{"id":"https://openalex.org/W1996282922","doi":"https://doi.org/10.1007/s00405-013-2400-9","title":"Molecular diagnostic alterations in squamous cell carcinoma of the head and neck and potential diagnostic applications","display_name":"Molecular diagnostic alterations in squamous cell carcinoma of the head and neck and potential diagnostic applications","publication_year":2013,"publication_date":"2013-03-06","ids":{"openalex":"https://openalex.org/W1996282922","doi":"https://doi.org/10.1007/s00405-013-2400-9","mag":"1996282922","pmid":"https://pubmed.ncbi.nlm.nih.gov/23467835"},"language":"en","primary_location":{"id":"doi:10.1007/s00405-013-2400-9","doi":"https://doi.org/10.1007/s00405-013-2400-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00405-013-2400-9","pdf_url":null,"source":{"id":"https://openalex.org/S163740676","display_name":"European Archives of Oto-Rhino-Laryngology","issn_l":"0937-4477","issn":["0937-4477","1434-4726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Archives of Oto-Rhino-Laryngology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10651/17621","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059315630","display_name":"Jennifer Leigh Hunt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Hunt","raw_affiliation_strings":["Department of Pathology and Laboratory Services, College of Medicine, University of Arkansas for Medical Sciences, Arkansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Services, College of Medicine, University of Arkansas for Medical Sciences, Arkansas, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021672110","display_name":"Leon E. Barnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leon Barnes","raw_affiliation_strings":["Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006075716","display_name":"James S. Lewis","orcid":"https://orcid.org/0000-0001-9002-1283","observed_orcids":["https://orcid.org/0000-0001-9002-1283"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James S. Lewis","raw_affiliation_strings":["Department of Pathology and Immunology and Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology and Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086077613","display_name":"Magdy E. Mahfouz","orcid":"https://orcid.org/0000-0002-0616-6365","observed_orcids":["https://orcid.org/0000-0002-0616-6365"]},"institutions":[{"id":"https://openalex.org/I130309236","display_name":"Kafrelsheikh University","ror":"https://ror.org/04a97mm30","country_code":"EG","type":"education","lineage":["https://openalex.org/I130309236"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Magdy E. Mahfouz","raw_affiliation_strings":["Faculty of Science, Kafrelsheikh University, Kafrelsheikh, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, Kafrelsheikh University, Kafrelsheikh, Egypt","institution_ids":["https://openalex.org/I130309236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111556212","display_name":"Pieter Johannes Slootweg","orcid":"https://orcid.org/0000-0001-6363-5167","observed_orcids":["https://orcid.org/0000-0001-6363-5167"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pieter J. Slootweg","raw_affiliation_strings":["Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035360576","display_name":"Lester D.\ufffdR. Thompson","orcid":"https://orcid.org/0000-0003-3714-1432","observed_orcids":["https://orcid.org/0000-0003-3714-1432"]},"institutions":[{"id":"https://openalex.org/I4210116015","display_name":"Woodland Hills Medical Center","ror":"https://ror.org/02bx0ak73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lester D. R. Thompson","raw_affiliation_strings":["Department of Pathology, Woodland Hills Medical Center, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Woodland Hills Medical Center, California, USA","institution_ids":["https://openalex.org/I4210116015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087130137","display_name":"Antonio Cardesa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio Cardesa","raw_affiliation_strings":["Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046926709","display_name":"Kenneth O. Devaney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802853113","display_name":"Henry Ford Allegiance Health","ror":"https://ror.org/028tezs28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802853113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth O. Devaney","raw_affiliation_strings":["Department of Pathology, Allegiance Health, Jackson, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Allegiance Health, Jackson, MI, USA","institution_ids":["https://openalex.org/I2802853113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077818","display_name":"Douglas R. Gnepp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas R. Gnepp","raw_affiliation_strings":["Department of Pathology, Warren Alpert School of Medicine at Brown University, Rhode Island Hospital, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Warren Alpert School of Medicine at Brown University, Rhode Island Hospital, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021281217","display_name":"William H. Westra","orcid":"https://orcid.org/0000-0001-5568-6634","observed_orcids":["https://orcid.org/0000-0001-5568-6634"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William H. Westra","raw_affiliation_strings":["Departments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008617030","display_name":"Juan Pablo Rodrigo","orcid":"https://orcid.org/0000-0003-3063-0890","observed_orcids":["https://orcid.org/0000-0003-3063-0890"]},"institutions":[{"id":"https://openalex.org/I4210133994","display_name":"Hospital Universitario Central de Asturias","ror":"https://ror.org/03v85ar63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210133994","https://openalex.org/I4405258403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan P. Rodrigo","raw_affiliation_strings":["Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain","Instituto Universitario de Oncolog\u00eda del Principado de Asturias, Oviedo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain","institution_ids":["https://openalex.org/I4210133994"]},{"raw_affiliation_string":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias, Oviedo, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075057487","display_name":"Julia Anne Woolgar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julia A. Woolgar","raw_affiliation_strings":["Oral Pathology, School of Dentistry and Dental Hospital, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral Pathology, School of Dentistry and Dental Hospital, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054848341","display_name":"Alessandra Rinaldo","orcid":"https://orcid.org/0000-0001-7956-6709","observed_orcids":["https://orcid.org/0000-0001-7956-6709"]},"institutions":[{"id":"https://openalex.org/I129043915","display_name":"University of Udine","ror":"https://ror.org/05ht0mh31","country_code":"IT","type":"education","lineage":["https://openalex.org/I129043915"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Rinaldo","raw_affiliation_strings":["ENT Clinic, University of Udine, Piazzale S. Maria della Misericordia, I-33100, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ENT Clinic, University of Udine, Piazzale S. Maria della Misericordia, I-33100, Udine, Italy","institution_ids":["https://openalex.org/I129043915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015064139","display_name":"Asterios G. Triantafyllou","orcid":"https://orcid.org/0000-0001-8752-5595","observed_orcids":["https://orcid.org/0000-0001-8752-5595"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Asterios Triantafyllou","raw_affiliation_strings":["Oral Pathology, School of Dentistry and Dental Hospital, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral Pathology, School of Dentistry and Dental Hospital, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005861774","display_name":"Robert Paul Takes","orcid":"https://orcid.org/0000-0003-4784-0499","observed_orcids":["https://orcid.org/0000-0003-4784-0499"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert P. Takes","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027111963","display_name":"Alfio Ferlito","orcid":"https://orcid.org/0000-0002-8247-8002","observed_orcids":["https://orcid.org/0000-0002-8247-8002"]},"institutions":[{"id":"https://openalex.org/I129043915","display_name":"University of Udine","ror":"https://ror.org/05ht0mh31","country_code":"IT","type":"education","lineage":["https://openalex.org/I129043915"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alfio Ferlito","raw_affiliation_strings":["ENT Clinic, University of Udine, Piazzale S. Maria della Misericordia, I-33100, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ENT Clinic, University of Udine, Piazzale S. Maria della Misericordia, I-33100, Udine, Italy","institution_ids":["https://openalex.org/I129043915"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5027111963"],"corresponding_institution_ids":["https://openalex.org/I129043915"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":null,"fwci":1.1997,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.69303797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"271","issue":"2","first_page":"211","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/molecular-diagnostic-markers","display_name":"molecular diagnostic markers","score":0.7360000014305115},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.996999979019165},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ras","display_name":"Ras","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ccnd1","display_name":"CCND1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/braf","display_name":"BRAF","score":1.0},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":1.0},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":1.0},{"id":"https://openalex.org/keywords/notches","display_name":"notches","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":1.0},{"id":"https://openalex.org/keywords/targeted-therapy-resistance","display_name":"targeted therapy resistance","score":0.8669999837875366},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.7988086938858032},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6706350445747375},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6666633486747742},{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.6024681925773621},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5418605804443359},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5188494920730591},{"id":"https://openalex.org/C179786068","wikidata":"https://www.wikidata.org/wiki/Q16257937","display_name":"Molecular diagnostics","level":2,"score":0.4448099434375763},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.4130327105522156},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37809351086616516},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3444559574127197},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33434319496154785},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3328273594379425},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2843058407306671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.272441565990448}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018773","descriptor_name":"Genes, erbB-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019942","descriptor_name":"Genes, p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s00405-013-2400-9","doi":"https://doi.org/10.1007/s00405-013-2400-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00405-013-2400-9","pdf_url":null,"source":{"id":"https://openalex.org/S163740676","display_name":"European Archives of Oto-Rhino-Laryngology","issn_l":"0937-4477","issn":["0937-4477","1434-4726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Archives of Oto-Rhino-Laryngology","raw_type":"journal-article"},{"id":"pmid:23467835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23467835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","raw_type":"Journal Article"},{"id":"pmh:oai:digibuo.uniovi.es:10651/17621","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10651/17621","pdf_url":null,"source":{"id":"https://openalex.org/S4306402334","display_name":"Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educaci\u00f3n, Cultura y Deporte)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801976130","host_organization_name":"Ministerio de Educaci\u00f3n Cultura y Deporte","host_organization_lineage":["https://openalex.org/I2801976130"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SCOPUS","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/137464","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/137464","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/137464","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/137464","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Archives of Oto-Rhino-Laryngology, 271, 211 - 23","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:digibuo.uniovi.es:10651/17621","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10651/17621","pdf_url":null,"source":{"id":"https://openalex.org/S4306402334","display_name":"Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educaci\u00f3n, Cultura y Deporte)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801976130","host_organization_name":"Ministerio de Educaci\u00f3n Cultura y Deporte","host_organization_lineage":["https://openalex.org/I2801976130"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SCOPUS","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":156,"referenced_works":["https://openalex.org/W45019959","https://openalex.org/W45574800","https://openalex.org/W1491728704","https://openalex.org/W1586268638","https://openalex.org/W1759636304","https://openalex.org/W1783393452","https://openalex.org/W1963828558","https://openalex.org/W1964550379","https://openalex.org/W1967727795","https://openalex.org/W1968108709","https://openalex.org/W1971492107","https://openalex.org/W1971836864","https://openalex.org/W1976004034","https://openalex.org/W1976183506","https://openalex.org/W1978089748","https://openalex.org/W1980181140","https://openalex.org/W1980443648","https://openalex.org/W1980992111","https://openalex.org/W1983019576","https://openalex.org/W1985095741","https://openalex.org/W1985555097","https://openalex.org/W1987575156","https://openalex.org/W1987584071","https://openalex.org/W1989916529","https://openalex.org/W1990449713","https://openalex.org/W1990956554","https://openalex.org/W1992031126","https://openalex.org/W1992495998","https://openalex.org/W1995412342","https://openalex.org/W1996749665","https://openalex.org/W1997148726","https://openalex.org/W1998516111","https://openalex.org/W1999965800","https://openalex.org/W2000572121","https://openalex.org/W2001186850","https://openalex.org/W2003984225","https://openalex.org/W2004315195","https://openalex.org/W2004637409","https://openalex.org/W2005092992","https://openalex.org/W2005145657","https://openalex.org/W2005628661","https://openalex.org/W2005887025","https://openalex.org/W2006532235","https://openalex.org/W2011271315","https://openalex.org/W2014343565","https://openalex.org/W2014468183","https://openalex.org/W2015725869","https://openalex.org/W2016503230","https://openalex.org/W2017286592","https://openalex.org/W2017756000","https://openalex.org/W2019669018","https://openalex.org/W2020259966","https://openalex.org/W2022734652","https://openalex.org/W2022892077","https://openalex.org/W2024034994","https://openalex.org/W2024927331","https://openalex.org/W2028496196","https://openalex.org/W2028666543","https://openalex.org/W2029311767","https://openalex.org/W2029542200","https://openalex.org/W2032438201","https://openalex.org/W2035420402","https://openalex.org/W2037803591","https://openalex.org/W2038822025","https://openalex.org/W2040358045","https://openalex.org/W2043620121","https://openalex.org/W2043808543","https://openalex.org/W2049284365","https://openalex.org/W2049723491","https://openalex.org/W2050161865","https://openalex.org/W2053269672","https://openalex.org/W2055588547","https://openalex.org/W2056123952","https://openalex.org/W2059911078","https://openalex.org/W2060763328","https://openalex.org/W2061200607","https://openalex.org/W2062312459","https://openalex.org/W2064651903","https://openalex.org/W2070045233","https://openalex.org/W2071480068","https://openalex.org/W2072346087","https://openalex.org/W2077858999","https://openalex.org/W2079286299","https://openalex.org/W2079701251","https://openalex.org/W2084951542","https://openalex.org/W2086220621","https://openalex.org/W2087377792","https://openalex.org/W2089585500","https://openalex.org/W2089806859","https://openalex.org/W2091621595","https://openalex.org/W2093802161","https://openalex.org/W2097094801","https://openalex.org/W2097521644","https://openalex.org/W2100235133","https://openalex.org/W2102079974","https://openalex.org/W2105595995","https://openalex.org/W2107832538","https://openalex.org/W2108679528","https://openalex.org/W2109773010","https://openalex.org/W2111662371","https://openalex.org/W2113360092","https://openalex.org/W2115644310","https://openalex.org/W2118073504","https://openalex.org/W2121456155","https://openalex.org/W2121854540","https://openalex.org/W2124285219","https://openalex.org/W2124600360","https://openalex.org/W2127096583","https://openalex.org/W2127605299","https://openalex.org/W2127761660","https://openalex.org/W2127784700","https://openalex.org/W2130728096","https://openalex.org/W2130880475","https://openalex.org/W2132292472","https://openalex.org/W2132580270","https://openalex.org/W2133183695","https://openalex.org/W2133671622","https://openalex.org/W2135124600","https://openalex.org/W2137569018","https://openalex.org/W2138526447","https://openalex.org/W2139599388","https://openalex.org/W2140377768","https://openalex.org/W2141274038","https://openalex.org/W2142434083","https://openalex.org/W2142439497","https://openalex.org/W2142869330","https://openalex.org/W2143762715","https://openalex.org/W2144066241","https://openalex.org/W2148174696","https://openalex.org/W2148242501","https://openalex.org/W2150110887","https://openalex.org/W2150455500","https://openalex.org/W2150705064","https://openalex.org/W2152332206","https://openalex.org/W2153013045","https://openalex.org/W2153260785","https://openalex.org/W2155029995","https://openalex.org/W2155457504","https://openalex.org/W2155598934","https://openalex.org/W2157331935","https://openalex.org/W2158193206","https://openalex.org/W2158508310","https://openalex.org/W2159664205","https://openalex.org/W2161916387","https://openalex.org/W2162754930","https://openalex.org/W2167985694","https://openalex.org/W2170996817","https://openalex.org/W2171138371","https://openalex.org/W2320299038","https://openalex.org/W2321698899","https://openalex.org/W2331348829","https://openalex.org/W2335162820","https://openalex.org/W2405772486","https://openalex.org/W3191734867","https://openalex.org/W4211070369","https://openalex.org/W4251333818"],"related_works":["https://openalex.org/W2055247678","https://openalex.org/W1987900382","https://openalex.org/W56020840","https://openalex.org/W2001186850","https://openalex.org/W7045400603","https://openalex.org/W2076287811","https://openalex.org/W1989237682","https://openalex.org/W4401773097","https://openalex.org/W2021511985","https://openalex.org/W347086323"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}