{"id":"https://openalex.org/W1995980971","doi":"https://doi.org/10.1038/sj.bjp.0707605","title":"Role of the NO/cGMP/K ATP pathway in the protective effects of sildenafil against ethanol\u2010induced gastric damage in rats","display_name":"Role of the NO/cGMP/K ATP pathway in the protective effects of sildenafil against ethanol\u2010induced gastric damage in rats","publication_year":2007,"publication_date":"2007-12-10","ids":{"openalex":"https://openalex.org/W1995980971","doi":"https://doi.org/10.1038/sj.bjp.0707605","mag":"1995980971","pmid":"https://pubmed.ncbi.nlm.nih.gov/18071300","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2259210"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjp.0707605","doi":"https://doi.org/10.1038/sj.bjp.0707605","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0707605","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707605","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707605","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039266429","display_name":"Jand Venes Rolim Medeiros","orcid":"https://orcid.org/0000-0002-7234-3382","observed_orcids":["https://orcid.org/0000-0002-7234-3382"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J V R Medeiros","raw_affiliation_strings":["Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Ceara, Brazil","Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Ceara, Brazil","institution_ids":["https://openalex.org/I243754102"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006675114","display_name":"Gemima G. Gadelha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"G G Gadelha","raw_affiliation_strings":["Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","institution_ids":["https://openalex.org/I243754102"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S J Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"S J Lima","raw_affiliation_strings":["Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","institution_ids":["https://openalex.org/I243754102"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005458968","display_name":"Joyce A. Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J A Garcia","raw_affiliation_strings":["Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","institution_ids":["https://openalex.org/I243754102"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032275911","display_name":"Pedro Marcos Gomes Soares","orcid":"https://orcid.org/0000-0003-0606-2539","observed_orcids":["https://orcid.org/0000-0003-0606-2539"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"P M G Soares","raw_affiliation_strings":["Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","institution_ids":["https://openalex.org/I243754102"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021603539","display_name":"Arm\u00eanio Aguiar dos Santos","orcid":"https://orcid.org/0000-0003-0912-3720","observed_orcids":["https://orcid.org/0000-0003-0912-3720"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A A Santos","raw_affiliation_strings":["Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","institution_ids":["https://openalex.org/I243754102"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086070985","display_name":"Gerly Anne de Castro Brito","orcid":"https://orcid.org/0000-0002-8214-4379","observed_orcids":["https://orcid.org/0000-0002-8214-4379"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"G A C Brito","raw_affiliation_strings":["Department of Morphology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R A Ribeiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"R A Ribeiro","raw_affiliation_strings":["Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","institution_ids":["https://openalex.org/I243754102"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066579546","display_name":"Marcellus Henrique Loiola Ponte de Souza","orcid":"https://orcid.org/0000-0003-2376-3433","observed_orcids":["https://orcid.org/0000-0003-2376-3433"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"M H L P Souza","raw_affiliation_strings":["Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Ceara\u0301, Fortaleza, Ceara, Brazil","institution_ids":["https://openalex.org/I243754102"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil","institution_ids":["https://openalex.org/I243754102"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066579546"],"corresponding_institution_ids":["https://openalex.org/I243754102"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":3.483,"has_fulltext":true,"cited_by_count":105,"citation_normalized_percentile":{"value":0.91447249,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"153","issue":"4","first_page":"721","last_page":"727"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.45089998841285706,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.45089998841285706,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.16439999639987946,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.08389999717473984,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sildenafil","display_name":"sildenafil","score":1.0},{"id":"https://openalex.org/keywords/ethanol-induced-gastric-lesions","display_name":"ethanol-induced gastric injury","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9380000233650208},{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gastroprotective-effect","display_name":"gastroprotection","score":0.7799999713897705},{"id":"https://openalex.org/keywords/phosphodiesterase-inhibition","display_name":"phosphodiesterase inhibition","score":0.8669999837875366},{"id":"https://openalex.org/keywords/guanylate-cyclase","display_name":"guanylate cyclase","score":0.8090000152587891},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.7590000033378601},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8799999952316284},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":0.9449999928474426},{"id":"https://openalex.org/keywords/diazoxide","display_name":"diazoxide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.36000001430511475},{"id":"https://openalex.org/keywords/gastric-hemorrhage","display_name":"gastric bleeding","score":0.7509999871253967},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.871999979019165},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2776768464","wikidata":"https://www.wikidata.org/wiki/Q191521","display_name":"Sildenafil","level":2,"score":0.9507356882095337},{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.9419373273849487},{"id":"https://openalex.org/C2779872217","wikidata":"https://www.wikidata.org/wiki/Q420009","display_name":"Diazoxide","level":3,"score":0.8589626550674438},{"id":"https://openalex.org/C74534348","wikidata":"https://www.wikidata.org/wiki/Q410798","display_name":"cGMP-specific phosphodiesterase type 5","level":3,"score":0.616178035736084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.54905766248703},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5254216194152832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49525704979896545},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48607924580574036},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.4355967044830322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3366493582725525},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.07582512497901917},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068677","descriptor_name":"Sildenafil Citrate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003981","descriptor_name":"Diazoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005905","descriptor_name":"Glyburide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010438","descriptor_name":"Peptic Ulcer Hemorrhage","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010438","descriptor_name":"Peptic Ulcer Hemorrhage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010438","descriptor_name":"Peptic Ulcer Hemorrhage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010438","descriptor_name":"Peptic Ulcer Hemorrhage","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054086","descriptor_name":"KATP Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054086","descriptor_name":"KATP Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054706","descriptor_name":"Cyclic Nucleotide Phosphodiesterases, Type 5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058986","descriptor_name":"Phosphodiesterase 5 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjp.0707605","doi":"https://doi.org/10.1038/sj.bjp.0707605","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0707605","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707605","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:18071300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18071300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2259210","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2259210/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/sj.bjp.0707605","doi":"https://doi.org/10.1038/sj.bjp.0707605","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0707605","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707605","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995980971.pdf","grobid_xml":"https://content.openalex.org/works/W1995980971.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W433649","https://openalex.org/W33612069","https://openalex.org/W100235837","https://openalex.org/W1647673633","https://openalex.org/W1838828609","https://openalex.org/W1889139395","https://openalex.org/W1979526473","https://openalex.org/W1983768623","https://openalex.org/W1995631245","https://openalex.org/W2015951828","https://openalex.org/W2019759992","https://openalex.org/W2029491963","https://openalex.org/W2031790322","https://openalex.org/W2042922625","https://openalex.org/W2044869734","https://openalex.org/W2049076878","https://openalex.org/W2054818418","https://openalex.org/W2055990587","https://openalex.org/W2063503589","https://openalex.org/W2063576996","https://openalex.org/W2065317766","https://openalex.org/W2066694908","https://openalex.org/W2076670842","https://openalex.org/W2081515290","https://openalex.org/W2083384475","https://openalex.org/W2118811017","https://openalex.org/W2125142347","https://openalex.org/W2256648060","https://openalex.org/W2260255165","https://openalex.org/W2338245682"],"related_works":["https://openalex.org/W7120377144","https://openalex.org/W7027878236","https://openalex.org/W3088572579","https://openalex.org/W7202073142","https://openalex.org/W2070220076","https://openalex.org/W2118811017","https://openalex.org/W7097617001","https://openalex.org/W7054912902","https://openalex.org/W2101594919","https://openalex.org/W2563946413"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Sildenafil":[3,168,224],"is":[4,25],"a":[5,146,226],"selective":[6],"inhibitor":[7],"of":[8,20,37,45,124,150,161,188,199,221,236],"cGMP-specific":[9],"phosphodiesterase.":[10],"Sildenafil,":[11],"acting":[12],"via":[13],"NO-dependent":[14],"mechanisms,":[15],"prevents":[16],"indomethacin-induced":[17],"gastropathy.":[18],"Activation":[19],"ATP-sensitive":[21],"potassium":[22],"channels":[23],"(K(ATP))":[24],"involved":[26],"in":[27,41,174],"gastric":[28,49,132,137,172,196,203,209,231],"defence.":[29],"Our":[30],"objective":[31],"was":[32,143],"to":[33,130],"evaluate":[34],"the":[35,38,42,77,111,182,195,219,234,237],"role":[36],"NO/cGMP/K(ATP)":[39,238],"pathway":[40],"protective":[43,197,210,227],"effects":[44,220],"sildenafil":[46,114,200],"against":[47,201,229],"ethanol-induced":[48,171,202,230],"damage.":[50,133,204],"EXPERIMENTAL":[51],"APPROACH:":[52],"Rats":[53],"were":[54,152],"treated":[55],"with":[56,65,96,145],"L-NAME":[57,72,176],"(1":[58,98,115],"or":[59,64,90,95,140],"3":[60,91],"mg":[61,68,74,83,92,99,105,116],"kg(-1),":[62,69,75,84,93,100,106,117],"i.p.)":[63,70,94,101],"L-arginine":[66],"(200":[67],"+":[71,102],"(3":[73,104],"i.p.),":[76,85],"guanylate":[78,189],"cyclase":[79,190],"inhibitor,":[80],"ODQ":[81,192],"(10":[82],"glibenclamide":[86,97,213],"(0.1,":[87],"0.3,":[88],"1":[89],"diazoxide":[103,215],"i.p.).":[107],"After":[108],"thirty":[109],"minutes,":[110],"rats":[112],"received":[113],"by":[118,121,185,191],"gavage),":[119],"followed":[120],"intragastric":[122],"instillation":[123],"absolute":[125],"ethanol":[126],"(4":[127],"ml":[128],"kg(-1))":[129],"induce":[131],"One":[134],"hour":[135],"later,":[136],"damage":[138,173,232],"(haemorrhagic":[139],"ulcerative":[141],"lesions)":[142],"measured":[144],"planimetry":[147],"programme.":[148],"Samples":[149],"stomach":[151],"also":[153],"taken":[154],"for":[155,159],"histopathological":[156],"assessment":[157],"and":[158,164],"assays":[160],"tissue":[162],"glutathione":[163],"haemoglobin.":[165],"KEY":[166],"RESULTS:":[167],"significantly":[169,180],"reduced":[170],"rats.":[175],"alone,":[177],"without":[178],"L-arginine,":[179],"reversed":[181,207],"protection":[183],"afforded":[184],"sildenafil.":[186,222],"Inhibition":[187],"completely":[193],"abolished":[194],"effect":[198,228],"Glibenclamide":[205],"alone":[206],"sildenafil's":[208],"effect.":[211],"However,":[212],"plus":[214],"did":[216],"not":[217],"alter":[218],"CONCLUSIONS:":[223],"had":[225],"through":[233],"activation":[235],"pathway.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
