{"id":"https://openalex.org/W1996009798","doi":"https://doi.org/10.1159/000080106","title":"Analysis of the Effects of Halothane on Gi-Coupled Muscarinic M2 Receptor Signaling in Xenopus Oocytes Using a Chimeric G\u03b1 Protein","display_name":"Analysis of the Effects of Halothane on Gi-Coupled Muscarinic M2 Receptor Signaling in Xenopus Oocytes Using a Chimeric G\u03b1 Protein","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1996009798","doi":"https://doi.org/10.1159/000080106","mag":"1996009798","pmid":"https://pubmed.ncbi.nlm.nih.gov/15452370"},"language":"en","primary_location":{"id":"doi:10.1159/000080106","doi":"https://doi.org/10.1159/000080106","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000080106","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112666681","display_name":"Kouichiro Minami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouichiro Minami","raw_affiliation_strings":["Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu 807-8555, Japan. kminami@med.uoeh-u.ac.jp","Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu 807-8555, Japan. kminami@med.uoeh-u.ac.jp","institution_ids":["https://openalex.org/I188700360"]},{"raw_affiliation_string":"Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu, and","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062146842","display_name":"Yasuhito Uezono","orcid":"https://orcid.org/0000-0003-1208-1453","observed_orcids":["https://orcid.org/0000-0003-1208-1453"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhito Uezono","raw_affiliation_strings":["Department of Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079974765","display_name":"Munehiro Shiraishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Munehiro Shiraishi","raw_affiliation_strings":["Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu, and","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011719864","display_name":"Takashi Okamoto","orcid":"https://orcid.org/0000-0001-6531-210X","observed_orcids":["https://orcid.org/0000-0001-6531-210X"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Okamoto","raw_affiliation_strings":["Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu, and","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038494327","display_name":"Junichi Ogata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun-ichi Ogata","raw_affiliation_strings":["Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu, and","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051991684","display_name":"Takafumi Horishita","orcid":"https://orcid.org/0000-0002-1981-7630","observed_orcids":["https://orcid.org/0000-0002-1981-7630"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Horishita","raw_affiliation_strings":["Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu, and","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023489068","display_name":"Kohtaro Taniyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohtaro Taniyama","raw_affiliation_strings":["Department of Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073066826","display_name":"Akio Shigematsu","orcid":"https://orcid.org/0000-0002-5741-6360","observed_orcids":["https://orcid.org/0000-0002-5741-6360"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Shigematsu","raw_affiliation_strings":["Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu, and","institution_ids":["https://openalex.org/I188700360"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.22,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.4906708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"72","issue":"3","first_page":"205","last_page":"212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/halothane","display_name":"halothane","score":0.9980000257492065},{"id":"https://openalex.org/keywords/m2-muscarinic-receptor","display_name":"M2 muscarinic receptor","score":0.9769999980926514},{"id":"https://openalex.org/keywords/gi-coupled-receptors","display_name":"Gi-coupled receptors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/anesthetic-targets","display_name":"anesthetic targets","score":0.5879999995231628},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.7350000143051147},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.7559999823570251},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.6669999957084656},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.6970000267028809},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.7096933126449585},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6594595313072205},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.651562511920929},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.6440108418464661},{"id":"https://openalex.org/C83730767","wikidata":"https://www.wikidata.org/wiki/Q24778884","display_name":"G alpha subunit","level":4,"score":0.4878523349761963},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4273432791233063},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.4247607886791229},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.4144245684146881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3980090320110321},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3902750015258789},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3901710510253906},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3518332839012146},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.31374800205230713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2525726556777954},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.21407142281532288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09175589680671692},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006221","descriptor_name":"Halothane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006221","descriptor_name":"Halothane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006221","descriptor_name":"Halothane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033661","descriptor_name":"Oocysts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D033661","descriptor_name":"Oocysts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D033661","descriptor_name":"Oocysts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D033661","descriptor_name":"Oocysts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033661","descriptor_name":"Oocysts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033661","descriptor_name":"Oocysts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043585","descriptor_name":"Receptor, Muscarinic M2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D043585","descriptor_name":"Receptor, Muscarinic M2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D043585","descriptor_name":"Receptor, Muscarinic M2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000080106","doi":"https://doi.org/10.1159/000080106","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000080106","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},{"id":"pmid:15452370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15452370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310756","display_name":"Japan Research Foundation for Clinical Pharmacology","ror":"https://ror.org/02900by63"},{"id":"https://openalex.org/F4320316454","display_name":"University of Occupational and Environmental Health","ror":"https://ror.org/020p3h829"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1482828226","https://openalex.org/W1493864045","https://openalex.org/W1745534060","https://openalex.org/W1755902553","https://openalex.org/W1916235480","https://openalex.org/W1974018894","https://openalex.org/W1978997108","https://openalex.org/W1995952358","https://openalex.org/W2003804085","https://openalex.org/W2006118160","https://openalex.org/W2014078270","https://openalex.org/W2017788959","https://openalex.org/W2036790219","https://openalex.org/W2040684084","https://openalex.org/W2046053481","https://openalex.org/W2048733671","https://openalex.org/W2050531815","https://openalex.org/W2055989053","https://openalex.org/W2066310846","https://openalex.org/W2070090561","https://openalex.org/W2071168119","https://openalex.org/W2085588834","https://openalex.org/W2094733949","https://openalex.org/W2113776450","https://openalex.org/W2121166553","https://openalex.org/W2132805001","https://openalex.org/W2164960641","https://openalex.org/W2169527010","https://openalex.org/W2185418071","https://openalex.org/W2199386566","https://openalex.org/W2289222529","https://openalex.org/W2417239478"],"related_works":["https://openalex.org/W1917714559","https://openalex.org/W2011014082","https://openalex.org/W2095013577","https://openalex.org/W2410119723","https://openalex.org/W2089086780","https://openalex.org/W2966742404","https://openalex.org/W2070288681","https://openalex.org/W2017663972","https://openalex.org/W2053365431","https://openalex.org/W2114446441"],"abstract_inverted_index":{"Metabotropic":[0],"G":[1,68,73,76,85,121,145,156,171,179,187,204,219,326],"protein-coupled":[2],"receptors":[3,17,22,29,61,89,344],"have":[4,30],"recently":[5],"been":[6,31],"recognized":[7],"as":[8,19,98],"targets":[9,35],"for":[10,36],"anesthetics":[11,47,336],"and":[12,24,198,218,276],"analgesics.":[13],"In":[14,214],"particular,":[15],"G(q)-coupled":[16],"such":[18,97,294],"muscarinic":[20,115],"M(1)":[21],"(M(1)R)":[23],"5-hydroxytryptamine":[25],"(5-HT)":[26],"type":[27,195],"2A":[28],"reported":[32],"to":[33,56,90,92,331],"be":[34,329],"anesthetics.":[37],"Much":[38],"less":[39],"is":[40],"known,":[41],"however,":[42,289],"about":[43],"the":[44,119,150,169,234,252,263,305,321,333,340,346],"effects":[45,334],"of":[46,59,84,100,149,168,236,262,280,283,323,335,342],"on":[48,339],"G(i)-coupled":[49,60,88,114,193,343],"receptors.":[50],"Here":[51],"we":[52],"report":[53],"a":[54,66,221,230,259],"method":[55],"analyze":[57],"functions":[58],"in":[62,110,130,140,189,206,229,272,293,345],"Xenopus":[63,111,190,347],"oocytes":[64,112,131,141,215,273,295],"expressing":[65,132,274,325],"chimeric":[67,72,120],"alpha":[69],"protein.":[70],"A":[71],"alpha(q)":[74],"protein":[75,253],"alpha(qi5),":[77,220],"which":[78,161],"contains":[79],"carboxy-terminus":[80],"five":[81],"amino":[82],"acids":[83],"alpha(i),":[86],"enables":[87],"couple":[91],"Gq-coupled":[93],"receptor-mediated":[94],"downstream":[95],"pathways":[96],"activation":[99],"phospholipase":[101],"C.":[102],"We":[103],"determined":[104],"acetylcholine":[105],"(ACh)-induced":[106],"Ca(2+)-activated":[107,211],"Cl(-)":[108,138,152,212,227,265,284],"currents":[109,129,139,176,228,266,285],"coexpressing":[113,142,216],"M(2)receptors":[116],"(M(2)R)":[117],"with":[118,144,203,233,251,297],"alpha(qi5).":[122,146],"Although":[123],"ACh":[124,271],"did":[125],"not":[126,291],"induce":[127],"any":[128],"M(2)R":[133,143,217,275],"alone,":[134],"it":[135],"caused":[136,209],"robust":[137,210],"The":[147,278],"EC(50)":[148],"ACh-induced":[151,170],"current":[153],"mediated":[154],"through":[155],"alpha(qi5)":[157,205,327],"was":[158,162,290],"0.2":[159],"micromol/l,":[160],"2.2":[163],"times":[164],"higher":[165],"than":[166,313],"that":[167,240,302,320],"protein-activated":[172],"inwardly":[173],"rectifying":[174],"K(+)":[175],"activated":[177],"by":[178,268,287,308],"beta":[180],"gamma":[181],"subunits":[182],"liberated":[183],"from":[184],"endogenously":[185],"expressed":[186],"alpha(i)":[188],"oocytes.":[191],"Other":[192],"somatostatin":[194],"2,":[196],"5-HT(1A)":[197],"delta-opioid":[199],"receptors,":[200],"when":[201],"coexpressed":[202],"oocytes,":[207],"also":[208],"currents.":[213],"volatile":[222],"anesthetic":[223],"halothane":[224,241,303],"inhibited":[225],"M(2)R-induced":[226,243,306],"concentration-dependent":[231],"manner":[232],"IC(50)":[235],"1.1":[237],"mmol/l,":[238],"suggesting":[239],"inhibits":[242,304],"cellular":[244],"responses":[245],"at":[246,310],"clinically":[247],"relevant":[248],"concentrations.":[249],"Treatment":[250],"kinase":[254],"C":[255],"inhibitor":[256],"GF109203X":[257],"produced":[258],"3.5-fold":[260],"enhancement":[261],"initial":[264],"induced":[267],"1":[269],"micromol/l":[270],"G(qi5).":[277],"rate":[279],"halothane-induced":[281],"inhibition":[282],"elicited":[286],"ACh,":[288],"changed":[292],"pretreated":[296],"GF109203X.":[298],"These":[299],"findings":[300,318],"suggest":[301,319],"signaling":[307],"acting":[309],"sites":[311],"other":[312],"PKC":[314],"activity.":[315],"Collectively":[316],"these":[317],"use":[322],"oocyte":[324,348],"would":[328],"helpful":[330],"examine":[332],"or":[337],"analgesics":[338],"function":[341],"expression":[349],"system.":[350]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
