{"id":"https://openalex.org/W1996009455","doi":"https://doi.org/10.1016/j.ultrasmedbio.2005.05.007","title":"Preparation, characterization and in vivo observation of phospholipid-based gas-filled microbubbles containing hirudin","display_name":"Preparation, characterization and in vivo observation of phospholipid-based gas-filled microbubbles containing hirudin","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W1996009455","doi":"https://doi.org/10.1016/j.ultrasmedbio.2005.05.007","mag":"1996009455","pmid":"https://pubmed.ncbi.nlm.nih.gov/16176790"},"language":"en","primary_location":{"id":"doi:10.1016/j.ultrasmedbio.2005.05.007","doi":"https://doi.org/10.1016/j.ultrasmedbio.2005.05.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ultrasmedbio.2005.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S109113098","display_name":"Ultrasound in Medicine & Biology","issn_l":"0301-5629","issn":["0301-5629","1879-291X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasound in Medicine &amp; Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029921464","display_name":"Ying-Zheng Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying-Zheng Zhao","raw_affiliation_strings":["Beijing Institute of Pharmacology and Toxicology, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046871112","display_name":"Haidong Liang","orcid":"https://orcid.org/0000-0002-5437-066X","observed_orcids":["https://orcid.org/0000-0002-5437-066X"]},"institutions":[{"id":"https://openalex.org/I2802357497","display_name":"Bristol General Hospital","ror":"https://ror.org/00h3hwc05","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802357497"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hai-Dong Liang","raw_affiliation_strings":["Department of Medical Physics and Bioengineering, Bristol General Hospital, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics and Bioengineering, Bristol General Hospital, Bristol, UK","institution_ids":["https://openalex.org/I2802357497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113808631","display_name":"Xingguo Mei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xing-Guo Mei","raw_affiliation_strings":["Beijing Institute of Pharmacology and Toxicology, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Pharmacology and Toxicology, Beijing, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110084202","display_name":"Michael Halliwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802357497","display_name":"Bristol General Hospital","ror":"https://ror.org/00h3hwc05","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802357497"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Halliwell","raw_affiliation_strings":["Department of Medical Physics and Bioengineering, Bristol General Hospital, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics and Bioengineering, Bristol General Hospital, Bristol, UK","institution_ids":["https://openalex.org/I2802357497"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113808631"],"corresponding_institution_ids":[],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":1.9743,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.84286684,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"9","first_page":"1237","last_page":"1243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11401","display_name":"Minerals Flotation and Separation Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gas-filled-microbubbles","display_name":"gas-filled microbubbles","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hirudin","display_name":"hirudin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.7960000038146973},{"id":"https://openalex.org/keywords/nacl-concentration","display_name":"NaCl concentration","score":0.7269999980926514},{"id":"https://openalex.org/keywords/echogenicity","display_name":"echogenicity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/ultrasound-mediated-drug-delivery","display_name":"ultrasound-mediated drug delivery","score":0.9039999842643738},{"id":"https://openalex.org/keywords/liver-imaging","display_name":"liver imaging","score":0.5699999928474426},{"id":"https://openalex.org/keywords/microbubble-stability","display_name":"microbubble stability","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2778271848","wikidata":"https://www.wikidata.org/wiki/Q386715","display_name":"Hirudin","level":4,"score":0.7940713167190552},{"id":"https://openalex.org/C104628117","wikidata":"https://www.wikidata.org/wiki/Q3964828","display_name":"Sonication","level":2,"score":0.7821890115737915},{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.71300208568573},{"id":"https://openalex.org/C206111553","wikidata":"https://www.wikidata.org/wiki/Q3501532","display_name":"Echogenicity","level":3,"score":0.573458194732666},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.5609557628631592},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5405787825584412},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.5383890867233276},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5375726819038391},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4973340332508087},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45162150263786316},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4126852750778198},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.2759039103984833},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.15870699286460876},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11079221963882446},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10124433040618896},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0963904857635498},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005612","descriptor_name":"Freeze Drying","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006629","descriptor_name":"Hirudins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006629","descriptor_name":"Hirudins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014465","descriptor_name":"Ultrasonics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ultrasmedbio.2005.05.007","doi":"https://doi.org/10.1016/j.ultrasmedbio.2005.05.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ultrasmedbio.2005.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S109113098","display_name":"Ultrasound in Medicine & Biology","issn_l":"0301-5629","issn":["0301-5629","1879-291X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasound in Medicine &amp; Biology","raw_type":"journal-article"},{"id":"pmid:16176790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16176790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasound in medicine & biology","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.4099999964237213,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1964696510","https://openalex.org/W1984001852","https://openalex.org/W1993362223","https://openalex.org/W1995364201","https://openalex.org/W1997466944","https://openalex.org/W1998220101","https://openalex.org/W2005751180","https://openalex.org/W2006434443","https://openalex.org/W2015799066","https://openalex.org/W2021781580","https://openalex.org/W2031686813","https://openalex.org/W2040000146","https://openalex.org/W2045446074","https://openalex.org/W2049889769","https://openalex.org/W2051569838","https://openalex.org/W2059601842","https://openalex.org/W2070289031","https://openalex.org/W2072174352","https://openalex.org/W2076867170","https://openalex.org/W2092307069","https://openalex.org/W2092357079","https://openalex.org/W2130546300","https://openalex.org/W2153057832","https://openalex.org/W2397380947","https://openalex.org/W2423424575"],"related_works":["https://openalex.org/W2112779776","https://openalex.org/W3029283573","https://openalex.org/W2969713130","https://openalex.org/W2367769645","https://openalex.org/W2369132055","https://openalex.org/W2005350388","https://openalex.org/W2216257567","https://openalex.org/W2148926898","https://openalex.org/W4236850857","https://openalex.org/W2981793622"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
