{"id":"https://openalex.org/W1995599094","doi":"https://doi.org/10.1073/pnas.86.15.5849","title":"Cellular responses to Pyrularia thionin are mediated by Ca2+ influx and phospholipase A2 activation and are inhibited by thionin tyrosine iodination.","display_name":"Cellular responses to Pyrularia thionin are mediated by Ca2+ influx and phospholipase A2 activation and are inhibited by thionin tyrosine iodination.","publication_year":1989,"publication_date":"1989-08-01","ids":{"openalex":"https://openalex.org/W1995599094","doi":"https://doi.org/10.1073/pnas.86.15.5849","mag":"1995599094","pmid":"https://pubmed.ncbi.nlm.nih.gov/2503825","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/297728"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.86.15.5849","doi":"https://doi.org/10.1073/pnas.86.15.5849","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.86.15.5849","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/297728","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Evans","raw_affiliation_strings":["Department of Chemistry, Brigham Young University, Provo, UT 84602"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brigham Young University, Provo, UT 84602","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y D Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y D Wang","raw_affiliation_strings":["Department of Chemistry, Brigham Young University, Provo, UT 84602"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brigham Young University, Provo, UT 84602","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039954083","display_name":"K P Shaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]},{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K P Shaw","raw_affiliation_strings":["Department of Chemistry, Brigham Young University, Provo, UT 84602","tDepartment of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brigham Young University, Provo, UT 84602","institution_ids":["https://openalex.org/I100005738"]},{"raw_affiliation_string":"tDepartment of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111523486","display_name":"Leo P. Vernon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L P Vernon","raw_affiliation_strings":["Department of Chemistry, Brigham Young University, Provo, UT 84602"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brigham Young University, Provo, UT 84602","institution_ids":["https://openalex.org/I100005738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5267,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.91849634,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"86","issue":"15","first_page":"5849","last_page":"5853"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thionin","display_name":"thionin","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pyrularia-pubera","display_name":"Pyrularia pubera","score":0.9259999990463257},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.7879999876022339},{"id":"https://openalex.org/keywords/phospholipase-a2-activation","display_name":"phospholipase A2 activation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.800000011920929},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/membrane-depolarization","display_name":"membrane depolarization","score":0.9679999947547913},{"id":"https://openalex.org/keywords/calcium-channels","display_name":"calcium channels","score":0.5370000004768372},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":0.6610000133514404},{"id":"https://openalex.org/keywords/nickel-inhibition","display_name":"nickel inhibition","score":0.6140000224113464},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.7369999885559082},{"id":"https://openalex.org/keywords/quinacrine","display_name":"quinacrine","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hepatocyte-viability","display_name":"hepatocyte viability","score":0.7289999723434448},{"id":"https://openalex.org/keywords/lymphocyte-viability","display_name":"lymphocyte viability","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mouse-lethality","display_name":"mouse lethality","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.8167995810508728},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.7376473546028137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5577210783958435},{"id":"https://openalex.org/C2776551241","wikidata":"https://www.wikidata.org/wiki/Q24768001","display_name":"Phospholipase A2","level":3,"score":0.508784830570221},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4686673879623413},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4371117055416107},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.43276792764663696},{"id":"https://openalex.org/C97664909","wikidata":"https://www.wikidata.org/wiki/Q24723833","display_name":"Myotoxin","level":4,"score":0.4137153923511505},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3876160979270935},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3177594542503357},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19101369380950928},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007454","descriptor_name":"Iodides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010740","descriptor_name":"Phospholipases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011796","descriptor_name":"Quinacrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.86.15.5849","doi":"https://doi.org/10.1073/pnas.86.15.5849","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.86.15.5849","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:297728","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/297728","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:2503825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2503825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:297728","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/297728","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G486208270","display_name":null,"funder_award_id":"NS 25296","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320309309","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320338415","display_name":"U.S. Army Medical Research and Development Command","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1512797429","https://openalex.org/W1811451239","https://openalex.org/W1975989818","https://openalex.org/W1978770531","https://openalex.org/W1994334416","https://openalex.org/W1996024251","https://openalex.org/W1999134056","https://openalex.org/W2012080746","https://openalex.org/W2018393723","https://openalex.org/W2023986134","https://openalex.org/W2037997397","https://openalex.org/W2040577840","https://openalex.org/W2050407053","https://openalex.org/W2055131405","https://openalex.org/W2069800646","https://openalex.org/W2072482644","https://openalex.org/W2077384220","https://openalex.org/W2085485991","https://openalex.org/W2092930692","https://openalex.org/W2093036682","https://openalex.org/W2120590897","https://openalex.org/W2127292160","https://openalex.org/W2141260882","https://openalex.org/W2156565513","https://openalex.org/W2315769172","https://openalex.org/W2317175907","https://openalex.org/W2398660514"],"related_works":["https://openalex.org/W1976748412","https://openalex.org/W2128394337","https://openalex.org/W2033641814","https://openalex.org/W1999134056","https://openalex.org/W2058202280","https://openalex.org/W2027909218","https://openalex.org/W1994231550","https://openalex.org/W2023224340","https://openalex.org/W2620256364","https://openalex.org/W2523155969"],"abstract_inverted_index":{"Pyrularia":[0,6,51,144,191,250,292],"thionin,":[1],"isolated":[2],"from":[3],"nuts":[4],"of":[5,13,23,54,58,78,102,113,121,128,138,143,151,170,187,227,247,263,270,277,284,291,299,314,319],"pubera,":[7],"is":[8,266],"a":[9,99,148,195,253,260,267,296],"strongly":[10],"basic":[11],"peptide":[12,315,321],"47":[14],"amino":[15,18],"acids.":[16],"The":[17,163,222,244],"acid":[19],"sequence":[20],"and":[21,37,44,70,81,88,126,159,168,179,214,230,240,259,286],"configuration":[22],"its":[24],"four":[25],"disulfide":[26],"bonds":[27],"place":[28],"this":[29],"plant":[30],"peptide,":[31],"known":[32],"to":[33,95,147,249,257,295],"be":[34],"hemolytic,":[35],"cytotoxic,":[36],"neurotoxic,":[38],"among":[39],"the":[40,176,282,320],"thionins.":[41],"We":[42],"report":[43],"compare":[45],"several":[46],"cellular":[47,302,323],"responses":[48,93],"mediated":[49,164],"by":[50,84,109,119,135,182,190,201,234],"thionin:":[52],"hemolysis":[53,280],"human":[55],"erythrocytes,":[56,285],"activation":[57,211,269],"an":[59,306],"endogenous":[60],"phospholipase":[61,155,209,271],"A2":[62,156,210,272],"in":[63,75,90,161,175,275,281,311],"Swiss":[64],"3T3":[65],"cells,":[66],"cytotoxicity":[67],"toward":[68],"HeLa":[69],"mouse":[71,105,114],"B16":[72],"melanoma":[73],"cells":[74,107,172,248],"culture,":[76],"viability":[77,226],"rat":[79,228],"hepatocytes":[80,229],"lymphocytes":[82,232],"measured":[83,108,118,233],"trypan":[85,235],"blue":[86,236],"exclusion,":[87],"lethality":[89,160],"mice.":[91,162],"Cellular":[92],"related":[94,149,268],"ion":[96],"movement":[97],"include":[98],"toxin-mediated":[100],"influx":[101,166,262],"Ca2+":[103,165,174,197],"into":[104,167],"P388":[106,115,171],"Fura-2":[110],"fluorescence,":[111],"depolarization":[112,127,169,206,258],"plasma":[116],"membrane":[117,139,254,278],"fluorescence":[120],"bis(1,3-diethylthiobarbituric":[122],"acid)trimethine":[123],"oxonol":[124],"(bisoxonol),":[125],"frog":[129],"(Rana":[130],"pipiens)":[131],"sartorius":[132,188],"muscle":[133,189,205],"determined":[134],"direct":[136],"measurement":[137],"potential.":[140],"Graded":[141],"iodination":[142],"thionin":[145,192,251,293],"leads":[146,294],"loss":[150,276],"activity":[152],"for":[153,225,309],"hemolysis,":[154],"activation,":[157],"cytotoxicity,":[158],"require":[173],"external":[177],"medium":[178],"are":[180],"inhibited":[181],"100":[183],"microM":[184],"Ni2+.":[185],"Depolarization":[186],"also":[193,207],"requires":[194],"functional":[196],"channel,":[198],"as":[199],"shown":[200],"verapamil":[202],"inhibition.":[203],"This":[204],"involves":[208,252],"because":[212],"dexamethasone":[213],"quinacrin,":[215],"but":[216],"not":[217],"indomethacin,":[218],"protect":[219],"against":[220],"depolarization.":[221],"IC50":[223],"values":[224],"splenic":[231],"exclusion":[237],"were":[238],"0.17":[239],"40":[241],"microM,":[242],"respectively.":[243],"general":[245],"response":[246],"alteration":[255],"leading":[256],"channel-mediated":[261],"Ca2+.":[264],"There":[265],"that":[273],"results":[274],"integrity,":[279],"case":[283],"eventually":[287],"cell":[288],"death.":[289],"Iodination":[290],"corresponding":[297],"inhibition":[298],"all":[300],"three":[301],"responses,":[303],"which":[304],"indicates":[305],"essential":[307],"role":[308],"tyrosine":[310],"either":[312],"maintenance":[313],"structure":[316],"or":[317],"interaction":[318],"with":[322],"membranes.":[324]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
