{"id":"https://openalex.org/W1995627884","doi":"https://doi.org/10.1002/pmic.200800874","title":"Phosphoproteomic analysis of the human pathogen Trypanosoma cruzi at the epimastigote stage","display_name":"Phosphoproteomic analysis of the human pathogen Trypanosoma cruzi at the epimastigote stage","publication_year":2009,"publication_date":"2009-07-01","ids":{"openalex":"https://openalex.org/W1995627884","doi":"https://doi.org/10.1002/pmic.200800874","mag":"1995627884","pmid":"https://pubmed.ncbi.nlm.nih.gov/19579231","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2752742"},"language":"en","primary_location":{"id":"doi:10.1002/pmic.200800874","doi":"https://doi.org/10.1002/pmic.200800874","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pmic.200800874","pdf_url":null,"source":{"id":"https://openalex.org/S182655450","display_name":"PROTEOMICS","issn_l":"1615-9853","issn":["1615-9853","1615-9861"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2752742","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037253743","display_name":"Ernesto Satoshi Nakayasu","orcid":"https://orcid.org/0000-0002-4056-2695","observed_orcids":["https://orcid.org/0000-0002-4056-2695"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernesto S. Nakayasu","raw_affiliation_strings":["The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA","The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066823431","display_name":"Matthew R. Gaynor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R. Gaynor","raw_affiliation_strings":["The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072224258","display_name":"Tiago J. P. Sobreira","orcid":"https://orcid.org/0000-0002-0217-0084","observed_orcids":["https://orcid.org/0000-0002-0217-0084"]},"institutions":[{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Tiago J. P. Sobreira","raw_affiliation_strings":["Group of Computational Biology, Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), Sa\u0303o Paulo, SP, Brazil","Group of Computational Biology, Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group of Computational Biology, Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), Sa\u0303o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I4405258467"]},{"raw_affiliation_string":"Group of Computational Biology, Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101794167","display_name":"Jeremy A. Ross","orcid":"https://orcid.org/0000-0002-1790-0174","observed_orcids":["https://orcid.org/0000-0002-1790-0174"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy A. Ross","raw_affiliation_strings":["The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054601444","display_name":"Igor Correia de Almeida","orcid":"https://orcid.org/0000-0002-2443-8213","observed_orcids":["https://orcid.org/0000-0002-2443-8213"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Igor C. Almeida","raw_affiliation_strings":["The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA","institution_ids":["https://openalex.org/I164936912"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054601444"],"corresponding_institution_ids":["https://openalex.org/I164936912"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":4.2529,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.94092498,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"13","first_page":"3489","last_page":"3506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":1.0},{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"phosphoproteomics","score":0.9100000262260437},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/serine-threonine-phosphorylation","display_name":"serine/threonine phosphorylation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.8700000047683716},{"id":"https://openalex.org/keywords/phosphatase","display_name":"phosphatase","score":0.9539999961853027},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.828000009059906},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.8339999914169312},{"id":"https://openalex.org/keywords/parasite-physiology","display_name":"parasite physiology","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.7840524315834045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7226800918579102},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6615251302719116},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.6365194916725159},{"id":"https://openalex.org/C6675166","wikidata":"https://www.wikidata.org/wiki/Q7187538","display_name":"Phosphoproteomics","level":5,"score":0.5542998909950256},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5470325946807861},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.47076180577278137},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4600832462310791},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.4123355746269226},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.387276828289032},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.29604196548461914},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20944330096244812},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.0922011137008667},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005407","descriptor_name":"Flagella","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010768","descriptor_name":"Phosphoserine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016053","descriptor_name":"RNA, Protozoan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/pmic.200800874","doi":"https://doi.org/10.1002/pmic.200800874","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pmic.200800874","pdf_url":null,"source":{"id":"https://openalex.org/S182655450","display_name":"PROTEOMICS","issn_l":"1615-9853","issn":["1615-9853","1615-9861"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS","raw_type":"journal-article"},{"id":"pmid:19579231","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19579231","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteomics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2752742","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2752742","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Proteomics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2752742","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2752742","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Proteomics","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1340722568","display_name":"Border Biomedical Research Center","funder_award_id":"G12RR008124","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2671105022","display_name":"SCORE Program at The University of Texas at El Paso","funder_award_id":"S06GM008012","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5523074791","display_name":null,"funder_award_id":"5S06GM08012-37","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000036683","display_name":null,"funder_award_id":"5S06GM08012-37","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W86636718","https://openalex.org/W1119770864","https://openalex.org/W1494495256","https://openalex.org/W1518972222","https://openalex.org/W1892410119","https://openalex.org/W1967609695","https://openalex.org/W1970365407","https://openalex.org/W1974116356","https://openalex.org/W1991297784","https://openalex.org/W1997056666","https://openalex.org/W2002609852","https://openalex.org/W2004912026","https://openalex.org/W2007852796","https://openalex.org/W2009745787","https://openalex.org/W2013276329","https://openalex.org/W2021217831","https://openalex.org/W2021749857","https://openalex.org/W2021861756","https://openalex.org/W2023166266","https://openalex.org/W2026834239","https://openalex.org/W2033199777","https://openalex.org/W2041924725","https://openalex.org/W2043039488","https://openalex.org/W2047098445","https://openalex.org/W2053235121","https://openalex.org/W2060369427","https://openalex.org/W2063620211","https://openalex.org/W2064722724","https://openalex.org/W2071410887","https://openalex.org/W2075490509","https://openalex.org/W2076614415","https://openalex.org/W2076629995","https://openalex.org/W2079841403","https://openalex.org/W2081027140","https://openalex.org/W2081130105","https://openalex.org/W2083363252","https://openalex.org/W2089546334","https://openalex.org/W2092746438","https://openalex.org/W2101155271","https://openalex.org/W2101553897","https://openalex.org/W2102693496","https://openalex.org/W2104726963","https://openalex.org/W2107367762","https://openalex.org/W2110348183","https://openalex.org/W2113422555","https://openalex.org/W2126934950","https://openalex.org/W2127230663","https://openalex.org/W2129777487","https://openalex.org/W2136970996","https://openalex.org/W2149024161","https://openalex.org/W2150238266","https://openalex.org/W2155159495","https://openalex.org/W2159356176","https://openalex.org/W2163204288","https://openalex.org/W2165460636","https://openalex.org/W2167350014","https://openalex.org/W2169691209","https://openalex.org/W2424468219","https://openalex.org/W2911416752","https://openalex.org/W2984170037","https://openalex.org/W4211252435"],"related_works":["https://openalex.org/W142117187","https://openalex.org/W2081960629","https://openalex.org/W2966680788","https://openalex.org/W3013934900","https://openalex.org/W4396579453","https://openalex.org/W2078883698","https://openalex.org/W7139033183","https://openalex.org/W7100540751","https://openalex.org/W2135467990","https://openalex.org/W3016635439"],"abstract_inverted_index":{"Trypanosoma":[0],"cruzi":[1,74],"is":[2,41],"the":[3,25,49,53,57,118,167,181,185],"etiologic":[4],"agent":[5],"of":[6,12,30,48,56,70,120,184],"Chagas":[7],"disease,":[8],"which":[9],"affects":[10],"millions":[11],"people":[13],"in":[14,24,126,147,176,188],"Latin":[15],"America":[16],"and":[17,28,81,106,113,138,141,156,174,191],"has":[18,85],"become":[19],"a":[20,65],"public":[21],"health":[22],"concern":[23],"United":[26],"States":[27],"areas":[29],"Europe.":[31],"The":[32,129],"possibility":[33],"that":[34],"kinase":[35],"inhibitors":[36],"represent":[37],"novel":[38],"anti-parasitic":[39],"agents":[40],"currently":[42],"being":[43],"explored.":[44],"However,":[45],"fundamental":[46],"understanding":[47],"cell-signaling":[50],"networks":[51],"requires":[52],"detailed":[54],"analysis":[55,84,116],"involved":[58],"phosphorylated":[59],"proteins.":[60,92],"Here,":[61],"we":[62],"have":[63],"performed":[64],"comprehensive":[66],"MS-based":[67],"phosphorylation":[68,95],"mapping":[69],"phosphoproteins":[71,131,187],"from":[72,89],"T.":[73,127,177],"epimastigote":[75],"forms.":[76],"Our":[77],"LC-MS/MS,":[78],"dual-stage":[79],"fragmentation,":[80],"multistage":[82],"activation":[83],"identified":[86,130,186],"237":[87],"phosphopeptides":[88],"119":[90],"distinct":[91],"Furthermore,":[93],"220":[94],"sites":[96],"were":[97,132],"unambiguously":[98],"mapped:":[99],"148":[100],"on":[101,104,108,144],"serine,":[102],"57":[103],"threonine,":[105],"8":[107],"tyrosine.":[109],"In":[110],"addition,":[111],"immunoprecipitation":[112],"Western":[114],"blotting":[115],"confirmed":[117],"presence":[119],"at":[121],"least":[122],"seven":[123],"tyrosine-phosphorylated":[124],"proteins":[125],"cruzi.":[128,178],"subjected":[133],"to":[134],"Gene":[135],"Ontology,":[136],"InterPro,":[137],"BLAST":[139],"analysis,":[140],"categorized":[142],"based":[143],"their":[145],"role":[146],"cell":[148],"structure,":[149],"motility,":[150],"transportation,":[151],"metabolism,":[152],"pathogenesis,":[153],"DNA/RNA/protein":[154],"turnover,":[155],"signaling.":[157],"Taken":[158],"together,":[159],"our":[160],"phosphoproteomic":[161],"data":[162],"provide":[163],"new":[164],"insights":[165],"into":[166],"molecular":[168],"mechanisms":[169],"governed":[170],"by":[171],"protein":[172],"kinases":[173],"phosphatases":[175],"We":[179],"discuss":[180],"potential":[182],"roles":[183],"parasite":[189],"physiology":[190],"drug":[192],"development.":[193]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}