{"id":"https://openalex.org/W1996147758","doi":"https://doi.org/10.1530/eje.0.1310215","title":"Aldosterone response to adrenocorticotrophin and furosemide in primary aldosteronism after prolonged spironolactone treatment","display_name":"Aldosterone response to adrenocorticotrophin and furosemide in primary aldosteronism after prolonged spironolactone treatment","publication_year":1994,"publication_date":"1994-09-01","ids":{"openalex":"https://openalex.org/W1996147758","doi":"https://doi.org/10.1530/eje.0.1310215","mag":"1996147758","pmid":"https://pubmed.ncbi.nlm.nih.gov/7921203"},"language":"en","primary_location":{"id":"doi:10.1530/eje.0.1310215","doi":"https://doi.org/10.1530/eje.0.1310215","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1310215","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052669907","display_name":"Atsuko Yagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsuko Yagi","raw_affiliation_strings":["Second Department of Internal Medicine, Gunma University School of Medicine, Japan","The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Gunma University School of Medicine, Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006548715","display_name":"Sh\u00fbichi Ichikawa","orcid":"https://orcid.org/0000-0003-4703-637X","observed_orcids":["https://orcid.org/0000-0003-4703-637X"]},"institutions":[{"id":"https://openalex.org/I4405255989","display_name":"Cardiovascular Hospital of Central Japan","ror":"https://ror.org/03mwd2t56","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405255989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Ichikawa","raw_affiliation_strings":["Cardiovascular Hospital of Central Japan, Hokkitsu-Mura, Gunma Prefecture, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Hospital of Central Japan, Hokkitsu-Mura, Gunma Prefecture, Gunma, Japan","institution_ids":["https://openalex.org/I4405255989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102376631","display_name":"Tetsuo Sakamaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Sakamaki","raw_affiliation_strings":["The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030645224","display_name":"Zenpei Ono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Zempei Ono","raw_affiliation_strings":["The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113974051","display_name":"Kunio Sato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunio Sato","raw_affiliation_strings":["The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111605340","display_name":"Tetsuya Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Nakamura","raw_affiliation_strings":["The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111775722","display_name":"Hironosuke Sakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironosuke Sakamoto","raw_affiliation_strings":["The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113964613","display_name":"Kazuhiko Murata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Murata","raw_affiliation_strings":["The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052669907"],"corresponding_institution_ids":["https://openalex.org/I165735259"],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":null,"fwci":0.2664,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.4949398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"131","issue":"3","first_page":"215","last_page":"220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-aldosteronism","display_name":"primary aldosteronism","score":1.0},{"id":"https://openalex.org/keywords/spironolactone","display_name":"spironolactone","score":0.9810000061988831},{"id":"https://openalex.org/keywords/aldosterone-secretion","display_name":"aldosterone secretion","score":0.9679999947547913},{"id":"https://openalex.org/keywords/furosemide-test","display_name":"furosemide test","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9179999828338623},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.925000011920929},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C2776379505","wikidata":"https://www.wikidata.org/wiki/Q422188","display_name":"Spironolactone","level":3,"score":0.9289222955703735},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.8906061053276062},{"id":"https://openalex.org/C2777955127","wikidata":"https://www.wikidata.org/wiki/Q388801","display_name":"Furosemide","level":2,"score":0.8745811581611633},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8207220435142517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8148193955421448},{"id":"https://openalex.org/C2780233176","wikidata":"https://www.wikidata.org/wiki/Q1939330","display_name":"Primary aldosteronism","level":3,"score":0.7479522824287415},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.6292287707328796},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5665801763534546},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.510312020778656},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.42393332719802856},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3726363182067871},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.3417922854423523},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.05256053805351257}],"mesh":[{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005665","descriptor_name":"Furosemide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011187","descriptor_name":"Posture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013148","descriptor_name":"Spironolactone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1530/eje.0.1310215","doi":"https://doi.org/10.1530/eje.0.1310215","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1310215","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:7921203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7921203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2326477443","https://openalex.org/W2129549457","https://openalex.org/W2394736113","https://openalex.org/W34041833","https://openalex.org/W2471476726","https://openalex.org/W1996998228","https://openalex.org/W2026977131","https://openalex.org/W264698295","https://openalex.org/W4232667251","https://openalex.org/W2046908882"],"abstract_inverted_index":{"We":[0,183],"evaluated":[1],"the":[2,51,62,65,104,107,118,124,130,135,138,145,168,194,206],"effects":[3],"of":[4,106],"prolonged":[5],"spironolactone":[6,210],"treatment":[7],"on":[8,103,191],"aldosterone":[9,46,67,121,140,165,186],"secretion":[10,187],"in":[11,50,123,129,144,167,193],"patients":[12,17,55,131,147,170,196],"with":[13,25,197],"primary":[14,198],"aldosteronism.":[15],"The":[16],"were":[18],"hospitalized":[19],"and":[20,64,81,200],"underwent":[21],"a":[22,48],"furosemide":[23,52,58,108],"test":[24,109],"or":[26],"without":[27],"dexamethasone,":[28],"as":[29,31],"well":[30],"an":[32],"adrenocorticotrophin":[33],"(ACTH)":[34],"test.":[35,53],"In":[36,54,134],"untreated":[37,125,146,195],"patients,":[38,126],"neither":[39],"plasma":[40,45,66,120,139],"renin":[41],"activity":[42],"(PRA)":[43],"nor":[44],"showed":[47],"response":[49,166],"receiving":[56,132],"spironolactone,":[57],"increased":[59,142],"significantly":[60,143],"both":[61],"PRA":[63],"concentration":[68,122,141],"(from":[69,148,171],"2.6":[70],"+/-":[71,75,84,88,95,150,154,173,177],"0.8":[72],"to":[73,86,116,152,175],"7.0":[74],"2.0":[76],"micrograms.l-1.h-1":[77],"(p":[78,91,110],"<":[79,92,158],"0.05)":[80],"from":[82],"345.6":[83],"55.8":[85],"492.7":[87],"76.8":[89],"ng/l":[90],"0.05),":[93],"mean":[94],"SEM,":[96],"respectively).":[97],"Dexamethasone":[98],"administration":[99],"had":[100],"no":[101,163],"effect":[102],"results":[105],">":[111,181],"0.1).":[112,182],"However,":[113],"dexamethasone":[114],"tended":[115],"decrease":[117],"basal":[119],"but":[127,160],"not":[128],"spironolactone.":[133],"ACTH":[136,192],"test,":[137],"549.0":[149],"69.8":[151],"1169.3":[153],"165.5":[155],"ng/l,":[156,179],"p":[157,180],"0.01),":[159],"there":[161],"was":[162],"significant":[164],"spironolactone-treated":[169],"885.5":[172],"204.9":[174],"1260.3":[176],"289.2":[178],"conclude":[184],"that":[185],"is":[188,201],"mainly":[189],"dependent":[190],"aldosteronism":[199],"more":[202],"strongly":[203],"regulated":[204],"by":[205],"renin-angiotensin":[207],"system":[208],"during":[209],"treatment.":[211]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
