{"id":"https://openalex.org/W1996067634","doi":"https://doi.org/10.1016/s0306-4522(97)00096-1","title":"The contribution of supraspinal, peripheral and intrinsic spinal circuits to the pattern and magnitude of fos-like immunoreactivity in the lumbar spinal cord of the rat withdrawing from morphine","display_name":"The contribution of supraspinal, peripheral and intrinsic spinal circuits to the pattern and magnitude of fos-like immunoreactivity in the lumbar spinal cord of the rat withdrawing from morphine","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W1996067634","doi":"https://doi.org/10.1016/s0306-4522(97)00096-1","mag":"1996067634","pmid":"https://pubmed.ncbi.nlm.nih.gov/9284361"},"language":"en","primary_location":{"id":"doi:10.1016/s0306-4522(97)00096-1","doi":"https://doi.org/10.1016/s0306-4522(97)00096-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0306-4522(97)00096-1","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0306-4522(97)00096-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016095314","display_name":"Dana S Rohde","orcid":"https://orcid.org/0009-0002-7872-9363","observed_orcids":["https://orcid.org/0009-0002-7872-9363"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D.S. Rohde","raw_affiliation_strings":["Biomedical Sciences Program, University of California San Francisco, 94143, U.S.A","Biomedical Sciences Program, University of California San Francisco, San Franscisco, CA 94143, U.S.A","Departments of Anatomy, Physiology, and Anesthesia, University of California San Francisco, San Franscisco, CA 94143, U.S.A","W. M. Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Franscisco, CA 94143, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Program, University of California San Francisco, 94143, U.S.A","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Biomedical Sciences Program, University of California San Francisco, San Franscisco, CA 94143, U.S.A","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Departments of Anatomy, Physiology, and Anesthesia, University of California San Francisco, San Franscisco, CA 94143, U.S.A","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"W. M. Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Franscisco, CA 94143, U.S.A","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035754174","display_name":"Warren R. McKay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W.R. McKay","raw_affiliation_strings":["Departments of Anatomy, Physiology, and Anesthesia, University of California San Francisco, San Franscisco, CA 94143, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy, Physiology, and Anesthesia, University of California San Francisco, San Franscisco, CA 94143, U.S.A","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108228204","display_name":"David S. Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.S. Chang","raw_affiliation_strings":["NYU School of Medicine, New York, NY 10016, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU School of Medicine, New York, NY 10016, U.S.A","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008895579","display_name":"Catherine Abbadie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Abbadie","raw_affiliation_strings":["Departments of Anatomy, Physiology, and Anesthesia, University of California San Francisco, San Franscisco, CA 94143, U.S.A","W. M. Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Franscisco, CA 94143, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy, Physiology, and Anesthesia, University of California San Francisco, San Franscisco, CA 94143, U.S.A","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"W. M. Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Franscisco, CA 94143, U.S.A","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007740596","display_name":"Allan I. Basbaum","orcid":"https://orcid.org/0000-0002-1710-6333","observed_orcids":["https://orcid.org/0000-0002-1710-6333"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.I. Basbaum","raw_affiliation_strings":["Biomedical Sciences Program, University of California San Francisco, San Franscisco, CA 94143, U.S.A","Departments of Anatomy, Physiology, and Anesthesia, University of California San Francisco, San Franscisco, CA 94143, U.S.A","W. M. Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Franscisco, CA 94143, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Program, University of California San Francisco, San Franscisco, CA 94143, U.S.A","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Departments of Anatomy, Physiology, and Anesthesia, University of California San Francisco, San Franscisco, CA 94143, U.S.A","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"W. M. Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Franscisco, CA 94143, U.S.A","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016095314"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.049,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.73096207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"80","issue":"2","first_page":"599","last_page":"612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morphine-withdrawal","display_name":"morphine withdrawal","score":0.9869999885559082},{"id":"https://openalex.org/keywords/fos-immunoreactivity","display_name":"Fos-like immunoreactivity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lumbar-spinal-cord","display_name":"lumbar spinal cord","score":0.9729999899864197},{"id":"https://openalex.org/keywords/superficial-dorsal-horn","display_name":"superficial dorsal horn","score":0.7979999780654907},{"id":"https://openalex.org/keywords/naloxone-methiodide","display_name":"naloxone methiodide","score":0.8180000185966492},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.5559999942779541},{"id":"https://openalex.org/keywords/spinal-cord-transection","display_name":"spinal cord transection","score":0.7210000157356262},{"id":"https://openalex.org/keywords/dorsal-rhizotomy","display_name":"dorsal rhizotomy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/c-fibers","display_name":"C-fibers","score":0.8190000057220459},{"id":"https://openalex.org/keywords/deafferentation","display_name":"deafferentation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/opioid-tolerance","display_name":"opioid tolerance","score":0.5989999771118164},{"id":"https://openalex.org/keywords/intrathecal-administration","display_name":"intrathecal administration","score":0.5419999957084656},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.7620849609375},{"id":"https://openalex.org/C2909382400","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Lumbar Spinal Cord","level":3,"score":0.7176828384399414},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.6203837990760803},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.52015620470047},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5006792545318604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48607566952705383},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.4693295359611511},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4521581530570984},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4436095952987671},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4182330071926117},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3318752944469452},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.312115877866745},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003655","descriptor_name":"Decerebrate State","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009021","descriptor_name":"Morphine Dependence","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009021","descriptor_name":"Morphine Dependence","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009021","descriptor_name":"Morphine Dependence","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017933","descriptor_name":"Peripheral Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019051","descriptor_name":"Rhizotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0306-4522(97)00096-1","doi":"https://doi.org/10.1016/s0306-4522(97)00096-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0306-4522(97)00096-1","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"pmid:9284361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9284361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0306-4522(97)00096-1","doi":"https://doi.org/10.1016/s0306-4522(97)00096-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0306-4522(97)00096-1","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3804584341","display_name":"SPINAL MECHANISMS OF OPIOID ANALGESIA AND TOLERANCE","funder_award_id":"R01DA008377","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W29671035","https://openalex.org/W61881615","https://openalex.org/W70761295","https://openalex.org/W199647589","https://openalex.org/W1537638589","https://openalex.org/W1883060277","https://openalex.org/W1972250954","https://openalex.org/W1974164498","https://openalex.org/W1974358824","https://openalex.org/W1975464141","https://openalex.org/W1977742625","https://openalex.org/W1981935824","https://openalex.org/W1986694311","https://openalex.org/W1987230136","https://openalex.org/W1988059170","https://openalex.org/W1989138468","https://openalex.org/W1989423171","https://openalex.org/W1990378025","https://openalex.org/W1991774850","https://openalex.org/W1996364906","https://openalex.org/W1996698149","https://openalex.org/W1998126770","https://openalex.org/W1998191034","https://openalex.org/W2001026574","https://openalex.org/W2001313375","https://openalex.org/W2004491740","https://openalex.org/W2005656584","https://openalex.org/W2006330090","https://openalex.org/W2020776282","https://openalex.org/W2022012727","https://openalex.org/W2026378984","https://openalex.org/W2032997748","https://openalex.org/W2033525233","https://openalex.org/W2039457981","https://openalex.org/W2043323520","https://openalex.org/W2045798386","https://openalex.org/W2050445424","https://openalex.org/W2051001717","https://openalex.org/W2054995879","https://openalex.org/W2058693989","https://openalex.org/W2060058702","https://openalex.org/W2062177483","https://openalex.org/W2063622065","https://openalex.org/W2063765075","https://openalex.org/W2068281454","https://openalex.org/W2070602043","https://openalex.org/W2072291822","https://openalex.org/W2076798747","https://openalex.org/W2082483555","https://openalex.org/W2084043489","https://openalex.org/W2086128968","https://openalex.org/W2089620901","https://openalex.org/W2090697433","https://openalex.org/W2091106502","https://openalex.org/W2092584483","https://openalex.org/W2094378668","https://openalex.org/W2094568924","https://openalex.org/W2107224500","https://openalex.org/W2127282142","https://openalex.org/W2132829674","https://openalex.org/W2146958131","https://openalex.org/W2201897764","https://openalex.org/W2214956132","https://openalex.org/W2403818092","https://openalex.org/W4248029472"],"related_works":["https://openalex.org/W2005656584","https://openalex.org/W2011727049","https://openalex.org/W1794995310","https://openalex.org/W2410999611","https://openalex.org/W2045824420","https://openalex.org/W1983556145","https://openalex.org/W1537638589","https://openalex.org/W2047907151","https://openalex.org/W2070621554","https://openalex.org/W2167262614"],"abstract_inverted_index":{"Withdrawal":[0],"from":[1,185,247],"morphine":[2,69,184],"evokes":[3],"increases":[4,158],"in":[5,8,13,159,162,196,205,216,243,261,285,299,319,322,338,362],"Fos-like":[6,27,160,194,214,263,297,320],"immunoreactivity":[7,161,195,215,264,298,321],"the":[9,14,22,25,45,58,90,104,115,123,145,197,220,236,286,294,316,330,344,368,373],"spinal":[10,95,105,127,199,348],"cord,":[11],"particularly":[12],"superficial":[15,59],"dorsal":[16,60,130,287,369],"horn,":[17],"laminae":[18,163,217,323],"I/II.":[19],"To":[20,62],"determine":[21],"origin":[23],"of":[24,55,103,122,144,183,211,231,250,272,296,306,336,346,359,375],"increased":[26,213,237,360],"immunoreactivity,":[28],"we":[29,65,302,341],"selectively":[30],"targeted":[31],"central":[32],"or":[33,48,70,136,281],"peripheral":[34,186],"opioid":[35,139,187,307,363],"receptors":[36,188],"with":[37,68,108,172,329],"naloxone-methiodide,":[38],"an":[39],"antagonist":[40,140],"that":[41,203,235,254,304,343,372],"does":[42],"not":[43,178,192,292,311],"cross":[44],"blood-brain":[46],"barrier,":[47],"induced":[49,142],"withdrawal":[50,83,182,242,354],"after":[51,87,240,265,333],"eliminating":[52],"possible":[53],"sources":[54],"input":[56],"to":[57,166,223,270,282,315,367],"horn.":[61,288],"induce":[63,193],"tolerance,":[64],"implanted":[66],"rats":[67,91,245],"placebo":[71],"pellets":[72,76],"(75":[73],"mg,":[74],"six":[75],"over":[77],"three":[78],"days).":[79],"On":[80],"day":[81],"4,":[82],"was":[84],"precipitated":[85],"and":[86,98,152,219,325,371,383],"1":[88],"h,":[89],"were":[92],"killed,":[93],"their":[94],"cords":[96],"removed":[97],"50":[99],"microm":[100],"transverse":[101],"sections":[102],"cord":[106,200,349],"immunoreacted":[107],"a":[109,224,248,312,357],"rabbit":[110],"polyclonal":[111],"antiserum":[112],"directed":[113],"against":[114],"Fos":[116,146,238,350,376],"protein.":[117,147],"In":[118],"placebo-pelleted":[119],"rats,":[120,301,340],"none":[121],"different":[124],"procedures,":[125],"viz.":[126],"transection,":[128],"unilateral":[129],"rhizotomy":[131,266],"(L4-S2),":[132],"neonatal":[133],"capsaicin":[134,290],"treatment":[135,171],"direct":[137],"intrathecal":[138,209,334],"injection,":[141],"expression":[143,239,351,377],"However,":[148,208],"both":[149],"spinally":[150],"transected":[151],"rhizotomized":[153],"withdrawing":[154,168,300],"animals":[155],"showed":[156],"significant":[157],"I/II,":[164],"compared":[165],"intact":[167],"rats.":[169,207],"Neonatal":[170],"capsaicin,":[173],"which":[174],"eliminates":[175],"C-fibres,":[176],"did":[177,191,228,291],"alter":[179,293],"Fos-like-immunoreactivity.":[180],"Selective":[181],"by":[189,276,381],"naloxone-methiodide":[190,212,337],"lumbar":[198,347],"greater":[201,225],"than":[202,227],"recorded":[204,332],"nonwithdrawing":[206],"injection":[210,230,335],"I/II":[218],"ventral":[221],"horn":[222,370],"extent":[226],"subcutaneous":[229],"naloxone.":[232],"We":[233],"hypothesize":[234],"systemic":[241,353],"spinally-transected":[244],"results":[246,331],"loss":[249,271],"descending":[251],"inhibitory":[252,273,386],"control":[253],"is":[255,310,355,378],"activated":[256],"during":[257],"withdrawal.":[258],"The":[259],"increase":[260,318],"withdrawal-induced":[262,317],"may":[267],"be":[268],"secondary":[269],"controls":[274],"exerted":[275],"large":[277],"diameter":[278],"primary":[279,384],"afferents":[280],"deafferentation-induced":[283],"reorganization":[284],"Since":[289],"magnitude":[295,374],"conclude":[303,342],"hyperactivity":[305],"receptor-laden":[308],"C-fibres":[309],"necessary":[313],"contributor":[314],"I":[324],"II.":[326],"Taken":[327],"together":[328],"tolerant":[339],"pattern":[345],"following":[352],"primarily":[356],"consequence":[358],"activity":[361],"receptor-containing":[364],"circuits":[365],"intrinsic":[366],"normally":[379],"dampened":[380],"supraspinal":[382],"afferent-derived":[385],"inputs.":[387]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}