{"id":"https://openalex.org/W1995809495","doi":"https://doi.org/10.1159/000022775","title":"Generating Consistent Genotypic Configurations for Multi-Allelic Loci and Large Complex Pedigrees","display_name":"Generating Consistent Genotypic Configurations for Multi-Allelic Loci and Large Complex Pedigrees","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W1995809495","doi":"https://doi.org/10.1159/000022775","mag":"1995809495","pmid":"https://pubmed.ncbi.nlm.nih.gov/9463795"},"language":"en","primary_location":{"id":"doi:10.1159/000022775","doi":"https://doi.org/10.1159/000022775","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000022775","pdf_url":null,"source":{"id":"https://openalex.org/S97696616","display_name":"Human Heredity","issn_l":"0001-5652","issn":["0001-5652","1423-0062"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-4"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Heredity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091771874","display_name":"Simon Charles Heath","orcid":"https://orcid.org/0000-0002-9550-0897","observed_orcids":["https://orcid.org/0000-0002-9550-0897"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Simon C. Heath","raw_affiliation_strings":["Department of Statistics, University of Washington, Seattle, USA. heath@linkage.rockefeller.edu","Department of Statistics, University of Washington, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, University of Washington, Seattle, USA. heath@linkage.rockefeller.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Statistics, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091771874"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":1.6202,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.82387563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"48","issue":"1","first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12056","display_name":"Markov Chains and Monte Carlo Methods","score":0.19480000436306,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.12300000339746475,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complex-pedigrees","display_name":"complex pedigrees","score":0.9639999866485596},{"id":"https://openalex.org/keywords/gibbs-sampling","display_name":"Gibbs sampling","score":0.6859999895095825},{"id":"https://openalex.org/keywords/markov-chain-monte-carlo","display_name":"Markov chain Monte Carlo","score":0.9629999995231628},{"id":"https://openalex.org/keywords/peeling","display_name":"peeling","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C22593422","wikidata":"https://www.wikidata.org/wiki/Q3242583","display_name":"Pedigree chart","level":3,"score":0.9235115051269531},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6136216521263123},{"id":"https://openalex.org/C158424031","wikidata":"https://www.wikidata.org/wiki/Q1191905","display_name":"Gibbs sampling","level":3,"score":0.5911060571670532},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5757089257240295},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5700894594192505},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5680646300315857},{"id":"https://openalex.org/C111350023","wikidata":"https://www.wikidata.org/wiki/Q1191869","display_name":"Markov chain Monte Carlo","level":3,"score":0.4793742001056671},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47737404704093933},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.4235225319862366},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.36927199363708496},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2705976665019989},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21991989016532898},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.14824900031089783},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11369696259498596},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.08981019258499146},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08836078643798828}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000022775","doi":"https://doi.org/10.1159/000022775","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000022775","pdf_url":null,"source":{"id":"https://openalex.org/S97696616","display_name":"Human Heredity","issn_l":"0001-5652","issn":["0001-5652","1423-0062"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-4"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Heredity","raw_type":"journal-article"},{"id":"pmid:9463795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9463795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human heredity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G263992270","display_name":null,"funder_award_id":"GM46255","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W109881820","https://openalex.org/W149404140","https://openalex.org/W1492992226","https://openalex.org/W1502870388","https://openalex.org/W1519466388","https://openalex.org/W1991311566","https://openalex.org/W1996525496","https://openalex.org/W2014960198","https://openalex.org/W2017488093","https://openalex.org/W2020999234","https://openalex.org/W2021521531","https://openalex.org/W2041024744","https://openalex.org/W2043432627","https://openalex.org/W2043613624","https://openalex.org/W2050705606","https://openalex.org/W2053127692","https://openalex.org/W2064465956","https://openalex.org/W2064779371","https://openalex.org/W2092350328","https://openalex.org/W2098745603","https://openalex.org/W2136796925","https://openalex.org/W4298221601"],"related_works":["https://openalex.org/W7097542414","https://openalex.org/W4249815815","https://openalex.org/W7100922141","https://openalex.org/W2050636949","https://openalex.org/W105403524","https://openalex.org/W2144798611","https://openalex.org/W7096049278","https://openalex.org/W2097023556","https://openalex.org/W2169882610","https://openalex.org/W120553839"],"abstract_inverted_index":{"Markov":[0],"chain":[1],"Monte":[2],"Carlo":[3],"techniques":[4],"have":[5],"been":[6,19],"applied":[7],"to":[8,32,72],"many":[9],"different":[10],"genetic":[11,37],"analysis":[12],"problems.":[13],"Gibbs":[14,45],"sampling":[15,46],"in":[16,77],"particular":[17],"has":[18],"widely":[20],"used":[21],"because":[22,27],"of":[23,58,83],"its":[24],"simplicity":[25],"and":[26,36,67,85,101],"it":[28],"can":[29],"be":[30],"extended":[31],"arbitrarily":[33],"complex":[34,65,96],"pedigrees":[35,66],"models":[38],"(albeit":[39],"with":[40,53,63],"modifications":[41],"for":[42,107],"multi-allelic":[43,68],"loci).":[44],"requires":[47],"an":[48],"initial":[49],"genotypic":[50],"configuration,":[51],"consistent":[52],"observed":[54],"data,":[55],"the":[56],"generation":[57],"which":[59],"is":[60,88,92],"not":[61],"trivial":[62],"large":[64],"loci.":[69],"A":[70],"method":[71,91],"generate":[73],"feasible":[74],"genotype":[75,86],"configurations":[76],"these":[78],"circumstances":[79],"using":[80,94],"a":[81],"combination":[82],"peeling":[84],"elimination":[87],"described.":[89],"The":[90],"illustrated":[93],"two":[95],"multi-generation":[97],"pedigrees,":[98],"one":[99,102,108],"real":[100],"simulated,":[103],"each":[104],"partially":[105],"typed":[106],"highly":[109],"polymorphic":[110],"marker":[111],"locus.":[112]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}