{"id":"https://openalex.org/W1995758152","doi":"https://doi.org/10.1016/j.ymthe.2005.10.005","title":"Second-Generation Replication-Competent Oncolytic Adenovirus Armed with Improved Suicide Genes and ADP Gene Demonstrates Greater Efficacy without Increased Toxicity","display_name":"Second-Generation Replication-Competent Oncolytic Adenovirus Armed with Improved Suicide Genes and ADP Gene Demonstrates Greater Efficacy without Increased Toxicity","publication_year":2005,"publication_date":"2005-11-15","ids":{"openalex":"https://openalex.org/W1995758152","doi":"https://doi.org/10.1016/j.ymthe.2005.10.005","mag":"1995758152","pmid":"https://pubmed.ncbi.nlm.nih.gov/16290236"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2005.10.005","doi":"https://doi.org/10.1016/j.ymthe.2005.10.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2005.10.005","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ymthe.2005.10.005","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010493143","display_name":"Kenneth N. Barton","orcid":"https://orcid.org/0000-0002-5514-834X","observed_orcids":["https://orcid.org/0000-0002-5514-834X"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth N. Barton","raw_affiliation_strings":["Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052710017","display_name":"Dell L. Paielli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dell Paielli","raw_affiliation_strings":["Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067777035","display_name":"Yingshu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingshu Zhang","raw_affiliation_strings":["Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109342712","display_name":"Sweaty Koul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sweaty Koul","raw_affiliation_strings":["Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103503178","display_name":"Stephen L. Brown","orcid":"https://orcid.org/0000-0001-9000-3501","observed_orcids":["https://orcid.org/0000-0001-9000-3501"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen L. Brown","raw_affiliation_strings":["Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091841617","display_name":"Mei L\u00fc","orcid":"https://orcid.org/0000-0002-3313-6428","observed_orcids":["https://orcid.org/0000-0002-3313-6428"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mei Lu","raw_affiliation_strings":["Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI 48202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI 48202, USA","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015910036","display_name":"John Curtis Seely","orcid":"https://orcid.org/0000-0003-1050-4096","observed_orcids":["https://orcid.org/0000-0003-1050-4096"]},"institutions":[{"id":"https://openalex.org/I4210090135","display_name":"Experimental Pathology Laboratories","ror":"https://ror.org/00dv9aw81","country_code":"US","type":"company","lineage":["https://openalex.org/I4210090135"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Seely","raw_affiliation_strings":["Experimental Pathology Laboratories, Inc., Research Triangle Park, NC 27701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology Laboratories, Inc., Research Triangle Park, NC 27701, USA","institution_ids":["https://openalex.org/I4210090135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649967","display_name":"Jae Ho Kim","orcid":"https://orcid.org/0000-0003-4323-4790","observed_orcids":["https://orcid.org/0000-0003-4323-4790"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jae Ho Kim","raw_affiliation_strings":["Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037922132","display_name":"Svend O. Freytag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Svend O. Freytag","raw_affiliation_strings":["Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, 48202, USA","institution_ids":["https://openalex.org/I154057602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":3.5663,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.93017552,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"2","first_page":"347","last_page":"356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-adenovirus","display_name":"oncolytic adenovirus","score":0.9610000252723694},{"id":"https://openalex.org/keywords/replication-competent-adenovirus","display_name":"replication-competent adenovirus","score":0.9549999833106995},{"id":"https://openalex.org/keywords/suicide-gene-therapy","display_name":"suicide gene therapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.6480000019073486},{"id":"https://openalex.org/keywords/intraprostatic-injection","display_name":"intraprostatic injection","score":0.8429999947547913},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.550000011920929},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.796999990940094},{"id":"https://openalex.org/keywords/canine-prostate","display_name":"canine prostate","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C34981463","wikidata":"https://www.wikidata.org/wiki/Q3311663","display_name":"Suicide gene","level":4,"score":0.7477244734764099},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5532177090644836},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.5490869879722595},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.5171034336090088},{"id":"https://openalex.org/C2777748644","wikidata":"https://www.wikidata.org/wiki/Q5201383","display_name":"Cytosine deaminase","level":4,"score":0.4958723485469818},{"id":"https://openalex.org/C2777283488","wikidata":"https://www.wikidata.org/wiki/Q7095181","display_name":"Oncolytic adenovirus","level":4,"score":0.4445282816886902},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.437974214553833},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.42504534125328064},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4038352370262146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35925745964050293},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.304471492767334},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.29388201236724854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22849997878074646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1458766758441925},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000260","descriptor_name":"Adenoviruses, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017503","descriptor_name":"Adenovirus E3 Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017503","descriptor_name":"Adenovirus E3 Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017503","descriptor_name":"Adenovirus E3 Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D041722","descriptor_name":"Genes, Transgenic, Suicide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050504","descriptor_name":"Oncolytic Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050504","descriptor_name":"Oncolytic Viruses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ymthe.2005.10.005","doi":"https://doi.org/10.1016/j.ymthe.2005.10.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2005.10.005","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"pmid:16290236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16290236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ymthe.2005.10.005","doi":"https://doi.org/10.1016/j.ymthe.2005.10.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2005.10.005","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1492631261","https://openalex.org/W1531535965","https://openalex.org/W1579265529","https://openalex.org/W1581549015","https://openalex.org/W1582164157","https://openalex.org/W1755993224","https://openalex.org/W1943398466","https://openalex.org/W1961949089","https://openalex.org/W1968436602","https://openalex.org/W1983766005","https://openalex.org/W1992322591","https://openalex.org/W2001758369","https://openalex.org/W2017576006","https://openalex.org/W2031641273","https://openalex.org/W2036581805","https://openalex.org/W2044700629","https://openalex.org/W2053981403","https://openalex.org/W2101348153","https://openalex.org/W2113127264","https://openalex.org/W2113534698","https://openalex.org/W2127935661","https://openalex.org/W2132002141","https://openalex.org/W2135792629","https://openalex.org/W2138863592","https://openalex.org/W2140544523","https://openalex.org/W2144624167","https://openalex.org/W2161025906","https://openalex.org/W2163010298","https://openalex.org/W2165671852","https://openalex.org/W2165699027","https://openalex.org/W2165703532","https://openalex.org/W2242902452","https://openalex.org/W6634431657","https://openalex.org/W6634740758","https://openalex.org/W6680910268","https://openalex.org/W6680955187"],"related_works":["https://openalex.org/W1943398466","https://openalex.org/W2003719920","https://openalex.org/W2019296882","https://openalex.org/W2089434317","https://openalex.org/W2275544203","https://openalex.org/W2135792629","https://openalex.org/W2044700629","https://openalex.org/W2138863592","https://openalex.org/W1497491139","https://openalex.org/W2094293953"],"abstract_inverted_index":{"Replication-competent":[0],"adenovirus-mediated":[1],"suicide":[2],"gene":[3,65],"therapy":[4],"has":[5,161],"proven":[6,162],"to":[7,74,128,152,163],"be":[8,28,164],"safe":[9,165],"in":[10,37,85,92,122,147,166,192],"humans":[11],"when":[12],"delivered":[13],"intraprostatically.":[14],"Although":[15],"signs":[16],"of":[17,95,99,105,142,159,187],"efficacy":[18,186],"are":[19],"emerging,":[20],"it":[21],"is":[22],"likely":[23],"that":[24,117],"further":[25],"improvements":[26],"will":[27,33],"needed":[29],"before":[30],"this":[31,41],"technology":[32],"have":[34,44],"widespread":[35],"applicability":[36],"the":[38,67,75,112,131,153,157,178,183,188],"clinic.":[39],"Toward":[40],"end,":[42],"we":[43],"developed":[45],"a":[46],"second-generation,":[47],"replication-competent":[48],"adenovirus":[49,68,191],"(Ad5-yCD/mutTK(SR39)rep-ADP)":[50],"containing":[51],"an":[52],"improved":[53,132],"yeast":[54],"cytosine":[55],"deaminase":[56],"(yCD)/mutant(SR39)":[57],"herpes":[58],"simplex":[59],"virus":[60],"thymidine":[61],"kinase":[62],"fusion":[63,134],"(yCD/mutTK(SR39))":[64],"and":[66,87,111,135,185],"death":[69],"protein":[70],"(ADP)":[71],"gene.":[72],"Relative":[73],"first-generation":[76],"Ad5-CD/TKrep":[77,155],"adenovirus,":[78,156],"Ad5-yCD/mutTK(SR39)rep-ADP":[79,143,190],"demonstrated":[80,116],"greater":[81,89],"tumor":[82,90,109],"cell":[83],"kill":[84],"vitro":[86],"significantly":[88,148],"control":[91],"preclinical":[93],"models":[94],"human":[96,108],"cancer.":[97],"Quantification":[98],"transgene":[100],"volume":[101],"following":[102],"direct":[103],"injection":[104,141],"fadenovirus":[106],"into":[107],"xenografts":[110],"na\u00efve":[113],"canine":[114],"prostate":[115,170],"ADP":[118,136],"enhanced":[119],"adenoviral":[120],"spread":[121],"vivo.":[123],"Toxicology":[124],"studies":[125],"were":[126],"performed":[127],"determine":[129],"whether":[130],"yCD/mutTK(SR39)":[133],"genes":[137],"increased":[138,149],"toxicity.":[139],"Intraprostatic":[140],"did":[144],"not":[145],"result":[146],"toxicity":[150],"relative":[151],"parental":[154],"latter":[158],"which":[160],"two":[167],"Phase":[168],"I":[169],"cancer":[171],"clinical":[172],"trials.":[173],"Together,":[174],"these":[175],"results":[176],"provide":[177],"scientific":[179],"basis":[180],"for":[181],"evaluating":[182],"safety":[184],"second-generation":[189],"humans.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}