{"id":"https://openalex.org/W1996105405","doi":"https://doi.org/10.1038/clpt.1991.136","title":"The pharmacokinetics of recombinant double-chain t-PA (duteplase): Effects of bolus injection, infusions, and administration by weight in patients with myocardial infarction","display_name":"The pharmacokinetics of recombinant double-chain t-PA (duteplase): Effects of bolus injection, infusions, and administration by weight in patients with myocardial infarction","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W1996105405","doi":"https://doi.org/10.1038/clpt.1991.136","mag":"1996105405","pmid":"https://pubmed.ncbi.nlm.nih.gov/1914361"},"language":"en","primary_location":{"id":"doi:10.1038/clpt.1991.136","doi":"https://doi.org/10.1038/clpt.1991.136","is_oa":false,"landing_page_url":"https://doi.org/10.1038/clpt.1991.136","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046497176","display_name":"Rudolph W. Koster","orcid":"https://orcid.org/0000-0002-7819-4330","observed_orcids":["https://orcid.org/0000-0002-7819-4330"]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":true,"raw_author_name":"Rudolph W Koster","raw_affiliation_strings":["Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands","Center for Human Drug Research, Academic Hospital Leiden","Department of Cardiology, Academic Medical Center, Amsterdam","Gaubius Institute TNO, Leiden","Wellcome Research Laboratories, Beckenham, Kent"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Center for Human Drug Research, Academic Hospital Leiden","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Department of Cardiology, Academic Medical Center, Amsterdam","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Gaubius Institute TNO, Leiden","institution_ids":["https://openalex.org/I148297040"]},{"raw_affiliation_string":"Wellcome Research Laboratories, Beckenham, Kent","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047227576","display_name":"Adam F. Cohen","orcid":"https://orcid.org/0000-0001-7452-6222","observed_orcids":["https://orcid.org/0000-0001-7452-6222","https://orcid.org/0009-0003-6971-7392"]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Adam F Cohen","raw_affiliation_strings":["Center for Human Drug Research, Academic Hospital Leiden","Department of Cardiology, Academic Medical Center, Amsterdam","Gaubius Institute TNO, Leiden","Wellcome Research Laboratories, Beckenham, Kent"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Drug Research, Academic Hospital Leiden","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Department of Cardiology, Academic Medical Center, Amsterdam","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Gaubius Institute TNO, Leiden","institution_ids":["https://openalex.org/I148297040"]},{"raw_affiliation_string":"Wellcome Research Laboratories, Beckenham, Kent","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108079163","display_name":"Cornelis Kluft","orcid":"https://orcid.org/0000-0001-5835-7254","observed_orcids":["https://orcid.org/0000-0001-5835-7254"]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Cornelis Kluft","raw_affiliation_strings":["Center for Human Drug Research, Academic Hospital Leiden","Department of Cardiology, Academic Medical Center, Amsterdam","Gaubius Institute TNO, Leiden","Wellcome Research Laboratories, Beckenham, Kent"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Drug Research, Academic Hospital Leiden","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Department of Cardiology, Academic Medical Center, Amsterdam","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Gaubius Institute TNO, Leiden","institution_ids":["https://openalex.org/I148297040"]},{"raw_affiliation_string":"Wellcome Research Laboratories, Beckenham, Kent","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108476895","display_name":"F J Kasper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Frans J Kasper","raw_affiliation_strings":["Center for Human Drug Research, Academic Hospital Leiden","Department of Cardiology, Academic Medical Center, Amsterdam","Gaubius Institute TNO, Leiden","Wellcome Research Laboratories, Beckenham, Kent"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Drug Research, Academic Hospital Leiden","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Department of Cardiology, Academic Medical Center, Amsterdam","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Gaubius Institute TNO, Leiden","institution_ids":["https://openalex.org/I148297040"]},{"raw_affiliation_string":"Wellcome Research Laboratories, Beckenham, Kent","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113683549","display_name":"Poll A. van der Wouw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Poll A van der Wouw","raw_affiliation_strings":["Center for Human Drug Research, Academic Hospital Leiden","Department of Cardiology, Academic Medical Center, Amsterdam","Gaubius Institute TNO, Leiden","Wellcome Research Laboratories, Beckenham, Kent"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Drug Research, Academic Hospital Leiden","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Department of Cardiology, Academic Medical Center, Amsterdam","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Gaubius Institute TNO, Leiden","institution_ids":["https://openalex.org/I148297040"]},{"raw_affiliation_string":"Wellcome Research Laboratories, Beckenham, Kent","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111623377","display_name":"Barry C. Weatherley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Barry C Weatherley","raw_affiliation_strings":["Center for Human Drug Research, Academic Hospital Leiden","Department of Cardiology, Academic Medical Center, Amsterdam","Gaubius Institute TNO, Leiden","Wellcome Research Laboratories, Beckenham, Kent"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Drug Research, Academic Hospital Leiden","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Department of Cardiology, Academic Medical Center, Amsterdam","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Gaubius Institute TNO, Leiden","institution_ids":["https://openalex.org/I148297040"]},{"raw_affiliation_string":"Wellcome Research Laboratories, Beckenham, Kent","institution_ids":["https://openalex.org/I87048295"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5046497176"],"corresponding_institution_ids":["https://openalex.org/I148297040","https://openalex.org/I2802928900","https://openalex.org/I4210133171","https://openalex.org/I87048295"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":0.7071,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.69919624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"50","issue":"3","first_page":"267","last_page":"277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.05510000139474869,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alteplase","display_name":"alteplase","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9319999814033508},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.972000002861023},{"id":"https://openalex.org/keywords/bolus-injection","display_name":"bolus injection","score":0.6759999990463257},{"id":"https://openalex.org/keywords/continuous-infusion","display_name":"continuous infusion","score":0.9010000228881836},{"id":"https://openalex.org/keywords/weight-based-dosing","display_name":"weight-based dosing","score":0.8659999966621399},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.902999997138977},{"id":"https://openalex.org/keywords/steady-state-plasma-concentration","display_name":"steady-state plasma concentration","score":0.765999972820282},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.746999979019165},{"id":"https://openalex.org/keywords/one-compartment-model","display_name":"one-compartment model","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7823024988174438},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.698030412197113},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.650409996509552},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6084622740745544},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5192756652832031},{"id":"https://openalex.org/C3020190219","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Intravenous bolus","level":2,"score":0.5072597861289978},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4253464937210083},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2946833372116089},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.27670809626579285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24608665704727173},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19776639342308044},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/clpt.1991.136","doi":"https://doi.org/10.1038/clpt.1991.136","is_oa":false,"landing_page_url":"https://doi.org/10.1038/clpt.1991.136","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:1914361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1914361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Clinical Trial"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/0a2c276b-c29d-4ca9-9bd1-6a2905d4e32c","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/the-pharmacokinetics-of-recombinant-doublechain-tpa-duteplase-effects-of-bolus-injection-infusions-and-administration-by-weight-in-patients-with-myocardial-infarction(0a2c276b-c29d-4ca9-9bd1-6a2905d4e32c).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical pharmacology and therapeutics, 50(3), 267 - 277. Wiley-Blackwell","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:oai-pmh.tno.nl:81001","doi":null,"is_oa":false,"landing_page_url":"https://resolver.tno.nl/uuid:5bfe1847-7aa5-4e8d-87d4-b052aa86f389","pdf_url":null,"source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Pharmacology and Therapeutics, 50(3), pp. 267-277.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/a399453c-99dc-49c1-9c99-eae9915bcde3","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/a399453c-99dc-49c1-9c99-eae9915bcde3","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Koster, R W, Cohen, A F, Kluft, C, Kasper, F J, van der Wouw, P A & Weatherley, B C 1991, 'The pharmacokinetics of recombinant double-chain t-PA (duteplase): effects of bolus injection, infusions, and administration by weight in patients with myocardial infarction', Clinical pharmacology and therapeutics, vol. 50, no. 3, pp. 267-277. https://doi.org/10.1038/clpt.1991.136","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1970532400","https://openalex.org/W2407195431","https://openalex.org/W2015830963","https://openalex.org/W2063519653","https://openalex.org/W2462175415","https://openalex.org/W2279335345","https://openalex.org/W2013113528","https://openalex.org/W2100954332","https://openalex.org/W1720936584","https://openalex.org/W2000426944"],"abstract_inverted_index":{"The":[0],"current":[1],"mode":[2],"of":[3,5,25,35,39,42,104,127,147,157,170,183,203,231],"administration":[4],"recombinant":[6],"tissue-type":[7],"plasminogen":[8],"activator":[9],"(rt-PA)":[10],"in":[11,50,76,91,115,123,135,143,192,240],"acute":[12,80],"myocardial":[13,81],"infarction":[14,82],"is":[15,28],"rather":[16],"complex,":[17],"although":[18],"the":[19,22,196,204,232,241],"rationale":[20],"for":[21],"different":[23,216],"components":[24],"this":[26,174],"scheme":[27,57],"not":[29,214],"clearly":[30],"established.":[31],"We":[32],"compared":[33],"pharmacokinetics":[34],"a":[36,56,59,63,70,92,165,225,237],"continuous":[37],"infusion":[38,68,75],"38.5":[40],"MU":[41],"Burroughs":[43],"Wellcome":[44],"t-PA":[45,85,105,128],"(duteplase)":[46],"over":[47],"90":[48],"minutes":[49],"nine":[51],"patients":[52,78],"(phase":[53],"I)":[54],"with":[55,79],"including":[58],"0.04":[60],"MU/kg":[61,66,73],"bolus,":[62],"60-minute":[64],"0.36":[65],"lytic":[67,233],"and":[69,87,98,118,138,160,201,210],"180-minute":[71],"0.21":[72],"maintenance":[74],"15":[77],"(Phase":[83],"II).":[84],"activity":[86,106,148],"antigen":[88,129],"were":[89,101],"fitted":[90],"one-compartment":[93],"model":[94],"from":[95,217],"which":[96],"model-dependent":[97],"model-independent":[99],"parameters":[100],"derived.":[102],"Clearance":[103,126,146,159],"was":[107,130,149,175],"1020":[108],"+/-":[109,112,120,132,140],"465":[110],"(mean":[111],"SD)":[113],"ml/min":[114,122,134,142],"phase":[116,124,136,144,193,218],"I":[117,137],"1359":[119],"590":[121],"II.":[125,145],"666":[131],"230":[133],"704":[139],"199":[141],"significantly":[150,176,215],"(p":[151],"less":[152],"than":[153,156],"0.01)":[154],"higher":[155],"antigen.":[158],"steady-state":[161,205],"plasma":[162,206],"levels":[163],"showed":[164,223],"large":[166],"interindividual":[167],"variability":[168],"(coefficient":[169,182],"variation,":[171,184],"56.4%),":[172],"but":[173],"reduced":[177],"by":[178,180,208],"dosing":[179],"weight":[181],"28.9%;":[185],"p":[186],"=":[187],"0.031).":[188],"A":[189,220],"10%":[190],"bolus":[191,226],"II":[194],"shortened":[195],"time":[197],"to":[198,235],"reach":[199],"75%":[200],"90%":[202],"level":[207,239],"4":[209],"5":[211],"minutes,":[212],"respectively,":[213],"I.":[219],"simulation":[221],"study":[222],"that":[224],"should":[227],"be":[228],"approximately":[229],"15%":[230],"dose":[234],"achieve":[236],"maximal":[238],"shortest":[242],"period.":[243]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}