{"id":"https://openalex.org/W1996045643","doi":"https://doi.org/10.1093/jac/8.2.153","title":"Gentamicin-resistant Kiebsiella aerogenes as a clinically-significant source of transferable antibiotic resistance","display_name":"Gentamicin-resistant Kiebsiella aerogenes as a clinically-significant source of transferable antibiotic resistance","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W1996045643","doi":"https://doi.org/10.1093/jac/8.2.153","mag":"1996045643","pmid":"https://pubmed.ncbi.nlm.nih.gov/7024243"},"language":"en","primary_location":{"id":"doi:10.1093/jac/8.2.153","doi":"https://doi.org/10.1093/jac/8.2.153","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/8.2.153","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110067481","display_name":"M.W. Casewell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. W. Casewell","raw_affiliation_strings":["Department of Microbiology, St Thomas's Hospital Medical School London, SE1 7EH, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, St Thomas's Hospital Medical School London, SE1 7EH, England","institution_ids":["https://openalex.org/I1324925910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080101341","display_name":"H. Talsania","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H. G. Talsania","raw_affiliation_strings":["Department of Microbiology, St Thomas's Hospital Medical School London, SE1 7EH, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, St Thomas's Hospital Medical School London, SE1 7EH, England","institution_ids":["https://openalex.org/I1324925910"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037751799","display_name":"S. Knight","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Knight","raw_affiliation_strings":["Department of Microbiology, St Thomas's Hospital Medical School London, SE1 7EH, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, St Thomas's Hospital Medical School London, SE1 7EH, England","institution_ids":["https://openalex.org/I1324925910"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1324925910"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":1.0374,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.67186282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"2","first_page":"153","last_page":"160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterobacter-aerogenes","display_name":"Enterobacter aerogenes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gentamicin-resistance","display_name":"gentamicin resistance","score":0.9919999837875366},{"id":"https://openalex.org/keywords/plasmid-mediated-antimicrobial-resistance","display_name":"plasmid-mediated antibiotic resistance","score":0.7879999876022339},{"id":"https://openalex.org/keywords/transferable-resistance","display_name":"transferable resistance","score":0.6759999990463257},{"id":"https://openalex.org/keywords/escherichia-coli-k-12","display_name":"Escherichia coli K-12","score":0.9010000228881836},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.75},{"id":"https://openalex.org/keywords/aminoglycoside-resistance","display_name":"aminoglycoside resistance","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cephalosporin-resistance","display_name":"cephalosporin resistance","score":0.9200000166893005},{"id":"https://openalex.org/keywords/trimethoprim-resistance","display_name":"trimethoprim resistance","score":0.7210000157356262},{"id":"https://openalex.org/keywords/chloramphenicol-resistance","display_name":"chloramphenicol resistance","score":0.8100000023841858},{"id":"https://openalex.org/keywords/tetracycline-resistance","display_name":"tetracycline resistance","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ampicillin-resistance","display_name":"ampicillin resistance","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2779913634","wikidata":"https://www.wikidata.org/wiki/Q1050019","display_name":"Carbenicillin","level":4,"score":0.9470928907394409},{"id":"https://openalex.org/C2780923616","wikidata":"https://www.wikidata.org/wiki/Q193045","display_name":"Tetracycline","level":3,"score":0.8194670677185059},{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.814365029335022},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.8122388124465942},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7552382946014404},{"id":"https://openalex.org/C2776265613","wikidata":"https://www.wikidata.org/wiki/Q644487","display_name":"Enterobacter aerogenes","level":4,"score":0.7117982506752014},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.6614042520523071},{"id":"https://openalex.org/C2778473333","wikidata":"https://www.wikidata.org/wiki/Q274515","display_name":"Chloramphenicol","level":3,"score":0.6276138424873352},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5356888771057129},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5039452910423279},{"id":"https://openalex.org/C183641309","wikidata":"https://www.wikidata.org/wiki/Q306264","display_name":"Amp resistance","level":4,"score":0.49390488862991333},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4651528298854828},{"id":"https://openalex.org/C2779116282","wikidata":"https://www.wikidata.org/wiki/Q131854","display_name":"Klebsiella","level":4,"score":0.4501006603240967},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.43985143303871155},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4230969548225403},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05928677320480347},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003227","descriptor_name":"Conjugation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jac/8.2.153","doi":"https://doi.org/10.1093/jac/8.2.153","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/8.2.153","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmid:7024243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7024243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.960.7285","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.960.7285","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jac.oxfordjournals.org/content/8/2/153.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100533568","https://openalex.org/W2041299982","https://openalex.org/W2082399244","https://openalex.org/W1529497015","https://openalex.org/W2464710947","https://openalex.org/W2119381352","https://openalex.org/W1983928966","https://openalex.org/W2402884873","https://openalex.org/W2016556322","https://openalex.org/W1804908526"],"abstract_inverted_index":{"Of":[0],"108":[1],"epidemiologically-distinct":[2],"strains":[3,97],"of":[4,28,42,51,96,128,140,147,159],"gentamicin-resistant":[5],"Klebsiella":[6,152],"aerogenes":[7],"collected":[8],"from":[9,117],"12":[10],"hospitals":[11,121],"in":[12,61,87,113,119,122],"six":[13],"countries,":[14],"86":[15],"(80%)":[16],"transferred":[17,54],"multiple":[18,109,160],"antibiotic":[19],"resistance":[20,55,64,110,142,161],"to":[21,56,63,65,71,77,101,133],"Escherichia":[22],"coli":[23],"K12.":[24],"For":[25],"77":[26],"(90%)":[27],"the":[29,32,52,144],"successful":[30],"donors":[31,53],"resistances":[33,132],"were":[34,85,99,111],"conferred":[35,131],"by":[36],"single":[37,120,148],"plasmids":[38,106,130,149],"with":[39],"molecular":[40],"weights":[41],"between":[43],"25":[44],"and":[45,70,83,93,125,136,143,164],"130":[46],"megadaltons.":[47],"Forty-eight":[48],"per":[49],"cent":[50],"chloramphenicol,":[57,78],"tetracycline,":[58,79],"sulphamethoxazole,":[59,81],"ampicillin/carbenicillin,":[60,80],"addition":[62],"at":[66],"least":[67],"two":[68],"aminoglycosides":[69],"one":[72],"or":[73],"more":[74,166],"cephalosporins.":[75],"Resistances":[76],"gentamicin":[82],"trimethoprim":[84,135],"transferable":[86,141],"89,":[88],"75,":[89],"74,":[90,91],"67":[92],"58%,":[94],"respectively,":[95],"that":[98,151],"resistant":[100],"these":[102,129],"agents.":[103],"Six":[104],"\u2018epidemic\u2019":[105],"conferring":[107],"extensive":[108],"found":[112],"21":[114],"different":[115],"serotypes":[116],"patients":[118],"London,":[123],"Munich":[124],"Sydney.":[126],"Three":[127],"gentamicin,":[134],"sulphamethoxazole.":[137],"The":[138],"frequency":[139],"intrageneric":[145],"spread":[146],"suggests":[150],"species":[153],"serves":[154],"as":[155],"an":[156],"important":[157],"source":[158],"for":[162],"this":[163],"other":[165],"pathogenic":[167],"species.":[168]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}