{"id":"https://openalex.org/W1996102786","doi":"https://doi.org/10.5649/jjphcs1975.15.437","title":"Comparison of saliva stimulation methods for noninvasive therapeutic drug monitoring by using saliva samples.","display_name":"Comparison of saliva stimulation methods for noninvasive therapeutic drug monitoring by using saliva samples.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W1996102786","doi":"https://doi.org/10.5649/jjphcs1975.15.437","mag":"1996102786"},"language":"en","primary_location":{"id":"doi:10.5649/jjphcs1975.15.437","doi":"https://doi.org/10.5649/jjphcs1975.15.437","is_oa":true,"landing_page_url":"https://doi.org/10.5649/jjphcs1975.15.437","pdf_url":"https://www.jstage.jst.go.jp/article/jjphcs1975/15/6/15_6_437/_pdf","source":{"id":"https://openalex.org/S2764454917","display_name":"Japanese Journal of Hospital Pharmacy","issn_l":"0389-9098","issn":["0389-9098","2185-9477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4327904648","host_organization_name":"Japanese Society of Pharmaceutical Health Care and Sciences","host_organization_lineage":["https://openalex.org/P4327904648"],"host_organization_lineage_names":["Japanese Society of Pharmaceutical Health Care and Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Hospital Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jjphcs1975/15/6/15_6_437/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103627756","display_name":"Yoshihiro Katagiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149146","display_name":"Shimane University Hospital","ror":"https://ror.org/03nvpm562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210149146"]},{"id":"https://openalex.org/I4405285000","display_name":"Shimane Medical University","ror":"https://ror.org/04kg5pk90","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828","https://openalex.org/I4405285000"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YOSHIHIRO KATAGIRI","raw_affiliation_strings":["Department of Pharmacy, Shimane Medical University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shimane Medical University Hospital","institution_ids":["https://openalex.org/I4210149146","https://openalex.org/I4405285000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022938601","display_name":"S Nagasako","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149146","display_name":"Shimane University Hospital","ror":"https://ror.org/03nvpm562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210149146"]},{"id":"https://openalex.org/I4405285000","display_name":"Shimane Medical University","ror":"https://ror.org/04kg5pk90","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828","https://openalex.org/I4405285000"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SADAO NAGASAKO","raw_affiliation_strings":["Department of Pharmacy, Shimane Medical University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shimane Medical University Hospital","institution_ids":["https://openalex.org/I4210149146","https://openalex.org/I4405285000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110126884","display_name":"Masakazu Hayashibara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149146","display_name":"Shimane University Hospital","ror":"https://ror.org/03nvpm562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210149146"]},{"id":"https://openalex.org/I4405285000","display_name":"Shimane Medical University","ror":"https://ror.org/04kg5pk90","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828","https://openalex.org/I4405285000"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MASAKAZU HAYASHIBARA","raw_affiliation_strings":["Department of Pharmacy, Shimane Medical University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shimane Medical University Hospital","institution_ids":["https://openalex.org/I4210149146","https://openalex.org/I4405285000"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108411960","display_name":"Kikuo Iwamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149146","display_name":"Shimane University Hospital","ror":"https://ror.org/03nvpm562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210149146"]},{"id":"https://openalex.org/I4405285000","display_name":"Shimane Medical University","ror":"https://ror.org/04kg5pk90","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828","https://openalex.org/I4405285000"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KIKUO IWAMOTO","raw_affiliation_strings":["Department of Pharmacy, Shimane Medical University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shimane Medical University Hospital","institution_ids":["https://openalex.org/I4210149146","https://openalex.org/I4405285000"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1542,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.78913288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"6","first_page":"437","last_page":"444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.08219999819993973,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.04520000144839287,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.8209999799728394},{"id":"https://openalex.org/keywords/salivary-ph","display_name":"salivary pH","score":0.8190000057220459},{"id":"https://openalex.org/keywords/salivary-flow-rate","display_name":"salivary flow rate","score":0.9940000176429749},{"id":"https://openalex.org/keywords/salivary-composition","display_name":"salivary composition","score":0.9279999732971191},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.8519999980926514},{"id":"https://openalex.org/keywords/diurnal-variation","display_name":"diurnal variation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mexiletine-hydrochloride","display_name":"mexiletine hydrochloride","score":0.8399999737739563},{"id":"https://openalex.org/keywords/non-invasive-drug-monitoring","display_name":"non-invasive drug monitoring","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.9322424530982971},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6358120441436768},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5153045654296875},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5126708745956421},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.47861284017562866},{"id":"https://openalex.org/C2779744641","wikidata":"https://www.wikidata.org/wiki/Q9614","display_name":"Tongue","level":2,"score":0.4416859447956085},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4313582181930542},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.35995036363601685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3376920223236084},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2908754348754883},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21242642402648926},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07949331402778625}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5649/jjphcs1975.15.437","doi":"https://doi.org/10.5649/jjphcs1975.15.437","is_oa":true,"landing_page_url":"https://doi.org/10.5649/jjphcs1975.15.437","pdf_url":"https://www.jstage.jst.go.jp/article/jjphcs1975/15/6/15_6_437/_pdf","source":{"id":"https://openalex.org/S2764454917","display_name":"Japanese Journal of Hospital Pharmacy","issn_l":"0389-9098","issn":["0389-9098","2185-9477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4327904648","host_organization_name":"Japanese Society of Pharmaceutical Health Care and Sciences","host_organization_lineage":["https://openalex.org/P4327904648"],"host_organization_lineage_names":["Japanese Society of Pharmaceutical Health Care and Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Hospital Pharmacy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5649/jjphcs1975.15.437","doi":"https://doi.org/10.5649/jjphcs1975.15.437","is_oa":true,"landing_page_url":"https://doi.org/10.5649/jjphcs1975.15.437","pdf_url":"https://www.jstage.jst.go.jp/article/jjphcs1975/15/6/15_6_437/_pdf","source":{"id":"https://openalex.org/S2764454917","display_name":"Japanese Journal of Hospital Pharmacy","issn_l":"0389-9098","issn":["0389-9098","2185-9477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4327904648","host_organization_name":"Japanese Society of Pharmaceutical Health Care and Sciences","host_organization_lineage":["https://openalex.org/P4327904648"],"host_organization_lineage_names":["Japanese Society of Pharmaceutical Health Care and Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Hospital Pharmacy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1996102786.pdf","grobid_xml":"https://content.openalex.org/works/W1996102786.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W304065183","https://openalex.org/W2314862662","https://openalex.org/W6600417834","https://openalex.org/W6615650613"],"related_works":["https://openalex.org/W21351818","https://openalex.org/W4206178325","https://openalex.org/W2061145382","https://openalex.org/W959535830","https://openalex.org/W2085735900","https://openalex.org/W2464960214","https://openalex.org/W4299444332","https://openalex.org/W2083750310","https://openalex.org/W7139742027","https://openalex.org/W2766599305"],"abstract_inverted_index":{"To":[0],"find":[1],"out":[2],"an":[3],"appropriate":[4],"therapeutic":[5,117],"drug":[6,118],"monitoring":[7,119],"method":[8,54,80,115,126],"by":[9,120],"using":[10,121],"saliva,":[11],"we":[12],"investigated":[13],"the":[14,52,62,109,138,148],"effect":[15],"of":[16,19,34,66,73,85,144],"four":[17],"kinds":[18],"saliva":[20,122,139],"stimulation":[21,114],"methods":[22,35],"on":[23,137],"salivary":[24],"pH,":[25,39,86],"flow":[26,40,87],"rate":[27,41,88],"and":[28,42,59,68,76,89,103,111],"composition":[29],"in":[30,151],"normal":[31,152],"male":[32],"subjects.Each":[33],"showed":[36,81],"significantly":[37],"different":[38],"compositions":[43,90],"(total":[44,91],"protein,":[45,92],"K+and":[46],"creatinine":[47],"levels).It":[48],"was":[49,127],"observed":[50],"that":[51,99],"simplest":[53,110],"(i.e.":[55],"to":[56,100,129,133,140],"move":[57,101],"mouth":[58,102],"tongue)":[60],"had":[61],"smallest":[63],"inter-individual":[64,71],"variation":[65],"pH":[67],"relatively":[69],"small":[70],"variations":[72,84],"total":[74],"protein":[75],"Na+levels.In":[77],"addition,":[78],"this":[79,125],"no":[82],"diurnal":[83],"Na+and":[93],"K+levels).":[94],"The":[95],"present":[96],"results":[97],"suggest":[98],"tongue":[104],"for":[105,116],"salivation":[106],"may":[107],"be":[108,130],"most":[112],"suitable":[113],"samples.":[123],"Furthermore,":[124],"found":[128],"well":[131],"applicable":[132],"a":[134],"pilot":[135],"study":[136],"serum":[141],"concentration":[142],"ratio":[143],"mexiletine":[145],"hydrochloride":[146],"after":[147],"oral":[149],"administration":[150],"subject.":[153]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}