{"id":"https://openalex.org/W1996044010","doi":"https://doi.org/10.1038/sj.bjp.0704821","title":"Cyclo\u2010oxygenase\u20102 inhibition increases blood pressure in rats","display_name":"Cyclo\u2010oxygenase\u20102 inhibition increases blood pressure in rats","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W1996044010","doi":"https://doi.org/10.1038/sj.bjp.0704821","mag":"1996044010","pmid":"https://pubmed.ncbi.nlm.nih.gov/12163344","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1573449"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjp.0704821","doi":"https://doi.org/10.1038/sj.bjp.0704821","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0704821","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0704821","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0704821","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038185914","display_name":"Klaus H\u00f6cherl","orcid":"https://orcid.org/0000-0001-7278-0702","observed_orcids":["https://orcid.org/0000-0001-7278-0702"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Klaus H\u00f6cherl","raw_affiliation_strings":["Institut f\u00fcr Pharmakologie, Universit\u00e4tsstr. 31, 93040 Regensburg, Germany. klaus.hoecherl@chemie.uni-regensburg.de","Institut f\u00fcr Pharmakologie, Universit\u00e4tsstr. 31, 93040 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pharmakologie, Universit\u00e4tsstr. 31, 93040 Regensburg, Germany. klaus.hoecherl@chemie.uni-regensburg.de","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Institut f\u00fcr Pharmakologie, Universit\u00e4tsstr. 31, 93040 Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112070832","display_name":"Dierk Endemann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dierk Endemann","raw_affiliation_strings":["Institut fu\u0308r Innere Medizin II, Franz-Josef-Strau\u00df-Allee 1193053 Regensburg, Germany","Institut f\u00fcr Innere Medizin II, Franz\u2010Josef\u2010Strau\u00df\u2010Allee 1193053 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Innere Medizin II, Franz-Josef-Strau\u00df-Allee 1193053 Regensburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Institut f\u00fcr Innere Medizin II, Franz\u2010Josef\u2010Strau\u00df\u2010Allee 1193053 Regensburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010304720","display_name":"Martin Kammerl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin C Kammerl","raw_affiliation_strings":["Institut fu\u0308r Innere Medizin II, Franz-Josef-Strau\u00df-Allee 1193053 Regensburg, Germany","Institut f\u00fcr Innere Medizin II, Franz\u2010Josef\u2010Strau\u00df\u2010Allee 1193053 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Innere Medizin II, Franz-Josef-Strau\u00df-Allee 1193053 Regensburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Institut f\u00fcr Innere Medizin II, Franz\u2010Josef\u2010Strau\u00df\u2010Allee 1193053 Regensburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084329682","display_name":"H. Grobecker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Horst F Grobecker","raw_affiliation_strings":["Institut fu\u0308r Pharmakologie, Universita\u0308tsstr. 31, 93040 Regensburg, Germany","Institut f\u00fcr Pharmakologie, Universit\u00e4tsstr. 31, 93040 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Pharmakologie, Universita\u0308tsstr. 31, 93040 Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Institut f\u00fcr Pharmakologie, Universit\u00e4tsstr. 31, 93040 Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070999479","display_name":"Armin Kurtz","orcid":"https://orcid.org/0000-0003-3301-6546","observed_orcids":["https://orcid.org/0000-0003-3301-6546"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Armin Kurtz","raw_affiliation_strings":["Institut fu\u0308r Physiologie, Universita\u0308t Regensburg, Universita\u0308tsstr. 31, 93040 Regensburg, Germany","Institut f\u00fcr Physiologie, Universit\u00e4t Regensburg, Universit\u00e4tsstr. 31, 93040 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Physiologie, Universita\u0308t Regensburg, Universita\u0308tsstr. 31, 93040 Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Institut f\u00fcr Physiologie, Universit\u00e4t Regensburg, Universit\u00e4tsstr. 31, 93040 Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038185914"],"corresponding_institution_ids":["https://openalex.org/I60668342"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.2026,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.86511745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"136","issue":"8","first_page":"1117","last_page":"1126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.3003000020980835,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cox-2-inhibition","display_name":"COX-2 inhibition","score":0.9570000171661377},{"id":"https://openalex.org/keywords/rofecoxib","display_name":"rofecoxib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8880000114440918},{"id":"https://openalex.org/keywords/salt-intake","display_name":"salt intake","score":0.6690000295639038},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.7590000033378601},{"id":"https://openalex.org/keywords/6-keto-prostaglandin-f1-alpha","display_name":"6-keto-prostaglandin F1alpha","score":0.984000027179718},{"id":"https://openalex.org/keywords/thromboxane-b2","display_name":"thromboxane B2","score":0.8939999938011169},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system","display_name":"renin-angiotensin-aldosterone system","score":0.8320000171661377},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.9020000100135803},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.9150000214576721},{"id":"https://openalex.org/keywords/normotensive-rats","display_name":"normotensive rats","score":0.878000020980835},{"id":"https://openalex.org/keywords/fluid-retention","display_name":"fluid retention","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2778582115","wikidata":"https://www.wikidata.org/wiki/Q411412","display_name":"Rofecoxib","level":4,"score":0.9735137224197388},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7773825526237488},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7642596960067749},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.659486711025238},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.5608052015304565},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5041903257369995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4805881977081299},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.4690818190574646},{"id":"https://openalex.org/C2780978440","wikidata":"https://www.wikidata.org/wiki/Q416567","display_name":"Prostaglandin H2","level":4,"score":0.46553531289100647},{"id":"https://openalex.org/C2781080829","wikidata":"https://www.wikidata.org/wiki/Q3009646","display_name":"Thromboxane B2","level":3,"score":0.4444361925125122},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.4417068660259247},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.44140541553497314},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.3917781114578247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38530418276786804},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.37550562620162964},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2348051369190216},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21844199299812317},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1340252161026001},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004326","descriptor_name":"Drinking","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012982","descriptor_name":"Sodium, Dietary","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015121","descriptor_name":"6-Ketoprostaglandin F1 alpha","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/sj.bjp.0704821","doi":"https://doi.org/10.1038/sj.bjp.0704821","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0704821","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0704821","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:12163344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12163344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1573449","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1573449/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmh:oai:epub.uni-regensburg.de:72820","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/72820/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/sj.bjp.0704821","doi":"https://doi.org/10.1038/sj.bjp.0704821","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0704821","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0704821","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1996044010.pdf","grobid_xml":"https://content.openalex.org/works/W1996044010.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W104012062","https://openalex.org/W1561747056","https://openalex.org/W1747865589","https://openalex.org/W1851629571","https://openalex.org/W1922681024","https://openalex.org/W1953904210","https://openalex.org/W1965595628","https://openalex.org/W1966901144","https://openalex.org/W1976060163","https://openalex.org/W1980590005","https://openalex.org/W1984520701","https://openalex.org/W1988486622","https://openalex.org/W1989141136","https://openalex.org/W2001214229","https://openalex.org/W2001510918","https://openalex.org/W2003295462","https://openalex.org/W2003374359","https://openalex.org/W2017504730","https://openalex.org/W2018035901","https://openalex.org/W2018630281","https://openalex.org/W2020563114","https://openalex.org/W2024233889","https://openalex.org/W2025462421","https://openalex.org/W2026107702","https://openalex.org/W2026362575","https://openalex.org/W2026628125","https://openalex.org/W2027279601","https://openalex.org/W2030491299","https://openalex.org/W2030894817","https://openalex.org/W2038410983","https://openalex.org/W2042274378","https://openalex.org/W2043660839","https://openalex.org/W2052364512","https://openalex.org/W2063842505","https://openalex.org/W2071361630","https://openalex.org/W2074498996","https://openalex.org/W2076042282","https://openalex.org/W2096099192","https://openalex.org/W2098291803","https://openalex.org/W2114014099","https://openalex.org/W2114303015","https://openalex.org/W2116591884","https://openalex.org/W2121612337","https://openalex.org/W2123295634","https://openalex.org/W2125471714","https://openalex.org/W2145117388","https://openalex.org/W2151863220","https://openalex.org/W2159143497","https://openalex.org/W2166629377","https://openalex.org/W2218591732","https://openalex.org/W2263048471","https://openalex.org/W2272191632","https://openalex.org/W2292947726","https://openalex.org/W2325271872","https://openalex.org/W2414644352","https://openalex.org/W2461502030","https://openalex.org/W2461746347","https://openalex.org/W2487373758"],"related_works":["https://openalex.org/W1974114127","https://openalex.org/W2063842505","https://openalex.org/W3121626603","https://openalex.org/W67232752","https://openalex.org/W2032019773","https://openalex.org/W2037650808","https://openalex.org/W2132413787","https://openalex.org/W2145201522","https://openalex.org/W2001805133","https://openalex.org/W1992111716"],"abstract_inverted_index":{"1":[0],"It":[1],"is":[2,35,252],"known":[3],"that":[4,233,244],"nonselective":[5],"cyclo-oxygenase":[6],"(COX)":[7],"inhibitors":[8,29],"have":[9],"small":[10],"but":[11,153,184,221],"significant":[12],"effects":[13,90],"on":[14,23,55,66,88,94,157,197,204,246,254],"blood":[15,57,242],"pressure":[16,58,243],"(BP),":[17],"most":[18],"notably":[19],"in":[20,60,72,96,115,138,155,174,186],"hypertensive":[21,75],"patients":[22],"antihypertensive":[24],"medication.":[25],"Whether":[26],"selective":[27,51],"COX-2":[28,52,92,237],"also":[30],"interfere":[31],"with":[32,49],"BP":[33,95],"regulation":[34],"not":[36,154,185,217,272,279],"well":[37],"understood.":[38],"Therefore,":[39],"we":[40,80],"aimed":[41],"to":[42,280,298],"examine":[43],"the":[44,67,89,198,286,294],"effect":[45],"of":[46,70,85,91,111,171,200,236,241,288,293],"chronic":[47,234],"treatment":[48],"a":[50,82,119,282],"inhibitor":[53],"(rofecoxib)":[54],"systolic":[56],"(sBP)":[59],"normotensive":[61],"Wistar-Kyoto":[62],"rats":[63,76,117,156,187],"(WKY)":[64],"and":[65,107,211,257,267],"developmental":[68],"changes":[69,199],"sBP":[71,106,137],"young":[73],"spontaneously":[74],"(SHR).":[77],"In":[78],"addition,":[79],"investigated":[81],"possible":[83],"influence":[84,196],"salt":[86,121,144,147,159,182,190,262],"intake":[87,160,266],"inhibition":[93,235],"these":[97],"two":[98],"rat":[99,140,176],"strains.":[100],"2":[101],"Rofecoxib":[102,134,166,193],"dose":[103],"dependently":[104],"increased":[105],"decreased":[108,168],"plasma":[109,169,222],"levels":[110,170],"6-keto":[112,172],"prostaglandin":[113],"(PG)F(1alpha)":[114],"WKY":[116],"fed":[118,142,178],"normal":[120,143,179],"diet":[122,148],"(0.6%":[123],"NaCl,":[124,150,162],"wt":[125,151,163],"wt(-1)),":[126,152],"without":[127],"affecting":[128],"serum":[129],"thromboxane":[130],"(TX)B(2)":[131],"levels.":[132],"3":[133],"significantly":[135,167,227],"elevated":[136],"both":[139,175],"strains":[141,177],"or":[145,180],"high":[146,181],"(8%":[149],"low":[158,189],"(0.02%":[161],"wt(-1)).":[164],"4":[165],"PGF(1alpha)":[173],"diet,":[183],"during":[188],"intake.":[191,206],"5":[192],"exerted":[194],"no":[195],"body":[201,268],"weight":[202,269],"nor":[203],"water":[205,265],"Plasma":[207],"renin":[208,213],"activity":[209],"(PRA)":[210],"renocortical":[212],"mRNA":[214],"abundance":[215],"were":[216,271],"changed":[218,273],"by":[219,261,274],"rofecoxib,":[220,275],"aldosterone":[223],"concentration":[224],"(PAC)":[225],"was":[226],"reduced.":[228],"6":[229],"These":[230],"results":[231],"suggest":[232],"causes":[238],"an":[239,291,300],"increase":[240,251],"depends":[245],"prostacyclin":[247],"synthesis.":[248],"Furthermore,":[249],"this":[250],"independent":[253],"genetic":[255],"predisposition":[256],"can":[258],"be":[259,281,299],"prevented":[260],"deprivation.":[263],"Since":[264],"gain":[270],"fluid":[276],"retention":[277],"appears":[278,297],"major":[283],"reason":[284],"for":[285],"development":[287],"hypertension.":[289],"Similarly,":[290],"activation":[292],"renin-angiotensin-aldosterone":[295],"axis":[296],"unlikely":[301],"candidate":[302],"mechanism.":[303]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}