{"id":"https://openalex.org/W1995542407","doi":"https://doi.org/10.1254/jjp.30.587","title":"Effects of Polyamines on Ethylmorphine N-Demethylation in Rat Liver Microsomes","display_name":"Effects of Polyamines on Ethylmorphine N-Demethylation in Rat Liver Microsomes","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W1995542407","doi":"https://doi.org/10.1254/jjp.30.587","mag":"1995542407","pmid":"https://pubmed.ncbi.nlm.nih.gov/7206368"},"language":"en","primary_location":{"id":"doi:10.1254/jjp.30.587","doi":"https://doi.org/10.1254/jjp.30.587","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.30.587","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1254/jjp.30.587","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112177400","display_name":"Mitsukazu Kitada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsukazu Kitada","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Chiba 280, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Chiba 280, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033544033","display_name":"Naoko Yamaguchi","orcid":"https://orcid.org/0000-0002-6042-3529","observed_orcids":["https://orcid.org/0000-0002-6042-3529"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoko Yamaguchi","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Chiba 280, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Chiba 280, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049477700","display_name":"Kazuei Igarashi","orcid":"https://orcid.org/0000-0003-3751-3187","observed_orcids":["https://orcid.org/0000-0003-3751-3187"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuei Igarashi","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Chiba 280, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Chiba 280, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100856393","display_name":"Seiyu Hirose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiyu Hirose","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Chiba 280, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Chiba 280, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103936635","display_name":"Haruo Kitagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruo Kitagawa","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Chiba 280, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Chiba 280, Japan","institution_ids":["https://openalex.org/I159385669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I159385669"],"apc_list":null,"apc_paid":null,"fwci":1.9682,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.83988764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"5","first_page":"579","last_page":"586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6425999999046326,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6425999999046326,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.17579999566078186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyamines","display_name":"polyamines","score":0.984000027179718},{"id":"https://openalex.org/keywords/ethylmorphine","display_name":"ethylmorphine","score":0.9779999852180481},{"id":"https://openalex.org/keywords/n-demethylation","display_name":"N-demethylation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.6769999861717224},{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.9049999713897705},{"id":"https://openalex.org/keywords/diltiazem","display_name":"diltiazem","score":0.8399999737739563},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":1.0},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/conduction-delay","display_name":"conduction delay","score":0.8259999752044678},{"id":"https://openalex.org/keywords/his-bundle-electrogram","display_name":"His bundle electrogram","score":0.7179999947547913},{"id":"https://openalex.org/keywords/coronary-artery-occlusion","display_name":"coronary artery occlusion","score":0.6790000200271606},{"id":"https://openalex.org/keywords/rate-dependent-effects","display_name":"rate-dependent effects","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6496326923370361},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6241230368614197},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.6197580695152283},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5882022976875305},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.5579782128334045},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.5528249740600586},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5148307681083679},{"id":"https://openalex.org/C2780393670","wikidata":"https://www.wikidata.org/wiki/Q5172192","display_name":"Coronary occlusion","level":3,"score":0.49264365434646606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48871588706970215},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.18986693024635315}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004110","descriptor_name":"Diltiazem","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1254/jjp.30.587","doi":"https://doi.org/10.1254/jjp.30.587","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.30.587","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:7206368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7206368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1254/jjp.30.587","doi":"https://doi.org/10.1254/jjp.30.587","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.30.587","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W594429199","https://openalex.org/W1488511002","https://openalex.org/W1506421347","https://openalex.org/W1509553808","https://openalex.org/W1582769766","https://openalex.org/W1775749144","https://openalex.org/W1806194750","https://openalex.org/W1903873355","https://openalex.org/W1967351015","https://openalex.org/W1971054363","https://openalex.org/W1980312012","https://openalex.org/W1981035503","https://openalex.org/W1985693949","https://openalex.org/W1990495882","https://openalex.org/W1990887394","https://openalex.org/W1991234761","https://openalex.org/W2003531120","https://openalex.org/W2006038658","https://openalex.org/W2019027868","https://openalex.org/W2022961147","https://openalex.org/W2027454878","https://openalex.org/W2030246185","https://openalex.org/W2034950651","https://openalex.org/W2039936959","https://openalex.org/W2045954035","https://openalex.org/W2047249729","https://openalex.org/W2054128402","https://openalex.org/W2054173924","https://openalex.org/W2057494612","https://openalex.org/W2064914737","https://openalex.org/W2067502480","https://openalex.org/W2070026301","https://openalex.org/W2071941669","https://openalex.org/W2079089904","https://openalex.org/W2080258103","https://openalex.org/W2087494973","https://openalex.org/W2089997793","https://openalex.org/W2091660788","https://openalex.org/W2103145034","https://openalex.org/W2105331834","https://openalex.org/W2116323054","https://openalex.org/W2124743911","https://openalex.org/W2125550345","https://openalex.org/W2137605514","https://openalex.org/W2156444959","https://openalex.org/W2166382926","https://openalex.org/W2168526937","https://openalex.org/W2185850763","https://openalex.org/W2303023250","https://openalex.org/W2312637771","https://openalex.org/W2331435706","https://openalex.org/W2417297007","https://openalex.org/W2420857390","https://openalex.org/W6698065943"],"related_works":["https://openalex.org/W2041094662","https://openalex.org/W2410425318","https://openalex.org/W2051413992","https://openalex.org/W2017093590","https://openalex.org/W1964926866","https://openalex.org/W194135747","https://openalex.org/W2228657312","https://openalex.org/W2050679585","https://openalex.org/W2072544783","https://openalex.org/W2053457228"],"abstract_inverted_index":{"Effects":[0],"of":[1,30,52,64,114,197],"calcium":[2],"antagonists":[3],"and":[4,72,110,145,164],"lidocaine":[5,115],"on":[6,55,100],"the":[7,12,31,49,56,61,65,70,86,101,125,151,183,188,194],"conduction":[8,44,83,106,129,153,184],"delay":[9,84,107,130,154,185],"observed":[10],"in":[11,17,85,191],"ischemic":[13,71,87],"myocardium":[14],"were":[15],"studied":[16],"24":[18],"open-chest":[19],"anesthetized":[20],"dogs.":[21],"Acute":[22],"myocardial":[23,189],"ischemia":[24],"was":[25,46,108],"produced":[26,82],"by":[27,131,155,187],"complete":[28],"occlusion":[29,81,127],"left":[32],"anterior":[33],"descending":[34],"coronary":[35],"artery":[36],"(LAD)":[37],"for":[38],"5":[39],"to":[40,60,124],"10":[41],"minutes.":[42],"The":[43],"time":[45],"measured":[47],"from":[48,69],"initial":[50],"deflection":[51,63],"V":[53],"waves":[54],"His":[57],"bundle":[58],"electrograms":[59,67],"major":[62],"bipolar":[66],"recorded":[68],"non-ischemic":[73],"subepicardium":[74],"under":[75],"a":[76],"constant":[77,121],"atrial":[78],"pacing.":[79],"LAD":[80],"zone":[88],"(14.3":[89],"+/-":[90,133,157,166],"2.3":[91],"msec,":[92],"p":[93],"less":[94,137,161,170],"than":[95,138,162,171],"0.001)":[96,139],"with":[97,193],"no":[98],"effect":[99,196],"normal":[102],"zone.":[103],"This":[104],"ischemia-induced":[105,152],"reversible":[109],"rate-dependently":[111],"increased.":[112],"Administration":[113],"(2":[116],"mg/kg":[117,143,148],"bolus,":[118],"4.3":[119],"mg/kg/hr":[120],"infusion)":[122],"prior":[123],"second":[126],"increased":[128],"12.9":[132],"1.9":[134],"msec":[135,159,168],"(p":[136,160,169],"whereas":[140],"diltiazem":[141],"(0.4":[142],"i.v.)":[144,149],"verapamil":[146],"(0.3":[147],"reduced":[150],"12.7":[156],"4.9":[158],"0.05)":[163],"8.4":[165],"1.8":[167],"0.001),":[172],"respectively.":[173],"These":[174],"results":[175],"indicate":[176],"that":[177],"slow":[178],"channel":[179],"blocking":[180],"agents":[181],"reduce":[182],"induced":[186],"ischemia,":[190],"contrast":[192],"prolonging":[195],"lidocaine.":[198]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
