{"id":"https://openalex.org/W1996347014","doi":"https://doi.org/10.1006/niox.1998.0175","title":"Nitric Oxide Activates Granule-Associated DNase in Human Monocytes","display_name":"Nitric Oxide Activates Granule-Associated DNase in Human Monocytes","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W1996347014","doi":"https://doi.org/10.1006/niox.1998.0175","mag":"1996347014","pmid":"https://pubmed.ncbi.nlm.nih.gov/9731634"},"language":"en","primary_location":{"id":"doi:10.1006/niox.1998.0175","doi":"https://doi.org/10.1006/niox.1998.0175","is_oa":false,"landing_page_url":"https://doi.org/10.1006/niox.1998.0175","pdf_url":null,"source":{"id":"https://openalex.org/S152998702","display_name":"Nitric Oxide","issn_l":"1089-8603","issn":["1089-8603","1089-8611"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nitric Oxide","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/10171/20313","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051024704","display_name":"Rub\u00e9n P\u0131\u0301o","orcid":"https://orcid.org/0000-0002-6831-6111","observed_orcids":["https://orcid.org/0000-0002-6831-6111"]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rub\u00e9n P\u0131\u0301o","raw_affiliation_strings":["Department of Biochemistry, University of Navarra, 31080, Pamplona, Spain","Department of Biochemistry, University of Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Navarra, 31080, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Department of Biochemistry, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011593289","display_name":"Mar\u0131\u0301a J. L\u00f3pez-Zabalza","orcid":"https://orcid.org/0000-0002-4778-3319","observed_orcids":["https://orcid.org/0000-0002-4778-3319"]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u0131\u0301a J. L\u00f3pez-Zabalza","raw_affiliation_strings":["Department of Biochemistry, University of Navarra, 31080, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Navarra, 31080, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064771070","display_name":"Ana Rouzaut","orcid":"https://orcid.org/0000-0003-3226-9162","observed_orcids":["https://orcid.org/0000-0003-3226-9162"]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Rouzaut","raw_affiliation_strings":["Department of Biochemistry, University of Navarra, 31080, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Navarra, 31080, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103446319","display_name":"Esteban Santiago","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Esteban Santiago","raw_affiliation_strings":["Department of Biochemistry, University of Navarra, 31080, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Navarra, 31080, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078469152","display_name":"Natalia L\u00f3pez-Moratalla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Natalia L\u00f3pez-Moratalla","raw_affiliation_strings":["Department of Biochemistry, University of Navarra, 31080, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Navarra, 31080, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078469152"],"corresponding_institution_ids":["https://openalex.org/I88155538"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.3589,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.58145485,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":"3","first_page":"165","last_page":"173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.03480000048875809,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dnase","display_name":"DNase","score":0.7329999804496765},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.7400000095367432},{"id":"https://openalex.org/keywords/secretory-granules","display_name":"secretory granules","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cd14-cd16-monocytes","display_name":"CD14+CD16+ monocytes","score":0.8849999904632568},{"id":"https://openalex.org/keywords/monocyte-activation","display_name":"monocyte activation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.6610000133514404},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/calcium-dependence","display_name":"calcium dependence","score":0.7179999947547913},{"id":"https://openalex.org/keywords/zinc-inhibition","display_name":"zinc inhibition","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibitors","display_name":"nitric oxide synthase inhibitors","score":0.5559999942779541},{"id":"https://openalex.org/keywords/protein-a","display_name":"protein A","score":0.6269999742507935},{"id":"https://openalex.org/keywords/double-stranded-dna","display_name":"double-stranded DNA","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2777824588","wikidata":"https://www.wikidata.org/wiki/Q414783","display_name":"Dithiothreitol","level":3,"score":0.659604549407959},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.6377934217453003},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5865949988365173},{"id":"https://openalex.org/C2781462264","wikidata":"https://www.wikidata.org/wiki/Q78482053","display_name":"CD16","level":5,"score":0.5586428046226501},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.5372315645217896},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.5070405006408691},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5054707527160645},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.4743451178073883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4629778265953064},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4610961675643921},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.45702359080314636},{"id":"https://openalex.org/C58237431","wikidata":"https://www.wikidata.org/wiki/Q5958570","display_name":"Hypersensitive site","level":5,"score":0.4192141592502594},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.39142003655433655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3717024028301239},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3601865768432617},{"id":"https://openalex.org/C2779377703","wikidata":"https://www.wikidata.org/wiki/Q14901483","display_name":"Deoxyribonuclease I","level":4,"score":0.32146310806274414},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31752607226371765},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2207411527633667},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.20544123649597168},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17903324961662292},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1602812111377716},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1254865527153015},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.0},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.0},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003851","descriptor_name":"Deoxyribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004229","descriptor_name":"Dithiothreitol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019323","descriptor_name":"omega-N-Methylarginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1006/niox.1998.0175","doi":"https://doi.org/10.1006/niox.1998.0175","is_oa":false,"landing_page_url":"https://doi.org/10.1006/niox.1998.0175","pdf_url":null,"source":{"id":"https://openalex.org/S152998702","display_name":"Nitric Oxide","issn_l":"1089-8603","issn":["1089-8603","1089-8611"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nitric Oxide","raw_type":"journal-article"},{"id":"pmid:9731634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9731634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nitric oxide : biology and chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:dadun.unav.edu:10171/20313","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10171/20313","pdf_url":"https://hdl.handle.net/10171/20313","source":{"id":"https://openalex.org/S4306401514","display_name":"Deposito Adademico Digital Universidad De Navarra (University of Navarra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88155538","host_organization_name":"Universidad de Navarra","host_organization_lineage":["https://openalex.org/I88155538"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:dadun.unav.edu:10171/20313","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10171/20313","pdf_url":"https://hdl.handle.net/10171/20313","source":{"id":"https://openalex.org/S4306401514","display_name":"Deposito Adademico Digital Universidad De Navarra (University of Navarra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88155538","host_organization_name":"Universidad de Navarra","host_organization_lineage":["https://openalex.org/I88155538"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1996347014.pdf","grobid_xml":"https://content.openalex.org/works/W1996347014.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W43833714","https://openalex.org/W97542383","https://openalex.org/W1489532715","https://openalex.org/W1493323885","https://openalex.org/W1516037605","https://openalex.org/W1557119871","https://openalex.org/W1559184092","https://openalex.org/W1571460296","https://openalex.org/W1596698400","https://openalex.org/W1929009802","https://openalex.org/W1934025219","https://openalex.org/W1964743024","https://openalex.org/W1981667568","https://openalex.org/W1981883990","https://openalex.org/W1988465894","https://openalex.org/W1992961556","https://openalex.org/W2000075945","https://openalex.org/W2004658589","https://openalex.org/W2014286993","https://openalex.org/W2014746174","https://openalex.org/W2021864452","https://openalex.org/W2026125174","https://openalex.org/W2031886438","https://openalex.org/W2033885400","https://openalex.org/W2048723286","https://openalex.org/W2057943668","https://openalex.org/W2059680068","https://openalex.org/W2061825312","https://openalex.org/W2066840310","https://openalex.org/W2068790232","https://openalex.org/W2072849495","https://openalex.org/W2074443913","https://openalex.org/W2080567147","https://openalex.org/W2084609653","https://openalex.org/W2089747387","https://openalex.org/W2130929490","https://openalex.org/W2137495367","https://openalex.org/W2142617031","https://openalex.org/W2163459118","https://openalex.org/W2165389027","https://openalex.org/W2167973356","https://openalex.org/W2170834275","https://openalex.org/W2320556745","https://openalex.org/W2344904906","https://openalex.org/W2397701088","https://openalex.org/W2397954748","https://openalex.org/W2417367233","https://openalex.org/W2463427900","https://openalex.org/W3101546822","https://openalex.org/W4285719527","https://openalex.org/W4313323083"],"related_works":["https://openalex.org/W7097034789","https://openalex.org/W2313246465","https://openalex.org/W6989807082","https://openalex.org/W2413590670","https://openalex.org/W2084677014","https://openalex.org/W2471825451","https://openalex.org/W2139801480","https://openalex.org/W2001511989","https://openalex.org/W1965903434","https://openalex.org/W2395106844"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
