{"id":"https://openalex.org/W1995600224","doi":"https://doi.org/10.1089/aid.1995.11.335","title":"Increase in Sensitivity to Soluble CD4 by Primary HIV Type 1 Isolates after Passage through C8166 Cells: Association with Sequence Differences in the First Constant (C1) Region of Glycoprotein 120","display_name":"Increase in Sensitivity to Soluble CD4 by Primary HIV Type 1 Isolates after Passage through C8166 Cells: Association with Sequence Differences in the First Constant (C1) Region of Glycoprotein 120","publication_year":1995,"publication_date":"1995-03-01","ids":{"openalex":"https://openalex.org/W1995600224","doi":"https://doi.org/10.1089/aid.1995.11.335","mag":"1995600224","pmid":"https://pubmed.ncbi.nlm.nih.gov/7786580"},"language":"en","primary_location":{"id":"doi:10.1089/aid.1995.11.335","doi":"https://doi.org/10.1089/aid.1995.11.335","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.1995.11.335","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084243063","display_name":"Sherry L. Orloff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SHERRY L. ORLOFF","raw_affiliation_strings":["Immunology Branch, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Branch, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012262684","display_name":"CLAUDIU I. BANDEA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CLAUDIU I. BANDEA","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. SUSAN KENNEDY","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. SUSAN KENNEDY","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081463463","display_name":"Graham P. Allaway","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"GRAHAM P. ALLAWAY","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035255731","display_name":"Paul Jay Maddon","orcid":"https://orcid.org/0000-0002-2264-6270","observed_orcids":["https://orcid.org/0000-0002-2264-6270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PAUL J. MADDON","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111826368","display_name":"J. Steven McDougal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. STEVEN McDOUGAL","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1745,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.78282828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"3","first_page":"335","last_page":"342"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/soluble-cd4","display_name":"soluble CD4","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gp120","display_name":"gp120","score":0.656000018119812},{"id":"https://openalex.org/keywords/c8166-cells","display_name":"C8166 cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/virus-adaptation","display_name":"viral adaptation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/neutralization-resistance","display_name":"neutralization resistance","score":0.7749999761581421},{"id":"https://openalex.org/keywords/primary-hiv-1-isolates","display_name":"primary HIV-1 isolates","score":0.800000011920929},{"id":"https://openalex.org/keywords/limiting-dilution-cloning","display_name":"limiting dilution cloning","score":0.5049999952316284},{"id":"https://openalex.org/keywords/viral-sequence-variation","display_name":"viral sequence variation","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.6848037838935852},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5826506018638611},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5788838863372803},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5116091370582581},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49968791007995605},{"id":"https://openalex.org/C92825506","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Protein primary structure","level":4,"score":0.4686657190322876},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36581283807754517},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35506176948547363},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3356410562992096},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30229294300079346},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1422308385372162}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015726","descriptor_name":"Giant Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/aid.1995.11.335","doi":"https://doi.org/10.1089/aid.1995.11.335","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.1995.11.335","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},{"id":"pmid:7786580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7786580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS research and human retroviruses","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1521884339","https://openalex.org/W1522102057","https://openalex.org/W1580210412","https://openalex.org/W1591407811","https://openalex.org/W1627689349","https://openalex.org/W1723922714","https://openalex.org/W1773346304","https://openalex.org/W1828257538","https://openalex.org/W1876598876","https://openalex.org/W1895363198","https://openalex.org/W1896104373","https://openalex.org/W1928433960","https://openalex.org/W1933773138","https://openalex.org/W1935273093","https://openalex.org/W1948783050","https://openalex.org/W1966924896","https://openalex.org/W1971362909","https://openalex.org/W1982887925","https://openalex.org/W1983925230","https://openalex.org/W1986159600","https://openalex.org/W1991539551","https://openalex.org/W2021785678","https://openalex.org/W2022974362","https://openalex.org/W2032260999","https://openalex.org/W2064702350","https://openalex.org/W2069407559","https://openalex.org/W2071516463","https://openalex.org/W2078115409","https://openalex.org/W2083690910","https://openalex.org/W2090198182","https://openalex.org/W2097501261","https://openalex.org/W2104497833","https://openalex.org/W2128135205","https://openalex.org/W2152975649","https://openalex.org/W2168894864"],"related_works":["https://openalex.org/W1971362909","https://openalex.org/W1976950601","https://openalex.org/W2154240092","https://openalex.org/W2152975649","https://openalex.org/W1983925230","https://openalex.org/W1580210412","https://openalex.org/W1571147984","https://openalex.org/W2078115409","https://openalex.org/W1828257538","https://openalex.org/W2023966753"],"abstract_inverted_index":{"Primary":[0],"isolates":[1],"of":[2,13,84,90,92,102,106,128,148,170],"human":[3],"immunodeficiency":[4],"virus":[5,50],"type":[6],"1":[7],"(HIV-1)":[8],"were":[9,42,54,78,95,108,141],"obtained":[10],"by":[11,35,81],"coculture":[12],"peripheral":[14],"blood":[15],"lymphocytes":[16],"(PBLs)":[17],"from":[18,23,158],"HIV-1-infected":[19],"people":[20],"with":[21,69,138,185],"PBLs":[22],"uninfected":[24],"donors.":[25],"These":[26],"viral":[27,171],"stocks":[28,41,51,61,77],"tend":[29],"to":[30,33,56,110,151,161,168,188],"be":[31],"resistant":[32],"neutralization/inactivation":[34],"soluble":[36],"CD4":[37],"(sCD4).":[38],"When":[39],"these":[40],"passed":[43],"through":[44],"the":[45,100,120,131,143,159,162,166,174],"T":[46],"cell":[47],"line":[48],"C8166,":[49],"emerged":[52],"that":[53,136,177],"sensitive":[55,109],"sCD4.":[57,111,189],"Pre-":[58,74],"and":[59,65,75,113,156],"post-C8166":[60,76,103],"maintained":[62],"their":[63],"sCD4-resistant":[64,160],"-sensitive":[66],"phenotypes,":[67],"respectively,":[68],"further":[70],"passage":[71],"in":[72,119,142,153,173,182],"PBLs.":[73],"biologically":[79],"cloned":[80],"two":[82],"cycles":[83],"limiting":[85],"dilution.":[86],"The":[87,133],"majority":[88,101],"(14":[89],"17)":[91],"pre-C8166":[93,175],"clones":[94,104],"sCD4":[96],"resistant,":[97],"and,":[98],"conversely,":[99],"(11":[105],"12)":[107],"Nucleotide":[112],"predicted":[114],"amino":[115],"acid":[116],"sequence":[117],"analysis":[118],"env":[121],"(gp120)":[122],"region":[123,147],"revealed":[124],"a":[125,179],"limited":[126],"number":[127],"differences":[129,135],"between":[130],"clones.":[132],"only":[134],"sorted":[137],"biological":[139],"phenotype":[140,164],"first":[144],"constant":[145],"(C1)":[146],"gp120.":[149],"Adaptation":[150],"growth":[152],"C8166":[154,183],"cells":[155],"conversion":[157],"sCD4-sensitive":[163],"represent":[165],"emergence":[167],"prominence":[169],"species":[172],"stock":[176],"have":[178],"replication":[180],"advantage":[181],"coincident":[184],"increased":[186],"sensitivity":[187]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
