{"id":"https://openalex.org/W1995686306","doi":"https://doi.org/10.1021/jp4047215","title":"Lipid Fluid\u2013Gel Phase Transition Induced Alamethicin Orientational Change Probed by Sum Frequency Generation Vibrational Spectroscopy","display_name":"Lipid Fluid\u2013Gel Phase Transition Induced Alamethicin Orientational Change Probed by Sum Frequency Generation Vibrational Spectroscopy","publication_year":2013,"publication_date":"2013-07-20","ids":{"openalex":"https://openalex.org/W1995686306","doi":"https://doi.org/10.1021/jp4047215","mag":"1995686306","pmid":"https://pubmed.ncbi.nlm.nih.gov/24124624","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3792402"},"language":"en","primary_location":{"id":"doi:10.1021/jp4047215","doi":"https://doi.org/10.1021/jp4047215","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp4047215","pdf_url":null,"source":{"id":"https://openalex.org/S95739953","display_name":"The Journal of Physical Chemistry C","issn_l":"1932-7447","issn":["1932-7447","1932-7455"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry C","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3792402","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102940794","display_name":"Pei Yang","orcid":"https://orcid.org/0009-0008-4922-7405","observed_orcids":["https://orcid.org/0009-0008-4922-7405","https://orcid.org/0009-0008-3213-603X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pei Yang","raw_affiliation_strings":["Department\rof Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109,\rUnited States","Department#R#of Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109,#R#United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109,\rUnited States","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department#R#of Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109,#R#United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004916075","display_name":"Fu\u2010Gen Wu","orcid":"https://orcid.org/0000-0003-1773-2868","observed_orcids":["https://orcid.org/0000-0003-1773-2868"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fu-Gen Wu","raw_affiliation_strings":["Department\rof Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109,\rUnited States","Department#R#of Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109,#R#United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109,\rUnited States","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department#R#of Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109,#R#United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054123780","display_name":"Zhan Chen","orcid":"https://orcid.org/0000-0001-8687-8348","observed_orcids":["https://orcid.org/0000-0001-8687-8348"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhan Chen","raw_affiliation_strings":["Department\rof Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109,\rUnited States","Department#R#of Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109,#R#United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109,\rUnited States","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department#R#of Chemistry, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109,#R#United States","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054123780"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.4942,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.81126205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"117","issue":"33","first_page":"17039","last_page":"17049"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.047600001096725464,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alamethicin","display_name":"alamethicin","score":1.0},{"id":"https://openalex.org/keywords/peptide-orientation","display_name":"peptide orientation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9010000228881836},{"id":"https://openalex.org/keywords/supported-lipid-bilayers","display_name":"supported lipid bilayers","score":0.8659999966621399},{"id":"https://openalex.org/keywords/distributed-model-predictive-control","display_name":"distributed model predictive control","score":0.7279999852180481},{"id":"https://openalex.org/keywords/membrane-insertion","display_name":"membrane insertion","score":0.46000000834465027},{"id":"https://openalex.org/keywords/transmembrane-orientation","display_name":"transmembrane orientation","score":0.765999972820282},{"id":"https://openalex.org/keywords/peptide-concentration-dependence","display_name":"peptide concentration dependence","score":0.6010000109672546},{"id":"https://openalex.org/keywords/membrane-structural-changes","display_name":"membrane structural changes","score":0.531000018119812},{"id":"https://openalex.org/keywords/sum-frequency-generation-spectroscopy","display_name":"sum frequency generation spectroscopy","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2780985075","wikidata":"https://www.wikidata.org/wiki/Q4705902","display_name":"Alamethicin","level":4,"score":0.988776445388794},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.774146318435669},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.7161613702774048},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.6420491933822632},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6362767219543457},{"id":"https://openalex.org/C76564549","wikidata":"https://www.wikidata.org/wiki/Q17154515","display_name":"Lipid bilayer phase behavior","level":4,"score":0.633202314376831},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.528335690498352},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43190473318099976},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.4218660295009613},{"id":"https://openalex.org/C63491327","wikidata":"https://www.wikidata.org/wiki/Q6888332","display_name":"Model lipid bilayer","level":5,"score":0.42096078395843506},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.41350260376930237},{"id":"https://openalex.org/C122398194","wikidata":"https://www.wikidata.org/wiki/Q6815129","display_name":"Membrane fluidity","level":3,"score":0.41120046377182007},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.40108585357666016},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2494267225265503},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14357727766036987},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08536851406097412},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/jp4047215","doi":"https://doi.org/10.1021/jp4047215","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp4047215","pdf_url":null,"source":{"id":"https://openalex.org/S95739953","display_name":"The Journal of Physical Chemistry C","issn_l":"1932-7447","issn":["1932-7447","1932-7455"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry C","raw_type":"journal-article"},{"id":"pmid:24124624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24124624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry. C, Nanomaterials and interfaces","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3105031","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3792402","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3792402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3792402","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Phys Chem C Nanomater Interfaces","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3105031","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3792402","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G297101869","display_name":"SFG Investigation of Peptide and Protein Orientations in Membranes","funder_award_id":"R01GM081655","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W62413238","https://openalex.org/W1968591561","https://openalex.org/W1977343510","https://openalex.org/W1982889499","https://openalex.org/W1987847765","https://openalex.org/W1991450428","https://openalex.org/W1992651388","https://openalex.org/W1995599572","https://openalex.org/W2003381975","https://openalex.org/W2003670177","https://openalex.org/W2005325726","https://openalex.org/W2006285489","https://openalex.org/W2018149397","https://openalex.org/W2021084546","https://openalex.org/W2023209557","https://openalex.org/W2026125051","https://openalex.org/W2027662469","https://openalex.org/W2029046066","https://openalex.org/W2030474358","https://openalex.org/W2032752853","https://openalex.org/W2033417954","https://openalex.org/W2034337706","https://openalex.org/W2036438916","https://openalex.org/W2038391042","https://openalex.org/W2041515897","https://openalex.org/W2042595932","https://openalex.org/W2045111209","https://openalex.org/W2048741757","https://openalex.org/W2051290691","https://openalex.org/W2053670655","https://openalex.org/W2053960417","https://openalex.org/W2054602599","https://openalex.org/W2056750771","https://openalex.org/W2059884070","https://openalex.org/W2060515103","https://openalex.org/W2064133581","https://openalex.org/W2064526432","https://openalex.org/W2065230010","https://openalex.org/W2065660960","https://openalex.org/W2067765459","https://openalex.org/W2067821192","https://openalex.org/W2071375115","https://openalex.org/W2073894126","https://openalex.org/W2074970514","https://openalex.org/W2081055581","https://openalex.org/W2081202276","https://openalex.org/W2083212567","https://openalex.org/W2084114424","https://openalex.org/W2089738031","https://openalex.org/W2099421924","https://openalex.org/W2117739601","https://openalex.org/W2119200410","https://openalex.org/W2121242766","https://openalex.org/W2129501307","https://openalex.org/W2168799938","https://openalex.org/W2321069291","https://openalex.org/W4237244040"],"related_works":["https://openalex.org/W2067765459","https://openalex.org/W2048741757","https://openalex.org/W7098258685","https://openalex.org/W2058771789","https://openalex.org/W2094085376","https://openalex.org/W2784449992","https://openalex.org/W2059623621","https://openalex.org/W2064526432","https://openalex.org/W2167540970","https://openalex.org/W2022570645"],"abstract_inverted_index":{"Alamethicin":[0],"has":[1,23],"been":[2,24],"extensively":[3],"studied":[4,275],"as":[5,14,129,139],"an":[6,228],"antimicrobial":[7,28],"peptide":[8,143,195,208,253,295],"(AMP)":[9],"and":[10,179,268,282],"is":[11,32],"widely":[12],"used":[13],"a":[15,140,194,198,206,225,243,247,251,260],"simple":[16],"model":[17,130],"for":[18],"ion":[19],"channel":[20],"proteins.":[21],"It":[22],"shown":[25],"that":[26,170],"the":[27,44,47,51,85,88,91,103,114,156,163,175,187,216,235,238,276,280],"activity":[29],"of":[30,46,87,94,117,142,155,177,201,210,237,255,279],"AMPs":[31,95],"related":[33],"to":[34,98,227,246],"their":[35,288],"cell":[36,52,56,107,131],"membrane":[37,79,92],"orientation,":[38],"which":[39],"may":[40],"be":[41,67],"influenced":[42],"by":[43,161],"phase":[45,60,64,77,86,153,181,218,236,270,284],"lipid":[48,126,157,184,188,219,239,271,285],"molecules":[49,119,292],"in":[50,69,75,191],"membrane.":[53],"The":[54,152],"\"healthy\"":[55],"membranes":[57],"contain":[58],"fluid":[59,178,217,244,267,281],"lipids,":[61],"while":[62,263],"gel":[63,180,248,269,283],"lipids":[65,89],"can":[66],"found":[68],"injured":[70],"or":[71,74,137],"aged":[72],"cells":[73],"some":[76],"separated":[78],"regions.":[80],"Thus,":[81],"investigations":[82],"on":[83,106,174],"how":[84],"influences":[90],"orientation":[93,222,233,262],"are":[96,190],"important":[97],"understand":[99],"more":[100],"details":[101],"regarding":[102],"AMP's":[104],"action":[105],"membranes.":[108],"In":[109],"this":[110],"study,":[111],"we":[112],"determined":[113],"orientational":[115],"changes":[116,154,241,278],"alamethicin":[118,171,213,258,291],"associated":[120,264],"with":[121,133,193,197,265,290],"planar":[122],"substrate":[123],"supported":[124],"single":[125],"bilayers":[127,158,185,189,286],"(serving":[128],"membranes)":[132],"different":[134,294],"phases":[135],"(fluid":[136],"gel)":[138],"function":[141],"concentration":[144,200,209,254],"using":[145],"sum":[146],"frequency":[147],"generation":[148],"(SFG)":[149],"vibrational":[150],"spectroscopy.":[151],"were":[159],"realized":[160],"varying":[162],"sample":[164],"temperature.":[165],"Our":[166],"SFG":[167],"results":[168],"indicated":[169],"lies":[172],"down":[173],"surface":[176],"1,2-dimyristoyl(d54)-sn-glycero-3-phosphocholine":[182],"(d-DMPC)":[183],"when":[186,234],"contact":[192],"solution":[196],"low":[199],"0.84":[202],"\u03bcM.":[203],"However,":[204],"at":[205,293],"medium":[207],"10.80":[211],"\u03bcM,":[212,257],"inserts":[214],"into":[215],"bilayer.":[220],"Its":[221],"switches":[223],"from":[224,242],"transmembrane":[226,261],"in-plane":[229],"(or":[230],"lying":[231],"down)":[232],"bilayer":[240],"state":[245],"state.":[249],"At":[250],"high":[252],"21.60":[256],"adopts":[259],"both":[266],"bilayers.":[272],"We":[273],"also":[274],"structural":[277],"upon":[287],"interactions":[289],"concentrations.":[296]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}