{"id":"https://openalex.org/W1995767597","doi":"https://doi.org/10.1074/jbc.m706136200","title":"The Association of GSK3\u03b2 with E2F1 Facilitates Nerve Growth Factor-induced Neural Cell Differentiation","display_name":"The Association of GSK3\u03b2 with E2F1 Facilitates Nerve Growth Factor-induced Neural Cell Differentiation","publication_year":2008,"publication_date":"2008-03-27","ids":{"openalex":"https://openalex.org/W1995767597","doi":"https://doi.org/10.1074/jbc.m706136200","mag":"1995767597","pmid":"https://pubmed.ncbi.nlm.nih.gov/18367454"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m706136200","doi":"https://doi.org/10.1074/jbc.m706136200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m706136200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m706136200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100736734","display_name":"Fangfang Zhou","orcid":"https://orcid.org/0000-0003-1870-7584","observed_orcids":["https://orcid.org/0000-0003-1870-7584","https://orcid.org/0009-0005-2760-2436"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangfang Zhou","raw_affiliation_strings":["State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China","State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363498","display_name":"Long Zhang","orcid":"https://orcid.org/0000-0001-8139-0474","observed_orcids":["https://orcid.org/0000-0001-8139-0474","https://orcid.org/0009-0001-9526-3836","https://orcid.org/0000-0002-5125-0224"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Long Zhang","raw_affiliation_strings":["Department of Stomatology, Chinese People's Liberation Army General Hospital, Beijing 100853, China","State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, Chinese People's Liberation Army General Hospital, Beijing 100853, China","institution_ids":["https://openalex.org/I4210160531"]},{"raw_affiliation_string":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100675356","display_name":"Aijun Wang","orcid":"https://orcid.org/0000-0002-2985-3627","observed_orcids":["https://orcid.org/0000-0002-2985-3627"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aijun Wang","raw_affiliation_strings":["State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bo Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Song","raw_affiliation_strings":["State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101862687","display_name":"Kai Gong","orcid":"https://orcid.org/0000-0003-4982-6957","observed_orcids":["https://orcid.org/0000-0003-4982-6957"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Gong","raw_affiliation_strings":["State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101772126","display_name":"Lihai Zhang","orcid":"https://orcid.org/0000-0003-3172-6309","observed_orcids":["https://orcid.org/0000-0003-3172-6309"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lihai Zhang","raw_affiliation_strings":["Department of Stomatology, Chinese People's Liberation Army General Hospital, Beijing 100853, China","State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, Chinese People's Liberation Army General Hospital, Beijing 100853, China","institution_ids":["https://openalex.org/I4210160531"]},{"raw_affiliation_string":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057728335","display_name":"Min Hu","orcid":"https://orcid.org/0009-0005-5591-8809","observed_orcids":["https://orcid.org/0009-0005-5591-8809","https://orcid.org/0000-0002-2547-5868"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Hu","raw_affiliation_strings":["Department of Stomatology, Chinese People's Liberation Army General Hospital, Beijing 100853, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, Chinese People's Liberation Army General Hospital, Beijing 100853, China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102855006","display_name":"Xiufang Zhang","orcid":"https://orcid.org/0000-0001-7837-8167","observed_orcids":["https://orcid.org/0000-0001-7837-8167"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiufang Zhang","raw_affiliation_strings":["State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103400008","display_name":"Nanming Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nanming Zhao","raw_affiliation_strings":["State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100869308","display_name":"Yandao Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yandao Gong","raw_affiliation_strings":["State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100869308"],"corresponding_institution_ids":["https://openalex.org/I99065089"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.7729,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.83392427,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"283","issue":"21","first_page":"14506","last_page":"14515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.3384000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.3384000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.13699999451637268,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.8920000195503235},{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":1.0},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neural-cell-differentiation","display_name":"neural cell differentiation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.8399999737739563},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8709999918937683},{"id":"https://openalex.org/keywords/kinase-independent-regulation","display_name":"kinase-independent regulation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.7870000004768372},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9959999918937683},{"id":"https://openalex.org/keywords/p15","display_name":"p15","score":0.996999979019165},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8989999890327454},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C183022183","wikidata":"https://www.wikidata.org/wiki/Q15333016","display_name":"E2F1","level":4,"score":0.6461076736450195},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.6413495540618896},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5914018154144287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5887868404388428},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.5786855816841125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5571281909942627},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5450206398963928},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10971274971961975},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09893935918807983},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050687","descriptor_name":"E2F1 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050687","descriptor_name":"E2F1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m706136200","doi":"https://doi.org/10.1074/jbc.m706136200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m706136200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:18367454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18367454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m706136200","doi":"https://doi.org/10.1074/jbc.m706136200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m706136200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W114787214","https://openalex.org/W1554815317","https://openalex.org/W1968495382","https://openalex.org/W1980759602","https://openalex.org/W1999523595","https://openalex.org/W2003431470","https://openalex.org/W2007573950","https://openalex.org/W2009214757","https://openalex.org/W2013457152","https://openalex.org/W2017715649","https://openalex.org/W2025744983","https://openalex.org/W2032729242","https://openalex.org/W2041503766","https://openalex.org/W2053692735","https://openalex.org/W2054446345","https://openalex.org/W2055878844","https://openalex.org/W2056607822","https://openalex.org/W2063120457","https://openalex.org/W2064055742","https://openalex.org/W2067968784","https://openalex.org/W2070939832","https://openalex.org/W2080939902","https://openalex.org/W2098470595","https://openalex.org/W2099082103","https://openalex.org/W2101747038","https://openalex.org/W2105105956","https://openalex.org/W2108958930","https://openalex.org/W2110160400","https://openalex.org/W2121619780","https://openalex.org/W2125904354","https://openalex.org/W2139117855","https://openalex.org/W2155507705","https://openalex.org/W2157905883","https://openalex.org/W2163501419","https://openalex.org/W2166298779","https://openalex.org/W2169623736","https://openalex.org/W2186312706","https://openalex.org/W2223377387","https://openalex.org/W2282748845","https://openalex.org/W2316083089","https://openalex.org/W2324260531","https://openalex.org/W2791873134"],"related_works":["https://openalex.org/W2021390529","https://openalex.org/W2105105956","https://openalex.org/W2223377387","https://openalex.org/W2746550275","https://openalex.org/W2041503766","https://openalex.org/W1998650978","https://openalex.org/W2114031650","https://openalex.org/W1521542349","https://openalex.org/W1837000375","https://openalex.org/W2142578494"],"abstract_inverted_index":{"It":[0],"is":[1],"widely":[2],"acknowledged":[3],"that":[4,36,149],"E2F1":[5,21,60,78,93,118,156],"and":[6,22,56,70,92,94,115,136,160],"GSK3beta":[7,23,49,69,74,91,113,123,150],"are":[8],"both":[9,53],"involved":[10],"in":[11,24,37,103,119,166,177],"the":[12,18,38,54,88,104,110,129,139,153,178],"process":[13,105],"of":[14,40,90,106,132,155],"cell":[15,25],"differentiation.":[16,108,181],"However,":[17],"relationship":[19],"between":[20],"differentiation":[26,39],"has":[27],"yet":[28],"to":[29],"be":[30],"discovered.":[31],"Here,":[32],"we":[33],"provide":[34],"evidence":[35],"PC12":[41,107,180],"cells":[42],"induced":[43],"by":[44,79,99,127,142],"nerve":[45],"growth":[46],"factor":[47],"(NGF),":[48],"was":[50,65],"increased":[51],"at":[52,61],"mRNA":[55],"protein":[57],"levels,":[58],"whereas":[59],"these":[62],"two":[63],"levels":[64],"decreased.":[66],"Both":[67],"wild-type":[68],"its":[71,81,163],"kinase-defective":[72],"mutant":[73],"KM":[75],"can":[76,151],"inhibit":[77,162],"promoting":[80],"ubiquitination":[82,154],"through":[83],"physical":[84,158],"interaction.":[85],"In":[86],"addition,":[87],"colocalization":[89],"their":[95],"subcellular":[96],"distribution,":[97],"regulated":[98],"NGF,":[100],"were":[101],"observed":[102],"At":[109],"tissue":[111],"level,":[112],"colocalized":[114],"interacted":[116],"with":[117],"mouse":[120],"hippocampus.":[121],"Furthermore,":[122],"facilitated":[124],"neurite":[125],"outgrowth":[126],"rescuing":[128],"promoter":[130],"activities":[131],"Cdk":[133],"inhibitors":[134],"p21":[135],"p15":[137],"from":[138],"inhibition":[140],"caused":[141],"E2F1.":[143],"To":[144],"summarize,":[145],"our":[146],"findings":[147],"suggest":[148],"promote":[152],"via":[157],"interaction":[159],"thus":[161],"transcription":[164],"activity":[165,169],"a":[167],"kinase":[168],"independent":[170],"manner,":[171],"which":[172],"plays":[173],"an":[174],"important":[175],"role":[176],"NGF-induced":[179]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
