{"id":"https://openalex.org/W1995807121","doi":"https://doi.org/10.3109/00365520903342166","title":"Short hairpin RNA targeting \u03b2-catenin suppresses cell proliferation and induces apoptosis in human gastric carcinoma cells","display_name":"Short hairpin RNA targeting \u03b2-catenin suppresses cell proliferation and induces apoptosis in human gastric carcinoma cells","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W1995807121","doi":"https://doi.org/10.3109/00365520903342166","mag":"1995807121","pmid":"https://pubmed.ncbi.nlm.nih.gov/19958059"},"language":"en","primary_location":{"id":"doi:10.3109/00365520903342166","doi":"https://doi.org/10.3109/00365520903342166","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365520903342166","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100739577","display_name":"Hong Jiang","orcid":"https://orcid.org/0000-0001-9481-9807","observed_orcids":["https://orcid.org/0000-0001-9481-9807","https://orcid.org/0000-0002-6026-6068","https://orcid.org/0000-0003-2075-3272","https://orcid.org/0009-0002-4982-445X"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Jiang","raw_affiliation_strings":["Department of Gastrointestinal Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China","Departments of Gastrointestinal Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Departments of Gastrointestinal Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianguo Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianguo Xia","raw_affiliation_strings":["General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jian Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153426","display_name":"Taian City Central Hospital","ror":"https://ror.org/04vsn7g65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153426"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Kang","raw_affiliation_strings":["Department of Anorectal Surgery, Central Hospital of Taian, Taian, Shandong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anorectal Surgery, Central Hospital of Taian, Taian, Shandong, People's Republic of China","institution_ids":["https://openalex.org/I4210153426"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013660443","display_name":"Yong-Bin Ding","orcid":"https://orcid.org/0009-0004-7097-6225","observed_orcids":["https://orcid.org/0009-0004-7097-6225"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongbin Ding","raw_affiliation_strings":["General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102218579","display_name":"WU Wen-xi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wenxi Wu","raw_affiliation_strings":["Departments of Gastrointestinal Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Gastrointestinal Surgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102218579"],"corresponding_institution_ids":["https://openalex.org/I4210152119"],"apc_list":null,"apc_paid":null,"fwci":0.9385,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.71394725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"44","issue":"12","first_page":"1452","last_page":"1462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.625},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.8379999995231628},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8420000076293945},{"id":"https://openalex.org/keywords/apoptosis-related-gene-expression","display_name":"apoptosis-related gene expression","score":0.7870000004768372},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.8851179480552673},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7157849669456482},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6581999659538269},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6207300424575806},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5836488008499146},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5203016400337219},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.4877853989601135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4702685475349426},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4619441628456116},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4319346845149994},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4288644790649414},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4259561598300934},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3305564522743225},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32960283756256104},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2918579876422882},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04382696747779846},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/00365520903342166","doi":"https://doi.org/10.3109/00365520903342166","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365520903342166","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:19958059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19958059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.75,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1517251498","https://openalex.org/W1533671266","https://openalex.org/W1553510815","https://openalex.org/W1554815317","https://openalex.org/W1939041072","https://openalex.org/W1969534054","https://openalex.org/W1972372574","https://openalex.org/W1979547093","https://openalex.org/W1985146880","https://openalex.org/W2001935103","https://openalex.org/W2002522440","https://openalex.org/W2003605454","https://openalex.org/W2012612087","https://openalex.org/W2045269964","https://openalex.org/W2054273226","https://openalex.org/W2069561137","https://openalex.org/W2072778582","https://openalex.org/W2094142935","https://openalex.org/W2095489186","https://openalex.org/W2100301498","https://openalex.org/W2101676794","https://openalex.org/W2105292806","https://openalex.org/W2105423180","https://openalex.org/W2139885850","https://openalex.org/W2146167376","https://openalex.org/W2149726781","https://openalex.org/W2165200182","https://openalex.org/W2313246197"],"related_works":["https://openalex.org/W2086939997","https://openalex.org/W2141829960","https://openalex.org/W1939041072","https://openalex.org/W2089126414","https://openalex.org/W2359338479","https://openalex.org/W2134919398","https://openalex.org/W2091722004","https://openalex.org/W7149832937","https://openalex.org/W1971766804","https://openalex.org/W2349774241"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Aberrant":[1],"activation":[2],"of":[3,20,33,71,95,185,206],"Wnt/beta-catenin":[4,21],"signaling":[5,22],"is":[6],"involved":[7,178],"in":[8,23,45,112,116,165,179,190],"various":[9],"cancers,":[10],"including":[11],"human":[12],"gastric":[13,25,46,166,207],"cancer.":[14,208],"Here":[15],"we":[16],"investigate":[17,91],"the":[18,69,82,92,173],"role":[19],"regulating":[24],"cancer":[26,47,167],"cell":[27,75,124,128,192],"apoptosis.":[28,182],"MATERIAL":[29],"AND":[30],"METHODS:":[31],"Expression":[32],"beta-catenin":[34,40,72,110,117,139,180,186,199],"was":[35,59,101,130,177],"investigated":[36,61],"after":[37],"transfection":[38],"with":[39],"short":[41],"hairpin":[42],"RNA":[43],"(shRNA)":[44],"cells":[48],"by":[49,62,81,187],"Western":[50],"blotting":[51],"and":[52,77,86,119,123,150,152,163,194],"immunofluorescence":[53],"analysis.":[54,89],"beta-catenin/T-cell":[55],"factor":[56],"transcriptional":[57],"activity":[58],"also":[60],"using":[63,103],"a":[64,98,104,113,202],"luciferase":[65],"reporter":[66],"assay.":[67],"Next,":[68],"effects":[70],"shRNA":[73,108,137,188],"on":[74],"proliferation":[76,193],"apoptosis":[78,129],"were":[79],"evaluated":[80],"3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium":[83],"Bromide":[84],"assay":[85],"flow":[87],"cytometric":[88],"To":[90],"precise":[93],"mechanism":[94],"these":[96],"effects,":[97],"comprehensive":[99,133],"analysis":[100,134,170],"performed":[102],"cDNA":[105],"microarray.":[106],"RESULTS:":[107],"targeting":[109,138],"resulted":[111,189],"significant":[114],"decrease":[115],"expression,":[118],"its":[120],"nuclear":[121,174],"localization":[122],"proliferation.":[125],"Meanwhile,":[126],"increased":[127],"confirmed.":[131],"The":[132],"showed":[135],"that":[136,172,198],"upregulated":[140],"26":[141],"apoptosis-related":[142,155],"genes":[143,156],"(including":[144,157],"PERP,":[145],"TRAF3,":[146],"PDCD2,":[147],"TNFRSF25,":[148],"AKT2":[149],"YWHAZ)":[151],"downregulated":[153],"48":[154],"MALT1,":[158],"IRAK1,":[159],"TNFAIP3,":[160],"PPP1R13L,":[161],"TRIP":[162],"YWHAB)":[164],"cells.":[168],"Pathway":[169],"suggested":[171],"factor-kappaB":[175],"pathway":[176],"knockdown-induced":[181],"CONCLUSIONS:":[183],"Attenuation":[184],"suppressed":[191],"apparent":[195],"apoptosis,":[196],"suggesting":[197],"may":[200],"be":[201],"target":[203],"for":[204],"therapy":[205]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}