{"id":"https://openalex.org/W1996004607","doi":"https://doi.org/10.3892/or.2012.1915","title":"AAV2-mediated gene transfer of VEGF-Trap with potent suppression of primary breast tumor growth and spontaneous pulmonary metastases by long-term expression","display_name":"AAV2-mediated gene transfer of VEGF-Trap with potent suppression of primary breast tumor growth and spontaneous pulmonary metastases by long-term expression","publication_year":2012,"publication_date":"2012-07-16","ids":{"openalex":"https://openalex.org/W1996004607","doi":"https://doi.org/10.3892/or.2012.1915","mag":"1996004607","pmid":"https://pubmed.ncbi.nlm.nih.gov/22824831"},"language":"en","primary_location":{"id":"doi:10.3892/or.2012.1915","doi":"https://doi.org/10.3892/or.2012.1915","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2012.1915","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2012.1915/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/or.2012.1915/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103120278","display_name":"Lian Lu","orcid":"https://orcid.org/0000-0001-5707-2150","observed_orcids":["https://orcid.org/0000-0001-5707-2150"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"LIAN LU","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, PR China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102156504","display_name":"Shuntao Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"SHUN-TAO LUO","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100707883","display_name":"Shi H","orcid":"https://orcid.org/0000-0002-9958-9892","observed_orcids":["https://orcid.org/0000-0002-9958-9892"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HUA SHAN SHI","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085750703","display_name":"Meng Li","orcid":"https://orcid.org/0000-0002-1749-9253","observed_orcids":["https://orcid.org/0000-0002-1749-9253"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"MENG LI","raw_affiliation_strings":["West China Medical School , Sichuan University , Sichuan 610041 , P.R. China","State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West China Medical School , Sichuan University , Sichuan 610041 , P.R. China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034124613","display_name":"HAI LONG ZHANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HAI LONG ZHANG","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077651803","display_name":"Sha He","orcid":"https://orcid.org/0000-0002-3378-4628","observed_orcids":["https://orcid.org/0000-0002-3378-4628"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"SHA SHA HE","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351125","display_name":"Yan Liu","orcid":"https://orcid.org/0000-0002-9123-4974","observed_orcids":["https://orcid.org/0000-0002-9123-4974"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YAN LIU","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101957044","display_name":"Ying Pan","orcid":"https://orcid.org/0000-0001-7007-2921","observed_orcids":["https://orcid.org/0000-0001-7007-2921"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YING PAN","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100785358","display_name":"Yang Li","orcid":"https://orcid.org/0000-0003-3855-7720","observed_orcids":["https://orcid.org/0000-0003-3855-7720","https://orcid.org/0009-0008-5920-7889"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"LI YANG","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.42,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.54659495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"28","issue":"4","first_page":"1332","last_page":"1338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aav2","display_name":"AAV2","score":0.7710000276565552},{"id":"https://openalex.org/keywords/vegf-trap","display_name":"VEGF trap","score":0.9200000166893005},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6299999952316284},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7519999742507935},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/4t1-tumor-model","display_name":"4T1 tumor model","score":0.6959999799728394},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/soluble-vegf-receptor","display_name":"soluble VEGF receptor","score":0.7039999961853027},{"id":"https://openalex.org/keywords/sustained-gene-expression","display_name":"sustained gene expression","score":0.6700000166893005},{"id":"https://openalex.org/keywords/tumor-cell-apoptosis","display_name":"tumor cell apoptosis","score":0.652999997138977},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.953000009059906},{"id":"https://openalex.org/keywords/angiogenic-factors","display_name":"angiogenic factors","score":0.7250000238418579},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7973283529281616},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6556000709533691},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5958184599876404},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5572938323020935},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.5385689735412598},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4964326024055481},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.44135814905166626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43229836225509644},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41906648874282837},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4180123209953308},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.41705700755119324},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4156104624271393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3538323640823364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2653595805168152},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.12720343470573425},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012259","descriptor_name":"Ribonuclease, Pancreatic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013939","descriptor_name":"Thymidine Phosphorylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.2012.1915","doi":"https://doi.org/10.3892/or.2012.1915","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2012.1915","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2012.1915/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:22824831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22824831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/or.2012.1915","doi":"https://doi.org/10.3892/or.2012.1915","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2012.1915","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2012.1915/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8584689526","display_name":null,"funder_award_id":"2010CB529900","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320334924","display_name":"Program for New Century Excellent Talents in University","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1996004607.pdf","grobid_xml":"https://content.openalex.org/works/W1996004607.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W55352385","https://openalex.org/W1487084354","https://openalex.org/W1573363574","https://openalex.org/W1583699618","https://openalex.org/W1762724222","https://openalex.org/W1783580437","https://openalex.org/W1854803455","https://openalex.org/W1892096673","https://openalex.org/W1969328947","https://openalex.org/W1977601636","https://openalex.org/W1977999028","https://openalex.org/W1980725734","https://openalex.org/W1982246723","https://openalex.org/W1983376387","https://openalex.org/W1983763042","https://openalex.org/W1985712533","https://openalex.org/W2000000541","https://openalex.org/W2001375090","https://openalex.org/W2010388612","https://openalex.org/W2013044761","https://openalex.org/W2023061657","https://openalex.org/W2026621524","https://openalex.org/W2036751011","https://openalex.org/W2043850275","https://openalex.org/W2047470479","https://openalex.org/W2050193680","https://openalex.org/W2072928113","https://openalex.org/W2105669313","https://openalex.org/W2106350749","https://openalex.org/W2117087331","https://openalex.org/W2131158944","https://openalex.org/W2131798870","https://openalex.org/W2134486949","https://openalex.org/W2141720204","https://openalex.org/W2156367667","https://openalex.org/W2413007786","https://openalex.org/W2417237803"],"related_works":["https://openalex.org/W2119629056","https://openalex.org/W2077595741","https://openalex.org/W2141720204","https://openalex.org/W2124784163","https://openalex.org/W1980725734","https://openalex.org/W2059193290","https://openalex.org/W2023693731","https://openalex.org/W2041333705","https://openalex.org/W1979242769","https://openalex.org/W1974312026"],"abstract_inverted_index":{"Vascular":[0],"endothelial":[1],"growth":[2,18,37,119],"factor":[3],"(VEGF)":[4],"is":[5,46,178],"an":[6],"important":[7],"signaling":[8],"protein":[9,88],"and":[10,19,38,53,105,120,131,167,181,188],"a":[11,41,78,90,111,179],"predominant":[12],"mediator":[13],"of":[14,23,30,35,61,85,125,150,158,176],"angiogenesis":[15],"in":[16,28,48,58,89,108,138,152],"tumor":[17,36,118,133,186],"metastasis.":[20,39],"Therefore,":[21],"antagonism":[22],"the":[24,94,122,139,148,156],"VEGF":[25,86,151],"pathway":[26],"results":[27],"inhibition":[29],"abnormal":[31],"angiogenesis,":[32],"then":[33],"suppression":[34],"VEGF-Trap,":[40],"high-affinity":[42],"soluble":[43],"decoy":[44],"receptor,":[45],"currently":[47],"phase":[49],"II":[50],"clinical":[51],"trails,":[52],"has":[54],"demonstrated":[55],"more":[56],"efficacy":[57],"different":[59],"types":[60],"solid":[62],"tumors":[63],"by":[64],"intravenous":[65],"injection":[66],"every":[67],"two":[68],"weeks.":[69],"In":[70],"our":[71],"study,":[72],"we":[73],"used":[74],"recombinant":[75],"AAV2":[76],"as":[77,163],"delivery":[79],"vehicle":[80],"to":[81,184],"achieve":[82],"long-lasting":[83],"expression":[84,107,175],"Trap":[87],"mouse":[91],"model":[92],"for":[93],"first":[95],"time.":[96],"We":[97],"report":[98],"that":[99,172],"AAV2-VEGF-Trap":[100,142],"can":[101,143],"be":[102],"safely":[103],"administered":[104],"sustained":[106],"vivo":[109],"via":[110],"single":[112],"intravenously":[113],"administration,":[114],"simultaneously":[115],"suppressing":[116],"primary":[117],"preventing":[121],"pulmonary":[123,191],"metastases":[124],"4T1":[126],"tumors.":[127],"Decreased":[128],"microvessel":[129],"density":[130],"increased":[132],"cell":[134],"apoptosis":[135],"were":[136],"observed":[137],"treatment":[140],"group.":[141],"obviously":[144],"decrease":[145],"not":[146],"only":[147],"concentration":[149,157],"sera,":[153],"but":[154],"also":[155],"other":[159],"angiogenic":[160],"factors,":[161],"such":[162],"aFGF,":[164],"bFGF,":[165],"angiopoietin-1":[166],"others.":[168],"These":[169],"studies":[170],"suggest":[171],"AAV-mediated":[173],"long-term":[174],"VEGF-Trap":[177],"useful":[180],"safe":[182],"tool":[183],"block":[185],"progression":[187],"inhibit":[189],"spontaneous":[190],"metastases.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
