{"id":"https://openalex.org/W1995641125","doi":"https://doi.org/10.1111/j.1582-4934.2009.00955.x","title":"Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathway","display_name":"Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathway","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W1995641125","doi":"https://doi.org/10.1111/j.1582-4934.2009.00955.x","mag":"1995641125","pmid":"https://pubmed.ncbi.nlm.nih.gov/19874424","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3822745"},"language":"en","primary_location":{"id":"doi:10.1111/j.1582-4934.2009.00955.x","doi":"https://doi.org/10.1111/j.1582-4934.2009.00955.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2009.00955.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2009.00955.x","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2009.00955.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102799293","display_name":"Junhan Li","orcid":"https://orcid.org/0000-0001-7666-2404","observed_orcids":["https://orcid.org/0000-0001-7666-2404"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junhan Li","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe Miki-CHO, Kita-gun, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe Miki-CHO, Kita-gun, Kagawa, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056441333","display_name":"Koji Murao","orcid":"https://orcid.org/0000-0002-7335-7196","observed_orcids":["https://orcid.org/0000-0002-7335-7196"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Koji Murao","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe Miki-CHO, Kita-gun, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe Miki-CHO, Kita-gun, Kagawa, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024573727","display_name":"Hitomi Imachi","orcid":"https://orcid.org/0000-0002-2179-5039","observed_orcids":["https://orcid.org/0000-0002-2179-5039"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitomi Imachi","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe Miki-CHO, Kita-gun, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe Miki-CHO, Kita-gun, Kagawa, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037384250","display_name":"Hisashi Masugata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisashi Masugata","raw_affiliation_strings":["Department of Integrated Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Kagawa, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017566247","display_name":"Hisakazu Iwama","orcid":"https://orcid.org/0000-0003-3615-7846","observed_orcids":["https://orcid.org/0000-0003-3615-7846"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisakazu Iwama","raw_affiliation_strings":["Life Science Research Center, Kagawa University, Miki-cho, Kita-gun, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Science Research Center, Kagawa University, Miki-cho, Kita-gun, Kagawa, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036582762","display_name":"Satoshi Tada","orcid":"https://orcid.org/0000-0003-1883-3839","observed_orcids":["https://orcid.org/0000-0003-1883-3839"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Tada","raw_affiliation_strings":["Department of Laboratory Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Kagawa, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028159062","display_name":"Guo-Xing Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Guo-Xing Zhang","raw_affiliation_strings":["Department of Physiology II, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology II, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ryoji Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryoji Kobayashi","raw_affiliation_strings":["Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109070453","display_name":"Toshihiko Ishida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiko Ishida","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe Miki-CHO, Kita-gun, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe Miki-CHO, Kita-gun, Kagawa, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078658497","display_name":"Hiroshi Tokumitsu","orcid":"https://orcid.org/0000-0002-2193-6794","observed_orcids":["https://orcid.org/0000-0002-2193-6794"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Tokumitsu","raw_affiliation_strings":["Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa","institution_ids":["https://openalex.org/I201933988"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056441333"],"corresponding_institution_ids":["https://openalex.org/I201933988"],"apc_list":{"value":5210,"currency":"USD","value_usd":5210},"apc_paid":null,"fwci":0.9886,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.76977829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"5","first_page":"1083","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exendin-4","display_name":"exendin-4","score":1.0},{"id":"https://openalex.org/keywords/abca1","display_name":"ABCA1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/camkk","display_name":"CaMKK","score":0.7720000147819519},{"id":"https://openalex.org/keywords/camkiv","display_name":"CaMKIV","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.8029999732971191},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.6809999942779541},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7710000276565552},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/calcium-calmodulin-dependent-protein-kinase","display_name":"calcium/calmodulin-dependent protein kinase","score":0.7649999856948853},{"id":"https://openalex.org/keywords/sto-609","display_name":"STO-609","score":0.7799999713897705},{"id":"https://openalex.org/keywords/ins-1-cells","display_name":"INS-1 cells","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C2777704780","wikidata":"https://www.wikidata.org/wiki/Q21115210","display_name":"ABCA1","level":4,"score":0.7955915927886963},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5777022242546082},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5258023142814636},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5082446932792664},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.48474547266960144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47461119294166565},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45337340235710144},{"id":"https://openalex.org/C143937172","wikidata":"https://www.wikidata.org/wiki/Q303568","display_name":"Phosphoenolpyruvate carboxykinase","level":3,"score":0.4424762725830078},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4197882413864136},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3600292205810547},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2904263138771057},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17059558629989624},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14258044958114624},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.13210716843605042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0783199667930603}],"mesh":[{"descriptor_ui":"D000077270","descriptor_name":"Exenatide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014688","descriptor_name":"Venoms","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054734","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064286","descriptor_name":"ATP Binding Cassette Transporter 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1582-4934.2009.00955.x","doi":"https://doi.org/10.1111/j.1582-4934.2009.00955.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2009.00955.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2009.00955.x","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3359397","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3822745","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3822745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3822745","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Mol Med","raw_type":"Text"},{"id":"pmid:19874424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19874424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular and molecular medicine","raw_type":"Journal Article"},{"id":"mag:3145114356","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000512316","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1111/j.1582-4934.2009.00955.x","doi":"https://doi.org/10.1111/j.1582-4934.2009.00955.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2009.00955.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2009.00955.x","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1995641125.pdf"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1483911606","https://openalex.org/W1985105947","https://openalex.org/W1992898297","https://openalex.org/W2005766127","https://openalex.org/W2017518223","https://openalex.org/W2071014862","https://openalex.org/W2100025585","https://openalex.org/W2145824107","https://openalex.org/W2151101257","https://openalex.org/W2159205789"],"related_works":["https://openalex.org/W1964918526","https://openalex.org/W2014860490","https://openalex.org/W2808881593","https://openalex.org/W2162348697","https://openalex.org/W1822262068","https://openalex.org/W2134203514","https://openalex.org/W2136564386","https://openalex.org/W2098812327","https://openalex.org/W2981631448","https://openalex.org/W4390910847"],"abstract_inverted_index":{"ATP-binding":[0],"cassette":[1],"transporter":[2],"A1":[3],"(ABCA1)":[4],"in":[5,56,99,123,152,165,188,195],"pancreatic":[6,196],"beta":[7,197],"cells":[8,60,166],"influences":[9],"insulin":[10,189],"secretion":[11,190],"and":[12,191],"glucose":[13],"homeostasis.":[14],"This":[15],"study":[16],"investigates":[17],"whether":[18],"the":[19,23,40,78,81,124,172],"long-acting":[20],"agonist":[21],"of":[22,70,74,80,94,104,126,132,141,158,171],"glucagon-like":[24],"peptide":[25],"1,":[26],"namely":[27],"exendin-4,":[28],"which":[29],"mediates":[30],"stimulatory":[31],"effects":[32],"on":[33,89],"ABCA1":[34,47,90,95,115,149,159,178],"gene":[35,54,179],"expression,":[36],"could":[37],"interfere":[38],"with":[39,62,106,168],"Ca(2+)/calmodulin":[41],"(CaM)-dependent":[42],"protein":[43,96,160],"kinase":[44],"(CaMK)":[45],"cascade.":[46],"promoter":[48,116,150],"activity":[49,65,151],"was":[50,66,97,162],"examined":[51],"by":[52,68,175],"reporter":[53],"assay":[55],"rat":[57],"insulin-secreting":[58],"INS-1":[59,153],"incubated":[61],"exendin-4.":[63,144],"CaMKIV":[64,87,133],"assessed":[67],"detection":[69],"activation-loop":[71],"phosphorylation":[72,134],"(Thr(196))":[73],"CaMKIV.":[75],"We":[76],"investigated":[77],"influence":[79],"constitutively":[82],"active":[83],"form":[84],"(CaMKIVc)":[85],"or":[86,147],"knockdown":[88],"expression.":[91],"Increased":[92],"abundance":[93],"noted":[98],"response":[100],"to":[101,120,143],"rising":[102],"concentrations":[103],"exendin-4":[105,156,176,183],"maximum":[107],"induction":[108,157],"at":[109],"10":[110,139],"nM.":[111],"Exendin-4":[112],"also":[113],"stimulated":[114,177],"activity,":[117],"but":[118],"failed":[119],"do":[121],"so":[122],"presence":[125],"STO-609,":[127],"a":[128],"CaMKK":[129],"inhibitor.":[130],"Up-regulation":[131],"(at":[135],"Thr(196))":[136],"peaked":[137],"after":[138],"min.":[140],"exposure":[142],"CaMKIVc":[145],"enhanced":[146],"up-regulated":[148],"cells.":[154,198],"Furthermore,":[155],"expression":[161],"significantly":[163],"suppressed":[164],"treated":[167],"CaMKIV-siRNA.":[169],"Activation":[170],"CaMKK/CaMKIV":[173],"cascade":[174],"transcription,":[180],"indicating":[181],"that":[182],"plays":[184],"an":[185],"important":[186],"role":[187],"cholesterol":[192],"ester":[193],"content":[194]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}