{"id":"https://openalex.org/W1995657433","doi":"https://doi.org/10.1038/oby.2009.343","title":"Pericardial Fat Volume Correlates With Inflammatory Markers: The Framingham Heart Study","display_name":"Pericardial Fat Volume Correlates With Inflammatory Markers: The Framingham Heart Study","publication_year":2009,"publication_date":"2009-10-29","ids":{"openalex":"https://openalex.org/W1995657433","doi":"https://doi.org/10.1038/oby.2009.343","mag":"1995657433","pmid":"https://pubmed.ncbi.nlm.nih.gov/19875999","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3014610"},"language":"en","primary_location":{"id":"doi:10.1038/oby.2009.343","doi":"https://doi.org/10.1038/oby.2009.343","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2009.343","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2009.343","source":{"id":"https://openalex.org/S29918858","display_name":"Obesity","issn_l":"1930-7381","issn":["1930-7381","1930-739X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2009.343","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031462581","display_name":"Thomas M. Tadros","orcid":"https://orcid.org/0000-0002-2397-038X","observed_orcids":["https://orcid.org/0000-0002-2397-038X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Tadros","raw_affiliation_strings":["National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA","Division of Cardiology, Boston University Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Division of Cardiology, Boston University Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008596377","display_name":"Joseph M. Massaro","orcid":"https://orcid.org/0000-0002-2682-4812","observed_orcids":["https://orcid.org/0000-0002-2682-4812"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Massaro","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA","National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073146916","display_name":"Guido Aranha Rosito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guido A. Rosito","raw_affiliation_strings":["Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024590816","display_name":"Udo Hoffmann","orcid":"https://orcid.org/0000-0001-5514-769X","observed_orcids":["https://orcid.org/0000-0001-5514-769X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Udo Hoffmann","raw_affiliation_strings":["Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004656494","display_name":"Ramachandran Srini Vasan","orcid":"https://orcid.org/0000-0001-7357-5970","observed_orcids":["https://orcid.org/0000-0001-7357-5970"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramachandran S. Vasan","raw_affiliation_strings":["Divisions of Cardiology and Preventative Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA","National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Cardiology and Preventative Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064623534","display_name":"Martin G. Larson","orcid":"https://orcid.org/0000-0002-9631-1254","observed_orcids":["https://orcid.org/0000-0002-9631-1254"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin G. Larson","raw_affiliation_strings":["Department of Mathematics, Boston University, Boston, Massachusetts, USA","National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Boston University, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048859763","display_name":"John F. Keaney","orcid":"https://orcid.org/0000-0002-0866-1837","observed_orcids":["https://orcid.org/0000-0002-0866-1837"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F. Keaney","raw_affiliation_strings":["Division of Cardiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103544412","display_name":"Izabella Lipinska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Izabella Lipinska","raw_affiliation_strings":["Division of Cardiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035126983","display_name":"James B. Meigs","orcid":"https://orcid.org/0000-0002-2439-2657","observed_orcids":["https://orcid.org/0000-0002-2439-2657"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James B. Meigs","raw_affiliation_strings":["Department of Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043655881","display_name":"Sekar Kathiresan","orcid":"https://orcid.org/0000-0002-6724-032X","observed_orcids":["https://orcid.org/0000-0002-6724-032X","https://orcid.org/0000-0002-3711-7101","https://orcid.org/0000-0002-6201-5334"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sekar Kathiresan","raw_affiliation_strings":["Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084614356","display_name":"Christopher J. O\u2019Donnell","orcid":"https://orcid.org/0000-0002-2667-8624","observed_orcids":["https://orcid.org/0000-0002-2667-8624"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. O'Donnell","raw_affiliation_strings":["Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108093361","display_name":"Caroline S. Fox","orcid":"https://orcid.org/0000-0002-3992-8557","observed_orcids":["https://orcid.org/0000-0002-3992-8557"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline S. Fox","raw_affiliation_strings":["Department of Endocrinology, Diabetes, and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA","National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Diabetes, and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210123017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064309113","display_name":"Emelia J. Benjamin","orcid":"https://orcid.org/0000-0003-4076-2336","observed_orcids":["https://orcid.org/0000-0003-4076-2336"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emelia J. Benjamin","raw_affiliation_strings":["Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA","Department of Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","Division of Cardiology, Boston University Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA","National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Cardiology, Boston University Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210123017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5064309113"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081","https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210123017"],"apc_list":{"value":4980,"currency":"USD","value_usd":4980},"apc_paid":null,"fwci":2.6577,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.90362999,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"5","first_page":"1039","last_page":"1045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12291","display_name":"Pericarditis and Cardiac Tamponade","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pericardial-fat","display_name":"pericardial fat","score":0.9589999914169312},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7639999985694885},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.921999990940094},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9750000238418579},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/urinary-isoprostanes","display_name":"urinary isoprostanes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/regional-adiposity","display_name":"regional adiposity","score":0.859000027179718},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.5049999952316284},{"id":"https://openalex.org/keywords/framingham-offspring-study","display_name":"Framingham Offspring Study","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7199708223342896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6648110747337341},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.559493362903595},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5559136867523193},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.5385943055152893},{"id":"https://openalex.org/C2909124604","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Intra-Abdominal Fat","level":5,"score":0.4946114718914032},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.45902639627456665},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.4160270094871521},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.34940874576568604},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.24659767746925354},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.18917402625083923},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.12701022624969482},{"id":"https://openalex.org/C3020796190","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Visceral fat","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055105","descriptor_name":"Waist Circumference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/oby.2009.343","doi":"https://doi.org/10.1038/oby.2009.343","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2009.343","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2009.343","source":{"id":"https://openalex.org/S29918858","display_name":"Obesity","issn_l":"1930-7381","issn":["1930-7381","1930-739X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity","raw_type":"journal-article"},{"id":"pmid:19875999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19875999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity (Silver Spring, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3014610","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3014610","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Obesity (Silver Spring)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/oby.2009.343","doi":"https://doi.org/10.1038/oby.2009.343","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2009.343","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2009.343","source":{"id":"https://openalex.org/S29918858","display_name":"Obesity","issn_l":"1930-7381","issn":["1930-7381","1930-739X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1035741774","display_name":null,"funder_award_id":"HL-076784","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1490530680","display_name":null,"funder_award_id":"HC25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G150102659","display_name":null,"funder_award_id":"DK080140","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2106774427","display_name":null,"funder_award_id":"RR 01066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G250621538","display_name":null,"funder_award_id":"N01\u2010HC25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3042145041","display_name":null,"funder_award_id":"N01-HC-25195","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3493866547","display_name":"General Clinical Research Center","funder_award_id":"M01RR001066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3665864103","display_name":"Aldosterone in Vascular Remodeling and Dysfunction","funder_award_id":"K24HL004334","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3667269547","display_name":null,"funder_award_id":"N01-HC","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4551567088","display_name":"Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study","funder_award_id":"R01AG028321","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5164707915","display_name":null,"funder_award_id":"N01-HC-025195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5312414234","display_name":"INFLAMMATION:  CORRELATES AND PROGNOSIS IN FRAMINGHAM","funder_award_id":"R01HL064753","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5572931172","display_name":"Epidemiology of Precursors to Type 2 Diabetes","funder_award_id":"K24DK080140","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5663137130","display_name":null,"funder_award_id":"HL064753","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6151559349","display_name":"Framingham: Inflammation, Genes & Cardiovascular Disease","funder_award_id":"R01HL076784","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G641917991","display_name":"The Framingham Heart Study","funder_award_id":"n01hc25195-41-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7603022272","display_name":null,"funder_award_id":"M01-RR","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995657433.pdf","grobid_xml":"https://content.openalex.org/works/W1995657433.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1555070335","https://openalex.org/W1580333814","https://openalex.org/W1964431186","https://openalex.org/W1975979383","https://openalex.org/W1983997573","https://openalex.org/W1988123856","https://openalex.org/W1989400130","https://openalex.org/W1990438961","https://openalex.org/W1993530806","https://openalex.org/W1997300200","https://openalex.org/W2016318825","https://openalex.org/W2018444446","https://openalex.org/W2029378482","https://openalex.org/W2032520632","https://openalex.org/W2040151193","https://openalex.org/W2053299529","https://openalex.org/W2058610272","https://openalex.org/W2067504868","https://openalex.org/W2082053713","https://openalex.org/W2083947509","https://openalex.org/W2088118463","https://openalex.org/W2102009612","https://openalex.org/W2119473645","https://openalex.org/W2121144531","https://openalex.org/W2123435373","https://openalex.org/W2124263104","https://openalex.org/W2131398405","https://openalex.org/W2132513629","https://openalex.org/W2134204898","https://openalex.org/W2135369261","https://openalex.org/W2139682187","https://openalex.org/W2139959600","https://openalex.org/W2151353276","https://openalex.org/W2157653707","https://openalex.org/W2161496857","https://openalex.org/W2162728371","https://openalex.org/W2163786417","https://openalex.org/W2164898309","https://openalex.org/W2585745345","https://openalex.org/W4324114082"],"related_works":["https://openalex.org/W2118606707","https://openalex.org/W7042705262","https://openalex.org/W1975650738","https://openalex.org/W2139940317","https://openalex.org/W1984100669","https://openalex.org/W161533157","https://openalex.org/W132934887","https://openalex.org/W2139839031","https://openalex.org/W4388596154","https://openalex.org/W1993960486"],"abstract_inverted_index":{"The":[0],"objective":[1],"of":[2,24,63,110,155,239],"this":[3],"study":[4],"was":[5],"to":[6,60,106,126,147],"determine":[7,107],"whether":[8],"systemic":[9],"inflammatory":[10,65,112],"and":[11,19,42,53,57,85,97,140,188,211,219,241,247,258,260],"oxidative":[12,242,261],"stress":[13,243],"marker":[14,113,149],"concentrations":[15,62,114],"correlate":[16],"with":[17,115,160,229,234,245],"pericardial":[18,41,195,235,246],"intrathoracic":[20,43,201,230,248],"fat":[21,44,116,119,162,170,178,186,249],"volumes.":[22],"Participants":[23],"the":[25,108,122,148,156,252],"Framingham":[26],"Offspring":[27],"Study":[28],"(n":[29,137,144],"=":[30,138,145,217,223],"1,175,":[31],"53%":[32],"women,":[33],"mean":[34],"age":[35],"59":[36],"+/-":[37],"9":[38],"years)":[39],"had":[40],"volumes":[45],"assessed":[46],"by":[47],"multidetector":[48],"computed":[49],"tomography":[50],"(MDCT)":[51],"scans,":[52],"provided":[54],"fasting":[55],"blood":[56],"urine":[58],"samples":[59],"measure":[61],"14":[64],"markers:":[66],"C-reactive":[67],"protein":[68],"(CRP),":[69],"interleukin-6,":[70],"monocyte":[71],"chemoattractant":[72],"protein-1":[73],"(MCP-1),":[74],"CD40":[75],"ligand,":[76],"fibrinogen,":[77],"intracellular":[78],"adhesion":[79],"molecule-1,":[80],"lipoprotein-associated":[81],"phospholipase":[82],"A(2)":[83],"activity":[84],"mass,":[86],"myeloperoxidase,":[87],"osteoprotegerin,":[88],"P-selectin,":[89],"tumor":[90,93,141],"necrosis":[91,94,142],"factor-alpha,":[92],"factor":[95],"receptor-2,":[96],"urinary":[98,135,189,220],"isoprostanes.":[99],"Multivariable":[100],"linear":[101],"regression":[102],"models":[103,130],"were":[104,131],"used":[105],"association":[109,254],"log-transformed":[111],"volumes,":[117,250],"using":[118],"volume":[120],"as":[121],"dependent":[123],"variable.":[124],"Due":[125],"smaller":[127],"sample":[128],"sizes,":[129],"rerun":[132],"after":[133,204],"adding":[134],"isoprostanes":[136,190,221],"961)":[139],"factor-alpha":[143],"813)":[146],"panel.":[150],"Upon":[151],"backward":[152],"elimination,":[153],"four":[154],"biomarkers":[157],"correlated":[158,244],"positively":[159],"each":[161,169,177,185],"depot:":[163],"CRP":[164,215],"(P":[165,173,181,191,216,222],"<":[166,174,182,192,198],"0.0001":[167],"for":[168,176,184,194,200,206],"depot),":[171,179,187],"interleukin-6":[172],"0.05":[175],"MCP-1":[180],"0.01":[183,193],"fat;":[196],"P":[197],"0.001":[199],"fat).":[202],"Even":[203],"adjusting":[205],"BMI,":[207],"waist":[208],"circumference":[209],"(WC),":[210],"abdominal":[212],"visceral":[213],"fat,":[214,231],"0.0001)":[218],"0.02)":[224],"demonstrated":[225],"significant":[226],"positive":[227],"associations":[228],"but":[232],"not":[233],"fat.":[236],"Multiple":[237],"markers":[238],"inflammation":[240,259],"extending":[251],"known":[253],"between":[255],"regional":[256],"adiposity":[257],"stress.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}