(staurosporine":[52],"genistein),":[54],"C":[57,84,171,216],"(phorbol":[59],"myristic":[60,151],"acetate":[61,152],"bisindolylmaleimide),":[63],"serine/threonine":[65],"phosphatase":[66,141],"inhibitor":[67,73],"(okadaic":[68],"acid),":[69,82],"phosphatidylinositol":[71,143,208],"3-kinase":[72,144,209],"(worthmannin),":[74],"phospholipase":[75,83,170,212,215],"A2":[76,168,213],"(bromophenacyl":[78],"bromide":[79],"nordihydroguaiaretic":[81],"(p-chloromercuriphenyl":[86],"sulfonate":[87],"neomycin":[89],"sulfate),":[90],"actin-filament":[92],"depolymerizer":[93],"(cytochalasin":[94],"D),":[95],"microtubule":[98,240],"disrupting":[99],"agent":[100],"(colchicine).":[101],"Inhibitor-treated":[102],"macrophages":[103],"then":[105],"incubated":[106],"P.":[110,187],"phagocytosed":[114,125,179],"determined":[116,194],"microscopically.":[117],"results":[119,182],"showed":[120],"percentage":[122],"organisms":[126],"decreased":[127],"when":[128],"kinase,":[136,201],"C,":[139,204],"inhibitors.":[145],"Of":[146],"interest,":[147],"preincubation":[148],"phorbol":[150],"for":[153],"30":[154],"min":[155],"increased":[156],"ability":[158],"phagocytose":[163],"organisms.":[166,180],"Phospholipase":[167],"only":[173],"slightly":[174],"reduced":[175],"number":[177],"indicated":[183],"that":[184],"opsonophagocytosis":[185,227],"might":[192],"be":[193,220,235],"activation":[197],"phosphatases,":[206],"inhibitor.":[210],"Both":[211],"would":[217,231],"appear":[218,233],"involved":[221],"lesser":[224],"extent.":[225],"also":[232],"dependent":[236],"upon":[237],"actin":[238],"polymerization.":[241]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}