{"id":"https://openalex.org/W1996005105","doi":"https://doi.org/10.1006/geno.2002.6804","title":"Canine PKD1 Is a Single-Copy Gene: Genomic Organization and Comparative Analysis","display_name":"Canine PKD1 Is a Single-Copy Gene: Genomic Organization and Comparative Analysis","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W1996005105","doi":"https://doi.org/10.1006/geno.2002.6804","mag":"1996005105","pmid":"https://pubmed.ncbi.nlm.nih.gov/12079289"},"language":"en","primary_location":{"id":"doi:10.1006/geno.2002.6804","doi":"https://doi.org/10.1006/geno.2002.6804","is_oa":false,"landing_page_url":"https://doi.org/10.1006/geno.2002.6804","pdf_url":null,"source":{"id":"https://openalex.org/S146035217","display_name":"Genomics","issn_l":"0888-7543","issn":["0888-7543","1089-8646"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019573210","display_name":"William R. Dackowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William R Dackowski","raw_affiliation_strings":["Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051467752","display_name":"Hilary F. Luderer","orcid":"https://orcid.org/0000-0002-3737-946X","observed_orcids":["https://orcid.org/0000-0002-3737-946X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hilary F Luderer","raw_affiliation_strings":["Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024925978","display_name":"Partha Manavalan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Partha Manavalan","raw_affiliation_strings":["Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069061776","display_name":"Nikolay O. Bukanov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikolay O Bukanov","raw_affiliation_strings":["Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035214552","display_name":"Ryan J. Russo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan J Russo","raw_affiliation_strings":["Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113584789","display_name":"Bruce Roberts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce L Roberts","raw_affiliation_strings":["Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113700879","display_name":"Katherine Wood Klinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine W Klinger","raw_affiliation_strings":["Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041479317","display_name":"Oxana Ibraghimov\u2010Beskrovnaya","orcid":"https://orcid.org/0000-0001-5347-5825","observed_orcids":["https://orcid.org/0000-0001-5347-5825"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oxana Ibraghimov-Beskrovnaya","raw_affiliation_strings":["Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, 5 Mountain Road, Framingham, Massachusetts, 01701-9322, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2980,"currency":"USD","value_usd":2980},"apc_paid":null,"fwci":0.884,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.73339733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"80","issue":"1","first_page":"105","last_page":"112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pkd1","display_name":"PKD1","score":0.9279999732971191},{"id":"https://openalex.org/keywords/polycystin-1","display_name":"polycystin-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/autosomal-dominant-polycystic-kidney-disease","display_name":"autosomal dominant polycystic kidney disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dog-genome","display_name":"dog genome","score":0.6740000247955322},{"id":"https://openalex.org/keywords/exon-intron-structure","display_name":"exon-intron structure","score":0.8389999866485596},{"id":"https://openalex.org/keywords/polypyrimidine-tract","display_name":"polypyrimidine tract","score":0.7490000128746033},{"id":"https://openalex.org/keywords/leucine-rich-repeat-domain","display_name":"leucine-rich repeat domain","score":0.7960000038146973},{"id":"https://openalex.org/keywords/homology","display_name":"homology","score":0.37700000405311584},{"id":"https://openalex.org/keywords/cyst-formation","display_name":"cyst formation","score":0.6060000061988831},{"id":"https://openalex.org/keywords/tubulogenesis","display_name":"tubulogenesis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mdck-cells","display_name":"MDCK cells","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.5830000042915344},{"id":"https://openalex.org/keywords/homophilic-interactions","display_name":"homophilic interactions","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8945858478546143},{"id":"https://openalex.org/C100773827","wikidata":"https://www.wikidata.org/wiki/Q82302467","display_name":"PKD1","level":4,"score":0.8623476028442383},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.7033443450927734},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.6730613708496094},{"id":"https://openalex.org/C2780145431","wikidata":"https://www.wikidata.org/wiki/Q15443105","display_name":"Polycystic kidney disease","level":3,"score":0.641156017780304},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6270872354507446},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.6168895959854126},{"id":"https://openalex.org/C2776266639","wikidata":"https://www.wikidata.org/wiki/Q2732398","display_name":"Autosomal dominant polycystic kidney disease","level":3,"score":0.563931941986084},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5579297542572021},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43996235728263855},{"id":"https://openalex.org/C22322919","wikidata":"https://www.wikidata.org/wiki/Q5533501","display_name":"Genomic organization","level":4,"score":0.42220890522003174},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37067556381225586},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2921825349330902},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.15432682633399963}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050396","descriptor_name":"TRPP Cation Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/geno.2002.6804","doi":"https://doi.org/10.1006/geno.2002.6804","is_oa":false,"landing_page_url":"https://doi.org/10.1006/geno.2002.6804","pdf_url":null,"source":{"id":"https://openalex.org/S146035217","display_name":"Genomics","issn_l":"0888-7543","issn":["0888-7543","1089-8646"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"journal-article"},{"id":"pmid:12079289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12079289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1551136355","https://openalex.org/W1795473064","https://openalex.org/W1975304761","https://openalex.org/W1985471941","https://openalex.org/W1990249568","https://openalex.org/W2002807867","https://openalex.org/W2002962124","https://openalex.org/W2003544045","https://openalex.org/W2011293197","https://openalex.org/W2015656666","https://openalex.org/W2022323737","https://openalex.org/W2036329296","https://openalex.org/W2043943421","https://openalex.org/W2065881793","https://openalex.org/W2066100382","https://openalex.org/W2071133433","https://openalex.org/W2072263359","https://openalex.org/W2081659168","https://openalex.org/W2088937372","https://openalex.org/W2093401766","https://openalex.org/W2097722745","https://openalex.org/W2101122454","https://openalex.org/W2106882534","https://openalex.org/W2117852779","https://openalex.org/W2122042273","https://openalex.org/W2123017921","https://openalex.org/W2136800297","https://openalex.org/W2155895966","https://openalex.org/W2158152313","https://openalex.org/W2168133891","https://openalex.org/W2173267258","https://openalex.org/W2182327842","https://openalex.org/W2319095608","https://openalex.org/W6671132811","https://openalex.org/W6745119887"],"related_works":["https://openalex.org/W1908011278","https://openalex.org/W2117852779","https://openalex.org/W1973963740","https://openalex.org/W2132358253","https://openalex.org/W2097722745","https://openalex.org/W2041079557","https://openalex.org/W2065881793","https://openalex.org/W7014613802","https://openalex.org/W2033779646","https://openalex.org/W2133532840"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}