{"id":"https://openalex.org/W1995648866","doi":"https://doi.org/10.1021/bi9003777","title":"Amyloid-\u03b2(1\u221242) Fibrillar Precursors Are Optimal for Inducing Tumor Necrosis Factor-\u03b1 Production in the THP-1 Human Monocytic Cell Line","display_name":"Amyloid-\u03b2(1\u221242) Fibrillar Precursors Are Optimal for Inducing Tumor Necrosis Factor-\u03b1 Production in the THP-1 Human Monocytic Cell Line","publication_year":2009,"publication_date":"2009-08-20","ids":{"openalex":"https://openalex.org/W1995648866","doi":"https://doi.org/10.1021/bi9003777","mag":"1995648866","pmid":"https://pubmed.ncbi.nlm.nih.gov/19694428","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2749082"},"language":"en","primary_location":{"id":"doi:10.1021/bi9003777","doi":"https://doi.org/10.1021/bi9003777","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi9003777","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2749082","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074806248","display_name":"Deepa Ajit","orcid":"https://orcid.org/0000-0002-6062-7070","observed_orcids":["https://orcid.org/0000-0002-6062-7070"]},"institutions":[{"id":"https://openalex.org/I208333798","display_name":"University of Missouri\u2013St. Louis","ror":"https://ror.org/037cnag11","country_code":"US","type":"education","lineage":["https://openalex.org/I208333798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepa Ajit","raw_affiliation_strings":["Department of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri, St. Louis, Missouri 63121","Department of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri, St. Louis, Missouri 63121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri, St. Louis, Missouri 63121","institution_ids":["https://openalex.org/I208333798"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri, St. Louis, Missouri 63121, USA","institution_ids":["https://openalex.org/I208333798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050719363","display_name":"Maria L. D. Udan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I208333798","display_name":"University of Missouri\u2013St. Louis","ror":"https://ror.org/037cnag11","country_code":"US","type":"education","lineage":["https://openalex.org/I208333798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria L. D. Udan","raw_affiliation_strings":["Department of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri, St. Louis, Missouri 63121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri, St. Louis, Missouri 63121","institution_ids":["https://openalex.org/I208333798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045061504","display_name":"Geeta S. Paranjape","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I208333798","display_name":"University of Missouri\u2013St. Louis","ror":"https://ror.org/037cnag11","country_code":"US","type":"education","lineage":["https://openalex.org/I208333798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geeta Paranjape","raw_affiliation_strings":["Department of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri, St. Louis, Missouri 63121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri, St. Louis, Missouri 63121","institution_ids":["https://openalex.org/I208333798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051869254","display_name":"Michael R. Nichols","orcid":"https://orcid.org/0000-0001-5458-218X","observed_orcids":["https://orcid.org/0000-0001-5458-218X"]},"institutions":[{"id":"https://openalex.org/I208333798","display_name":"University of Missouri\u2013St. Louis","ror":"https://ror.org/037cnag11","country_code":"US","type":"education","lineage":["https://openalex.org/I208333798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael R. Nichols","raw_affiliation_strings":["Department of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri, St. Louis, Missouri 63121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri, St. Louis, Missouri 63121","institution_ids":["https://openalex.org/I208333798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051869254"],"corresponding_institution_ids":["https://openalex.org/I208333798"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.2091,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.86317916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"48","issue":"38","first_page":"9011","last_page":"9021"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8180000185966492},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.8970000147819519},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8199999928474426},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/amyloid-beta-aggregation","display_name":"amyloid-beta aggregation","score":0.652999997138977},{"id":"https://openalex.org/keywords/aggregation-kinetics","display_name":"aggregation kinetics","score":0.39399999380111694},{"id":"https://openalex.org/keywords/proinflammatory-response","display_name":"pro-inflammatory response","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C204258353","wikidata":"https://www.wikidata.org/wiki/Q7670282","display_name":"THP1 cell line","level":3,"score":0.9631366729736328},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6730470657348633},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6140586137771606},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5072042942047119},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4489797055721283},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.43551933765411377},{"id":"https://openalex.org/C198352243","wikidata":"https://www.wikidata.org/wiki/Q37105","display_name":"Line (geometry)","level":2,"score":0.4208306074142456},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3510722517967224},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33264756202697754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2643798589706421},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.262728214263916},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2298271656036377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2054959237575531},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08071649074554443},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi9003777","doi":"https://doi.org/10.1021/bi9003777","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi9003777","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:19694428","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19694428","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2749082","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2749082","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2749082","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2749082","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3086810708","display_name":"Functional Interaction of Amyloid-b Protein with Glial Toll-Like Receptors","funder_award_id":"R15AG033913","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309568","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06"},{"id":"https://openalex.org/F4320334492","display_name":"Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch","ror":null},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1217317373","https://openalex.org/W1494074009","https://openalex.org/W1602771322","https://openalex.org/W1613451007","https://openalex.org/W1768493813","https://openalex.org/W1977687419","https://openalex.org/W1980825524","https://openalex.org/W1981570625","https://openalex.org/W1983877884","https://openalex.org/W1987327052","https://openalex.org/W1988254695","https://openalex.org/W1991763618","https://openalex.org/W1993262901","https://openalex.org/W1995650022","https://openalex.org/W2002123695","https://openalex.org/W2004098528","https://openalex.org/W2005814061","https://openalex.org/W2010441033","https://openalex.org/W2014272598","https://openalex.org/W2029554137","https://openalex.org/W2030452219","https://openalex.org/W2033847972","https://openalex.org/W2041425500","https://openalex.org/W2045560271","https://openalex.org/W2049167261","https://openalex.org/W2051651977","https://openalex.org/W2059804089","https://openalex.org/W2067121616","https://openalex.org/W2070712644","https://openalex.org/W2071728536","https://openalex.org/W2072327749","https://openalex.org/W2073516240","https://openalex.org/W2074274825","https://openalex.org/W2076260194","https://openalex.org/W2082431283","https://openalex.org/W2094411486","https://openalex.org/W2107015337","https://openalex.org/W2109956926","https://openalex.org/W2121963977","https://openalex.org/W2126950194","https://openalex.org/W2128111072","https://openalex.org/W2128635872","https://openalex.org/W2132154794","https://openalex.org/W2133631618","https://openalex.org/W2135482947","https://openalex.org/W2143811153","https://openalex.org/W2145904082","https://openalex.org/W2149399096","https://openalex.org/W2150999725","https://openalex.org/W2156193029","https://openalex.org/W2162624035","https://openalex.org/W2168025729","https://openalex.org/W4296759749"],"related_works":["https://openalex.org/W2519349109","https://openalex.org/W2277120524","https://openalex.org/W1993780955","https://openalex.org/W2067121616","https://openalex.org/W2010441033","https://openalex.org/W2095360998","https://openalex.org/W2545305028","https://openalex.org/W2523759117","https://openalex.org/W2162158185","https://openalex.org/W2057224622"],"abstract_inverted_index":{"Pathological":[0],"studies":[1,21],"have":[2,22],"determined":[3],"that":[4,180,194,232,264],"fibrillar":[5,190,234,269],"forms":[6],"of":[7,43,49,52,62,77,111,133,139,162,170,189,200,225,247,254],"amyloid-beta":[8],"protein":[9],"(Abeta)":[10],"comprise":[11],"the":[12,35,38,97,126,140,160,171,181,187,198,221,226,238,248],"characteristic":[13],"neuritic":[14],"plaques":[15,39],"in":[16,57,81,84,115,211,278],"Alzheimer's":[17],"disease":[18],"(AD).":[19],"These":[20],"also":[23],"revealed":[24],"significant":[25],"inflammatory":[26,68],"markers":[27],"such":[28,204],"as":[29,105,205],"activated":[30],"microglia":[31],"and":[32,83,244],"cytokines":[33],"surrounding":[34],"plaques.":[36],"Although":[37],"are":[40,46],"a":[41,74,106,129,275],"hallmark":[42],"AD,":[44],"they":[45],"only":[47],"part":[48],"an":[50,67,230,255,265],"array":[51],"Abeta":[53,64,78,91,131],"aggregate":[54],"morphologies":[55],"observed":[56],"vivo.":[58],"Interestingly,":[59],"not":[60,123],"all":[61],"these":[63],"deposits":[65],"provoke":[66],"response.":[69],"Since":[70],"structural":[71],"polymorphism":[72],"is":[73,271],"prominent":[75],"feature":[76],"aggregation":[79,94,173],"both":[80],"vitro":[82],"vivo,":[85],"we":[86],"sought":[87],"to":[88,153,219,240],"clarify":[89],"which":[90,163],"morphology":[92],"or":[93,196,209],"species":[95,257],"induces":[96],"strongest":[98],"proinflammatory":[99,259,276],"response":[100,184,277],"using":[101],"human":[102],"THP-1":[103,279],"monocytes":[104],"model":[107],"system.":[108],"An":[109],"aliquot":[110],"freshly":[112],"reconstituted":[113],"Abeta(1-42)":[114,172,201,227,249,268],"sterile":[116],"water":[117],"(100":[118],"microM,":[119],"pH":[120,214],"3.6)":[121],"did":[122],"effectively":[124],"stimulate":[125,220],"cells":[127],"at":[128,142,213],"final":[130],"concentration":[132],"15":[134],"microM.":[135],"However,":[136],"quiescent":[137],"incubation":[138],"peptide":[141,206],"4":[143],"degrees":[144],"C":[145],"for":[146,273],"48-96":[147],"h":[148],"greatly":[149],"enhanced":[150],"its":[151,217],"ability":[152,218,239],"induce":[154,241],"tumor":[155],"necrosis":[156],"factor-alpha":[157],"(TNFalpha)":[158],"production,":[159,243],"level":[161,199],"surprisingly":[164],"declined":[165],"upon":[166],"further":[167,252],"aggregation.":[168],"Imaging":[169],"solutions":[174],"with":[175,186,229,258],"atomic":[176],"force":[177],"microscopy":[178],"indicated":[179],"best":[182],"cellular":[183],"coincided":[185],"appearance":[188],"structures,":[191],"yet":[192],"conditions":[193],"accelerated":[195],"increased":[197],"fibril":[202],"formation":[203],"concentration,":[207],"temperature,":[208],"reconstitution":[210],"NaOH/PBS":[212],"7.4":[215],"diminished":[216],"cells.":[222],"Finally,":[223],"depletion":[224],"solution":[228,250],"antibody":[231],"recognizes":[233],"oligomers":[235],"dramatically":[236],"weakened":[237],"TNFalpha":[242],"size-exclusion":[245],"separation":[246],"provided":[251],"characterization":[253],"aggregated":[256],"activity.":[260],"The":[261],"findings":[262],"suggested":[263],"intermediate":[266],"stage":[267],"precursor":[270],"optimal":[272],"inducing":[274],"monocytes.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}