{"id":"https://openalex.org/W1995975429","doi":"https://doi.org/10.1111/j.1432-1033.1970.tb00868.x","title":"Effect of Trypsin on Mitochondrial and Microsomal Enzymes","display_name":"Effect of Trypsin on Mitochondrial and Microsomal Enzymes","publication_year":1970,"publication_date":"1970-02-01","ids":{"openalex":"https://openalex.org/W1995975429","doi":"https://doi.org/10.1111/j.1432-1033.1970.tb00868.x","mag":"1995975429","pmid":"https://pubmed.ncbi.nlm.nih.gov/4315397"},"language":"en","primary_location":{"id":"doi:10.1111/j.1432-1033.1970.tb00868.x","doi":"https://doi.org/10.1111/j.1432-1033.1970.tb00868.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1970.tb00868.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1970.tb00868.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1970.tb00868.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048152297","display_name":"Bo Kuylenstierna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Kuylenstierna","raw_affiliation_strings":["Biokemiska Institutionen, Kungliga Universitetet Box 6409, S-11382 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biokemiska Institutionen, Kungliga Universitetet Box 6409, S-11382 Stockholm, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075675047","display_name":"Sven Hovm\u00f6ller","orcid":"https://orcid.org/0000-0003-1717-0455","observed_orcids":["https://orcid.org/0000-0003-1717-0455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Hovm\u00f6ller","raw_affiliation_strings":["Biokemiska Institutionen, Kungliga Universitetet Box 6409, S-11382 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biokemiska Institutionen, Kungliga Universitetet Box 6409, S-11382 Stockholm, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089739925","display_name":"Lars Ernster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Ernster","raw_affiliation_strings":["Biokemiska Institutionen, Kungliga Universitetet Box 6409, S-11382 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biokemiska Institutionen, Kungliga Universitetet Box 6409, S-11382 Stockholm, Sweden","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004270076","display_name":"David G. Nicholls","orcid":"https://orcid.org/0000-0001-5036-808X","observed_orcids":["https://orcid.org/0000-0001-5036-808X"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I2801978711","display_name":"Nottingham General Hospital","ror":"https://ror.org/02cqyyd50","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801978711"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. G. Nicholls","raw_affiliation_strings":["Department of Medicine, University of Nottingham, Nottingham General Hospital, Nottingham, NG1 6HA, Great Britain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Nottingham, Nottingham General Hospital, Nottingham, NG1 6HA, Great Britain","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I2801978711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2687,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.86817536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"3","first_page":"419","last_page":"426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypsin","display_name":"trypsin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/nadh-cytochrome-c-reductase","display_name":"NADH-cytochrome c reductase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/outer-mitochondrial-membrane","display_name":"mitochondrial outer membrane","score":0.8230000138282776},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ionic-strength","display_name":"ionic strength","score":0.8090000152587891},{"id":"https://openalex.org/keywords/adenylate-kinase","display_name":"adenylate kinase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/flavoprotein","display_name":"flavoprotein","score":0.8389999866485596},{"id":"https://openalex.org/keywords/electron-acceptors","display_name":"electron acceptors","score":0.6370000243186951},{"id":"https://openalex.org/keywords/enzyme-inactivation","display_name":"enzyme inactivation","score":0.5540000200271606},{"id":"https://openalex.org/keywords/mitochondrial-translocation","display_name":"mitochondrial translocation","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.663535475730896},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.597292959690094},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5257300138473511},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4782063961029053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44894102215766907}],"mesh":[{"descriptor_ui":"D000227","descriptor_name":"Adenine Nucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003580","descriptor_name":"Cytochromes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004492","descriptor_name":"Edetic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005292","descriptor_name":"Ferricyanides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007097","descriptor_name":"Imines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008566","descriptor_name":"Membranes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008566","descriptor_name":"Membranes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012402","descriptor_name":"Rotenone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1432-1033.1970.tb00868.x","doi":"https://doi.org/10.1111/j.1432-1033.1970.tb00868.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1970.tb00868.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1970.tb00868.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:4315397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4315397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1432-1033.1970.tb00868.x","doi":"https://doi.org/10.1111/j.1432-1033.1970.tb00868.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1970.tb00868.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1970.tb00868.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995975429.pdf","grobid_xml":"https://content.openalex.org/works/W1995975429.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W36253575","https://openalex.org/W67898808","https://openalex.org/W110782380","https://openalex.org/W126825652","https://openalex.org/W205927933","https://openalex.org/W572212820","https://openalex.org/W615008561","https://openalex.org/W1045084520","https://openalex.org/W1506043065","https://openalex.org/W1564990229","https://openalex.org/W1584749770","https://openalex.org/W1607139806","https://openalex.org/W1775749144","https://openalex.org/W1964041346","https://openalex.org/W1969805452","https://openalex.org/W1990556857","https://openalex.org/W2008336148","https://openalex.org/W2032807672","https://openalex.org/W2070263609","https://openalex.org/W2079361374","https://openalex.org/W2125562918","https://openalex.org/W2463334813","https://openalex.org/W2987743037","https://openalex.org/W4254606770"],"related_works":["https://openalex.org/W2008336148","https://openalex.org/W1505755110","https://openalex.org/W2200032390","https://openalex.org/W1512665279","https://openalex.org/W58141693","https://openalex.org/W2077801526","https://openalex.org/W1969805452","https://openalex.org/W2402200126","https://openalex.org/W200511621","https://openalex.org/W2037322029"],"abstract_inverted_index":{"1":[0],"The":[1,21,42,115,188],"rotenone-insensitive":[2],"NADH-cytochrome":[3,119,206,219],"c":[4,120,207,220],"reductase":[5,121,208,221],"system":[6,26,48,63,222],"of":[7,24,32,45,54,60,83,111,117,129,146,157,173,216],"rat":[8],"liver":[9,33],"mitochondria":[10,159,175],"and":[11,97,169,204,223],"isolated":[12],"mitochondrial":[13,47,113,202,218,231],"outer":[14,230],"membrane":[15],"preparations":[16],"is":[17,27,86,124],"inactivated":[18],"by":[19,122,126,180],"trypsin.":[20,186],"trypsin":[22,43,104,123],"sensitivity":[23,44],"the":[25,46,55,61,81,108,112,118,143,158,174,198,201,214,217,229],"considerably":[28],"higher":[29],"than":[30],"that":[31,59,89,103,134],"microsomes":[34],"when":[35],"compared":[36],"on":[37,197,213],"equal":[38],"protein":[39,72],"basis.":[40],"2":[41],"decreases":[49],"with":[50,65,91,95,136,192],"increasing":[51,66],"ionic":[52,67,84],"strength":[53,85],"incubating":[56],"medium,":[57],"whereas":[58],"microsomal":[62,205],"increases":[64],"strength,":[68],"except":[69],"at":[70],"low":[71],"concentrations":[73],"(<":[74],"0.1":[75],"mg":[76],"protein/ml),":[77],"in":[78,226],"which":[79,176],"case":[80],"effect":[82],"similar":[87,132],"to":[88,133,160,185,194,228],"found":[90,135],"mitochondria.":[92],"3":[93],"Experiments":[94],"2,6-dichlorophenolindophenol":[96],"ferricyanide":[98],"as":[99,210,212],"electron":[100],"acceptors":[101],"indicate":[102],"does":[105,140],"not":[106,141,178],"inactivate":[107,142],"flavoprotein":[109],"component":[110],"system.":[114],"inactivation":[116],"accompanied":[125],"a":[127,161],"release":[128],"cytochrome":[130],"b5,":[131],"microsomes.":[137],"4":[138],"Trypsin":[139],"adenylate":[144,224],"kinase":[145,225],"intact":[147],"mitochondria,":[148],"but":[149],"readily":[150],"inactivates":[151],"this":[152,181],"enzyme":[153],"after":[154],"brief":[155],"exposure":[156],"hypotonic":[162],"medium":[163],"containing":[164],"EDTA.":[165],"Respiration,":[166],"respiratory":[167],"control,":[168],"various":[170],"translocator":[171],"functions":[172],"are":[177,190],"affected":[179],"treatment,":[182],"remain":[183],"insensitive":[184],"5":[187],"results":[189],"discussed":[191],"regard":[193],"their":[195],"bearing":[196],"distinction":[199],"between":[200],"(rotenone-insensitive)":[203],"systems,":[209],"well":[211],"location":[215],"relation":[227],"membrane.":[232]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
