{"id":"https://openalex.org/W1995924629","doi":"https://doi.org/10.1021/bi00439a002","title":"Down-regulation of cell growth and cell cycle regulated genes during chick osteoblast differentiation with the reciprocal expression of histone gene variants","display_name":"Down-regulation of cell growth and cell cycle regulated genes during chick osteoblast differentiation with the reciprocal expression of histone gene variants","publication_year":1989,"publication_date":"1989-06-27","ids":{"openalex":"https://openalex.org/W1995924629","doi":"https://doi.org/10.1021/bi00439a002","mag":"1995924629","pmid":"https://pubmed.ncbi.nlm.nih.gov/2476172"},"language":"en","primary_location":{"id":"doi:10.1021/bi00439a002","doi":"https://doi.org/10.1021/bi00439a002","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00439a002","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057554879","display_name":"Victoria Shalhoub","orcid":"https://orcid.org/0000-0002-9354-671X","observed_orcids":["https://orcid.org/0000-0002-9354-671X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Shalhoub","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112844477","display_name":"Louis C. Gerstenfeld","orcid":"https://orcid.org/0000-0002-0477-1211","observed_orcids":["https://orcid.org/0000-0002-0477-1211"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louis C. Gerstenfeld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009860720","display_name":"David Collart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Collart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031362021","display_name":"Jane B. Lian","orcid":"https://orcid.org/0000-0001-8683-9138","observed_orcids":["https://orcid.org/0000-0001-8683-9138"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jane B. Lian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103217263","display_name":"Gary S. Stein","orcid":"https://orcid.org/0000-0001-8762-5422","observed_orcids":["https://orcid.org/0000-0001-8762-5422"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary S. Stein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.1229,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.93582232,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"28","issue":"13","first_page":"5318","last_page":"5322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/histone-h1","display_name":"histone H1","score":0.8080000281333923},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9390000104904175},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.8820000290870667},{"id":"https://openalex.org/keywords/histone-mrna","display_name":"histone mRNA","score":0.5040000081062317},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.671999990940094},{"id":"https://openalex.org/keywords/mineralized-extracellular-matrix","display_name":"mineralized extracellular matrix","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7186572551727295},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6051739454269409},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5348129868507385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47689059376716614},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.46733152866363525},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4614931344985962},{"id":"https://openalex.org/C56428682","wikidata":"https://www.wikidata.org/wiki/Q24785535","display_name":"Histone H2A","level":4,"score":0.43337953090667725},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41066834330558777},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3808221220970154},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24709978699684143},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi00439a002","doi":"https://doi.org/10.1021/bi00439a002","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00439a002","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:2476172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2476172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:stein-1127","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/stein/128","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stein, Stein, Lian, vanWijnen Lab Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1660734645","display_name":"POST-TRANSCRIPTIONAL CONTROL OF HUMAN HISTONE GENES","funder_award_id":"R01GM032381","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G383666782","display_name":"Identification of Histone Gene Regulatory Sequences","funder_award_id":"R01GM032010","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G460737641","display_name":"OSTEOCALCIN FUNCTION IN RESORPTION","funder_award_id":"R01AR035166","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1529579173","https://openalex.org/W1574327030","https://openalex.org/W1922007066","https://openalex.org/W1964969571","https://openalex.org/W1968745074","https://openalex.org/W1974372264","https://openalex.org/W1987158652","https://openalex.org/W1992555811","https://openalex.org/W1992777043","https://openalex.org/W1996011102","https://openalex.org/W1997355841","https://openalex.org/W2009115308","https://openalex.org/W2010885715","https://openalex.org/W2015243763","https://openalex.org/W2016537897","https://openalex.org/W2021253208","https://openalex.org/W2021323848","https://openalex.org/W2024875576","https://openalex.org/W2033340114","https://openalex.org/W2034422186","https://openalex.org/W2036867570","https://openalex.org/W2041383836","https://openalex.org/W2044992849","https://openalex.org/W2045597319","https://openalex.org/W2050740740","https://openalex.org/W2053595085","https://openalex.org/W2069711301","https://openalex.org/W2070194131","https://openalex.org/W2073130464","https://openalex.org/W2075956107","https://openalex.org/W2077923531","https://openalex.org/W2078449730","https://openalex.org/W2080086131","https://openalex.org/W2104161119","https://openalex.org/W2143237072","https://openalex.org/W2154307044"],"related_works":["https://openalex.org/W2130273189","https://openalex.org/W1996730628","https://openalex.org/W2015243763","https://openalex.org/W55215458","https://openalex.org/W2130791143","https://openalex.org/W1890394592","https://openalex.org/W2109441210","https://openalex.org/W7096959927","https://openalex.org/W2079971241","https://openalex.org/W2107462009"],"abstract_inverted_index":{"Expression":[0],"of":[1,21,34,61,68,78,110,118,132,139,158,166,173,181,197,215,231,236,250,252],"cell":[2,9,182,217],"cycle":[3,218],"(core":[4],"and":[5,8,12,59,83,87,90,97,134,204],"H1":[6,84],"histone)":[7],"growth":[10],"(c-myc":[11],"c-fos)":[13],"regulated":[14,219],"genes":[15,62,86,184,221,239],"was":[16],"examined":[17],"in":[18,37,50,94,102,125,178,228],"primary":[19],"cultures":[20],"chick":[22],"calvarial":[23],"osteoblasts":[24,69],"during":[25,185,247],"a":[26,38,46,95,205,225,232],"developmental":[27,52],"sequence":[28,53],"associated":[29],"with":[30,200,244],"the":[31,35,51,65,88,108,116,140,144,155,164,179,195,216,229,237,248],"progressive":[32],"maturation":[33],"osteoblast":[36,186,253],"bonelike":[39],"mineralized":[40],"extracellular":[41],"matrix.":[42],"We":[43],"have":[44],"identified":[45],"transition":[47,74],"point":[48],"early":[49],"which":[54],"occurs":[55],"when":[56,143],"proliferation":[57,141,183],"ceases":[58],"expression":[60,121,160,230,251],"related":[63],"to":[64],"differentiated":[66],"phenotype":[67,254],"is":[70,122,161,222],"initiated.":[71],"During":[72],"this":[73],"period,":[75,142],"cellular":[76],"levels":[77],"RNA":[79,168,210],"transcripts":[80],"from":[81],"core":[82],"histone":[85,103,112,119,220,238],"c-myc":[89,133],"c-fos":[91,135],"protooncogenes":[92],"decrease":[93],"parallel":[96],"coordinate":[98],"manner.":[99],"The":[100],"decline":[101],"gene":[104,120],"transcription":[105,136,198],"that":[106,115,154,188,193,207,240],"accompanies":[107],"loss":[109],"accumulated":[111],"mRNA":[113],"indicates":[114],"downregulation":[117,157,214],"at":[123,150,163],"least,":[124],"part,":[126],"transcriptionally":[127],"mediated.":[128],"In":[129],"contrast,":[130],"persistence":[131],"following":[137],"completion":[138],"mRNAs":[145],"are":[146,176,241],"no":[147],"longer":[148],"present":[149],"detectable":[151],"levels,":[152],"suggests":[153],"initial":[156],"protooncogene":[159],"controlled":[162],"level":[165],"messenger":[167,209],"stability.":[169],"Thus,":[170],"two":[171],"types":[172],"signaling":[174],"mechanisms":[175],"operative":[177],"down-regulation":[180],"differentiation--one":[187],"impinges":[189],"on":[190],"regulatory":[191],"sequences":[192],"influence":[194],"interactions":[196],"factors":[199],"cis-acting":[201],"promoter":[202],"elements":[203],"second":[206],"modulates":[208],"turnover.":[211],"Of":[212],"significance,":[213],"accompanied":[223],"by":[224],"reciprocal":[226],"increase":[227],"structurally":[233],"distinct":[234],"subset":[235],"not":[242],"coupled":[243],"DNA":[245],"replication":[246],"period":[249],"markers.(ABSTRACT":[255],"TRUNCATED":[256],"AT":[257],"250":[258],"WORDS)":[259]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}