{"id":"https://openalex.org/W1996370126","doi":"https://doi.org/10.1165/ajrcmb.16.5.9160844","title":"Protein Tyrosine Phosphatases Mediate Cell Readhesion in Alveolar Epithelial Cells Mechanically Separated from In Vitro Matrix","display_name":"Protein Tyrosine Phosphatases Mediate Cell Readhesion in Alveolar Epithelial Cells Mechanically Separated from In Vitro Matrix","publication_year":1997,"publication_date":"1997-05-01","ids":{"openalex":"https://openalex.org/W1996370126","doi":"https://doi.org/10.1165/ajrcmb.16.5.9160844","mag":"1996370126","pmid":"https://pubmed.ncbi.nlm.nih.gov/9160844"},"language":"en","primary_location":{"id":"doi:10.1165/ajrcmb.16.5.9160844","doi":"https://doi.org/10.1165/ajrcmb.16.5.9160844","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb.16.5.9160844","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025964036","display_name":"Bonnie L. Oliver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B L Oliver","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069344410","display_name":"Chrystelle Garat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Garat","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060844243","display_name":"Robert Pytela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Pytela","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052576862","display_name":"Michael A. Matthay","orcid":"https://orcid.org/0000-0003-3039-8155","observed_orcids":["https://orcid.org/0000-0003-3039-8155"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Matthay","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":0.5954,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.61310195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"16","issue":"5","first_page":"613","last_page":"620"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.996999979019165},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.7250000238418579},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.7979999780654907},{"id":"https://openalex.org/keywords/paxillin","display_name":"paxillin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pp60src","display_name":"pp60src","score":0.921999990940094},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.8330000042915344},{"id":"https://openalex.org/keywords/phenylarsine-oxide","display_name":"phenylarsine oxide","score":0.9210000038146973},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.7860000133514404},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.6520000100135803},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C116581196","wikidata":"https://www.wikidata.org/wiki/Q14906591","display_name":"Paxillin","level":4,"score":0.8144224882125854},{"id":"https://openalex.org/C108391706","wikidata":"https://www.wikidata.org/wiki/Q15333532","display_name":"PTK2","level":5,"score":0.6838134527206421},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.681011438369751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6362451910972595},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.5939009785652161},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.5905365943908691},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.5900282859802246},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4975323975086212},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3696403503417969},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32301342487335205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30634891986846924},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.2615843117237091},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.1296215057373047}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016392","descriptor_name":"Proto-Oncogene Proteins pp60(c-src)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051416","descriptor_name":"Focal Adhesion Protein-Tyrosine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051419","descriptor_name":"Paxillin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1165/ajrcmb.16.5.9160844","doi":"https://doi.org/10.1165/ajrcmb.16.5.9160844","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb.16.5.9160844","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:9160844","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9160844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8055508284","display_name":"Lung Fluid Balance and Mesenchymal Stem Cells","funder_award_id":"R01HL051854","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1282498","https://openalex.org/W177624256","https://openalex.org/W1527739697","https://openalex.org/W1537459781","https://openalex.org/W1705619492","https://openalex.org/W1949178966","https://openalex.org/W1967265143","https://openalex.org/W1976655304","https://openalex.org/W1977426071","https://openalex.org/W1980554628","https://openalex.org/W1981462495","https://openalex.org/W1986639792","https://openalex.org/W1989297731","https://openalex.org/W2043707891","https://openalex.org/W2054779757","https://openalex.org/W2057150846","https://openalex.org/W2061099385","https://openalex.org/W2061229454","https://openalex.org/W2066367871","https://openalex.org/W2070556283","https://openalex.org/W2093629685","https://openalex.org/W2096569449","https://openalex.org/W2106726165","https://openalex.org/W2148849095","https://openalex.org/W2155959312","https://openalex.org/W2156451315","https://openalex.org/W2167305208","https://openalex.org/W2340094078","https://openalex.org/W2408890720","https://openalex.org/W2417754394","https://openalex.org/W2443848008","https://openalex.org/W2443851309"],"related_works":["https://openalex.org/W2158340099","https://openalex.org/W2342103121","https://openalex.org/W4389022302","https://openalex.org/W2047677581","https://openalex.org/W1983414601","https://openalex.org/W1745582732","https://openalex.org/W2231711532","https://openalex.org/W4386514813","https://openalex.org/W4290693644","https://openalex.org/W3172082242"],"abstract_inverted_index":{"Alveolar":[0],"epithelial":[1,13,26,52,69,198,214],"type":[2,27],"II":[3,28],"cells":[4,8,29,53,173,199],"are":[5,72,192,200],"the":[6,11,24,62,78,95,122,127,151],"progenitor":[7],"for":[9,212],"restoring":[10],"alveolar":[12,25,51,68,197,213],"barrier":[14],"after":[15,91,105,135,195],"acute":[16],"lung":[17,22],"injury.":[18],"During":[19],"repair":[20],"of":[21,46,49,82,94,117,126,139,157,170],"injury,":[23],"reepithelialize":[30],"denuded":[31],"air":[32],"spaces,":[33],"a":[34,145,179],"process":[35],"that":[36,65,77,188],"involves":[37],"breaking":[38],"and":[39,87,109,162,207],"reforming":[40],"cell":[41,70,140,215],"adhesions.":[42],"A":[43],"novel":[44],"technique":[45],"mechanical":[47,92,106,136],"separation":[48,93],"cultured":[50,196],"from":[54,203],"in":[55,153,204],"vitro":[56,205],"matrix":[57],"was":[58],"used":[59],"to":[60,99],"examine":[61],"intracellular":[63],"signals":[64],"result":[66],"when":[67],"adhesions":[71],"broken.":[73],"The":[74],"results":[75],"show":[76],"tyrosine":[79,123,147,154,180,190],"phosphorylation":[80,119,124,155],"levels":[81,156],"focal":[83,113,158],"adhesion":[84,114,159],"kinase,":[85,130,160],"paxillin,":[86],"pp60(src)":[88],"decreased":[89],"immediately":[90,194],"cells.":[96],"Levels":[97],"returned":[98],"nearly":[100],"normal":[101],"by":[102],"24":[103,175],"h":[104],"separation.":[107,137],"Paxillin":[108],"pp60(scr)":[110],"coprecipitated":[111],"with":[112,142],"kinase":[115,181],"regardless":[116],"their":[118,208],"state.":[120],"Interestingly,":[121],"level":[125],"mitogen-activated":[128],"protein":[129,146,189],"p42(erk2),":[131],"increased":[132],"15":[133],"min":[134],"Preincubation":[138],"monolayers":[141],"phenylarsine":[143],"oxide,":[144],"phosphatase":[148],"inhibitor,":[149,182],"blocked":[150],"decrease":[152],"paxillin":[161],"pp60(src).":[163],"Phenylarsine":[164],"oxide":[165],"incubation":[166],"also":[167],"prevented":[168],"readhesion":[169],"mechanically":[171,201],"separated":[172,202],"at":[174],"h,":[176],"but":[177],"genistein,":[178],"had":[183],"no":[184],"effect.":[185],"We":[186],"conclude":[187],"phosphatases":[191],"activated":[193],"matrix,":[206],"activation":[209],"is":[210],"required":[211],"readhesion.":[216]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}