{"id":"https://openalex.org/W1995785487","doi":"https://doi.org/10.1097/00000421-199406000-00016","title":"Extracorporeal Photopheresis and Recombinant Interferon Alfa 2b in Sezary Syndrome","display_name":"Extracorporeal Photopheresis and Recombinant Interferon Alfa 2b in Sezary Syndrome","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W1995785487","doi":"https://doi.org/10.1097/00000421-199406000-00016","mag":"1995785487","pmid":"https://pubmed.ncbi.nlm.nih.gov/8192114"},"language":"en","primary_location":{"id":"doi:10.1097/00000421-199406000-00016","doi":"https://doi.org/10.1097/00000421-199406000-00016","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000421-199406000-00016","pdf_url":null,"source":{"id":"https://openalex.org/S130927242","display_name":"American Journal of Clinical Oncology","issn_l":"0277-3732","issn":["0277-3732","1537-453X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031357885","display_name":"Eric C. Vonderheid","orcid":"https://orcid.org/0000-0002-6100-3403","observed_orcids":["https://orcid.org/0000-0002-6100-3403"]},"institutions":[{"id":"https://openalex.org/I2803028891","display_name":"Hahnemann University Hospital","ror":"https://ror.org/016bbv872","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2803028891"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric C. Vonderheid","raw_affiliation_strings":["Department of Medicine, Hahnemann University, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Hahnemann University, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I2803028891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023880605","display_name":"Robert D. Bigler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803028891","display_name":"Hahnemann University Hospital","ror":"https://ror.org/016bbv872","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2803028891"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Bigler","raw_affiliation_strings":["Department of Medicine, Division of Dermatology (E.C.V.), Department of Neoplastic Diseases (R.D.B.), Department of Radiation Oncology (B.M.), Hahnemann University: and Hahnemann University Medical School (A.S.G., S.J.N.), Philadelphia, Pennsylvania, U.S.A","Drexel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Dermatology (E.C.V.), Department of Neoplastic Diseases (R.D.B.), Department of Radiation Oncology (B.M.), Hahnemann University: and Hahnemann University Medical School (A.S.G., S.J.N.), Philadelphia, Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I2803028891"]},{"raw_affiliation_string":"Drexel University","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Adam S. Greenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803028891","display_name":"Hahnemann University Hospital","ror":"https://ror.org/016bbv872","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2803028891"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam S. Greenberg","raw_affiliation_strings":["Department of Medicine, Division of Dermatology (E.C.V.), Department of Neoplastic Diseases (R.D.B.), Department of Radiation Oncology (B.M.), Hahnemann University: and Hahnemann University Medical School (A.S.G., S.J.N.), Philadelphia, Pennsylvania, U.S.A","Drexel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Dermatology (E.C.V.), Department of Neoplastic Diseases (R.D.B.), Department of Radiation Oncology (B.M.), Hahnemann University: and Hahnemann University Medical School (A.S.G., S.J.N.), Philadelphia, Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I2803028891"]},{"raw_affiliation_string":"Drexel University","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055369603","display_name":"Stephanie J. Neukum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803028891","display_name":"Hahnemann University Hospital","ror":"https://ror.org/016bbv872","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2803028891"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie J. Neukum","raw_affiliation_strings":["Department of Medicine, Division of Dermatology (E.C.V.), Department of Neoplastic Diseases (R.D.B.), Department of Radiation Oncology (B.M.), Hahnemann University: and Hahnemann University Medical School (A.S.G., S.J.N.), Philadelphia, Pennsylvania, U.S.A","Drexel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Dermatology (E.C.V.), Department of Neoplastic Diseases (R.D.B.), Department of Radiation Oncology (B.M.), Hahnemann University: and Hahnemann University Medical School (A.S.G., S.J.N.), Philadelphia, Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I2803028891"]},{"raw_affiliation_string":"Drexel University","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089074301","display_name":"Bizhan Micaily","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803028891","display_name":"Hahnemann University Hospital","ror":"https://ror.org/016bbv872","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2803028891"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bizhan Micaily","raw_affiliation_strings":["Department of Medicine, Division of Dermatology (E.C.V.), Department of Neoplastic Diseases (R.D.B.), Department of Radiation Oncology (B.M.), Hahnemann University: and Hahnemann University Medical School (A.S.G., S.J.N.), Philadelphia, Pennsylvania, U.S.A","Drexel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Dermatology (E.C.V.), Department of Neoplastic Diseases (R.D.B.), Department of Radiation Oncology (B.M.), Hahnemann University: and Hahnemann University Medical School (A.S.G., S.J.N.), Philadelphia, Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I2803028891"]},{"raw_affiliation_string":"Drexel University","institution_ids":["https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6515,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.89037791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"17","issue":"3","first_page":"255","last_page":"263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sezary-syndrome","display_name":"S\u00e9zary syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/extracorporeal-photopheresis","display_name":"extracorporeal photopheresis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interferon-alpha-2b","display_name":"interferon alfa-2b","score":0.9539999961853027},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cutaneous-t-cell-lymphoma","display_name":"cutaneous T-cell lymphoma","score":0.8410000205039978},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9784225821495056},{"id":"https://openalex.org/C2781468836","wikidata":"https://www.wikidata.org/wiki/Q774032","display_name":"Photopheresis","level":3,"score":0.9372673630714417},{"id":"https://openalex.org/C2909962264","wikidata":"https://www.wikidata.org/wiki/Q774032","display_name":"Extracorporeal Photopheresis","level":4,"score":0.6765825152397156},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5256363153457642},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49360787868499756},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4795358180999756},{"id":"https://openalex.org/C2776780870","wikidata":"https://www.wikidata.org/wiki/Q5196687","display_name":"Cutaneous T-cell lymphoma","level":4,"score":0.46421197056770325},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.45676422119140625},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37803635001182556},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35125869512557983},{"id":"https://openalex.org/C2777756187","wikidata":"https://www.wikidata.org/wiki/Q1891209","display_name":"Mycosis fungoides","level":3,"score":0.3307778835296631},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.19145581126213074},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.08566677570343018},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077190","descriptor_name":"Interferon alpha-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012751","descriptor_name":"Sezary Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012751","descriptor_name":"Sezary Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017893","descriptor_name":"Photopheresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000421-199406000-00016","doi":"https://doi.org/10.1097/00000421-199406000-00016","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000421-199406000-00016","pdf_url":null,"source":{"id":"https://openalex.org/S130927242","display_name":"American Journal of Clinical Oncology","issn_l":"0277-3732","issn":["0277-3732","1537-453X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:8192114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8192114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2756306491","display_name":null,"funder_award_id":"5-R01-AR40404","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2996668482","display_name":"ANTIIDIOTYPE ANTIBODIES IN CUTANEOUS T-CELL LYMPHOMA","funder_award_id":"5r01ar040404-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4248715471","https://openalex.org/W4292671553","https://openalex.org/W2137439181","https://openalex.org/W7214195765","https://openalex.org/W2163364261","https://openalex.org/W2057873580","https://openalex.org/W2949426905","https://openalex.org/W2160696888","https://openalex.org/W2065432968","https://openalex.org/W1999405522"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,11,70,106,138,165,176,206,211,232,256,272,278,298],"this":[3,226],"pilot":[4],"study":[5],"was":[6,97,117,140,155,170,251],"to":[7,30,32,46,55,65,109,157,189,192,216,253],"evaluate":[8],"the":[9,68,115,136,147,204,249,260,269,279,287],"role":[10],"recombinant":[12],"interferon":[13,233],"alfa":[14],"2b":[15],"(rIFN-a)":[16],"as":[17,238],"adjunct":[18],"immunomodulatory":[19],"therapy":[20,154],"in":[21,41,53,99,119,132,172,195,225,240,290],"patients":[22,36,101,174,220,292],"with":[23,39,89,103,221,268,303],"Sezary":[24,197,223,285,305],"syndrome":[25,224],"who":[26],"were":[27,37,78],"considered":[28],"unlikely":[29],"respond":[31],"ExP":[33,161,207],"alone.":[34,274],"Six":[35],"treated":[38,102],"rIFN-a":[40,107,139,166,212,273],"doses":[42,105,164,210,271],"ranging":[43],"from":[44,151],"3":[45],"20":[47],"million":[48,111,143],"units":[49,112,144],"three":[50],"times":[51],"weekly":[52],"addition":[54],"two":[56],"consecutive":[57],"photopheresis":[58],"treatments":[59],"every":[60],"4":[61,100],"weeks.":[62],"In":[63],"addition,":[64],"better":[66],"measure":[67,297],"effect":[69],"treatment":[71,169],"on":[72],"circulating":[73],"neoplastic":[74],"T-cells,":[75],"cryopreserved":[76],"lymphocytes":[77],"studied":[79],"by":[80],"two-color":[81],"immunofluorescence":[82],"and":[83,114,127,185,208,300],"flow":[84],"cytometry,":[85],"using":[86],"anti-CD4":[87],"combined":[88,152],"anti-CD29,":[90],"anti-CD45RA,":[91],"or":[92,162,258],"anti-CD7.":[93],"Minimal":[94],"clinical":[95],"improvement":[96,129],"observed":[98],"low":[104,209],"(3":[108],"5":[110],"TIW),":[113],"response":[116,250,263,299],"sustained":[118,128],"only":[120],"1":[121,133],"patient.":[122],"However,":[123,230],"a":[124,254,294],"clinically":[125],"significant":[126],"did":[130],"occur":[131],"patient":[134,228],"after":[135],"dose":[137,234],"increased":[141],"(20":[142],"TIW).":[145],"Although":[146],"encountered":[148],"toxicity":[149],"profile":[150],"ExP/rIFN-a":[153],"similar":[156],"that":[158,203],"expected":[159],"for":[160,219,284],"comparable":[163],"given":[167],"separately,":[168],"discontinued":[171],"2":[173],"because":[175],"adverse":[177],"effects.":[178],"Three":[179],"antibody":[180,280],"pairs,":[181],"i.e.,":[182],"CD4+CD7-,":[183],"CD4+CD29+,":[184],"CD4+CD45RA-":[186],"subsets,":[187],"appeared":[188],"be":[190,217,236,246],"useful":[191],"monitor":[193],"changes":[194],"blood":[196],"cells":[198],"during":[199],"treatment.":[200],"We":[201],"conclude":[202],"combination":[205,255],"does":[213],"not":[214],"appear":[215],"effective":[218],"advanced":[222],"small":[227],"series.":[229],"escalation":[231],"may":[235],"beneficial":[237],"shown":[239],"one":[241],"patient,":[242],"but":[243],"it":[244],"cannot":[245],"discerned":[247],"whether":[248,259],"due":[252],"therapies,":[257],"same":[261],"therapeutic":[262],"would":[264],"have":[265],"been":[266],"achieved":[267],"higher":[270],"Moreover,":[275],"while":[276],"none":[277],"pairs":[281],"is":[282],"unique":[283],"cells,":[286],"CD4+CD7-":[288],"subset":[289],"appropriate":[291],"provided":[293],"good":[295],"objective":[296],"correlated":[301],"well":[302],"visual":[304],"cell":[306],"counts.":[307]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}