{"id":"https://openalex.org/W1995982232","doi":"https://doi.org/10.1002/pbc.20079","title":"Autoimmune lymphoproliferative syndrome: A cause of chronic splenomegaly, lymphadenopathy, and cytopenias in children\u2014report on diagnosis and management of five patients","display_name":"Autoimmune lymphoproliferative syndrome: A cause of chronic splenomegaly, lymphadenopathy, and cytopenias in children\u2014report on diagnosis and management of five patients","publication_year":2004,"publication_date":"2004-05-17","ids":{"openalex":"https://openalex.org/W1995982232","doi":"https://doi.org/10.1002/pbc.20079","mag":"1995982232","pmid":"https://pubmed.ncbi.nlm.nih.gov/15236285"},"language":"en","primary_location":{"id":"doi:10.1002/pbc.20079","doi":"https://doi.org/10.1002/pbc.20079","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.20079","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101454549","display_name":"Carlos S. Alvarado","orcid":"https://orcid.org/0000-0003-4121-8025","observed_orcids":["https://orcid.org/0000-0003-4121-8025"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carlos S. Alvarado","raw_affiliation_strings":["The AFLAC Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta at Egleston, USA. carlos_alvarado@oz.ped.emory.edu","The AFLAC Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta at Egleston, Department of Pediatrics, Division of Hematology/Oncology/BMT, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The AFLAC Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta at Egleston, USA. carlos_alvarado@oz.ped.emory.edu","institution_ids":["https://openalex.org/I4210146983"]},{"raw_affiliation_string":"The AFLAC Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta at Egleston, Department of Pediatrics, Division of Hematology/Oncology/BMT, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210146983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111598177","display_name":"Stephen E. Straus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen E. Straus","raw_affiliation_strings":["Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780836","display_name":"Shiyong Li","orcid":"https://orcid.org/0000-0003-0416-526X","observed_orcids":["https://orcid.org/0000-0003-0416-526X","https://orcid.org/0000-0002-7052-5203","https://orcid.org/0000-0001-7442-1826"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiyong Li","raw_affiliation_strings":["Department of Pathology, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111608995","display_name":"Janet K. Dale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet K. Dale","raw_affiliation_strings":["Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030101878","display_name":"Karen P. Mann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Mann","raw_affiliation_strings":["Department of Pathology, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anh Le","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anh Le","raw_affiliation_strings":["Department of Medicine, Lipid Research Laboratory, Veterans Administration Hospital, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Lipid Research Laboratory, Veterans Administration Hospital, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2799886695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108810254","display_name":"Stephen J. Lauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Lauer","raw_affiliation_strings":["The AFLAC Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta at Egleston, Department of Pediatrics, Division of Hematology/Oncology/BMT, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The AFLAC Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta at Egleston, Department of Pediatrics, Division of Hematology/Oncology/BMT, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210146983"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101454549"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210146983"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":0.6005,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.65952257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"43","issue":"2","first_page":"164","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-lymphoproliferative-syndrome","display_name":"autoimmune lymphoproliferative syndrome","score":1.0},{"id":"https://openalex.org/keywords/lymphadenopathy","display_name":"lymphadenopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytopenia","display_name":"cytopenia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.925000011920929},{"id":"https://openalex.org/keywords/lymphocyte-apoptosis","display_name":"lymphocyte apoptosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.593999981880188},{"id":"https://openalex.org/keywords/diagnosis","display_name":"diagnosis","score":0.4909999966621399},{"id":"https://openalex.org/keywords/disease-management","display_name":"disease management","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2778959938","wikidata":"https://www.wikidata.org/wiki/Q1151300","display_name":"Autoimmune lymphoproliferative syndrome","level":5,"score":0.9545242786407471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9236615896224976},{"id":"https://openalex.org/C2776995267","wikidata":"https://www.wikidata.org/wiki/Q4165484","display_name":"Lymphoproliferative disorders","level":3,"score":0.5473026633262634},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.534554123878479},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47973647713661194},{"id":"https://openalex.org/C2992972558","wikidata":"https://www.wikidata.org/wiki/Q2509220","display_name":"Blood cancer","level":3,"score":0.4506252110004425},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.44229185581207275},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42680612206459045},{"id":"https://openalex.org/C2910651325","wikidata":"https://www.wikidata.org/wiki/Q4165484","display_name":"Lymphoproliferative disease","level":3,"score":0.4145646095275879},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3801259696483612},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28742918372154236},{"id":"https://openalex.org/C3031857","wikidata":"https://www.wikidata.org/wiki/Q1649375","display_name":"Fas receptor","level":4,"score":0.26322877407073975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20274269580841064},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1337975263595581},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006402","descriptor_name":"Hematologic Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008206","descriptor_name":"Lymphatic Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008232","descriptor_name":"Lymphoproliferative Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013163","descriptor_name":"Splenomegaly","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/pbc.20079","doi":"https://doi.org/10.1002/pbc.20079","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.20079","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},{"id":"pmid:15236285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15236285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric blood & cancer","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W46306016","https://openalex.org/W248162401","https://openalex.org/W1660981305","https://openalex.org/W1967941999","https://openalex.org/W1973298156","https://openalex.org/W1976399964","https://openalex.org/W1979461967","https://openalex.org/W1980995033","https://openalex.org/W1982689124","https://openalex.org/W2025946997","https://openalex.org/W2036926929","https://openalex.org/W2089244519","https://openalex.org/W2106487775","https://openalex.org/W2138468700","https://openalex.org/W2144417352","https://openalex.org/W2154757961","https://openalex.org/W2159531745","https://openalex.org/W2159719957","https://openalex.org/W2165583831","https://openalex.org/W4205976928","https://openalex.org/W4238704139","https://openalex.org/W4322385172"],"related_works":["https://openalex.org/W2023694908","https://openalex.org/W7203840876","https://openalex.org/W1986508694","https://openalex.org/W1520810528","https://openalex.org/W2410741022","https://openalex.org/W2062631578","https://openalex.org/W3114111227","https://openalex.org/W2406137808","https://openalex.org/W2557571147","https://openalex.org/W2343911947"],"abstract_inverted_index":{"Autoimmune":[0],"lymphoproliferative":[1],"syndrome":[2],"(ALPS)":[3],"usually":[4],"manifests":[5],"in":[6,21,52,59,66,92],"early":[7],"childhood":[8],"with":[9,36],"splenomegaly,":[10,42],"lymphadenopathy,":[11],"and":[12,44,84],"cytopenias.":[13],"In":[14],"most":[15],"patients,":[16],"it":[17],"results":[18],"from":[19],"mutations":[20],"genes":[22],"that":[23],"regulate":[24],"lymphocyte":[25],"apoptosis":[26],"via":[27],"the":[28,53,88],"Fas":[29,54],"pathway.":[30],"Here,":[31],"we":[32],"report":[33],"five":[34,39],"children":[35,40],"ALPS.":[37],"All":[38],"had":[41,49],"cytopenias,":[43],"hypertriglyceridemia":[45],"at":[46],"presentation;":[47],"four":[48],"lymphadenopathy.":[50],"Mutations":[51],"receptor":[55],"gene":[56],"were":[57],"demonstrated":[58],"three":[60],"children.":[61],"Clinical":[62],"picture":[63],"is":[64],"variable:":[65],"only":[67],"one":[68],"child":[69],"manifestations":[70],"are":[71],"severe":[72],"enough":[73],"to":[74],"require":[75],"immunosuppressive":[76],"therapy.":[77],"Diagnosis":[78],"of":[79,87,102],"ALPS":[80],"can":[81,90],"be":[82],"challenging":[83],"increased":[85],"awareness":[86],"disease":[89],"result":[91],"more":[93],"directed":[94],"diagnostic":[95],"approaches":[96],"as":[97,99],"well":[98],"earlier":[100],"initiation":[101],"treatment.":[103]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
