{"id":"https://openalex.org/W1996264333","doi":"https://doi.org/10.1056/nejm200306193482523","title":"Interleukin-1\u2013Receptor Antagonist in the Muckle\u2013Wells Syndrome","display_name":"Interleukin-1\u2013Receptor Antagonist in the Muckle\u2013Wells Syndrome","publication_year":2003,"publication_date":"2003-06-18","ids":{"openalex":"https://openalex.org/W1996264333","doi":"https://doi.org/10.1056/nejm200306193482523","mag":"1996264333","pmid":"https://pubmed.ncbi.nlm.nih.gov/12815153"},"language":"en","primary_location":{"id":"doi:10.1056/nejm200306193482523","doi":"https://doi.org/10.1056/nejm200306193482523","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejm200306193482523","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM200306193482523?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM200306193482523?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033490022","display_name":"Philip Nigel Hawkins","orcid":"https://orcid.org/0000-0002-6983-9598","observed_orcids":["https://orcid.org/0000-0002-6983-9598","https://orcid.org/0000-0002-6979-0464"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip N. Hawkins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020344924","display_name":"Helen Jane Lachmann","orcid":"https://orcid.org/0000-0001-8378-2498","observed_orcids":["https://orcid.org/0000-0001-8378-2498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen J. Lachmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060095007","display_name":"Michael McDermott","orcid":"https://orcid.org/0000-0002-1015-0745","observed_orcids":["https://orcid.org/0000-0002-1015-0745"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael F. McDermott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":26.0219,"has_fulltext":false,"cited_by_count":656,"citation_normalized_percentile":{"value":0.99893683,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"348","issue":"25","first_page":"2583","last_page":"2584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9819999933242798},{"id":"https://openalex.org/keywords/muckle-wells-syndrome","display_name":"Muckle-Wells syndrome","score":0.9890000224113464},{"id":"https://openalex.org/keywords/il-1r1","display_name":"IL1R1","score":0.43700000643730164},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.41600000858306885},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.722000002861023},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8726449608802795},{"id":"https://openalex.org/C149892131","wikidata":"https://www.wikidata.org/wiki/Q14914156","display_name":"Interleukin 1 receptor antagonist","level":5,"score":0.6292825937271118},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5267543196678162},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.49843621253967285},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4680352509021759},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3741837441921234},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3453771471977234}],"mesh":[{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009404","descriptor_name":"Nephrotic Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053590","descriptor_name":"Interleukin 1 Receptor Antagonist Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1056/nejm200306193482523","doi":"https://doi.org/10.1056/nejm200306193482523","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejm200306193482523","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM200306193482523?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:12815153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12815153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Case Reports"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:8603","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/8603/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NEW ENGL J MED , 348 (25) 2583 - 2584. (2003)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1056/nejm200306193482523","doi":"https://doi.org/10.1056/nejm200306193482523","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejm200306193482523","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM200306193482523?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1996264333.pdf"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W1524848610","https://openalex.org/W2032140498","https://openalex.org/W2103402325","https://openalex.org/W2164013854","https://openalex.org/W2164450207"],"related_works":["https://openalex.org/W6908894475","https://openalex.org/W2163844261","https://openalex.org/W2126787991","https://openalex.org/W2038636068","https://openalex.org/W7096699180","https://openalex.org/W2067407289","https://openalex.org/W2176606419","https://openalex.org/W2025438474","https://openalex.org/W4302612141","https://openalex.org/W1861784875"],"abstract_inverted_index":{"To":[0],"the":[1],"Editor:":[2],"Studies":[3],"of":[4],"hereditary":[5],"inflammatory":[6],"disorders":[7],"have":[8],"identified":[9],"novel":[10],"genes":[11],"and":[12,20],"pathways":[13],"that":[14],"may":[15],"be":[16],"involved":[17],"in":[18,24],"inflammation":[19],"apoptosis":[21],"generally.":[22],"Mutations":[23],"one":[25],"such":[26],"gene,":[27],"variou...":[28]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":31},{"year":2012,"cited_by_count":29}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
