{"id":"https://openalex.org/W1996017104","doi":"https://doi.org/10.1097/ogx.0000000000000107","title":"Olaparib Maintenance Therapy in Patients With Platinum-Sensitive Relapsed Serous Ovarian Cancer","display_name":"Olaparib Maintenance Therapy in Patients With Platinum-Sensitive Relapsed Serous Ovarian Cancer","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1996017104","doi":"https://doi.org/10.1097/ogx.0000000000000107","mag":"1996017104"},"language":"en","primary_location":{"id":"doi:10.1097/ogx.0000000000000107","doi":"https://doi.org/10.1097/ogx.0000000000000107","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ogx.0000000000000107","pdf_url":null,"source":{"id":"https://openalex.org/S115789314","display_name":"Obstetrical & Gynecological Survey","issn_l":"0029-7828","issn":["0029-7828","1533-9866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrical &amp; Gynecological Survey","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079383798","display_name":"Jonathan Andrew Ledermann","orcid":"https://orcid.org/0000-0003-3799-3539","observed_orcids":["https://orcid.org/0000-0003-3799-3539"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan Ledermann","raw_affiliation_strings":["University college London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University college London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078567055","display_name":"Philipp Harter","orcid":"https://orcid.org/0000-0002-9663-5005","observed_orcids":["https://orcid.org/0000-0002-9663-5005"]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Harter","raw_affiliation_strings":["University\u00a0of\u00a0Duisburg-Essen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University\u00a0of\u00a0Duisburg-Essen","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009351129","display_name":"Charlie Gourley","orcid":"https://orcid.org/0000-0002-2377-7221","observed_orcids":["https://orcid.org/0000-0002-2377-7221"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charlie Gourley","raw_affiliation_strings":["University of Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Edinburgh","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021894535","display_name":"Michael Leonard Friedlander","orcid":"https://orcid.org/0000-0003-3090-795X","observed_orcids":["https://orcid.org/0000-0003-3090-795X"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael Friedlander","raw_affiliation_strings":["University Of New south Wales"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Of New south Wales","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058535647","display_name":"Ignace B. Vergote","orcid":"https://orcid.org/0000-0002-7589-8981","observed_orcids":["https://orcid.org/0000-0002-7589-8981"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ignace Vergote","raw_affiliation_strings":[", KU Leuven"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", KU Leuven","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047753094","display_name":"Gordon J.S. Rustin","orcid":"https://orcid.org/0000-0002-2749-5467","observed_orcids":["https://orcid.org/0000-0002-2749-5467"]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]},{"id":"https://openalex.org/I4210161180","display_name":"Mount Vernon Hospital","ror":"https://ror.org/00w9htx78","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210161180"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gordon Rustin","raw_affiliation_strings":["Mount Vernon Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Vernon Hospital","institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I4210161180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085126287","display_name":"Clare L. Scott","orcid":"https://orcid.org/0000-0002-3689-5956","observed_orcids":["https://orcid.org/0000-0002-3689-5956"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Clare L. Scott","raw_affiliation_strings":["Royal Melbourne Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Melbourne Hospital;","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084392138","display_name":"Werner Meier","orcid":"https://orcid.org/0000-0003-2508-5410","observed_orcids":["https://orcid.org/0000-0003-2508-5410"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Werner Meier","raw_affiliation_strings":["Evangelisches"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evangelisches","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058238015","display_name":"Ronnie Shapira\u2010Frommer","orcid":"https://orcid.org/0000-0001-6170-080X","observed_orcids":["https://orcid.org/0000-0001-6170-080X"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ronnie Shapira-Frommer","raw_affiliation_strings":["Sheba Medical Center At Tel Hashomer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheba Medical Center At Tel Hashomer","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039578268","display_name":"Tamar Safra","orcid":"https://orcid.org/0000-0001-6910-6426","observed_orcids":["https://orcid.org/0000-0001-6910-6426"]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Tamar Safra","raw_affiliation_strings":["Tel-Aviv Sourasky Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tel-Aviv Sourasky Medical Center;","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067743297","display_name":"Daniela Elena Matei","orcid":"https://orcid.org/0000-0003-2169-5035","observed_orcids":["https://orcid.org/0000-0003-2169-5035"]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Matei","raw_affiliation_strings":["Indiana University-Purdue University Indianapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University-Purdue University Indianapolis","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064212341","display_name":"Anitra Fielding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anitra Fielding","raw_affiliation_strings":["AstraZeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111855870","display_name":"Stuart Spencer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stuart Spencer","raw_affiliation_strings":["AstraZeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087646089","display_name":"Brian Andrew Dougherty","orcid":"https://orcid.org/0000-0002-0093-1142","observed_orcids":["https://orcid.org/0000-0002-0093-1142"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian Dougherty","raw_affiliation_strings":["AstraZeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111925004","display_name":"Maria C. M. Orr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maria Orr","raw_affiliation_strings":["AstraZeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088925365","display_name":"Darren Hodgson","orcid":"https://orcid.org/0000-0002-6631-9626","observed_orcids":["https://orcid.org/0000-0002-6631-9626"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Darren Hodgson","raw_affiliation_strings":["AstraZeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045263771","display_name":"J. Carl Barrett","orcid":"https://orcid.org/0000-0003-4042-9859","observed_orcids":["https://orcid.org/0000-0003-4042-9859"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Carl Barrett","raw_affiliation_strings":["AstraZeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058249824","display_name":"Ursula A. Matulonis","orcid":"https://orcid.org/0000-0002-3103-6992","observed_orcids":["https://orcid.org/0000-0002-3103-6992"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ursula Matulonis","raw_affiliation_strings":["Dana Farber Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":13,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6028,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.67748757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"69","issue":"10","first_page":"594","last_page":"596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.8709999918937683},{"id":"https://openalex.org/keywords/serous-ovarian-cancer","display_name":"serous ovarian cancer","score":0.8389999866485596},{"id":"https://openalex.org/keywords/brca-mutations","display_name":"BRCA mutations","score":0.7170000076293945},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/platinum-sensitive-recurrent-ovarian-cancer","display_name":"platinum-sensitive recurrent ovarian cancer","score":0.8579999804496765},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9779999852180481},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.765999972820282},{"id":"https://openalex.org/keywords/parp-inhibitor-resistance","display_name":"PARP inhibitor resistance","score":0.5889999866485596},{"id":"https://openalex.org/keywords/parp-inhibitor-sensitivity","display_name":"PARP inhibitor sensitivity","score":0.41999998688697815},{"id":"https://openalex.org/keywords/germline-and-somatic-mutations","display_name":"germline and somatic mutations","score":0.6549999713897705},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.9491497874259949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8955160975456238},{"id":"https://openalex.org/C2780194787","wikidata":"https://www.wikidata.org/wiki/Q4836333","display_name":"BRCA mutation","level":4,"score":0.7667336463928223},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7187522649765015},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6975706815719604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6681052446365356},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5374273657798767},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.44987550377845764},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44665899872779846},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.444598913192749},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3256937563419342},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.06336134672164917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.04795461893081665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/ogx.0000000000000107","doi":"https://doi.org/10.1097/ogx.0000000000000107","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ogx.0000000000000107","pdf_url":null,"source":{"id":"https://openalex.org/S115789314","display_name":"Obstetrical & Gynecological Survey","issn_l":"0029-7828","issn":["0029-7828","1533-9866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrical &amp; Gynecological Survey","raw_type":"journal-article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1457968","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1457968/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OBSTETRICAL &amp; GYNECOLOGICAL SURVEY , 69 (10) pp. 594-596. (2014)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2130078242","https://openalex.org/W4236289131","https://openalex.org/W2737389832","https://openalex.org/W2760558025","https://openalex.org/W2088376108","https://openalex.org/W2257499491","https://openalex.org/W2160466424","https://openalex.org/W2033816200","https://openalex.org/W7033011867","https://openalex.org/W4387824914"],"abstract_inverted_index":{"Greater":[0],"than":[1,104,316],"20%":[2],"of":[3,5,30,117,125,159,269,285,349,396,421,489,506,544],"cases":[4],"high-grade":[6,56],"serous":[7,57,81,533],"ovarian":[8,58,82,534],"cancer":[9,83,535],"are":[10],"due":[11,34],"to":[12,35,133,165,174,190,206,214,221,254,259,351,423],"germline":[13],"or":[14,156,170,198,297,460],"somatically":[15],"acquired":[16],"BRCA":[17,36,53,102,138,238,261,300,305,435,446,518,538,559],"mutations.":[18,37],"Poly(ADP-ribose)":[19],"polymerase":[20,42],"inhibitors":[21],"have":[22,166,540],"been":[23],"investigated":[24],"as":[25],"treatment":[26,72,147],"for":[27,266,431],"a":[28,121,168,294,304,311,346,358,418,537,554],"number":[29],"tumors,":[31],"including":[32],"those":[33,106,318,520],"One":[38],"potent":[39],"oral":[40,74,149,192],"poly(ADP-ribose)":[41],"inhibitor,":[43],"olaparib,":[44],"has":[45],"shown":[46,167],"antitumor":[47],"activity":[48],"in":[49,76,98,105,232,274,281,319,361,410,468,474,487,491,497,521,566],"patients":[50,77,99,136,152,245,271,362,432,490,502,515,529],"with":[51,73,78,100,107,137,148,303,345,363,417,433,516,530,536],"both":[52],"and":[54,120,162,223,242,257,444,478,495,519],"sporadic":[55],"cancer.":[59],"A":[60],"previous":[61],"randomized,":[62],"double-blind,":[63],"placebo-controlled":[64],"phase":[65],"2":[66,155,408],"study":[67,228],"showed":[68],"that":[69,92,528,553],"twice-daily":[70],"maintenance":[71,146,548],"olaparib":[75,93,193,256,276,309,470,493,547],"platinum-sensitive":[79,531],"recurrent":[80],"significantly":[84,312],"improved":[85],"progression-free":[86],"survival":[87,119,399],"(PFS).":[88],"Subgroup":[89],"analysis":[90,116,124,395],"suggested":[91],"may":[94],"increase":[95],"PFS":[96,231,315],"longer":[97,313],"known":[101,265,295],"status":[103,263,561],"unknown":[108],"mutation":[109,262,306,539,560],"status.":[110,239],"Data":[111],"from":[112,127,144,546],"the":[113,128,215,233,270,275,282,320,339,367,407,413,469,475,492,498,522,541],"second":[114],"interim":[115],"overall":[118,234,398,411,523],"retrospective,":[122],"preplanned":[123],"data":[126,551],"above":[129],"trial":[130],"were":[131,163,181,246,251,429,465],"used":[132],"determine":[134],"whether":[135],"mutations":[139],"would":[140],"most":[141,176,216,456],"likely":[142],"benefit":[143,360,565],"daily":[145,197],"olaparib.":[150],"Enrolled":[151],"had":[153,293,310,357],"received":[154,308],"more":[157],"courses":[158],"platinum-based":[160,178,210,218],"regimens":[161],"required":[164],"partial":[169],"complete":[171],"objective":[172,212],"response":[173,188,213],"their":[175],"recent":[177,217],"regimen.":[179],"Patients":[180,302],"randomly":[182,252],"assigned":[183,253],"using":[184],"an":[185],"interactive":[186],"voice":[187],"system":[189],"receive":[191,255],"400":[194],"mg":[195],"twice":[196],"matching":[199],"placebo.":[200,260],"Randomization":[201],"was":[202,230,264,343,371,415,512],"stratified":[203,236],"by":[204,237],"time":[205],"progression":[207],"on":[208,558],"penultimate":[209],"regimen,":[211],"regimen":[219],"prior":[220],"randomization,":[222],"ethnic":[224],"descent.":[225],"The":[226,455,509,550],"primary":[227],"outcome":[229],"population,":[235],"Between":[240],"2008":[241],"2010,":[243],"265":[244],"enrolled.":[247],"Among":[248],"these,":[249,286],"136":[250],"129":[258],"254":[267],"(96%)":[268],"(131":[272],"[96%]":[273],"group":[277,322,471,494],"vs":[278,332,379,472,481],"123":[279],"[95%]":[280],"placebo":[283,321,476,499],"group);":[284],"74":[287],"(56%)":[288],"versus":[289],"62":[290],"(50%),":[291],"respectively,":[292],"deleterious":[296,299],"suspected":[298],"mutation.":[301],"who":[307],"median":[314,397],"did":[317],"(11.2":[323],"months":[324,334,374,381],"[95%":[325,335,375,382],"confidence":[326],"interval":[327],"{CI},":[328],"83":[329],"months\u2013not":[330],"calculable]":[331],"4.3":[333],"CI,":[336,376,383,389,439,450],"3.0\u20135.4":[337],"months];":[338,385],"hazard":[340],"ratio":[341],"(HR)":[342],"0.18,":[344],"95%":[347,388,419,438,449],"CI":[348,420],"0.10":[350],"0.31;":[352],"P":[353,391,425,441,452],"<":[354],"0.0001.":[355],"Olaparib":[356],"similar":[359,430,513],"wild-type":[364,445],"BRCA,":[365],"but":[366],"difference":[368,405],"between":[369,406],"groups":[370,409],"lower":[372],"(7.4":[373],"5.5\u201310.3":[377],"months]":[378],"5.5":[380],"3.7\u20135.6":[384],"HR,":[386],"0.54;":[387],"0.34\u20130.85;":[390],"=":[392,426,442,453],"0.007).":[393],"Interim":[394],"(58%":[400],"maturity)":[401],"found":[402],"no":[403],"significant":[404],"survival;":[412],"HR":[414],"0.88,":[416],"0.64":[422],"1.21;":[424],"0.44.":[427],"Results":[428],"mutated":[434,517],"(HR,":[436,447],"0.73;":[437],"0.45\u20131.17;":[440],"0.19)":[443],"0.99;":[448],"0.63\u20131.55;":[451],"0.96).":[454],"common":[457],"grade":[458],"3":[459],"worse":[461],"adverse":[462,484,507],"events":[463,485],"reported":[464],"fatigue":[466],"(7%":[467],"3%":[473],"group)":[477],"anemia":[479],"(5%":[480],"<1%).":[482],"Serious":[483],"occurred":[486],"18%":[488],"9%":[496],"group.":[500],"Few":[501],"discontinued":[503],"therapy":[504],"because":[505],"events.":[508],"tolerability":[510],"profile":[511],"among":[514],"population.":[524,568],"These":[525],"findings":[526],"show":[527],"relapsed":[532],"greatest":[542],"likelihood":[543],"benefiting":[545],"therapy.":[549],"suggest":[552],"therapeutic":[555],"approach":[556],"based":[557],"could":[562],"maximize":[563],"clinical":[564],"this":[567]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
