{"id":"https://openalex.org/W1996066682","doi":"https://doi.org/10.1074/jbc.m112410200","title":"Contraction Regulation of Akt in Rat Skeletal Muscle","display_name":"Contraction Regulation of Akt in Rat Skeletal Muscle","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W1996066682","doi":"https://doi.org/10.1074/jbc.m112410200","mag":"1996066682","pmid":"https://pubmed.ncbi.nlm.nih.gov/11809761"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m112410200","doi":"https://doi.org/10.1074/jbc.m112410200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112410200","pdf_url":"https://www.sciencedirect.com/science/article/pii/S002192581852007X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S002192581852007X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012147587","display_name":"Kei Sakamoto","orcid":"https://orcid.org/0000-0001-8839-5980","observed_orcids":["https://orcid.org/0000-0001-8839-5980"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Kei Sakamoto","raw_affiliation_strings":["Research Division, Joslin Diabetes Center and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA","Graduate School of Integrated Science, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama, Japan","Research Division, Joslin Diabetes Center and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293231726","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Graduate School of Integrated Science, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama, Japan","institution_ids":["https://openalex.org/I89630735"]},{"raw_affiliation_string":"Research Division, Joslin Diabetes Center and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020890107","display_name":"Michael F. Hirshman","orcid":"https://orcid.org/0000-0001-8728-6379","observed_orcids":["https://orcid.org/0000-0001-8728-6379"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael F. Hirshman","raw_affiliation_strings":["Research Division, Joslin Diabetes Center and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080176195","display_name":"William G. Aschenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William G. Aschenbach","raw_affiliation_strings":["Research Division, Joslin Diabetes Center and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039947894","display_name":"Laurie J. Goodyear","orcid":"https://orcid.org/0000-0002-6299-2928","observed_orcids":["https://orcid.org/0000-0002-6299-2928"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laurie J. Goodyear","raw_affiliation_strings":["Research Division, Joslin Diabetes Center and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center and the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5039947894"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293231726","https://openalex.org/I136199984"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.0976,"has_fulltext":true,"cited_by_count":193,"citation_normalized_percentile":{"value":0.9643178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"277","issue":"14","first_page":"11910","last_page":"11917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.7914999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.7914999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.09030000120401382,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.06849999725818634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.9739999771118164},{"id":"https://openalex.org/keywords/skeletal-muscle-contraction","display_name":"skeletal muscle contraction","score":0.9649999737739563},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/akt-isoforms","display_name":"Akt isoforms","score":0.8840000033378601},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/wortmannin","display_name":"wortmannin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3","display_name":"glycogen synthase kinase-3","score":0.9150000214576721},{"id":"https://openalex.org/keywords/glycogen-synthase","display_name":"glycogen synthase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/muscle-fiber-type","display_name":"muscle fiber type","score":0.7730000019073486},{"id":"https://openalex.org/keywords/sciatic-nerve-stimulation","display_name":"sciatic nerve stimulation","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6742982864379883},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6657227873802185},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.6269469261169434},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.5268940925598145},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3846961259841919},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3510781228542328},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35028135776519775},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3339931070804596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31997883319854736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3045651912689209},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.17006376385688782}],"mesh":[{"descriptor_ui":"D000077191","descriptor_name":"Wortmannin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006006","descriptor_name":"Glycogen Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038341","descriptor_name":"Glycogen Synthase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m112410200","doi":"https://doi.org/10.1074/jbc.m112410200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112410200","pdf_url":"https://www.sciencedirect.com/science/article/pii/S002192581852007X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11809761","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11809761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m112410200","doi":"https://doi.org/10.1074/jbc.m112410200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112410200","pdf_url":"https://www.sciencedirect.com/science/article/pii/S002192581852007X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1117239162","display_name":null,"funder_award_id":"AR45670","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G135832157","display_name":null,"funder_award_id":"AR-42238","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2053692761","display_name":"Glycogen metabolism in contracting skeletal muscle","funder_award_id":"5f32dk059769-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2302556178","display_name":"Exercise Regulation of Glucose Metabolism in Skeletal Muscle","funder_award_id":"R01AR045670","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6931444884","display_name":null,"funder_award_id":"DK 59769","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1996066682.pdf","grobid_xml":"https://content.openalex.org/works/W1996066682.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1492422933","https://openalex.org/W1496238527","https://openalex.org/W1496297920","https://openalex.org/W1567219202","https://openalex.org/W1585751449","https://openalex.org/W1791888878","https://openalex.org/W1841050729","https://openalex.org/W1876033686","https://openalex.org/W1908445283","https://openalex.org/W1964631519","https://openalex.org/W1969161473","https://openalex.org/W1970529208","https://openalex.org/W1972307668","https://openalex.org/W1977919095","https://openalex.org/W1985601500","https://openalex.org/W1986503768","https://openalex.org/W1990841830","https://openalex.org/W1994957003","https://openalex.org/W2001866120","https://openalex.org/W2004199183","https://openalex.org/W2004806132","https://openalex.org/W2012533273","https://openalex.org/W2017394099","https://openalex.org/W2017641447","https://openalex.org/W2018926746","https://openalex.org/W2019691564","https://openalex.org/W2019802189","https://openalex.org/W2030372123","https://openalex.org/W2030720692","https://openalex.org/W2030904535","https://openalex.org/W2031532881","https://openalex.org/W2038594687","https://openalex.org/W2039193709","https://openalex.org/W2040098150","https://openalex.org/W2040143421","https://openalex.org/W2040466763","https://openalex.org/W2040546635","https://openalex.org/W2042925168","https://openalex.org/W2044693162","https://openalex.org/W2053073281","https://openalex.org/W2057939121","https://openalex.org/W2058138221","https://openalex.org/W2074883812","https://openalex.org/W2089582113","https://openalex.org/W2111371276","https://openalex.org/W2138391708","https://openalex.org/W2140439371","https://openalex.org/W2140664543","https://openalex.org/W2146157811","https://openalex.org/W2150470419","https://openalex.org/W2155534957","https://openalex.org/W2155653958","https://openalex.org/W2164782502","https://openalex.org/W2165604272","https://openalex.org/W2182146826","https://openalex.org/W2442275722","https://openalex.org/W4253418569"],"related_works":["https://openalex.org/W2123429890","https://openalex.org/W7097688670","https://openalex.org/W2086905944","https://openalex.org/W2291948362","https://openalex.org/W2167764734","https://openalex.org/W1980235364","https://openalex.org/W2284059261","https://openalex.org/W7101138950","https://openalex.org/W2168627519","https://openalex.org/W1774190872"],"abstract_inverted_index":{"The":[0,19,145],"protein":[1],"serine/threonine":[2],"kinase":[3,5],"Akt/protein":[4],"B":[6],"has":[7,37],"been":[8,38],"recognized":[9],"as":[10],"a":[11,141],"critical":[12],"signaling":[13,200],"mediator":[14],"for":[15,204],"multiple":[16,58],"cell":[17],"systems.":[18],"function":[20],"of":[21,92,117,136,207],"Akt":[22,35,54,95,119,155,178,199],"in":[23,45,57,86,131,133,182,211],"skeletal":[24,183,213],"muscle":[25,59,184,192],"is":[26,189,201],"not":[27,161,202],"well":[28],"understood,":[29],"and":[30,77,109,121,150,157,168,180,185,195,197],"whether":[31],"contractile":[32],"activity":[33,36,91,122,158,181,210],"stimulates":[34],"controversial.":[39],"In":[40,80],"the":[41,62,90,134,205],"current":[42],"study,":[43],"contraction":[44,85,176],"situ,":[46],"induced":[47],"via":[48],"sciatic":[49],"nerve":[50],"stimulation,":[51],"significantly":[52,88],"increased":[53,89,125],"Ser(473)":[55],"phosphorylation":[56,120,156,167,179],"types":[60],"including":[61],"extensor":[63],"digitorum":[64],"longus":[65],"(13-fold":[66],"over":[67],"basal),":[68],"plantaris":[69],"(5.8-fold),":[70],"red":[71],"gastrocnemius":[72,75],"(4.7-fold),":[73],"white":[74],"(3.3-fold),":[76],"soleus":[78],"(1.6-fold).":[79],"addition":[81],"to":[82,111,140],"increasing":[83],"phosphorylation,":[84],"situ":[87],"all":[93],"three":[94],"isoforms":[96],"(Akt1":[97],">":[98,100],"Akt2":[99],"Akt3)":[101],"with":[102,114],"maximal":[103],"activation":[104],"occurring":[105],"at":[106],"2.5":[107],"min":[108,116],"returning":[110],"base":[112],"line":[113],"15":[115],"contraction.":[118],"were":[123,129],"also":[124],"when":[126],"isolated":[127],"muscles":[128],"contracted":[130],"vitro":[132],"absence":[135],"systemic":[137],"factors,":[138],"although":[139],"much":[142],"lesser":[143],"extent.":[144],"phosphatidylinositol":[146],"3-kinase":[147],"inhibitors":[148],"wortmannin":[149],"LY294002":[151],"fully":[152],"inhibited":[153],"contraction-stimulated":[154,163],"but":[159],"did":[160],"diminish":[162],"glycogen":[164,169,208],"synthase":[165,170,209],"kinase-3":[166],"activity.":[171],"These":[172],"results":[173],"demonstrate":[174],"that":[175,186],"increases":[177],"this":[187],"stimulation":[188],"rapid,":[190],"transient,":[191],"fiber":[193],"type-specific,":[194],"wortmannin-":[196],"LY294002-inhibitable.":[198],"necessary":[203],"regulation":[206],"contracting":[212],"muscle.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}