{"id":"https://openalex.org/W1995499341","doi":"https://doi.org/10.1021/jm00152a013","title":"Antiarrhythmic activity of 17.beta.-aminoestratrienes. Comparison of 3-ols and 3-acetates with the corresponding 3-(3-amino-2-hydroxypropyl) ethers","display_name":"Antiarrhythmic activity of 17.beta.-aminoestratrienes. Comparison of 3-ols and 3-acetates with the corresponding 3-(3-amino-2-hydroxypropyl) ethers","publication_year":1986,"publication_date":"1986-02-01","ids":{"openalex":"https://openalex.org/W1995499341","doi":"https://doi.org/10.1021/jm00152a013","mag":"1995499341","pmid":"https://pubmed.ncbi.nlm.nih.gov/3005568"},"language":"en","primary_location":{"id":"doi:10.1021/jm00152a013","doi":"https://doi.org/10.1021/jm00152a013","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00152a013","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002989374","display_name":"John K. Campbell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. K. Campbell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081071528","display_name":"Robert T. Logan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. T. Logan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035160663","display_name":"Richard Marshall","orcid":"https://orcid.org/0000-0001-8278-167X","observed_orcids":["https://orcid.org/0000-0001-8278-167X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. J. Marshall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085886489","display_name":"George McGarry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. McGarry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077431394","display_name":"Thomas Sleigh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Sleigh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110078084","display_name":"EILEEN WINSLOW","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Winslow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.3649,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.62296053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"29","issue":"2","first_page":"244","last_page":"250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13185","display_name":"Phytochemistry and Bioactive Compounds","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiarrhythmic-activity","display_name":"antiarrhythmic activity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/aconitine-induced-arrhythmia","display_name":"aconitine-induced arrhythmia","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ischemia-induced-arrhythmia","display_name":"ischemia-induced arrhythmia","score":0.9470000267028809},{"id":"https://openalex.org/keywords/atrial-arrhythmias","display_name":"atrial arrhythmias","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"cardiac electrophysiology","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9386522769927979},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5970814228057861},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4102204144001007},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3636879324913025},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004963","descriptor_name":"Estrenes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004963","descriptor_name":"Estrenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011217","descriptor_name":"Practolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011405","descriptor_name":"Propafenone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011427","descriptor_name":"Propiophenones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm00152a013","doi":"https://doi.org/10.1021/jm00152a013","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00152a013","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:3005568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3005568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2952039694","https://openalex.org/W2412804454","https://openalex.org/W2904919658","https://openalex.org/W2020623687","https://openalex.org/W1995809214","https://openalex.org/W2086017613","https://openalex.org/W2002967053","https://openalex.org/W1993375282","https://openalex.org/W2032392383","https://openalex.org/W2472625815"],"abstract_inverted_index":{"The":[0],"antiarrhythmic":[1,41,90,122],"efficacy":[2,18],"of":[3,19,60,71,111,159],"17":[4,7],"beta-amino-":[5],"and":[6,10,22,49,54,100,103,123],"beta-amino-16":[8],"alpha-hydroxyestratrien-3-ols":[9],"3-acetates":[11],"(group":[12,25],"1)":[13],"was":[14,155],"compared":[15],"with":[16,32],"the":[17,56,80,98,151,160,170],"corresponding":[20],"3-[2-hydroxy-3-(isopropylamino)propyl]":[21],"3-[2-hydroxy-3-(tert-butylamino)propyl]":[23],"ethers":[24],"II),":[26],"substituents":[27],"which":[28,144],"are":[29],"usually":[30],"associated":[31],"beta-adrenoceptor":[33,124,141],"blocking":[34,125,142],"activity.":[35,114],"Group":[36,92,132],"I":[37,89,113,121,137],"compounds":[38,94],"exerted":[39,139],"potent":[40],"activity":[42,149],"against":[43,129],"both":[44,119],"aconitine-induced":[45],"arrhythmias":[46,51],"in":[47,52,85,97,150],"mice":[48],"ischemia-induced":[50,130],"rats":[53],"reduced":[55],"maximum":[57],"following":[58],"frequency":[59],"isolated":[61],"guinea":[62],"pig":[63],"atria.":[64],"Electrophysiological":[65],"studies":[66,105],"indicated":[67],"that":[68,107,157],"their":[69,148],"mechanism":[70],"action":[72],"is":[73],"due":[74],"to":[75,78],"an":[76],"ability":[77],"reduce":[79],"fast":[81],"inward":[82],"sodium":[83],"current":[84],"cardiac":[86],"cells":[87],"(class":[88],"action).":[91],"II":[93,133],"were":[95,109,127],"inactive":[96],"aconitine":[99],"atrial":[101],"tests":[102],"electrophysiological":[104],"confirmed":[106],"they":[108],"devoid":[110],"class":[112,120],"However,":[115],"these":[116],"compounds,":[117,134,138],"like":[118],"drugs,":[126],"active":[128],"arrhythmias.":[131],"unlike":[135],"group":[136,163],"nonspecific":[140],"actions,":[143],"may":[145],"account":[146],"for":[147],"rat":[152],"test.":[153],"It":[154],"concluded":[156],"introduction":[158],"3-substituted":[161],"ether":[162],"did":[164],"not":[165],"confer":[166],"any":[167],"advantage":[168],"over":[169],"parent":[171],"3-ol":[172],"or":[173],"3-acetate":[174],"compounds.":[175]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
