{"id":"https://openalex.org/W1995960307","doi":"https://doi.org/10.1016/0165-1110(90)90030-f","title":"The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program","display_name":"The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program","publication_year":1990,"publication_date":"1990-07-01","ids":{"openalex":"https://openalex.org/W1995960307","doi":"https://doi.org/10.1016/0165-1110(90)90030-f","mag":"1995960307","pmid":"https://pubmed.ncbi.nlm.nih.gov/2195332"},"language":"en","primary_location":{"id":"doi:10.1016/0165-1110(90)90030-f","doi":"https://doi.org/10.1016/0165-1110(90)90030-f","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-1110(90)90030-f","pdf_url":null,"source":{"id":"https://openalex.org/S4210174318","display_name":"Mutation Research/Reviews in Genetic Toxicology","issn_l":"0165-1110","issn":["0165-1110","1872-9347"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research/Reviews in Genetic Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070640128","display_name":"Kathleen H. Mavournin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen H. Mavournin","raw_affiliation_strings":["Biomedical and Environmental Information Analysis Section, Oak Ridge National Laboratory, TN 37831-6050"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical and Environmental Information Analysis Section, Oak Ridge National Laboratory, TN 37831-6050","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061445540","display_name":"David H. Blakey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David H. Blakey","raw_affiliation_strings":["Mutagenesis Section, Bureau of Chemical Hazards, Environmental Health Directorate,Department of National Health and Welfare, Ottawa, Ont. K1A 0L2 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mutagenesis Section, Bureau of Chemical Hazards, Environmental Health Directorate,Department of National Health and Welfare, Ottawa, Ont. K1A 0L2 Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112383175","display_name":"Michael C. Cimino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Cimino","raw_affiliation_strings":["Office of Toxic Substances, Health and Environmental Review Division (TS-796), U.S. Environmental Protection Agency, 401 M Street SW, Washington, DC 20460 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Toxic Substances, Health and Environmental Review Division (TS-796), U.S. Environmental Protection Agency, 401 M Street SW, Washington, DC 20460 U.S.A","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048541718","display_name":"Michael F. Salamone","orcid":"https://orcid.org/0000-0002-5246-5294","observed_orcids":["https://orcid.org/0000-0002-5246-5294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael F. Salamone","raw_affiliation_strings":["Biohazard Laboratory, Ontario Ministry of the Environment, P.O. Box 213, Resources Road, Rexdale, Ont. M9W 5L1 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biohazard Laboratory, Ontario Ministry of the Environment, P.O. Box 213, Resources Road, Rexdale, Ont. M9W 5L1 Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013008257","display_name":"John A. Heddle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192455969","display_name":"York University","ror":"https://ror.org/05fq50484","country_code":"CA","type":"education","lineage":["https://openalex.org/I192455969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John A. Heddle","raw_affiliation_strings":["Department of Biology, York University, 4700 Keele Street, Toronto, Ont. M3J 1P3 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, York University, 4700 Keele Street, Toronto, Ont. M3J 1P3 Canada","institution_ids":["https://openalex.org/I192455969"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.7049,"has_fulltext":false,"cited_by_count":446,"citation_normalized_percentile":{"value":0.9799061,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"239","issue":"1","first_page":"29","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micronucleus-test","display_name":"micronucleus test","score":0.9539999961853027},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.8320000171661377},{"id":"https://openalex.org/keywords/peripheral-blood","display_name":"peripheral blood","score":0.9259999990463257},{"id":"https://openalex.org/keywords/polychromatic-erythrocytes","display_name":"polychromatic erythrocytes","score":0.9729999899864197},{"id":"https://openalex.org/keywords/genotoxicity-testing","display_name":"genotoxicity testing","score":0.8289999961853027},{"id":"https://openalex.org/keywords/sample-size","display_name":"sample size","score":0.531000018119812},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.9391545057296753},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.81513512134552},{"id":"https://openalex.org/C36681516","wikidata":"https://www.wikidata.org/wiki/Q1700733","display_name":"Micronucleus","level":4,"score":0.7215436100959778},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5464632511138916},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.5437241196632385},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5314756035804749},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4890018701553345},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38552987575531006},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3838672935962677},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3460933566093445},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.32783496379852295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3118634819984436},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2932248115539551},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25475096702575684},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1879500448703766}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014484","descriptor_name":"United States Environmental Protection Agency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015162","descriptor_name":"Micronucleus Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015162","descriptor_name":"Micronucleus Tests","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0165-1110(90)90030-f","doi":"https://doi.org/10.1016/0165-1110(90)90030-f","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-1110(90)90030-f","pdf_url":null,"source":{"id":"https://openalex.org/S4210174318","display_name":"Mutation Research/Reviews in Genetic Toxicology","issn_l":"0165-1110","issn":["0165-1110","1872-9347"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research/Reviews in Genetic Toxicology","raw_type":"journal-article"},{"id":"pmid:2195332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2195332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8388000130653381}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":204,"referenced_works":["https://openalex.org/W289098103","https://openalex.org/W303911931","https://openalex.org/W1484470846","https://openalex.org/W1528576261","https://openalex.org/W1564152746","https://openalex.org/W1573033750","https://openalex.org/W1581046844","https://openalex.org/W1601932516","https://openalex.org/W1869373838","https://openalex.org/W1948421616","https://openalex.org/W1963689987","https://openalex.org/W1964240097","https://openalex.org/W1964417499","https://openalex.org/W1964932730","https://openalex.org/W1965406567","https://openalex.org/W1965590216","https://openalex.org/W1965947476","https://openalex.org/W1966224786","https://openalex.org/W1967508962","https://openalex.org/W1968562808","https://openalex.org/W1968647205","https://openalex.org/W1969180825","https://openalex.org/W1969595000","https://openalex.org/W1970039145","https://openalex.org/W1970292363","https://openalex.org/W1972433983","https://openalex.org/W1972539864","https://openalex.org/W1973922598","https://openalex.org/W1974321735","https://openalex.org/W1974550023","https://openalex.org/W1977532310","https://openalex.org/W1977667460","https://openalex.org/W1978319119","https://openalex.org/W1979505903","https://openalex.org/W1980298656","https://openalex.org/W1980503088","https://openalex.org/W1980508665","https://openalex.org/W1983608968","https://openalex.org/W1983642048","https://openalex.org/W1984460210","https://openalex.org/W1984770507","https://openalex.org/W1985458855","https://openalex.org/W1985990090","https://openalex.org/W1986255994","https://openalex.org/W1987521192","https://openalex.org/W1987651541","https://openalex.org/W1987662801","https://openalex.org/W1987665004","https://openalex.org/W1988208768","https://openalex.org/W1988223409","https://openalex.org/W1988342004","https://openalex.org/W1988608614","https://openalex.org/W1990272253","https://openalex.org/W1991472008","https://openalex.org/W1993888757","https://openalex.org/W1994827658","https://openalex.org/W1995159287","https://openalex.org/W1996545485","https://openalex.org/W1996750907","https://openalex.org/W1996984063","https://openalex.org/W1997551636","https://openalex.org/W1997678401","https://openalex.org/W1998054298","https://openalex.org/W1998101079","https://openalex.org/W1998964541","https://openalex.org/W1999324471","https://openalex.org/W2001550214","https://openalex.org/W2001941403","https://openalex.org/W2002057577","https://openalex.org/W2004120671","https://openalex.org/W2005074063","https://openalex.org/W2005716875","https://openalex.org/W2006386399","https://openalex.org/W2006768585","https://openalex.org/W2007511191","https://openalex.org/W2008417132","https://openalex.org/W2008452349","https://openalex.org/W2008623732","https://openalex.org/W2009046319","https://openalex.org/W2009117761","https://openalex.org/W2010590189","https://openalex.org/W2011079789","https://openalex.org/W2011838124","https://openalex.org/W2012567271","https://openalex.org/W2012850212","https://openalex.org/W2013150639","https://openalex.org/W2013481599","https://openalex.org/W2013750023","https://openalex.org/W2014126448","https://openalex.org/W2014698508","https://openalex.org/W2016452292","https://openalex.org/W2016681644","https://openalex.org/W2016750977","https://openalex.org/W2018276785","https://openalex.org/W2018475789","https://openalex.org/W2018659656","https://openalex.org/W2018902456","https://openalex.org/W2019172628","https://openalex.org/W2020226802","https://openalex.org/W2020865379","https://openalex.org/W2021470793","https://openalex.org/W2021636085","https://openalex.org/W2022079049","https://openalex.org/W2022681375","https://openalex.org/W2024587992","https://openalex.org/W2024818103","https://openalex.org/W2025020459","https://openalex.org/W2026395220","https://openalex.org/W2027469758","https://openalex.org/W2027703006","https://openalex.org/W2028385361","https://openalex.org/W2029983563","https://openalex.org/W2030960619","https://openalex.org/W2031207698","https://openalex.org/W2032893832","https://openalex.org/W2033533711","https://openalex.org/W2034019576","https://openalex.org/W2036326372","https://openalex.org/W2037930189","https://openalex.org/W2037934351","https://openalex.org/W2038277461","https://openalex.org/W2039546429","https://openalex.org/W2040005111","https://openalex.org/W2040813839","https://openalex.org/W2041279661","https://openalex.org/W2041848208","https://openalex.org/W2042000240","https://openalex.org/W2043486125","https://openalex.org/W2043579193","https://openalex.org/W2043640392","https://openalex.org/W2044171438","https://openalex.org/W2044910889","https://openalex.org/W2045297967","https://openalex.org/W2048347035","https://openalex.org/W2049563025","https://openalex.org/W2050582964","https://openalex.org/W2050757683","https://openalex.org/W2051241741","https://openalex.org/W2051485502","https://openalex.org/W2052373946","https://openalex.org/W2052528718","https://openalex.org/W2052689819","https://openalex.org/W2053493344","https://openalex.org/W2056170905","https://openalex.org/W2057199184","https://openalex.org/W2060215220","https://openalex.org/W2062181505","https://openalex.org/W2062362582","https://openalex.org/W2065540136","https://openalex.org/W2066494150","https://openalex.org/W2066509675","https://openalex.org/W2070408443","https://openalex.org/W2071234262","https://openalex.org/W2071992097","https://openalex.org/W2072344877","https://openalex.org/W2074167075","https://openalex.org/W2075377295","https://openalex.org/W2075631674","https://openalex.org/W2077527248","https://openalex.org/W2078241954","https://openalex.org/W2078271794","https://openalex.org/W2079009567","https://openalex.org/W2079122383","https://openalex.org/W2080176294","https://openalex.org/W2082717809","https://openalex.org/W2083525898","https://openalex.org/W2084261443","https://openalex.org/W2084565234","https://openalex.org/W2085133947","https://openalex.org/W2085874279","https://openalex.org/W2086592573","https://openalex.org/W2087633160","https://openalex.org/W2088328657","https://openalex.org/W2089005067","https://openalex.org/W2089147817","https://openalex.org/W2089898614","https://openalex.org/W2090865374","https://openalex.org/W2092291612","https://openalex.org/W2094093848","https://openalex.org/W2094524196","https://openalex.org/W2094990849","https://openalex.org/W2096806436","https://openalex.org/W2099496163","https://openalex.org/W2106353511","https://openalex.org/W2106673456","https://openalex.org/W2106810832","https://openalex.org/W2126020799","https://openalex.org/W2136261039","https://openalex.org/W2139097577","https://openalex.org/W2141774935","https://openalex.org/W2151558806","https://openalex.org/W2162849064","https://openalex.org/W2165183009","https://openalex.org/W2166378339","https://openalex.org/W2315819785","https://openalex.org/W2404164921","https://openalex.org/W2414245699","https://openalex.org/W2414285669","https://openalex.org/W2419520542","https://openalex.org/W2436518544","https://openalex.org/W2468765005","https://openalex.org/W3192966151","https://openalex.org/W4231547649","https://openalex.org/W4245671134"],"related_works":["https://openalex.org/W2407856755","https://openalex.org/W2161309067","https://openalex.org/W2043360060","https://openalex.org/W4255241257","https://openalex.org/W1601932516","https://openalex.org/W2060668370","https://openalex.org/W2064289648","https://openalex.org/W2963993158","https://openalex.org/W2010843211","https://openalex.org/W2970044297"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}